2025
Association between prostate radiation therapy and survival among patients with metastatic prostate cancer by extent of disease burden.
Palencia P, Zhao X, Kandala K, Smani S, Sivanesan N, Cavallo J, Leapman M. Association between prostate radiation therapy and survival among patients with metastatic prostate cancer by extent of disease burden. Journal Of Clinical Oncology 2025, 43 DOI: 10.1200/jco.2025.43.16_suppl.e17123.Peer-Reviewed Original ResearchMetastatic hormone-sensitive prostate cancerAndrogen deprivation therapyProstate radiation therapyMetastatic prostate cancerOverall survivalRadiation therapyProstate cancerM1c diseaseTreatment modalitiesRT to ADTTreated with androgen deprivation therapyAssociated with improved overall survivalHormone-sensitive prostate cancerAssociated with poor overall survivalPrimary local therapyExternal beam radiotherapyGleason grade groupCompare overall survivalNational Cancer DatabaseProstate cancer metastasisLog-rank testDisease burdenKaplan-Meier curvesCox proportional hazards modelsLow disease burdenTreatment discontinuation in desmoid tumors: Factors associated with better outcomes after sorafenib discontinuation.
Yi I, Gomes P, Hardy N, Rose B, Yu-Cherng C, Bialick S, Jonczak E, D'Amato G, Deshpande H, Carmagnani Pestana R, David B, Trent J, Campos F, Costa P. Treatment discontinuation in desmoid tumors: Factors associated with better outcomes after sorafenib discontinuation. Journal Of Clinical Oncology 2025, 43: 11562-11562. DOI: 10.1200/jco.2025.43.16_suppl.11562.Peer-Reviewed Original ResearchDesmoid tumorsMedian TFSPatients treated with sorafenibMulti-institutional retrospective analysisPalmar-plantar erythrodysesthesia syndromeSide effectsDuration of sorafenib treatmentDuration of systemic therapyFuture treatmentPatient stopped therapyOutcomes of patientsLog-rank testKaplan-Meier curvesTime of discontinuationFactors associated with better outcomesMonths of durationProgression of diseaseDiscontinued sorafenibSorafenib discontinuationSorafenib useStable diseasePartial responseDiscontinued therapySystemic therapyTreatment discontinuationAI-based volumetric six-tissue body composition quantification from CT cardiac attenuation scans for mortality prediction: a multicentre study
Yi J, Marcinkiewicz A, Shanbhag A, Miller R, Geers J, Zhang W, Killekar A, Manral N, Lemley M, Buchwald M, Kwiecinski J, Zhou J, Kavanagh P, Liang J, Builoff V, Ruddy T, Einstein A, Feher A, Miller E, Sinusas A, Berman D, Dey D, Slomka P. AI-based volumetric six-tissue body composition quantification from CT cardiac attenuation scans for mortality prediction: a multicentre study. The Lancet Digital Health 2025, 7: 100862. PMID: 40382274, PMCID: PMC12126277, DOI: 10.1016/j.landig.2025.02.002.Peer-Reviewed Original ResearchConceptsCT attenuation correctionEpicardial adipose tissueVisceral adipose tissuePrognostic valueAdipose tissuePerfusion imagingMedian follow-up timeHigher visceral adipose tissueIncreased all-cause mortality riskMuscle volume indexAttenuation correctionPredicting all-cause mortalityCardiac perfusion imagingKaplan-Meier curvesAll-cause mortality riskBody composition measurementsCox regression modelsAll-Cause MortalityReduced riskVolumetric measurementsIntramuscular adipose tissueMortality risk stratificationAI-based segmentationSubcutaneous adipose tissueIndex volumeReal world treatment patterns for recurrent and metastatic head and neck cancer in the post-KEYNOTE 048 era
Lee D, Pan A, Yaskolko M, Chiorazzi M, Bhatia A, Burtness B, Ishizuka J. Real world treatment patterns for recurrent and metastatic head and neck cancer in the post-KEYNOTE 048 era. Frontiers In Oncology 2025, 15: 1577509. PMID: 40416868, PMCID: PMC12099209, DOI: 10.3389/fonc.2025.1577509.Peer-Reviewed Original ResearchHead and neck squamous cell carcinomaCombined positive scoreAnti-PD1 monotherapyMetastatic head and neck squamous cell carcinomaOral cavity primariesMetastatic head and neck cancerNon-HPV-associated tumorsPatients treated first-lineToxicity of combined treatmentNeck squamous cell carcinomaReal-world treatment patternsHead and neck cancerFlatiron Health databaseAnti-PD1 therapyChemotherapy improves survivalHPV-associated diseasesFirst-line treatmentSquamous cell carcinomaLog-rank testSubgroup of patientsKaplan-Meier curvesTreatment group differencesKEYNOTE-048Non-HPVAnti-PD1The impact of PGT-A on time to live birth in IVF.
Eliner Y, Foley B, Bayer S, Thornton K, Penzias A, Sakkas D, Vaughan D. The impact of PGT-A on time to live birth in IVF. Fertility And Sterility 2025 PMID: 40222699, DOI: 10.1016/j.fertnstert.2025.04.006.Peer-Reviewed Original ResearchPGT-ALive birth rateLive birthsTime to pregnancyOocyte retrievalAge groupsHazard ratioNon-PGT-A groupPre-implantation genetic testingUniversity-affiliated fertility centerPGT-A groupShorter time to pregnancyPositive pregnancy rateSignificant differenceKaplan-Meier curvesBirth rateOne-year periodStatistically significant differencePropensity score matchingMiscarriage rateYounger age groupsNo significant differenceYounger patientsOlder age groupsEgg retrievalVariations in Antithrombotic Prescriptions and Evaluation of Extended Clopidogrel Therapy After Lower Extremity Revascularization for Peripheral Artery Disease
Wells N, Alameddine D, Dhanda U, Tran L, Silva D, Slade M, Guzman R, Ochoa Chaar C. Variations in Antithrombotic Prescriptions and Evaluation of Extended Clopidogrel Therapy After Lower Extremity Revascularization for Peripheral Artery Disease. Journal Of Vascular Surgery 2025 PMID: 40122313, DOI: 10.1016/j.jvs.2025.03.183.Peer-Reviewed Original ResearchLower extremity revascularizationPeripheral arterial diseaseDuration of clopidogrel therapyClopidogrel therapyAntithrombotic prescriptionAntithrombotic combinationsAntithrombotic therapyExtremity revascularizationArtery diseasePatients treated with clopidogrelAssociated with improved survivalClinical characteristics of patientsMedical records of patientsLong-term follow-upChronic renal insufficiencyMACE-free survivalAssociated with bleedingElectronic medical records of patientsAdverse cardiac eventsKaplan-Meier curvesRecords of patientsTertiary care centerCongestive heart failureLong-term outcomesComparison of patientsLong-term evaluation of the timing of corticosteroid therapy in an IgA nephropathy cohort
Hou W, Yang H, Chen P, Tang C, Zhou X, Liu L, Zhu L, Shi S, Lv J, Zhang H. Long-term evaluation of the timing of corticosteroid therapy in an IgA nephropathy cohort. Clinical Kidney Journal 2025, 18: sfaf076. PMID: 40322679, PMCID: PMC12044332, DOI: 10.1093/ckj/sfaf076.Peer-Reviewed Original ResearchEarly therapy groupCorticosteroid therapyHazard ratioPropensity score matchingTherapy groupSteroid initiationSteroid treatmentEGFR slopeIgAN patientsTiming of corticosteroid therapyPatients treated with corticosteroidsLong-term kidney functionEGFR decline >Composite renal outcomeSystemic corticosteroid therapyEarly corticosteroid therapyScore matchingKaplan-Meier curvesTime-averaged proteinuriaImmunoglobulin A nephropathyLong-term outcomesIgA nephropathy cohortProgressive IgANDelayed therapyRenal outcomesThe Natural History of Congenital Hepatic Hemangiomas
Ostertag-Hill C, Fevurly R, Kulungowski A, Christison-Lagay E, McGuire A, Rialon K, Duggan E, Murillo R, Zurakowski D, Staffa S, Alomari A, Kozakewich H, Al-Ibraheemi A, Fishman S, Dickie B. The Natural History of Congenital Hepatic Hemangiomas. The Journal Of Pediatrics 2025, 281: 114523. PMID: 40023218, DOI: 10.1016/j.jpeds.2025.114523.Peer-Reviewed Original ResearchCongenital hepatic hemangiomasCongenital HHHepatic hemangiomaMedical therapyRetrospective review of patientsNatural historyReview of patientsKaplan-Meier curvesMonths of ageCongenital hemangiomaRetrospective reviewClinical presentationRespiratory failureClinical behaviorHeart failureHH volumeHistological findingsEarly recognitionResidual volumeGeneralized Estimating EquationsIncorrect diagnosisHemangiomaPatientsNo differenceRate of involution
2024
Overall survival in TP53-mutated AML and MDS
Puzo C, Hager K, Rinder H, Weinberg O, Siddon A. Overall survival in TP53-mutated AML and MDS. Annals Of Hematology 2024, 103: 5359-5369. PMID: 39443370, DOI: 10.1007/s00277-024-06054-7.Peer-Reviewed Original ResearchOverall survivalBlast countTP53 mutationsSignificant predictors of OSP53 mutation typePredictors of OSAggressive disease biologyRetrospective chart reviewKaplan-Meier curvesYale-New Haven HospitalNext generation sequencingCox proportional hazards modelsProportional hazards modelComplex karyotypePoor OSP53 mutationsWHO criteriaChart reviewNew Haven HospitalPoor prognosisCo-mutationsPathogenic mutationsAMLICCS guidelinesMutation typeLong-term outcomes of elective endovascular vs open repair of popliteal artery aneurysms in the VISION database
Satam K, Brahmandam A, Zheng X, Mao J, Goodney P, Ochoa Chaar C. Long-term outcomes of elective endovascular vs open repair of popliteal artery aneurysms in the VISION database. Journal Of Vascular Surgery 2024, 81: 672-681.e2. PMID: 39454844, DOI: 10.1016/j.jvs.2024.10.026.Peer-Reviewed Original ResearchPopliteal artery aneurysm repairGreat saphenous veinLong-term outcomesVascular Quality InitiativeAneurysm repairAssociated with increased survivalShort hospital length of stayGreat saphenous vein bypassHospital length of stayRandomized multicenter studyCox proportional hazards regressionKaplan-Meier curvesAssociated with lower mortalityPopliteal aneurysm repairPopliteal artery aneurysmPeripheral vascular interventionsProportional hazards regressionLength of stayP2Y12 inhibitorsBaseline characteristicsMulticenter studyEndovascular therapyArtery aneurysmPropensity-matchedSubgroup analysisPatients with fibromyalgia have increased risk of 90-day postoperative adverse events following arthroscopic rotator cuff repair
Rancu A, Katsnelson B, Sanchez J, Winter A, Vasudevan R, Grauer J. Patients with fibromyalgia have increased risk of 90-day postoperative adverse events following arthroscopic rotator cuff repair. JSES International 2024, 9: 360-365. PMID: 40182261, PMCID: PMC11962560, DOI: 10.1016/j.jseint.2024.09.018.Peer-Reviewed Original ResearchRotator cuff repairPostoperative adverse eventsAdverse eventsArthroscopic rotator cuff repairCurrent Procedural TerminologyElixhauser Comorbidity IndexOccurrence of wound dehiscenceEmergency departmentUrinary tract infectionSymptomatic rotator cuff tearsAssociated with increased riskCuff repairLog-rank testYear of surgerySurgical site infectionSevere adverse eventsKaplan-Meier curvesAcute kidney injuryOccurrence of sepsisDeep vein thrombosisMinor adverse eventsRotator cuff repair patientsIndividual adverse eventsOdds of ED utilizationDiagnosis of fibromyalgiaDoes Subspecialty Matter: Outcomes after Ankle Fracture Surgery
Zhu J, Seddio A, Gouzoulis M, Grauer J. Does Subspecialty Matter: Outcomes after Ankle Fracture Surgery. Foot & Ankle Orthopaedics 2024, 9: 2473011424s00252. PMCID: PMC11664568, DOI: 10.1177/2473011424s00252.Peer-Reviewed Original ResearchAnkle fracture surgeryImplant removal rateFracture surgeryFellowship cohortAdverse eventsSubspecialty backgroundsReadmission ratesSurgeon's reportUrinary tract infectionKaplan-Meier curvesAcute kidney injurySurgical adverse eventsMultivariate logistic regressionAnkle surgeonAnkle fracturesPerioperative outcomesTract infectionsAnkleAdministrative datasetsNo significant differenceSurgical interventionKidney injurySurgery outcomesOperating surgeonLogistic regressionRecipient functional status impacts on short and long-term intestinal transplant outcomes in United States adults
Boateng S, Ameyaw P, Gyabaah S, Adjepong Y, Njei B. Recipient functional status impacts on short and long-term intestinal transplant outcomes in United States adults. World Journal Of Transplantation 2024, 14: 93561. PMID: 39295973, PMCID: PMC11317861, DOI: 10.5500/wjt.v14.i3.93561.Peer-Reviewed Original ResearchIntestinal transplant outcomesMedian survival timeTransplant outcomesSurvival outcomesFunctional statusUnited States adultsPost-transplant survival outcomesSurvival timeMultivariate Cox regressionPoor survival outcomesKaplan-Meier curvesKarnofsky performance statusFunctional impairmentHigher risk of mortalityRetrospective cohort studyPost-transplant outcomesSevere impairmentRisk of mortalityImpact post-transplant outcomesSevere functional impairmentMedian agePerformance statusPrognostic indicatorIntestinal transplantationKidney transplantationTumor response assessment in hepatocellular carcinoma treated with immunotherapy: imaging biomarkers for clinical decision-making
Sobirey R, Matuschewski N, Gross M, Lin M, Kao T, Kasolowsky V, Strazzabosco M, Stein S, Savic L, Gebauer B, Jaffe A, Duncan J, Madoff D, Chapiro J. Tumor response assessment in hepatocellular carcinoma treated with immunotherapy: imaging biomarkers for clinical decision-making. European Radiology 2024, 35: 73-83. PMID: 39033181, DOI: 10.1007/s00330-024-10955-6.Peer-Reviewed Original ResearchMedian overall survivalTumor response criteriaTumor response assessmentHepatocellular carcinoma patientsHepatocellular carcinomaTumor responseOverall survivalResponse criteriaResponse assessmentNon-respondersPoorer median overall survivalPrediction of tumor responsePredictive valueHepatocellular Carcinoma ImmunotherapyDisease controlPrognostic of survivalClinical baseline parametersLog-rank testKaplan-Meier curvesMultivariate Cox regressionPredicting Overall SurvivalCox regression modelsSurvival benefitStratify patientsMRI pre-Presentation and patterns of reinterventions after revascularization in patients with premature peripheral arterial disease
Sivakumar A, Satam K, Wu Z, Alameddine D, Aboian E, Chaer R, Schermerhorn M, Moreira C, Guzman R, Ochoa Chaar C. Presentation and patterns of reinterventions after revascularization in patients with premature peripheral arterial disease. Journal Of Vascular Surgery 2024, 80: 1776-1785.e1. PMID: 39002606, DOI: 10.1016/j.jvs.2024.07.021.Peer-Reviewed Original ResearchPremature peripheral arterial diseaseLower extremity revascularizationOlder patientsPeripheral arterial diseaseArtery diseaseRetrospective review of consecutive patientsReview of consecutive patientsDistressed Communities IndexAge of presentationFrequency of reinterventionsEnd-stage renal diseaseKaplan-Meier curvesOutcomes of lower extremity revascularizationLong-term outcomesCoronary artery diseaseMALE-free survivalAdverse limb eventsOverall survivalReintervention rateConsecutive patientsFrequent reinterventionsPerioperative complicationsRetrospective reviewNo significant differenceInstitutional experienceCorrelation of eTILs with recurrence free survival (RFS) in stage IIB-IIIA melanoma and use as biomarker for stratification for clinical trials.
Aung T, Zhang C, Espinoza G, Leung L, Moon J, Horst B, Ferringer T, Nastiuk K, Rimm D, Saenger Y. Correlation of eTILs with recurrence free survival (RFS) in stage IIB-IIIA melanoma and use as biomarker for stratification for clinical trials. Journal Of Clinical Oncology 2024, 42: 9567-9567. DOI: 10.1200/jco.2024.42.16_suppl.9567.Peer-Reviewed Original ResearchTumor-infiltrating lymphocytesRecurrence free survivalAmerican Joint Committee on CancerFree survivalInfiltrating lymphocytesRetrospective cohortClinical trialsQuantify tumor-infiltrating lymphocytesStage II-III melanomaTumor-infiltrating lymphocytes groupDiagnostic slidesIIb-IIIaRoswell Park Comprehensive Cancer CenterEarly-stage melanoma patientsCox modelStage IIB-IIICAdjuvant clinical trialsKaplan-Meier curvesMultivariate Cox modelUnivariate Cox modelCox proportional hazards modelsClinical pathological featuresGeisinger Medical CenterProportional hazards modelClinical trial designMortality burden of pre‐treatment weight loss in patients with non‐small‐cell lung cancer: A systematic literature review and meta‐analysis
Bonomi P, Crawford J, Dunne R, Roeland E, Smoyer K, Siddiqui M, McRae T, Rossulek M, Revkin J, Tarasenko L. Mortality burden of pre‐treatment weight loss in patients with non‐small‐cell lung cancer: A systematic literature review and meta‐analysis. Journal Of Cachexia Sarcopenia And Muscle 2024, 15: 1226-1239. PMID: 38650388, PMCID: PMC11294038, DOI: 10.1002/jcsm.13477.Peer-Reviewed Original ResearchNon-small-cell lung cancerInternational consensus criteriaHazard ratioStatistical heterogeneityMeta-analysisWeight lossLung cancerSubgroup analysisPre-treatment weight lossAssociated with inferior survivalImpact of cachexiaKaplan-Meier curvesRandom-effects modelInferior survivalOverall survivalWorse survivalSurvival outcomesHigher mortality riskAdult patientsPoor prognosisClinical decision-makingClinical trialsMultivariate analysisCachexiaIndependent reviewers screened titlesTreatment-free survival outcomes from the phase II study of nivolumab and salvage nivolumab/ipilimumab in advanced clear cell renal cell carcinoma (HCRN GU16-260-Cohort A)
Atkins M, Jegede O, Haas N, Mcdermott D, Bilen M, Stein M, Sosman J, Alter R, Plimack E, Ornstein M, Hurwitz M, Peace D, Einstein D, Catalano P, Hammers H, Regan M. Treatment-free survival outcomes from the phase II study of nivolumab and salvage nivolumab/ipilimumab in advanced clear cell renal cell carcinoma (HCRN GU16-260-Cohort A). Journal For ImmunoTherapy Of Cancer 2024, 12: e008293. PMID: 38604810, PMCID: PMC11015345, DOI: 10.1136/jitc-2023-008293.Peer-Reviewed Original ResearchConceptsTreatment-free survivalInternational Metastatic RCC Database ConsortiumFavorable-risk patientsNivolumab monotherapyPhase II study of nivolumabCessation of immunotherapyFavorable-risk diseaseProtocol therapy cessationStudy of nivolumabSystemic therapy initiationTreatment naive patientsPhase II studyRenal cell carcinomaKaplan-Meier curvesActive treatment approachPartitioned survival analysisCheckMate 067Stable diseaseProtocol therapyAdvanced melanomaTherapy initiationTreatment-freeCell carcinomaClear-cellProtocol treatmentSurvival Among Patients With High-Risk Gastrointestinal Cancers During the COVID-19 Pandemic
Janczewski L, Browner A, Cotler J, Palis B, Chan K, Joung R, Bentrem D, Merkow R, Boffa D, Nelson H. Survival Among Patients With High-Risk Gastrointestinal Cancers During the COVID-19 Pandemic. JAMA Network Open 2024, 7: e240160. PMID: 38441896, PMCID: PMC10915687, DOI: 10.1001/jamanetworkopen.2024.0160.Peer-Reviewed Original ResearchConceptsStage IV diseaseRetrospective cohort studyCohort studyQuality care deliveryIV diseaseOperative mortalityHigh riskPandemic-related stressorsAssociated with increased 1-year mortalityDiagnosis of stage IMultivariate logistic regressionCOVID-19 pandemicCare deliveryNational Cancer DatabaseKaplan-Meier curvesEvaluate 30-dayMain OutcomesFollow-up dataCancer communityPrepandemic levelsLogistic regressionCancer DatabaseCOVID-19COVID-19 infectionMalignant neoplasmsFemoral Head Core Decompressions: Characterization of Subsequent Conversion to Total Hip Arthroplasty and Related Complications
Jiang W, Sanchez J, Dhodapkar M, Li M, Wiznia D, Grauer J. Femoral Head Core Decompressions: Characterization of Subsequent Conversion to Total Hip Arthroplasty and Related Complications. JAAOS Global Research And Reviews 2024, 8: e24.00024. PMID: 38437034, PMCID: PMC10906578, DOI: 10.5435/jaaosglobal-d-24-00024.Peer-Reviewed Original Research
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