2015
Impact of obstructive sleep apnea and continuous positive airway pressure therapy on outcomes in patients with atrial fibrillation—Results from the Outcomes Registry for Better Informed Treatment of Atrial Fibrillation (ORBIT-AF)
Holmqvist F, Guan N, Zhu Z, Kowey PR, Allen LA, Fonarow GC, Hylek EM, Mahaffey KW, Freeman JV, Chang P, Holmes DN, Peterson ED, Piccini JP, Gersh BJ, Investigators O. Impact of obstructive sleep apnea and continuous positive airway pressure therapy on outcomes in patients with atrial fibrillation—Results from the Outcomes Registry for Better Informed Treatment of Atrial Fibrillation (ORBIT-AF). American Heart Journal 2015, 169: 647-654.e2. PMID: 25965712, DOI: 10.1016/j.ahj.2014.12.024.Peer-Reviewed Original ResearchConceptsObstructive sleep apneaBetter Informed TreatmentAtrial fibrillationOutcomes RegistrySleep apneaHigh riskStroke/transient ischemic attackContinuous positive airway pressure (CPAP) treatmentContinuous positive airway pressure therapyPrevalence of OSAInformed TreatmentImpact of OSAPositive airway pressure therapyPositive airway pressure treatmentAF progression rateHierarchical logistic regression modelingMajor cardiovascular outcomesRhythm control therapyAirway pressure therapyTransient ischemic attackLong-term outcomesRisk of deathLogistic regression modelingMore persistent formsCV death
2008
Sleep-Disordered Breathing in Children With Metabolic Syndrome: The Role of Leptin and Sympathetic Nervous System Activity and the Effect of Continuous Positive Airway Pressure
Nakra N, Bhargava S, Dzuira J, Caprio S, Bazzy-Asaad A. Sleep-Disordered Breathing in Children With Metabolic Syndrome: The Role of Leptin and Sympathetic Nervous System Activity and the Effect of Continuous Positive Airway Pressure. 2008, 122: e634-e642. PMID: 18762497, PMCID: PMC5117807, DOI: 10.1542/peds.2008-0154.Peer-Reviewed Original ResearchConceptsContinuous positive airway pressureSleep-disordered breathingSympathetic nervous system activityPositive airway pressureNervous system activityWhole-body insulin sensitivityMetabolic syndromeAirway pressureLeptin levelsInsulin sensitivitySystem activityExact testContinuous positive airway pressure (CPAP) treatmentPositive airway pressure treatmentC-reactive protein levelsOral glucose tolerance testGlucose tolerance testRole of leptinBMI z-scoreFisher's exact testOvernight polysomnographyBreathing groupMetabolic derangementsInsulin resistanceSleep Questionnaire
2003
Morbidity and mortality in obstructive sleep apnea syndrome 1: Effect of treatment on cardiovascular morbidity
Shepertycky M, AL‐BARRAK M, KRYGER M. Morbidity and mortality in obstructive sleep apnea syndrome 1: Effect of treatment on cardiovascular morbidity. Sleep And Biological Rhythms 2003, 1: 15-28. DOI: 10.1046/j.1446-9235.2003.00003.x.Peer-Reviewed Original ResearchObstructive sleep apnea syndromeSevere cardiovascular outcomesCongestive heart failureIschemic heart diseaseCardiovascular morbidityHeart failureCardiovascular outcomesPulmonary hypertensionSystemic hypertensionHeart diseaseCardiac arrhythmiasContinuous positive airway pressure (CPAP) treatmentPositive airway pressure treatmentOngoing population-based studyLarge ongoing trialsUntreated OSAS patientsIndependent risk factorDevelopment of hypertensionEpisodes of apneaSleep apnea syndromePopulation-based studyEffect of treatmentNocturnal hypoxemiaOSA patientsOSAS patients
1999
Quality of Life in Patients with Obstructive Sleep Apnea Effect of Nasal Continuous Positive Airway Pressure—A Prospective Study
D’Ambrosio C, Bowman T, Mohsenin V. Quality of Life in Patients with Obstructive Sleep Apnea Effect of Nasal Continuous Positive Airway Pressure—A Prospective Study. CHEST Journal 1999, 115: 123-129. PMID: 9925072, DOI: 10.1378/chest.115.1.123.Peer-Reviewed Original ResearchConceptsObstructive sleep apneaQuality of lifeMental healthMedical Outcomes Study Short Form-36 questionnaireNasal continuous positive airway pressure treatmentEffect of OSAContinuous positive airway pressure (CPAP) treatmentNasal continuous positive airway pressureDiagnosis of OSASocial functioningPositive airway pressure treatmentContinuous positive airway pressureShort Form-36 questionnaireEffect of nCPAPPositive airway pressureRespiratory disturbance indexSleep-disordered breathingBody mass indexEvents/hGender-matched populationCase series analysisSeverity of diseaseMagnitude of improvementNCPAP levelNCPAP therapy
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