2024
A kidney-hypothalamus axis promotes compensatory glucose production in response to glycosuria
Faniyan T, Zhang X, Morgan D, Robles J, Bathina S, Brookes P, Rahmouni K, Perry R, Chhabra K. A kidney-hypothalamus axis promotes compensatory glucose production in response to glycosuria. ELife 2024, 12 DOI: 10.7554/elife.91540.4.Peer-Reviewed Original ResearchGlucose productionEndogenous glucose productionReabsorption of nutrientsLoss of glucoseHypothalamic-pituitary-adrenal axisNormal energy supplyProteomic analysisCompensatory increaseAfferent renal nervesAfferent renal denervationPlasma proteomic analysisDefense mechanismsAcute phase proteinsRenal denervationKO miceSGLT2 inhibitorsKnockout miceRenal nervesAfferent nervesEfficiency of drugsBody's defense mechanismsGlycosuriaGlucosePhase proteinsTreat hyperglycemia
2022
Central Gαi2 Protein Mediated Neuro-Hormonal Control of Blood Pressure and Salt Sensitivity
Amraei R, Moreira J, Wainford R. Central Gαi2 Protein Mediated Neuro-Hormonal Control of Blood Pressure and Salt Sensitivity. Frontiers In Endocrinology 2022, 13: 895466. PMID: 35837296, PMCID: PMC9275552, DOI: 10.3389/fendo.2022.895466.Peer-Reviewed Original ResearchConceptsDietary sodium intakeG protein-coupled receptorsParaventricular nucleusBlood pressureSodium intakeElectrolyte homeostasisCentral angiotensin II type 1 receptorsAcute isotonic volume expansionAngiotensin II type 1 receptorII type 1 receptorSalt sensitivityMajor public health issueAcute pharmacological activationAfferent renal nervesNeuro-hormonal responseSalt-sensitive animalsDevelopment of hypertensionSalt-resistant ratsIsotonic volume expansionHypothalamic paraventricular nucleusMultiple G protein-coupled receptorsType 1 receptorNeuro-hormonal controlGαi/oPublic health issue
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