2025
Understanding Racial and Ethnic Disparities in Myasthenia Gravis Outcomes
McLaren N, Roy B, Nowak R. Understanding Racial and Ethnic Disparities in Myasthenia Gravis Outcomes. Neurology Clinical Practice 2025, 15: e200503. PMID: 40584640, PMCID: PMC12204767, DOI: 10.1212/cpj.0000000000200503.Peer-Reviewed Original ResearchLong-term outcomes of patientsOutcomes of patientsLong-term outcomesAA patientsNon-Hispanic patientsMyasthenia gravisWhite patientsHistory of thymomaLong-term outcome analysisRetrospective cohort studyYears of follow-up dataDiagnosis of MGRepetitive nerve stimulationFollow-up dataSingle-fiber electromyographyMG crisisClinical featuresClinical profileLogistic regression modelsEthnic differencesAntibody seropositivityCohort studyNerve stimulationOutcome analysisPatientsModerate alcohol-associated hepatitis: A real-world multicenter study
Idalsoaga F, Díaz L, Dunn W, Mehta H, Muñoz K, Caldentey V, Arnold J, Ayares G, Mortuza R, Sarin S, Maiwall R, Zhang W, Qian S, Simonetto D, Singal A, Elfeki M, Ramirez-Cadiz C, Malhi G, Ahmed A, Homsi H, Abid Z, Cabezas J, Echavarría V, Poca M, Soriano G, Cuyas B, Cots M, La Tijera M, Ayala-Valverde M, Perez D, Gomez J, Abraldes J, Al-Karaghouli M, Jalal P, Ibrahim M, García-Tsao G, Goyes D, Skladaný L, Havaj D, Sulejova K, Selcanova S, Rincón D, Chacko K, Restrepo J, Yaquich P, Toro L, Shah V, Arrese M, Kamath P, Bataller R, Arab J. Moderate alcohol-associated hepatitis: A real-world multicenter study. Hepatology Communications 2025, 9: e0673. PMID: 40131003, PMCID: PMC11936654, DOI: 10.1097/hc9.0000000000000673.Peer-Reviewed Original ResearchConceptsSevere alcohol-associated hepatitisNeutrophil-to-lymphocyte ratioMaddrey's discriminant functionModerate AHMultiple organ failureOrgan failureMulticenter retrospective cohort studyAlcohol-associated hepatitisCumulative survival rateRetrospective cohort studyReceiver operating characteristic curveLong-term outcomesShort-term mortalityMortality scoring systemsPrognostic factorsSerum bilirubinMELD scoreWell-characterized diseaseClinical profileMedian MELDCohort studyCox regressionMultivariate analysisTherapeutic strategiesSurvival rate
2024
USING MIXED EFFECTS GROWTH MODEL TO EXAMINE LONG-TERM COURSE OF PHYSICAL ACTIVITIES AMONG POSTSTROKE PATIENTS
Han L, Luzum G, Allore H, Askim T, Tan X, Thingstad P, Håberg A, Saltvedt I. USING MIXED EFFECTS GROWTH MODEL TO EXAMINE LONG-TERM COURSE OF PHYSICAL ACTIVITIES AMONG POSTSTROKE PATIENTS. Innovation In Aging 2024, 8: 739-739. PMCID: PMC11691767, DOI: 10.1093/geroni/igae098.2407.Peer-Reviewed Original ResearchPhysical activityUpright timeRehabilitation programPhysical activity of patientsPost-stroke rehabilitation programsLong-term PAProfessional follow-upEnvironment of communitiesPost-stroke patientsWalkable neighborhoodsPA coursesPoststroke patientsPost-strokeRandom interceptSocioeconomic environmentConfounding factorsLinear growth modelFollow-upClinical profileRestore functionDeclining coursePatientsProgramIndividualsConfoundingEnhancing patient representation learning with inferred family pedigrees improves disease risk prediction
Huang X, Arora J, Erzurumluoglu A, Stanhope S, Lam D, Arora J, Erzurumluoglu A, Lam D, Khoueiry P, Jensen J, Cai J, Lawless N, Kriegl J, Ding Z, de Jong J, Zhao H, Ding Z, Wang Z, de Jong J. Enhancing patient representation learning with inferred family pedigrees improves disease risk prediction. Journal Of The American Medical Informatics Association 2024, 32: 435-446. PMID: 39723811, PMCID: PMC11833479, DOI: 10.1093/jamia/ocae297.Peer-Reviewed Original ResearchConceptsElectronic health recordsDisease risk predictionElectronic health record researchFamily health historyGenetic aspects of diseaseRisk predictionInflammatory bowel disease subtypeHealth recordsHealth historyAspects of diseaseFamily relationsHealthcare ResearchPatient's disease riskInfluence of geneticsDisease riskDiagnosis dataFamily pedigreeEnvironmental exposuresRisk factorsDisease dependencyPatient representation learningClinical profileFamilyDisease subtypesRiskTorsemide vs Furosemide Among Patients With New-Onset vs Worsening Chronic Heart Failure
Krim S, Anand S, Greene S, Chen A, Wojdyla D, Vilaro J, Haught H, Herre J, Eisenstein E, Anstrom K, Pitt B, Velazquez E, Mentz R. Torsemide vs Furosemide Among Patients With New-Onset vs Worsening Chronic Heart Failure. JAMA Cardiology 2024, 9: 182-188. PMID: 37955908, PMCID: PMC10644243, DOI: 10.1001/jamacardio.2023.4776.Peer-Reviewed Original ResearchDe novo heart failureNovo heart failureChronic heart failureHeart failurePatient-reported outcomesCause mortalityHF typeKansas City Cardiomyopathy Questionnaire clinical summary scoreHigher glomerular filtration rateSignificant differencesHeart Failure TrialGlomerular filtration rateClinical summary scoreDiuretic strategyFirst rehospitalizationCause hospitalizationNew onsetTotal hospitalizationsClinical characteristicsClinical profileEjection fractionLoop diureticsFailure TrialHospitalization outcomesNatriuretic peptide
2023
Childhood maltreatment, dissociation and borderline personality disorder: Preliminary data on the mediational role of mentalizing in complex post‐traumatic stress disorder
Bateman A, Rüfenacht E, Perroud N, Debbané M, Nolte T, Shaverin L, Fonagy P. Childhood maltreatment, dissociation and borderline personality disorder: Preliminary data on the mediational role of mentalizing in complex post‐traumatic stress disorder. Psychology And Psychotherapy Theory Research And Practice 2023, 97: 58-74. PMID: 38108566, DOI: 10.1111/papt.12514.Peer-Reviewed Original ResearchPost-traumatic stress disorderBorderline personality disorderCo-occurring symptomsClinical profileComplex post-traumatic stress disorderComplex PTSDCo-occurring borderline personality disorderStress disorderChildhood sexual abuseDSM-IV Axis II DisordersDiagnosis of BPDPersonality disorderGroup of patientsSevere clinical profileDissociative symptomsStructured Clinical InterviewBPD diagnostic criteriaRoutine clinical servicesAxis II disordersChildhood maltreatmentChildhood trauma historyBPD severityDiagnostic criteriaPatientsClinical InterviewMentalization based treatment of youth on the psychotic spectrum: clinical profiles and outcomes for youth in the ECID
Dangerfield M, Decker L. Mentalization based treatment of youth on the psychotic spectrum: clinical profiles and outcomes for youth in the ECID. Frontiers In Psychiatry 2023, 14: 1206511. PMID: 37469356, PMCID: PMC10352583, DOI: 10.3389/fpsyt.2023.1206511.Peer-Reviewed Original ResearchMentalization-based treatmentPsychotic spectrumPsychotic disorder in adulthoodGeneralized Estimating EquationsClinically reliable changeDisorders in adulthoodMonths of treatmentTreatment of youthYear of treatmentClinically meaningful impactHigh-risk groupExtremely high-riskHigh-risk youthTotal severity scoreSymptom severityClinical profileSchool engagementSeverity scoreReliability changesHigh riskMeaningful impactClinical changesGroup effectEarly interventionTreatmentScreening strategies for glucose tolerance abnormalities and diabetes in people with cystic fibrosis
Weiss L, Reix P, Mosnier-Pudar H, Ronsin O, Beltrand J, Reynaud Q, Mely L, Burgel P, Stremler N, Rakotoarisoa L, Galderisi A, Perge K, Bendelac N, Abely M, Kessler L. Screening strategies for glucose tolerance abnormalities and diabetes in people with cystic fibrosis. Diabetes & Metabolism 2023, 49: 101444. PMID: 37030530, DOI: 10.1016/j.diabet.2023.101444.Peer-Reviewed Original ResearchConceptsGlucose tolerance abnormalitiesCystic fibrosis-related diabetesTolerance abnormalitiesCystic fibrosisAnnual oral glucose tolerance testOral glucose tolerance testGlucose tolerance testLong asymptomatic periodStage of diabetesNew comorbiditiesAsymptomatic periodClinical profileTolerance testNew diagnostic toolsPathophysiological knowledgeDiabetesNutritional outcomesPatientsFibrosisAbnormalitiesScreening strategyLife expectancyDiagnostic toolScreening methodComorbidities
2022
IGFBP-7 and Outcomes in Heart Failure With Reduced Ejection Fraction Findings From DAPA-HF
Adamson C, Welsh P, Docherty K, de Boer R, Diez M, Drożdż J, Dukát A, Inzucchi S, Køber L, Kosiborod M, Ljungman C, Martinez F, Ponikowski P, Sabatine M, Morrow D, Lindholm D, Hammarstedt A, Boulton D, Greasley P, Langkilde A, Solomon S, Sattar N, McMurray J, Jhund P. IGFBP-7 and Outcomes in Heart Failure With Reduced Ejection Fraction Findings From DAPA-HF. JACC Heart Failure 2022, 11: 291-304. PMID: 36592046, DOI: 10.1016/j.jchf.2022.09.004.Peer-Reviewed Original ResearchConceptsInsulin-like growth factor-binding protein 7IGFBP-7 levelsHeart failureN-terminal pro-B-type natriuretic peptidePro-B-type natriuretic peptideHigh-sensitivity troponin TCox proportional hazards modelBenefit of dapagliflozinDAPA-HF trialEjection fraction (EF) findingsIGFBP-7 concentrationsWorse clinical profileReduced ejection fractionAdverse clinical outcomesPotential prognostic biomarkerProportional hazards modelAdvanced HFrEFDAPA-HFCardiovascular deathHF outcomesNT-proBNPPrimary endpointClinical profileEjection fractionHighest tertileContemporary National Patterns of Eligibility and Use of Novel Lipid‐Lowering Therapies in the United States
Shen M, Nargesi A, Nasir K, Bhatt DL, Khera R. Contemporary National Patterns of Eligibility and Use of Novel Lipid‐Lowering Therapies in the United States. Journal Of The American Heart Association 2022, 11: e026075. PMID: 36102276, PMCID: PMC9683659, DOI: 10.1161/jaha.122.026075.Peer-Reviewed Original ResearchConceptsLipid-Lowering TherapyIcosapent ethylCardiology/American Heart Association (ACC/AHA) guideline recommendationsNutrition Examination Survey dataAddition of ezetimibeUse of statinsClinical practice guidelinesCurrent statin usePopulation health outcomesConclusions SixCardiovascular outcomesStatin useClinical profileGuideline recommendationsLipid profileNational HealthPCSK9iNovel therapiesNovel agentsPractice guidelinesUS adultsAmerican CollegeStatinsHealth outcomesTherapyMachine learning to define phenotypes and outcomes of patients hospitalized for heart failure with preserved ejection fraction: Findings from ASCEND-HF
Murray EM, Greene SJ, Rao VN, Sun JL, Alhanti BA, Blumer V, Butler J, Ahmad T, Mentz RJ. Machine learning to define phenotypes and outcomes of patients hospitalized for heart failure with preserved ejection fraction: Findings from ASCEND-HF. American Heart Journal 2022, 254: 112-121. PMID: 36007566, DOI: 10.1016/j.ahj.2022.08.009.Peer-Reviewed Original ResearchConceptsASCEND-HF trialAtrial fibrillationBlood pressureEjection fractionHeart failureLatent class analysisOutcomes of patientsLong-term outcomesYoung menFour-hour urine outputDistinct phenotypesAcute HFRenal impairmentClinical profileUrine outputASCEND-HFClinical benefitHeterogenous diseaseClinical dataOlder womenHFpEFPatientsOlder individualsCluster 3Asian womenDemographic and clinical characteristics of lithium‐treated older adults with bipolar disorder
Forlenza OV, Hajek T, Almeida OP, Beunders AJM, Blumberg HP, Briggs FBS, De‐Paula V, Dols A, Eyler LT, Forester BP, Gildengers A, Jimenez E, Korten NCM, Lafer B, McWhinney SR, Mulsant B, Rej S, Sarna K, Schouws S, Sutherland A, Tsai S, Vieta E, Yala J, Sajatovic M, initiative G. Demographic and clinical characteristics of lithium‐treated older adults with bipolar disorder. Acta Psychiatrica Scandinavica 2022, 146: 442-455. PMID: 35837985, PMCID: PMC9588573, DOI: 10.1111/acps.13474.Peer-Reviewed Original ResearchConceptsLithium usersBipolar disorderClinical characteristicsOlder adultsDepression Rating ScaleCross-sectional analysisGlobal cognitive stateCardiovascular comorbiditiesCross-sectional approachClinical profileMood stabilizersLithium therapySevere depressionPsychiatric diagnosisRating ScaleCurrent prescriptionGlobal AGEingDisordersRapid cyclingAdultsRelevant differencesSafety concernsLower scoresCurrent useMethodological limitationsSex Differences in Characteristics, Treatments, and Outcomes Among Patients Hospitalized for Non–ST-Segment–Elevation Myocardial Infarction in China: 2006 to 2015
Guo W, Du X, Gao Y, Hu S, Lu Y, Dreyer RP, Li X, Spatz ES, Masoudi FA, Krumholz HM, Zheng X. Sex Differences in Characteristics, Treatments, and Outcomes Among Patients Hospitalized for Non–ST-Segment–Elevation Myocardial Infarction in China: 2006 to 2015. Circulation Cardiovascular Quality And Outcomes 2022, 15: e008535-e008535. PMID: 35607994, PMCID: PMC9208815, DOI: 10.1161/circoutcomes.121.008535.Peer-Reviewed Original ResearchConceptsSegment elevation myocardial infarctionInvasive strategyMyocardial infarctionHospital mortalityHospital outcomesMultivariable logistic regression modelCardiovascular risk factorsElevation myocardial infarctionSex-related disparitiesQuality of careProportion of womenLogistic regression modelsSex differencesClinical characteristicsClinical profileRisk factorsClinical covariatesSex-specific differencesPatientsInfarctionST segmentSex gapChinese hospitalsMortalityWomenClinical Profile and Sex-Specific Recovery With Cardiac Rehabilitation After Coronary Artery Bypass Grafting Surgery
Safdar B, Mori M, Nowroozpoor A, Geirsson A, D'Onofrio G, Mangi AA. Clinical Profile and Sex-Specific Recovery With Cardiac Rehabilitation After Coronary Artery Bypass Grafting Surgery. Clinical Therapeutics 2022, 44: 846-858. PMID: 35570056, DOI: 10.1016/j.clinthera.2022.04.002.Peer-Reviewed Original ResearchConceptsCardiac rehabilitationElectronic health recordsComposite outcomeEndothelial functionClinical profileCoronary Artery Bypass Grafting SurgeryMajor adverse cardiac outcomesPostoperative blood transfusionTwelve-month mortalityCardiac risk factorsCoronary artery bypassPrimary composite outcomeRetrospective cohort studyHealth recordsAdverse cardiac outcomesCardiac risk profileKaplan-Meier analysisBody mass indexSex-specific outcomesKaplan-Meier plotsThoracic Surgeons registryAerobic exercise durationHigher hemoglobin AHealth care systemUrgent CABGSingle- vs. Multi-Item Assessment of Suicidal Ideation Among Adolescents.
Gratch I, Tezanos K, Fernades S, Bell K, Pollak O, Cha C. Single- vs. Multi-Item Assessment of Suicidal Ideation Among Adolescents. Rhode Island Medical Journal 2022, 105: 16-21. PMID: 35476730.Peer-Reviewed Original ResearchUnsupervised Machine Learning To Define Acute Hfpef Phenotypes: Findings From Ascend-hf
Murray E, Greene S, Rao V, Sun J, Alhanti B, Blumer V, Butler J, Ahmad T, Hernandez A, Mentz R. Unsupervised Machine Learning To Define Acute Hfpef Phenotypes: Findings From Ascend-hf. Journal Of Cardiac Failure 2022, 28: s10-s11. DOI: 10.1016/j.cardfail.2022.03.029.Peer-Reviewed Original ResearchSystolic blood pressureHFpEF phenotypeGroup patientsBaseline characteristicsBlood pressureHeart rateHigher systolic blood pressureLower systolic blood pressureDistinct baseline characteristicsDistinct patient phenotypesClinical trial cohortNatriuretic peptide concentrationsASCEND-HF trialTime of admissionFuture clinical trialsDistinct clinical outcomesLower heart rateHigher heart rateDistinct phenotypesHigh rateMedical comorbiditiesTrial cohortClinical profileEjection fractionHeart failureObsessive-Compulsive Disorder Treatment Based on Neurocircuits
Shephard E, Stern E, Miguel E. Obsessive-Compulsive Disorder Treatment Based on Neurocircuits. Psychiatric Annals 2022, 52: 152-156. DOI: 10.3928/00485713-20220317-01.Peer-Reviewed Original ResearchObsessive-compulsive disorderNew treatment approachesObsessive-compulsive disorder (OCD) treatmentClinical profileIndividual patientsGlobal burdenNeurocognitive alterationsPsychiatric disordersPsychiatric treatmentTreatment approachesDisorder treatmentPsychiatric conditionsClinical useSpecific neurocircuitsUnderlying neurobiological basisModels of OCDNeurobiological basisTreatmentNeurocircuitsDisordersPatientsClinical profile and treatment outcomes in patients with hereditary angioedema with normal C1 esterase inhibitor
Jones DH, Bansal P, Bernstein JA, Fatteh S, Harper J, Hsu FI, O’Connor M, Park N, Suez D. Clinical profile and treatment outcomes in patients with hereditary angioedema with normal C1 esterase inhibitor. World Allergy Organization Journal 2022, 15: 100621. PMID: 35145604, PMCID: PMC8804245, DOI: 10.1016/j.waojou.2021.100621.Peer-Reviewed Original ResearchManagement of HAEMost patientsHereditary angioedemaC1 esterase inhibitorAngioedema attacksHAE attacksMedian ageClinical profileSerum levelsRhC1-INHTreatment outcomesRecombinant human C1 esterase inhibitorNormal C1 esterase inhibitorEsterase inhibitorHuman C1 esterase inhibitorAcute HAE attacksHigh-dose antihistaminesUS treatment centersPatient-reported assessmentsLow serum levelsPatient-reported outcomesC1-INH deficiencyAvailability of treatmentImproved disease controlBreakthrough attacks
2021
Clinical significance of hepatosplenic thrombosis in vaccine-induced immune thrombotic thrombocytopenia after ChAdOx1 nCoV-19 vaccination
Hwang J, Han Y, Yon D, Lee S, Kim B, Lee S, Lee M, Park S, Koyanagi A, Jacob L, Tizaoui K, Kim S, Shin J, Smith L. Clinical significance of hepatosplenic thrombosis in vaccine-induced immune thrombotic thrombocytopenia after ChAdOx1 nCoV-19 vaccination. International Journal Of Infectious Diseases 2021, 116: 114-121. PMID: 34958931, DOI: 10.1016/j.ijid.2021.12.352.Peer-Reviewed Original ResearchConceptsVaccine-induced immune thrombotic thrombocytopeniaChAdOx1 nCoV-19 vaccineD-dimer levelsPlatelet countThrombotic thrombocytopeniaCases of vaccine-induced immune thrombotic thrombocytopeniaClinical significanceClinical profile of patientsHigher D-dimer levelsLow platelet countProfile of patientsCOVID-19 vaccine administrationD-dimerCase seriesClinical characteristicsCase reportClinical profileSevere presentationPubMed ePubsWeb of Science databasesThrombosisPatientsVaccine administrationThrombocytopeniaOrgan systemsClinical presentation of new onset refractory status epilepticus in children (the pSERG cohort)
Sculier C, Aguilar C, Gaspard N, Gaínza‐Lein M, Fernández I, Amengual‐Gual M, Anderson A, Arya R, Burrows B, Brenton J, Carpenter J, Chapman K, Clark J, Gaillard W, Glauser T, Goldstein J, Goodkin H, Gorman M, Lai Y, McDonough T, Mikati M, Nayak A, Peariso K, Riviello J, Rusie A, Sperberg K, Stredny C, Tasker R, Tchapyjnikov D, Vasquez A, Wainwright M, Wilfong A, Williams K, Loddenkemper T, pSERG. Clinical presentation of new onset refractory status epilepticus in children (the pSERG cohort). Epilepsia 2021, 62: 1629-1642. PMID: 34091885, PMCID: PMC8362203, DOI: 10.1111/epi.16950.Peer-Reviewed Original ResearchConceptsOnset refractory status epilepticusRefractory status epilepticusRefractory SEFebrile SEStatus epilepticusUnknown etiologyBaseline neurological functionSE onsetMedian ageProlonged SESE episodesClinical presentationPediatric patientsClinical characteristicsFever onsetClinical profileSubgroup analysisNeurological functionEpilepsy syndromesPatientsFeverDiagnostic criteriaEpilepticusEtiologyBaseline function
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