2025
The Molecular Basis of Polycystic Ovary Syndrome and Its Cardiometabolic Correlates: Exploring the Intersection and Its Clinical Implications—A Narrative Review
Mahabamunuge J, Sekula N, Lepore C, Kudrimoti M, Upadhyay A, Alshowaikh K, Li H, Seifer D, AlAshqar A. The Molecular Basis of Polycystic Ovary Syndrome and Its Cardiometabolic Correlates: Exploring the Intersection and Its Clinical Implications—A Narrative Review. Biomedicines 2025, 13: 709. PMID: 40149685, PMCID: PMC11940587, DOI: 10.3390/biomedicines13030709.Peer-Reviewed Original ResearchPolycystic ovary syndromeType 2 diabetes mellitusCardiometabolic morbidityIncreased cardiovascular riskDevelopment of hypertensionCardiovascular risk factorsNarrative reviewPotential clinical implicationsAndrogen excessEndothelial dysfunctionCardiovascular riskClinical conditionsPredisposed individualsTherapeutic strategiesAdipokine secretionRisk factorsInsulin resistanceCardiometabolic diseasesCardiovascular diseaseClinical implicationsMorbidityMellitusSyndromeMolecular mechanismsDisease
2024
Effects of Sodium-Glucose Cotransporter-2 Inhibitors on Kidney Outcomes across Baseline Cardiovascular-Kidney-Metabolic Conditions
Siddiqi T, Cherney D, Siddiqui H, Jafar T, Januzzi J, Khan M, Levin A, Marx N, Rangaswami J, Testani J, Usman M, Wanner C, Zannad F, Butler J. Effects of Sodium-Glucose Cotransporter-2 Inhibitors on Kidney Outcomes across Baseline Cardiovascular-Kidney-Metabolic Conditions. Journal Of The American Society Of Nephrology 2024, 36: 242-255. PMID: 39230974, PMCID: PMC11801753, DOI: 10.1681/asn.0000000000000491.Peer-Reviewed Original ResearchSodium-glucose cotransporter-2 inhibitorsType 2 diabetes mellitusChronic kidney diseaseEffects of sodium-glucose cotransporter-2 inhibitorsComposite kidney endpointCotransporter-2 inhibitorsKidney outcomesHeart failureKidney diseaseKidney endpointsHazard ratioDoubling of serum creatinineCombination of heart failureSustained doubling of serum creatininePlacebo-controlled trialReduced ejection fractionBaseline heart failureConfidence intervalsRandom-effects modelAlbuminuria progressionEjection fractionSerum creatinineReview ManagerMellitusPatientsWomen with Gestational Diabetes Mellitus Have Greater Formula Supplementation in the Hospital and at Home Despite Intention to Exclusively Breastfeed
Doughty K, Joe L, Taylor S. Women with Gestational Diabetes Mellitus Have Greater Formula Supplementation in the Hospital and at Home Despite Intention to Exclusively Breastfeed. Breastfeeding Medicine 2024, 19: 788-795. PMID: 39109418, DOI: 10.1089/bfm.2024.0192.Peer-Reviewed Original ResearchConceptsGestational diabetes mellitusFormula supplementationDiabetes mellitusGestational diabetes mellitus statusType 2 diabetes mellitusEstimate adjusted odds ratiosInfant feeding knowledgeAssociated with higher oddsMultivariate logistic regressionOdds of in-hospitalAdjusted odds ratiosProportion of womenIn-HospitalMedical historyOdds ratioFeeding knowledgeBreastfeeding intentionBreastfeedingHigher oddsMellitusMedical reasonsObjectives:</i></b>Public breastfeedingT2DMLogistic regression
2023
Adverse effects of gestational diabetes mellitus on fetal monocytes revealed by single-cell RNA sequencing
Yin M, Zhang Y, Li X, Liu S, Huang J, Yu H, Li X. Adverse effects of gestational diabetes mellitus on fetal monocytes revealed by single-cell RNA sequencing. IScience 2023, 27: 108637. PMID: 38188508, PMCID: PMC10770529, DOI: 10.1016/j.isci.2023.108637.Peer-Reviewed Original ResearchGestational diabetes mellitusCord blood mononuclear cellsBlood mononuclear cellsGDM mothersDiabetes mellitusMononuclear cellsCord bloodFetal monocytesMyeloid cellsMaternal gestational diabetes mellitusPeripheral blood mononuclear cellsAtherosclerotic cardiovascular diseasePrevalent metabolic disorderLong-term riskProliferation-related pathwaysCardiovascular diseaseMetabolic disordersNeutrophil granulocytesMetabolic diseasesSingle-cell RNA sequencingMonocytesPhagocytic abilityAdverse effectsPotential mechanismsMellitusGlucagon-like peptide 1 (GLP-1) receptor agonists as a protective factor for incident depression in patients with diabetes mellitus: A systematic review
Cooper D, Ramachandra R, Ceban F, Di Vincenzo J, Rhee T, Mansur R, Teopiz K, Gill H, Ho R, Cao B, Lui L, Jawad M, Arsenault J, Le G, Ramachandra D, Guo Z, McIntyre R. Glucagon-like peptide 1 (GLP-1) receptor agonists as a protective factor for incident depression in patients with diabetes mellitus: A systematic review. Journal Of Psychiatric Research 2023, 164: 80-89. PMID: 37331261, DOI: 10.1016/j.jpsychires.2023.05.041.Peer-Reviewed Original ResearchConceptsGLP-1 receptor agonistsGlucagon-like peptide-1 receptor agonistsPeptide-1 receptor agonistsIncident depressionDiabetes mellitusReceptor agonistType 2 diabetes mellitusRetrospective observational studyPubMed/MEDLINEEnglish-language articlesHigh interstudy heterogeneityGoogle Scholar databasesPaucity of literatureGlycemic controlNeuroprotective effectsAntidepressant propertiesNeuroprotective potentialInterstudy heterogeneityObservational studyPatientsSystematic reviewAgonistsMellitusScholar databasesProtective factorsNeurologic Complications of Babesiosis, United States, 2011–2021 - Volume 29, Number 6—June 2023 - Emerging Infectious Diseases journal - CDC
Locke S, O’Bryan J, Zubair A, Rethana M, Moffarah A, Krause P, Farhadian S. Neurologic Complications of Babesiosis, United States, 2011–2021 - Volume 29, Number 6—June 2023 - Emerging Infectious Diseases journal - CDC. Emerging Infectious Diseases 2023, 29: 1127-1135. PMID: 37209667, PMCID: PMC10202888, DOI: 10.3201/eid2906.221890.Peer-Reviewed Original ResearchConceptsNeurologic complicationsNeurologic symptomsRisk factorsYale-New Haven HospitalInfectious Diseases journal - CDCHigh-grade parasitemiaNeurologic risk factorsRange of symptomsAdult patientsRenal failureDiabetes mellitusFrequent symptomsHospital admissionImpaired consciousnessMedical recordsEndemic areasParasitic infectionsPatientsSymptomsIntraerythrocytic protozoaComplicationsBabesiosisNew HavenDeliriumMellitusD-22 | Trajectories of Patients Treated With Beta Blockers and Calcium Channel Blockers for Stable Ischemic Heart Disease and Diabetes Mellitus (from the Bypass Angioplasty Revascularization Investigation 2 Diabetes Trial)
Jamil Y, Park D, Chongthammakun V, Al Damluji A, Nanna M. D-22 | Trajectories of Patients Treated With Beta Blockers and Calcium Channel Blockers for Stable Ischemic Heart Disease and Diabetes Mellitus (from the Bypass Angioplasty Revascularization Investigation 2 Diabetes Trial). Journal Of The Society For Cardiovascular Angiography & Interventions 2023, 2: 100876. DOI: 10.1016/j.jscai.2023.100876.Peer-Reviewed Original ResearchImproved extremity tissue oxygenation with short-term exposure to textiles embedded with far infrared light emitting thermoactive particles in patients with diabetes mellitus
Athonvarangkul D, Wang K, Deng Y, Inzucchi S, Mayerson A. Improved extremity tissue oxygenation with short-term exposure to textiles embedded with far infrared light emitting thermoactive particles in patients with diabetes mellitus. Diabetes And Vascular Disease Research 2023, 20: 14791641231170282. PMID: 37073436, PMCID: PMC10123901, DOI: 10.1177/14791641231170282.Peer-Reviewed Original Research
2022
Association of multiple environmental risk factors with prevalent diabetes mellitus and obesity - Results from the population-based KORA FIT cohort in Augsburg, Germany
Niedermayer F, Wolf K, Zhang S, Dallavalle M, Schneider A, Peters A. Association of multiple environmental risk factors with prevalent diabetes mellitus and obesity - Results from the population-based KORA FIT cohort in Augsburg, Germany. ISEE Conference Abstracts 2022, 2022 DOI: 10.1289/isee.2022.p-1068.Peer-Reviewed Original ResearchObjectively-Measured Physical Activity and Sedentary Behaviors and Related Factors in Chinese Immigrants in the US with Prior Gestational Diabetes Mellitus
Huang S, Ash GI, Nam S, Jeon S, McMahon E, Whittemore R. Objectively-Measured Physical Activity and Sedentary Behaviors and Related Factors in Chinese Immigrants in the US with Prior Gestational Diabetes Mellitus. International Journal Of Environmental Research And Public Health 2022, 19: 11409. PMID: 36141683, PMCID: PMC9517195, DOI: 10.3390/ijerph191811409.Peer-Reviewed Original ResearchConceptsPrior gestational diabetes mellitusGestational diabetes mellitusPhysical activityDiabetes mellitusPA guidelinesMVPA minutesHigh-risk groupType 2 diabetesIntensity physical activityCross-sectional studySedentary behavior patternsMedian durationLower BMIMore MVPA minutesSedentary timeSedentary behaviorHip accelerometerPsychosocial characteristicsConsecutive daysRelated factorsGreater likelihoodWeeksMellitusMultiple regression analysisRegression analysisAssociation of kidney and cardiovascular outcomes in patients with type 2 diabetes mellitus: insights from the EMPA-REG OUTCOME trial
Sharma A, Inzucchi S, Testani J, Ofstad A, Fitchett D, Mattheus M, Verma S, Zannad F, Wanner C, Kraus B, Wagner-Golbs A. Association of kidney and cardiovascular outcomes in patients with type 2 diabetes mellitus: insights from the EMPA-REG OUTCOME trial. Diabetologie Und Stoffwechsel 2022, 17: s31-s32. DOI: 10.1055/s-0042-1746295.Peer-Reviewed Original ResearchHeterogeneity in the guidelines for the management of diabetic foot disease in the Caribbean
Sumpio B, McConnie S, Maharaj D. Heterogeneity in the guidelines for the management of diabetic foot disease in the Caribbean. PLOS Global Public Health 2022, 2: e0000446. PMID: 36962244, PMCID: PMC10021831, DOI: 10.1371/journal.pgph.0000446.Peer-Reviewed Original ResearchDiabetic foot diseaseDF diseaseFoot diseaseMultidisciplinary teamLower extremity amputation ratesAmputation ratePodiatric careDiabetes mellitusSubsequent amputationInternational Working GroupVascular surgeryDiseaseHealth careMultidisciplinary approachDF problemMinority of countriesCareGuidelinesImplementation of strategiesCaribbean countriesStructured programWorking GroupRespondent countriesMellitusSurgeryMetformin, phenformin, and galegine inhibit complex IV activity and reduce glycerol-derived gluconeogenesis
LaMoia TE, Butrico GM, Kalpage HA, Goedeke L, Hubbard BT, Vatner DF, Gaspar RC, Zhang XM, Cline GW, Nakahara K, Woo S, Shimada A, Hüttemann M, Shulman GI. Metformin, phenformin, and galegine inhibit complex IV activity and reduce glycerol-derived gluconeogenesis. Proceedings Of The National Academy Of Sciences Of The United States Of America 2022, 119: e2122287119. PMID: 35238637, PMCID: PMC8916010, DOI: 10.1073/pnas.2122287119.Peer-Reviewed Original ResearchConceptsGlucose-lowering effectPlasma glucose concentrationComplex I activityHepatic gluconeogenesisType 2 diabetes mellitusGlucose concentrationGlycerol-3-phosphate dehydrogenase activityI activityDiabetes mellitusSelective inhibitionMetforminInhibitionRelevant concentrationsGluconeogenesisPhenforminVivoMost studiesDehydrogenase activityGalegineMellitusWhen nerves fail: A cause of respiratory failure in a diabetic patient
Ayub M, Ayub T, Rasool W, Khan M, Ishaq M, Mba B. When nerves fail: A cause of respiratory failure in a diabetic patient. Caspian Journal Of Internal Medicine 2022, 13: 436-438. PMID: 35919641, PMCID: PMC9301228, DOI: 10.22088/cjim.13.2.436.Peer-Reviewed Original ResearchRespiratory failurePhrenic neuropathyDiabetes mellitusDiabetic patientsCompound action potential amplitudeLong-term respiratory supportUncommon clinical scenarioNerve conduction studiesAction potential amplitudeDiaphragmatic paresisRespiratory supportPhrenic nerveConduction studiesMechanical ventilationUnexplained shortnessPotential amplitudeClinical scenariosPatientsNeuropathyNerveFailureMellitusParesisShortnessSuspicion
2021
Determinants of elevated depressive symptoms in Chinese women with gestational diabetes mellitus
Huang S, Wischik DL, Whittemore R, Jeon S, Qing L, Guo J. Determinants of elevated depressive symptoms in Chinese women with gestational diabetes mellitus. Birth 2021, 49: 289-297. PMID: 34927281, DOI: 10.1111/birt.12605.Peer-Reviewed Original ResearchConceptsGestational diabetes mellitusElevated depressive symptomsDepressive symptomsChinese womenDiabetes mellitusPregnant womenMultiple logistic regression analysisMore emergency room visitsEpidemiological Survey Depression ScaleEmergency room visitsCross-sectional studyLogistic regression analysisRoom visitsActive coping skillsMean ageDepression ScaleSecondary data analysisHigher oddsHigh riskHealth outcomesHan ethnicitySymptomsWomenMellitusRegression analysisAutoimmunity May Explain Diabetes in a Subset of Patients With Recurrent Acute and Chronic Pancreatitis: A Pilot Study
Yadav D, Whitcomb D, Tang G, Slivka A, Bellin M, Consortium N, AlKaade S, Amann S, Anderson M, Banks P, Conwell D, Brand R, Cote G, Romagnuolo J, Forsmark C, Gardner T, Gelrud A, Guda N, Lewis M, Muniraj T, Sandhu B, Sherman S, Singh V, Wilcox C. Autoimmunity May Explain Diabetes in a Subset of Patients With Recurrent Acute and Chronic Pancreatitis: A Pilot Study. Clinical Gastroenterology And Hepatology 2021, 21: 226-228.e1. PMID: 34793964, DOI: 10.1016/j.cgh.2021.11.011.Peer-Reviewed Original ResearchConceptsChronic pancreatitisCytokine-induced beta-cell dysfunctionPancreatogenic diabetes mellitusPrimary pathophysiologic defectType 3c diabetesSubset of patientsBeta-cell dysfunctionRecurrent AcuteGlucose intoleranceDiabetes mellitusPathophysiologic defectsFibrotic changesInsulin deficiencyCell dysfunctionExocrine pancreasPilot studyPancreatitisMellitusAcuteDiabetesInflammationPatientsDysfunctionInjuryPancreasImplementation, interrupted: Identifying and leveraging factors that sustain after a programme interruption
Hennein R, Ggita J, Ssuna B, Shelley D, Akiteng AR, Davis JL, Katamba A, Armstrong-Hough M. Implementation, interrupted: Identifying and leveraging factors that sustain after a programme interruption. Global Public Health 2021, 17: 1868-1882. PMID: 34775913, PMCID: PMC10570963, DOI: 10.1080/17441692.2021.2003838.Peer-Reviewed Original ResearchConceptsDiabetes mellitusSocial ecological modelDM screeningClinic visitsTuberculosis clinicClinic staffClinicians' beliefsOuter settingInner settingClinicians' opportunitiesIntegrated careConsolidated FrameworkHealth systemGlucose test stripsImplementation researchClinicProgram interruptionInterruptionSettingMellitusCliniciansVisitsCareTCT-290 Safety and Efficacy of the Supreme Biodegradable Polymer Sirolimus-Eluting Stent in Patients With Diabetes Mellitus: Results From the PIONEER III Clinical Trial
Thomas A, Kereiakes D, Leon M, Baumbach A, Windecker S, Pietras C, Dressler O, Issever M, Curtis M, Bertolet B, Zidar J, Smits P, Diaz V, Mclaurin B, Cequier A, Takahashi A, Amoroso G, Kakuta T, Carney R, Saito S, Lansky A. TCT-290 Safety and Efficacy of the Supreme Biodegradable Polymer Sirolimus-Eluting Stent in Patients With Diabetes Mellitus: Results From the PIONEER III Clinical Trial. Journal Of The American College Of Cardiology 2021, 78: b119. DOI: 10.1016/j.jacc.2021.09.1143.Peer-Reviewed Original ResearchContinuous Glucose Monitoring for the Internist
Lee GS, Lupsa BC. Continuous Glucose Monitoring for the Internist. 2021, 105: 967-982. PMID: 34688421, DOI: 10.1016/j.mcna.2021.06.004.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsContinuous glucose monitoringContinuous glucose monitoring systemDiabetes mellitusGlucose monitoring systemGlucose monitoringGlycemic patternsType 2 diabetes mellitusType 1 diabetes mellitusTreatment regimenDiabetes careGlucose readingsHemoglobin AGlucose dataMellitusPatientsInterstitial fluidConvenient wearable devicesUse of diuretics and outcomes in patients with type 2 diabetes: findings from the EMPA‐REG OUTCOME trial
Pellicori P, Fitchett D, Kosiborod MN, Ofstad AP, Seman L, Zinman B, Zwiener I, Wanner C, George J, Inzucchi SE, Testani JM, Cleland JGF. Use of diuretics and outcomes in patients with type 2 diabetes: findings from the EMPA‐REG OUTCOME trial. European Journal Of Heart Failure 2021, 23: 1085-1093. PMID: 34031968, PMCID: PMC11497224, DOI: 10.1002/ejhf.2220.Peer-Reviewed Original ResearchConceptsUse of LDDiagnosis of HFHeart failureLoop diureticsHF diagnosisEMPA-REG OUTCOME trialType 2 diabetes mellitusSigns of congestionCardiovascular eventsCardiovascular mortalityOutcome trialsDiabetes mellitusPatient subgroupsPatientsDiagnosisHigh rateOutcomesMellitusT2DMDiureticsSymptomsMortalityBaselineTrials
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