2024
Examining Outcomes in Patients Admitted With Comorbid Peripheral Artery Disease and Microvascular Disease
Grubman S, Algara M, Smolderen K, Luna P, Walenczyk K, Scierka L, Cleman J, Siddiqui W, Romain G, Mena‐Hurtado C. Examining Outcomes in Patients Admitted With Comorbid Peripheral Artery Disease and Microvascular Disease. Journal Of The American Heart Association 2024, 13: e030710. PMID: 38166496, PMCID: PMC10863818, DOI: 10.1161/jaha.123.030710.Peer-Reviewed Original ResearchConceptsPeripheral artery diseaseMajor adverse cardiac eventsAdverse cardiac eventsMicrovascular diseaseMinor amputationHospital mortalityCardiac eventsArtery diseaseNational Readmission DatabaseFurther prospective researchNumber of patientsCommon risk factorsMultiple logistic regressionMajor amputationBaseline factorsFinal cohortCox regressionAdverse outcomesPAD groupSecondary diagnosisRisk factorsAnnual admissionsObservational studyPrevalent conditionHigh riskHypertension Management in Peripheral Artery Disease: A Mini Review
Kharawala A, Nagraj S, Pargaonkar S, Seo J, Kokkinidis D, Altin S. Hypertension Management in Peripheral Artery Disease: A Mini Review. Current Hypertension Reviews 2024, 20: 1-9. PMID: 38083897, DOI: 10.2174/0115734021267004231122061712.Peer-Reviewed Original ResearchPeripheral artery diseaseAngiotensin receptor blockersHypertension managementArtery diseaseAmerican Heart Association/American CollegeDevelopment of PADLower extremity peripheral artery diseaseConcomitant peripheral artery diseaseLower blood pressure levelsBlood pressure targetsGuideline-directed therapyUse of angiotensinLarge randomized trialsBlood pressure levelsTreatment of hypertensionMajor risk factorComplex patient populationWorse health outcomesPost Hoc AnalysisAntihypertensive medicationsHypertensive patientsReceptor blockersPressure targetsRandomized trialsAdequate therapy
2023
Impact of sex on Transcatheter aortic valve replacement outcomes: Results of a single-center study
See C, Wang Y, Yang Y, Tirziu D, Papoutsidakis N, Francese D, Kaple R, Cleman M, Lansky A, Forrest J. Impact of sex on Transcatheter aortic valve replacement outcomes: Results of a single-center study. International Journal Of Cardiology 2023, 398: 131643. PMID: 38065329, DOI: 10.1016/j.ijcard.2023.131643.Peer-Reviewed Original ResearchNew-generation valvesTranscatheter Aortic Valve Replacement OutcomesImpact of sexTAVR outcomesArtery diseaseYale-New Haven HospitalSTS mortality scorePeripheral artery diseaseSingle-center studyCoronary artery diseaseKaplan-Meier curvesLog-rank testNew Haven HospitalSex-based disparitiesSignificant differencesCardiovascular comorbiditiesSAPIEN 3Transfemoral accessSAPIEN XTConsecutive patientsCox modelingMortality scoreEvolut RFemale sexEvolut PRODifferences between Lower Extremity Arterial Occlusion vs. Stenosis and Predictors of Successful Endovascular Interventions
Kokkinidis D, Schizas D, Pargaonkar S, Karamanis D, Mylonas K, Hasemaki N, Palaiodimos L, Varrias D, Tzavellas G, Siasos G, Klonaris C, Kharawala A, Chlorogiannis D, Georgopoulos S, Bakoyiannis C. Differences between Lower Extremity Arterial Occlusion vs. Stenosis and Predictors of Successful Endovascular Interventions. Medicina 2023, 59: 2029. PMID: 38004078, PMCID: PMC10673017, DOI: 10.3390/medicina59112029.Peer-Reviewed Original ResearchConceptsChronic total occlusionHistory of malignancyCTO groupRevascularization proceduresSuccessful revascularizationLower extremity chronic total occlusionChronic limb-threatening ischemiaEnd-stage renal diseaseSuccessful endovascular interventionUse of aspirinBaseline clinical variablesLimb-threatening ischemiaPeripheral artery diseaseNegative predictorHigh disease burdenInterventional characteristicsAngiographic characteristicsAspirin useCTO patientsEndovascular revascularizationPositive predictorArtery diseaseStenosis patientsRenal diseaseVascular centersSex-specific analysis of intravascular lithotripsy for peripheral artery disease from the Disrupt PAD III observational study
Nagpal S, Altin S, McGinigle K, Mangalmurti S, Adams G, Shammas N, Mehrle A, Soukas P, Bertolet B, Lansky A. Sex-specific analysis of intravascular lithotripsy for peripheral artery disease from the Disrupt PAD III observational study. Journal Of Vascular Surgery 2023, 79: 358-365. PMID: 37925039, DOI: 10.1016/j.jvs.2023.10.058.Peer-Reviewed Original ResearchPeripheral artery diseaseLower extremity peripheral artery diseaseIntravascular lithotripsyResidual stenosisArtery diseaseAcute safetyObservational studyLow ankle-brachial indexUse of IVLChronic limb-threatening ischemiaFinal residual stenosisPeripheral intravascular lithotripsySevere lesion calcificationAnkle-brachial indexLimb-threatening ischemiaReference vessel sizeAbrupt vessel closureHigh complication rateRates of diabetesFisher's exact testSex-specific analysesAngiographic complicationsAtherectomy useIVL treatmentEfficacy outcomesAssociation Between Mental Health Burden, Clinical Presentation, and Outcomes in Individuals With Symptomatic Peripheral Artery Disease: A Scientific Statement From the American Heart Association
Smolderen K, Samaan Z, Decker C, Collins T, Lazar R, Itoga N, Mena-Hurtado C, Research O. Association Between Mental Health Burden, Clinical Presentation, and Outcomes in Individuals With Symptomatic Peripheral Artery Disease: A Scientific Statement From the American Heart Association. Circulation 2023, 148: 1511-1528. PMID: 37781785, DOI: 10.1161/cir.0000000000001178.Peer-Reviewed Original ResearchConceptsPsychological interventionsPeripheral artery diseaseMental healthStress reduction interventionsSymptomatic peripheral artery diseaseComorbid mental health conditionsMental health concernsRole of painMental health conditionsMental health burdenPAD careCognitive declineBehavioral health needsArtery diseaseCognitive dysfunctionPsychotropic interventionScientific statementPAD treatmentBehavior changeUse of opioidsAmerican Heart AssociationUse of benzodiazepinesChronic disease managementHealth behaviorsFragmentation of careIncidence, Microbiological Studies, and Factors Associated With Prosthetic Joint Infection After Total Knee Arthroplasty
Weinstein E, Stephens-Shields A, Newcomb C, Silibovsky R, Nelson C, O’Donnell J, Glaser L, Hsieh E, Hanberg J, Tate J, Akgün K, King J, Re V. Incidence, Microbiological Studies, and Factors Associated With Prosthetic Joint Infection After Total Knee Arthroplasty. JAMA Network Open 2023, 6: e2340457. PMID: 37906194, PMCID: PMC10618849, DOI: 10.1001/jamanetworkopen.2023.40457.Peer-Reviewed Original ResearchConceptsPrimary total knee arthroplastyProsthetic joint infectionTotal knee arthroplastyIncidence rate ratiosLate prosthetic joint infectionsPostoperative periodIncidence rateCohort studyOverall cohortJoint infectionKnee arthroplastyVeterans Affairs Surgical Quality Improvement Program dataElective primary total knee arthroplastyEarly prosthetic joint infectionHepatitis C virus infectionQuality Improvement Program dataVeterans Affairs Corporate Data WarehouseAutoimmune inflammatory arthritisPostoperative antibiotic useC virus infectionRisk factor modificationChronic kidney diseasePeripheral artery diseaseLate postoperative periodYears of carePatient knowledge and preferences for peripheral artery disease treatment
Smolderen K, Romain G, Gosch K, Arham A, Provance J, Spertus J, Poosala A, Shishehbor M, Safley D, Scott K, Stone N, Mena-Hurtado C. Patient knowledge and preferences for peripheral artery disease treatment. Vascular Medicine 2023, 28: 397-403. PMID: 37638882, PMCID: PMC10591804, DOI: 10.1177/1358863x231181613.Peer-Reviewed Original ResearchPeripheral artery diseaseTreatment goalsPatient knowledgeTreatment optionsTreatment preferencesHeart attack/strokeSymptomatic peripheral artery diseasePeripheral artery disease treatmentImportant treatment goalQuality of lifeCost of treatmentSpecific treatment goalsMulticenter registryPAD symptomsPain reliefSecondary preventionArtery diseaseTreatment choiceTreatment benefitPatient understandingPatientsMedical decision makingDisease managementClaudicationDisease treatmentLongitudinal Pathways Between Physical Activity, Depression, and Perceived Stress in Peripheral Artery Disease.
Yazgan I, Bartlett V, Romain G, Cleman J, Petersen-Crair P, Spertus J, Hardt M, Mena-Hurtado C, Smolderen K. Longitudinal Pathways Between Physical Activity, Depression, and Perceived Stress in Peripheral Artery Disease. Circulation Cardiovascular Quality And Outcomes 2023, 16: 544-553. PMID: 37470195, PMCID: PMC10561081, DOI: 10.1161/circoutcomes.122.009840.Peer-Reviewed Original ResearchConceptsPhysical activityPAD diagnosisDepressive symptomsLower physical activity scoresPerceived stressVascular specialty clinicsPeripheral artery diseasePhysical activity scoreSignificant depressive symptomsPatient Health QuestionnaireBehavioral health approachesSubsequent depressive symptomsINTERHEART studySymptomatic PADCardiovascular eventsPAD symptomsArtery diseaseInitial presentationActivity scoreSpecialty clinicHealth QuestionnairePatient's abilityTreatment goalsPAD managementPerceived Stress Scale2022 ACC/AHA guideline for the diagnosis and management of aortic disease A report of the American Heart Association/American College of Cardiology Joint Committee on Clinical Practice Guidelines
Members W, Isselbacher E, Preventza O, Black J, Augoustides J, Beck A, Bolen M, Braverman A, Bray B, Brown-Zimmerman M, Chen E, Collins T, DeAnda A, Fanola C, Girardi L, Hicks C, Hui D, Jones W, Kalahasti V, Kim K, Milewicz D, Oderich G, Ogbechie L, Promes S, Ross E, Schermerhorn M, Times S, Tseng E, Wang G, Woo Y, Members P, Faxon D, Upchurch G, Aday A, Azizzadeh A, Boisen M, Hawkins B, Kramer C, Luc J, MacGillivray T, Malaisrie S, Osteen K, Patel H, Patel P, Popescu W, Rodriguez E, Sorber R, Tsao P, Volgman A, Members A, Beckman J, Otto C, O'Gara P, Armbruster A, Birtcher K, de las Fuentes L, Deswal A, Dixon D, Gorenek B, Haynes N, Hernandez A, Joglar J, Jones W, Mark D, Mukherjee D, Palaniappan L, Piano M, Rab T, Spatz E, Tamis-Holland J. 2022 ACC/AHA guideline for the diagnosis and management of aortic disease A report of the American Heart Association/American College of Cardiology Joint Committee on Clinical Practice Guidelines. Journal Of Thoracic And Cardiovascular Surgery 2023, 166: e182-e331. PMID: 37389507, PMCID: PMC10784847, DOI: 10.1016/j.jtcvs.2023.04.023.Peer-Reviewed Original ResearchACC/AHA guidelinesAortic diseaseAHA guidelinesAmerican Heart Association/American CollegeAHA/ACC guidelinesBicuspid aortic valve diseasePeripheral artery diseaseManagement of patientsAortic valve diseaseClinical practice guidelinesThoracic aortic diseaseCare of patientsAdditional relevant studiesLong-term surveillanceComprehensive literature searchACC guidelinesArtery diseaseMedical therapySurgical treatmentValve diseaseCochrane LibraryFamily screeningComprehensive carePractice guidelinesAmerican CollegeRepresentativeness of Peripheral Artery Disease Randomized Clinical Trials Supporting Current Guidelines
Castro-Dominguez Y, Mena-Hurtado C, Algara M, Obas V, Ahmed Z, Romain G, Solaru K, Smolderen K. Representativeness of Peripheral Artery Disease Randomized Clinical Trials Supporting Current Guidelines. The American Journal Of Cardiology 2023, 201: 166-169. PMID: 37385170, DOI: 10.1016/j.amjcard.2023.05.053.Peer-Reviewed Original ResearchConceptsPeripheral artery diseasePAD guidelinesArtery diseaseRecent American Heart Association/American CollegeAmerican Heart Association/American CollegeLower extremity peripheral artery diseaseOlder adult patientsRace/ethnicity distributionAdult patientsPooled proportionMean ageClinical trialsCurrent guidelinesEpidemiologic studiesAmerican CollegeTrial participantsRCTsEthnicity distributionOlder adultsTrialsWomenPatientsDiseaseGuidelinesEthnic groupsHealth Disparities in Peripheral Artery Disease: A Scientific Statement From the American Heart Association
Allison M, Armstrong D, Goodney P, Hamburg N, Kirksey L, Lancaster K, Mena-Hurtado C, Misra S, Treat-Jacobson D, Solaru K, Health O. Health Disparities in Peripheral Artery Disease: A Scientific Statement From the American Heart Association. Circulation 2023, 148: 286-296. PMID: 37317860, PMCID: PMC11520198, DOI: 10.1161/cir.0000000000001153.Peer-Reviewed Original ResearchConceptsPeripheral artery diseaseArtery diseaseClinical effectsAmerican Heart AssociationMajor limb amputationCerebrovascular eventsHeart AssociationHigh prevalenceLimb amputationHealth disparitiesInequitable deliveryInequitable burdenScientific statementHigh rateCertain demographic groupsDiseasePotential novel solutionIndividual disabilityOverview statementDemographic groupsAmputationDisparitiesPrevalenceCareStructural inequitiesThe Potential Role of PET in the Management of Peripheral Artery Disease
Alashi A, Vermillion B, Sinusas A. The Potential Role of PET in the Management of Peripheral Artery Disease. Current Cardiology Reports 2023, 25: 831-839. PMID: 37314651, PMCID: PMC11542486, DOI: 10.1007/s11886-023-01904-8.Peer-Reviewed Original ResearchConceptsPeripheral artery diseaseArtery diseaseLower extremitiesManagement of PADSetting of PADEarly detectionLarge vessel diseaseManagement of patientsNon-invasive testsPositron emission tomography (PET) imagingEmission Tomography ImagingNon-invasive toolVascular inflammationVessel diseaseMicrovascular perfusionRoutine screeningBlood flowClinical researchPatientsDiseaseTomography imagingPET imagingSkeletal musclePotential roleSummaryThe purposePredictors of Revascularization in Lower-Extremity Peripheral Artery Disease: Insights From the PORTRAIT Study
Pokharel Y, Kokkinidis D, Wang J, Gosch K, Safley D, Spertus J, Mena-Hurtado C, Smolderen K. Predictors of Revascularization in Lower-Extremity Peripheral Artery Disease: Insights From the PORTRAIT Study. Journal Of Endovascular Therapy 2023, 32: 423-430. PMID: 37309164, DOI: 10.1177/15266028231179574.Peer-Reviewed Original ResearchPredictors of revascularizationEarly revascularizationPeripheral artery diseaseExtensive diseasePAD symptomsSymptom burdenArtery diseaseOdds ratioLower extremity peripheral artery diseaseAnkle-brachial index scoreGoal-directed medical therapyEarly revascularization proceduresKnee arterial segmentsLifestyle-limiting claudicationRutherford class 3Peripheral arterial diseaseMonths of presentationPatient-level predictorsLower extremity PADMain predictorsMedian odds ratioHierarchical logistic regressionSymptomatic PADDisease guidelinesMedical therapyObesity and Peripheral Artery Disease: Current Evidence and Controversies
Lempesis I, Varrias D, Sagris M, Attaran R, Altin E, Bakoyiannis C, Palaiodimos L, Dalamaga M, Kokkinidis D. Obesity and Peripheral Artery Disease: Current Evidence and Controversies. Current Obesity Reports 2023, 12: 264-279. PMID: 37243875, PMCID: PMC10220347, DOI: 10.1007/s13679-023-00510-7.Peer-Reviewed Original ResearchConceptsPeripheral artery diseaseArtery diseaseCurrent evidenceLower extremity peripheral artery diseaseHigher Body Mass IndexSignificant public health problemPurpose of ReviewObesityPresence of obesityPotential pathophysiologic mechanismsRisk of morbidityBody mass indexBody fat distributionProgression of atherosclerosisMajor risk factorPublic health problemPotential protective roleMendelian randomization studyObesity paradoxAggressive treatmentCardiovascular manifestationsMass indexNormal weightPad developmentPathophysiologic mechanismsRisk factorsObesity prevalence and variability in management practices for patients with symptomatic peripheral artery disease
Scierka L, Peri-Okonny P, Romain G, Mena-Hurtado C, Smolderen K. Obesity prevalence and variability in management practices for patients with symptomatic peripheral artery disease. Obesity Research & Clinical Practice 2023, 17: 264-268. PMID: 37225553, DOI: 10.1016/j.orcp.2023.05.002.Peer-Reviewed Original ResearchConceptsPeripheral arterial diseaseWeight loss medicationsObesity management strategiesMedian odds ratioDietary counselingLower extremity peripheral arterial diseaseSymptomatic peripheral artery diseaseDietary management strategiesSymptomatic PAD patientsPeripheral artery diseaseObesity prevalence ratesPrevalence of obesityPoor disease outcomeModifiable comorbiditiesPORTRAIT registryPAD patientsArtery diseaseArterial diseaseTreatment modalitiesObesity prevalenceOdds ratioDisease outcomePrevalence ratesPAD managementObesityInfluence of Lower Limb Ischemia on Skeletal Muscle Mass Depletion in Patients with Peripheral Artery Disease
Nishibe T, Kano M, Akiyama S, Chiba F, Nishibe M, Koizumi J, Dardik A. Influence of Lower Limb Ischemia on Skeletal Muscle Mass Depletion in Patients with Peripheral Artery Disease. Annals Of Vascular Surgery 2023, 94: 136-142. PMID: 37019357, DOI: 10.1016/j.avsg.2023.03.031.Peer-Reviewed Original ResearchConceptsAnkle-brachial pressure indexSkeletal muscle mass indexPeripheral artery diseaseSkeletal muscle massBioelectrical impedance analysisMuscle massLimb ischemiaArtery diseaseLow ankle-brachial pressure indexSkeletal muscle mass depletionSymptomatic peripheral artery diseaseTokyo Medical University HospitalMuscle mass depletionBrachial pressure indexLower limb ischemiaMuscle mass indexMedical University HospitalNonischemic legsExercise therapyIntermittent claudicationIschemic legDuplex scanEndovascular treatmentMass indexPhysical functionPatterns of Care and Outcomes of Ambulatory Endovascular Interventions in Lower Extremity Peripheral Arterial Disease
Chaturvedi A, Castro-Dominguez Y, Gertz Z, Lawson B, Chandrika P, Gupta R, Milioglou I, Sung J, Desai N, Vetrovec G, Kochar A, Guha A. Patterns of Care and Outcomes of Ambulatory Endovascular Interventions in Lower Extremity Peripheral Arterial Disease. The American Journal Of Cardiology 2023, 194: 17-26. PMID: 36924641, DOI: 10.1016/j.amjcard.2023.02.006.Peer-Reviewed Original ResearchConceptsPatterns of careEndovascular interventionCardiovascular eventsLower extremity peripheral arterial diseaseLower Extremity Endovascular InterventionsChronic kidney diseasePeripheral arterial diseasePeripheral artery diseasePrimary treatment modalityIschemic heart diseaseNon-Medicare insuranceUrban teaching facilityDisease refractoryUncontrolled hypertensionMost patientsArtery diseaseHeart failureArterial diseaseStudy cohortKidney diseaseMean ageNoninvasive managementTreatment modalitiesHeart diseaseFemale genderLower extremity symptoms and ankle–brachial index screening as predictors of cardiovascular outcomes in Black adults
Lee M, Smolderen K, Ionescu C, Hillegass W, Romain G, Mena-Hurtado C. Lower extremity symptoms and ankle–brachial index screening as predictors of cardiovascular outcomes in Black adults. Vascular Medicine 2023, 28: 197-204. PMID: 37293738, DOI: 10.1177/1358863x231151729.Peer-Reviewed Original ResearchConceptsPeripheral artery diseaseAbnormal ABILower extremity symptomsNormal ABILeg symptomsHigh riskBlack adultsExtremity symptomsStepwise Cox proportional hazards modelKaplan-Meier survival curvesCox proportional hazards modelAnkle-brachial indexFramingham risk factorsJackson Heart StudyProportional hazards modelCardiovascular outcomesCause mortalityArtery diseaseAsymptomatic diseaseAdverse outcomesMean ageSymptom assessmentAsymptomatic participantsRisk factorsSymptomatic participantsTP53-mediated clonal hematopoiesis confers increased risk for incident atherosclerotic disease
Zekavat S, Viana-Huete V, Matesanz N, Jorshery S, Zuriaga M, Uddin M, Trinder M, Paruchuri K, Zorita V, Ferrer-Pérez A, Amorós-Pérez M, Kunderfranco P, Carriero R, Greco C, Aroca-Crevillen A, Hidalgo A, Damrauer S, Ballantyne C, Niroula A, Gibson C, Pirruccello J, Griffin G, Ebert B, Libby P, Fuster V, Zhao H, Ghassemi M, Natarajan P, Bick A, Fuster J, Klarin D. TP53-mediated clonal hematopoiesis confers increased risk for incident atherosclerotic disease. Nature Cardiovascular Research 2023, 2: 144-158. PMID: 36949957, PMCID: PMC10026701, DOI: 10.1038/s44161-022-00206-6.Peer-Reviewed Original ResearchPeripheral artery diseaseIncident peripheral artery diseaseArtery diseaseAtherosclerotic diseaseChimeric miceIncident atherosclerotic diseaseCoronary artery diseaseAortic plaque sizeAccumulation of macrophagesMass General Brigham BiobankEntire arterial systemWhole-exome sequencingDNA damage repair genesCause mortalityCoronary arteryHematologic malignanciesPlaque macrophagesClinical dataTransplantation strategiesArterial systemPlaque sizeAtherosclerosisClonal hematopoiesisDiseaseIndeterminate potential
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