2023
Leptin-Mediated Induction of IL-6 Expression in Hofbauer Cells Contributes to Preeclampsia Pathogenesis
Ozmen A, Nwabuobi C, Tang Z, Guo X, Larsen K, Guller S, Blas J, Moore M, Kayisli U, Lockwood C, Guzeloglu-Kayisli O. Leptin-Mediated Induction of IL-6 Expression in Hofbauer Cells Contributes to Preeclampsia Pathogenesis. International Journal Of Molecular Sciences 2023, 25: 135. PMID: 38203306, PMCID: PMC10778808, DOI: 10.3390/ijms25010135.Peer-Reviewed Original ResearchConceptsIL-6 expressionHofbauer cellsP65 NF-κBIL-6NF-κBLeptin levelsPreeclampsia pathogenesisElevated serum interleukin-6 levelsSerum interleukin-6 levelsERK1/2 MAPKInterleukin-6 levelsPro-inflammatory phenotypeAnti-inflammatory phenotypeLeptin receptor expressionIL-6 productionPathogenesis of PEPlacental leptin productionPhosphorylation levelsERK1/2 MAPK inhibitorIL-6 regulationConcentration-dependent mannerPE patientsHuman pregnancySecond trimesterLeptin concentrationsAssociations of Trimester-Specific Exposure to Perchlorate, Thiocyanate, and Nitrate with Childhood Neurodevelopment: A Birth Cohort Study in China
Li J, Tu F, Wan Y, Qian X, Mahai G, Wang A, Ma J, Yang Z, Xia W, Xu S, Zheng T, Li Y. Associations of Trimester-Specific Exposure to Perchlorate, Thiocyanate, and Nitrate with Childhood Neurodevelopment: A Birth Cohort Study in China. Environmental Science And Technology 2023, 57: 20480-20493. PMID: 38015815, DOI: 10.1021/acs.est.3c06013.Peer-Reviewed Original ResearchMental Development IndexOffspring neurodevelopmentMaternal exposureQuantile sum regression analysesTrimester-specific analysesTrimester-specific exposureBirth cohort studyRegression analysisBayesian kernel machine regression (BKMR) analysisCohort studyEarly pregnancyFirst trimesterSecond trimesterPrenatal exposureChildhood neurodevelopmentUrinary thiocyanateBirth cohortTrimesterNeurodevelopmentUrine samplesSensitive windowExposureAssociationMixture exposurePoint decreaseIdentifying Pregnancies at Higher Risk for HPA-1a Alloimmunization and Fetal/Neonatal Alloimmune Thrombocytopenia (FNAIT): An International, Prospective, Natural History Study
Vander Haar E, Ware C, Allen G, Armstrong R, Black D, Bombara M, Dhanraj D, Lawrence L, Miller R, Nanda S, Paidas M, Patki K, Sitras V, Skupski D, Swarup M, Thorp J, Tiller H, Verweij J, Bussel J. Identifying Pregnancies at Higher Risk for HPA-1a Alloimmunization and Fetal/Neonatal Alloimmune Thrombocytopenia (FNAIT): An International, Prospective, Natural History Study. Blood 2023, 142: 1224. DOI: 10.1182/blood-2023-177657.Peer-Reviewed Original ResearchFetal/Neonatal Alloimmune ThrombocytopeniaHPA-1a alloimmunizationNeonatal alloimmune thrombocytopeniaPregnant womenHuman platelet antigensNatural history studiesFetal deathNeonatal thrombocytopeniaSecond trimesterPlatelet countAlloimmune thrombocytopeniaRisk pregnanciesWeek 10HPA-1a negative womenAdministration of prophylaxisAntenatal intravenous immunoglobulinHPA-1bb womenLifelong neurological impairmentMultiple European centersSevere neonatal thrombocytopeniaHigh-risk womenSingle-arm studyFetal platelet countGestational weeks 10First epidemiological studyIncorporating early pregnancy mental health screening and management into routine maternal care: experience from the Rajarata Pregnancy Cohort (RaPCo), Sri Lanka
Agampodi T, Amarasinghe G, Wickramasinghe A, Wickramasinghe N, Warnasekara J, Jayasinghe I, Hettiarachchi A, Nimesha D, Dilshani T, Senadheera S, Agampodi S. Incorporating early pregnancy mental health screening and management into routine maternal care: experience from the Rajarata Pregnancy Cohort (RaPCo), Sri Lanka. BMJ Global Health 2023, 8: e012852. PMID: 37748792, PMCID: PMC10533714, DOI: 10.1136/bmjgh-2023-012852.Peer-Reviewed Original ResearchConceptsEdinburgh Postnatal Depression ScaleMental health screeningMental health problemsPregnancy cohortSecond trimesterEarly pregnancyHealth screeningClinical InterviewHealth problemsPregnancy care programsRoutine maternal careTertiary care hospitalMental health service provisionPrimary healthcare levelHigher EPDS scoresPostnatal Depression ScaleWeeks of periodPregnancy-associated conditionsMental health gapPatient-centered careHealth service provisionHealth surveillance systemsCare hospitalMiddle-income countriesPregnant womenPerceived Stress and Depressive Symptoms Are Associated With Emotional Eating but Not Nutritional Intake During Pregnancy: A Prospective Cohort Study
Carandang R, Epel E, Radin R, Lewis J, Ickovics J, Cunningham S. Perceived Stress and Depressive Symptoms Are Associated With Emotional Eating but Not Nutritional Intake During Pregnancy: A Prospective Cohort Study. Journal Of Midwifery & Women's Health 2023, 69: 64-70. PMID: 37358371, DOI: 10.1111/jmwh.13537.Peer-Reviewed Original ResearchThird trimesterNutritional intakeDepressive symptomsPregnant womenPsychological distressEmotional eatingProspective cohort studySocial supportAssociation of changesDiverse pregnant womenHigher depressive symptomsLogistic regression modelsCohort studyProspective studySecond trimesterPregnancyTrimesterClinical sitesSymptomsIntakeMajor life eventsMental healthChange scoresWomenGreater likelihoodSerum creatinine and estimated glomerular filtration rate (eGFR) in early pregnancy and changes during the pregnancy
Agampodi S, Agampodi T, Amarasinghe G, Warnasekara J, Hettiarachchi A, Jayasinghe I, Koralegedara I, Abeyrathna P, Srimantha S, de Silva F, Gunarathne S, Wickramasinghe N. Serum creatinine and estimated glomerular filtration rate (eGFR) in early pregnancy and changes during the pregnancy. PLOS Global Public Health 2023, 3: e0000443. PMID: 36962935, PMCID: PMC10021427, DOI: 10.1371/journal.pgph.0000443.Peer-Reviewed Original ResearchGlomerular filtration rateWeeks of gestationRenal functionPregnant womenNonpregnant womenSerum creatinineSecond trimesterEarly pregnancyFiltration rateClinical practiceCommunity-based prospective cohort studyProspective population-based studyPre-existing medical conditionsProspective cohort studyHealthy pregnant womenCommunity-based cohortPopulation-based studyDifferent age strataMean eGFRCohort studyNewborn outcomesNonpregnant groupPregnancy cohortFirst trimesterMean SCr
2022
Prenatal Metal Exposures and Associations with Kidney Injury Biomarkers in Children
Politis M, Yao M, Gennings C, Tamayo-Ortiz M, Valvi D, Kim-Schulze S, Qi J, Amarasiriwardena C, Pantic I, Tolentino M, Estrada-Gutierrez G, Greenberg J, Téllez-Rojo M, Wright R, Sanders A, Rosa M. Prenatal Metal Exposures and Associations with Kidney Injury Biomarkers in Children. Toxics 2022, 10: 692. PMID: 36422900, PMCID: PMC9699100, DOI: 10.3390/toxics10110692.Peer-Reviewed Original ResearchKidney injury biomarkersInjury biomarkersKidney biomarkersGamma-induced protein 10Glomerular filtration rateBirth cohort studyAlpha-1-microglobulinQuantile sum (WQS) regressionPrenatal metal exposureKidney injuryCohort studyUrinary CdPregnant womenSecond trimesterKidney diseasePrenatal exposureFiltration rateCystatin CUrinary metalsNull associationProtein 10A1MMetal exposureBiomarkersProtein 1Low haptoglobin in pregnancy: physiological or intravascular hemolysis?
Villalba C, Choucair I, Vera M, Lee E, El-Khoury J. Low haptoglobin in pregnancy: physiological or intravascular hemolysis? American Journal Of Clinical Pathology 2022, 158: s6-s6. DOI: 10.1093/ajcp/aqac126.009.Peer-Reviewed Original ResearchAcute hemolytic transfusion reactionTrimester-specific reference intervalsNormal lactate dehydrogenaseSecond trimesterThird trimesterFirst trimesterReference intervalsIntravascular hemolysisLactate dehydrogenaseLow haptoglobinB-cell acute lymphoblastic leukemiaRemnant serum samplesDisease Control criteriaElevated total bilirubinRed cell transfusionNon-pregnant populationHemolytic transfusion reactionsHigh estrogen statesAcute lymphoblastic leukemiaLow haptoglobin levelsCombination of pregnancyQuality improvement projectOverall reference intervalRed cell unitsInduction chemotherapyHypertensive disorders during pregnancy and polycystic ovary syndrome are associated with child communication and social skills in a sex-specific and androgen-dependent manner
Firestein MR, Romeo RD, Winstead H, Goldman DA, Grobman WA, Haas DM, Parry S, Reddy UM, Silver RM, Wapner RJ, Champagne FA. Hypertensive disorders during pregnancy and polycystic ovary syndrome are associated with child communication and social skills in a sex-specific and androgen-dependent manner. Frontiers In Endocrinology 2022, 13: 1000732. PMID: 36246897, PMCID: PMC9559211, DOI: 10.3389/fendo.2022.1000732.Peer-Reviewed Original ResearchConceptsPolycystic ovary syndromeHyperandrogenic disordersOvary syndromeMaternal testosteroneHypertensive disordersNulliparous Pregnancy Outcomes StudyCohort study designPregnancy Outcomes StudyYears of ageAutism spectrum disorderSex-specific associationsHigher testosterone levelsChildren's brain developmentNeurodevelopmental outcomesAndrogen-dependent mannerSecond trimesterPrenatal exposureMonitoring MothersTestosterone levelsOutcome studiesPregnancyFemale controlsMaternal plasmaTestosteroneChild communicationAsthma in a prospective cohort of rural pregnant women from Sri Lanka: Need for better care during the pre-conceptional and antenatal period
Rajapakse S, Wickramasinghe N, Warnasekara J, Abeyrathna P, Amarasinghe G, Hettiarachchi AU, Jayasinghe IU, Koralegedara I, Agampodi TC, Agampodi SB. Asthma in a prospective cohort of rural pregnant women from Sri Lanka: Need for better care during the pre-conceptional and antenatal period. PLOS ONE 2022, 17: e0269888. PMID: 35834567, PMCID: PMC9282538, DOI: 10.1371/journal.pone.0269888.Peer-Reviewed Original ResearchConceptsNew-onset wheezePregnant womenSecond trimesterAsthmatic womenPregnancy outcomesPregnant asthmatic womenEligible pregnant womenProspective cohort studyLow birth weightPrevalence of wheezeEffect of asthmaRural pregnant womenMaternal care programmeCohort studyProspective cohortHospital admissionAntenatal periodAsthma prevalenceFirst trimesterBirth weightClinical assessmentHigh prevalenceWheezeAsthmaTrimesterLicit and illicit drug use across trimesters in pregnant women endorsing past-year substance use: Results from National Survey on Drug Use and Health (2009–2019)
Peltier MR, Roberts W, Verplaetse TL, Burke C, Zakiniaeiz Y, Moore K, McKee SA. Licit and illicit drug use across trimesters in pregnant women endorsing past-year substance use: Results from National Survey on Drug Use and Health (2009–2019). Archives Of Women's Mental Health 2022, 25: 819-827. PMID: 35737132, PMCID: PMC9359119, DOI: 10.1007/s00737-022-01244-6.Peer-Reviewed Original ResearchConceptsPast-month substance useFirst trimesterPast-year substance usePregnant womenIllicit substance useDrug useSubstance useThird trimesterCross-sectional population-based dataSignificant public health concernTrimester of pregnancyPrescription pain medicationPopulation-based dataPerinatal substance useIllicit drug useMethodsThe present studyPublic health concernMinority of womenNational surveyLicit substance usePain medicationSimilar low ratesSecond trimesterLate trimesterLicit substances
2021
Can Homocysteine Be Used to Identify Vitamin B12 or Folate Deficiencies During Pregnancy in Low Resource Settings?
Amarasinghe G, Jayasinghe I, Hettiarachchi A, Koralegedara I, Kappagoda C, Mendis W, Agampodi T, Agampodi S. Can Homocysteine Be Used to Identify Vitamin B12 or Folate Deficiencies During Pregnancy in Low Resource Settings? Current Developments In Nutrition 2021, 5: 5140707. PMCID: PMC8181706, DOI: 10.1093/cdn/nzab046_004.Peer-Reviewed Original ResearchAnemic pregnant womenPregnant womenHomocysteine levelsFolate deficiencyB12 levelsB12 deficiencyVitamin B12Folate levelsVitamin B12/folate deficiencyMedian hemoglobin levelSerum homocysteine levelsSerum total homocysteineWeeks of gestationRole of homocysteineUniversal iron supplementationElevated homocysteine levelsLow-resource settingsMiddle-income settingsHemoglobin levelsPregnancy cohortSecond trimesterHospital clinicIron supplementationTotal homocysteineNegative test
2020
First- and Second-Trimester Reference Intervals for Thyroid Function Testing in a US Population
Bunch DR, Firmender K, Harb R, El-Khoury JM. First- and Second-Trimester Reference Intervals for Thyroid Function Testing in a US Population. American Journal Of Clinical Pathology 2020, 155: 776-780. PMID: 33210132, DOI: 10.1093/ajcp/aqaa165.Peer-Reviewed Original ResearchConceptsThyroid-stimulating hormoneTrimester-specific reference intervalsThyroid function testsMIU/LPmol/LReference intervalsFunction testsUS populationSecond trimester prenatal screeningRoche analyzersThyroid function testingNegative screening resultsSpecific reference intervalsRoche Modular E170Singleton pregnanciesThyroglobulin antibodiesThyroid dysfunctionFirst trimesterSecond trimesterAdverse outcomesFunction testingFree thyroxineTotal triiodothyronineTotal thyroxineModular E170Associations between prenatal sunshine exposure and birth outcomes in China
Zhang X, Wang Y, Chen X, Zhang X. Associations between prenatal sunshine exposure and birth outcomes in China. The Science Of The Total Environment 2020, 713: 136472. PMID: 31955080, PMCID: PMC7047502, DOI: 10.1016/j.scitotenv.2019.136472.Peer-Reviewed Original Research
2019
Impact of Wildfire Smoke on Adverse Pregnancy Outcomes in Colorado, 2007–2015
Abdo M, Ward I, O’Dell K, Ford B, Pierce JR, Fischer EV, Crooks JL. Impact of Wildfire Smoke on Adverse Pregnancy Outcomes in Colorado, 2007–2015. International Journal Of Environmental Research And Public Health 2019, 16: 3720. PMID: 31581673, PMCID: PMC6801422, DOI: 10.3390/ijerph16193720.Peer-Reviewed Original ResearchConceptsAdverse pregnancy outcomesBirth weightPregnancy outcomesSecondary outcomesNeonatal intensive care unit admissionIntensive care unit admissionCare unit admissionLow birth weightPre-term birthSmoke PMZip codesLogistic regression modelsGestational hypertensionUnit admissionGestational diabetesPreterm birthMaternal exposurePrimary outcomeGestational ageFirst trimesterSecond trimesterAdverse outcomesFull gestationOutcomesRandom intercept
2018
Cervical funneling or intra‐amniotic debris and preterm birth in nulliparous women with midtrimester cervical length less than 30 mm
Saade G, Thom E, Grobman W, Iams J, Mercer B, Reddy U, Tita A, Rouse D, Sorokin Y, Wapner R, Leveno K, Blackwell S, Esplin M, Tolosa J, Thorp J, Caritis S, Vandorsten J, Network T. Cervical funneling or intra‐amniotic debris and preterm birth in nulliparous women with midtrimester cervical length less than 30 mm. Ultrasound In Obstetrics And Gynecology 2018, 52: 757-762. PMID: 29155504, PMCID: PMC5960623, DOI: 10.1002/uog.18960.Peer-Reviewed Original ResearchConceptsCervical funnelingMidtrimester cervical lengthCervical lengthPreterm birthWeeks' gestationNulliparous womenMedian cervical lengthSecondary cohort analysisNulliparous pregnant womenSecond trimester ultrasoundAsymptomatic nulliparous womenMultivariable adjustmentSingleton gestationsMulticenter trialMultivariable analysisTransvaginal ultrasoundSecond trimesterPregnant womenCohort analysisGestationWomenHigh rateWeeksUltrasoundLtGestational Weight Gain in Women With Polycystic Ovary Syndrome: A Controlled Study
Kent J, Dodson WC, Kunselman A, Pauli J, Stone A, Diamond MP, Coutifaris C, Schlaff WD, Alvero R, Casson P, Christman GM, Rosen RM, Hansen KR, Robinson R, Baker V, Usadi R, Santoro N, Zhang H, Eisenberg E, Legro RS, Network R. Gestational Weight Gain in Women With Polycystic Ovary Syndrome: A Controlled Study. The Journal Of Clinical Endocrinology & Metabolism 2018, 103: 4315-4323. PMID: 30085187, PMCID: PMC6194806, DOI: 10.1210/jc.2017-02764.Peer-Reviewed Original ResearchConceptsPreconception body mass indexGestational weight gainPolycystic ovary syndromeBody mass indexOvulatory controlsPregnancy complicationsOvary syndromeObese groupWeight gainSecond trimesterExcessive gestational weight gainPre-existing obesityProspective cohort studyNormal-weight womenContribution of diagnosisPreconception baselinePreconception weightGestational diabetesPerinatal outcomesCohort studyPerinatal complicationsSingleton pregnanciesMass indexNormal weightFirst trimester
2017
In utero exposure to maternal smoking is associated with DNA methylation alterations and reduced neuronal content in the developing fetal brain
Chatterton Z, Hartley B, Seok M, Mendelev N, Chen S, Milekic M, Rosoklija G, Stankov A, Trencevsja-Ivanovska I, Brennand K, Ge Y, Dwork A, Haghighi F. In utero exposure to maternal smoking is associated with DNA methylation alterations and reduced neuronal content in the developing fetal brain. Epigenetics & Chromatin 2017, 10: 4. PMID: 28149327, PMCID: PMC5270321, DOI: 10.1186/s13072-017-0111-y.Peer-Reviewed Original ResearchMeSH KeywordsBrainDNA MethylationFemaleFetal DevelopmentFetusGestational AgeGTP-Binding Protein alpha Subunits, Gq-G11HumansImmunohistochemistryInduced Pluripotent Stem CellsMaleMaternal ExposureNeural Stem CellsNeuronsPregnancyPregnancy Trimester, SecondPromoter Regions, GeneticSmokingSuccinate DehydrogenaseTubulinConceptsMaternal smokingDorsolateral prefrontal cortexNeuronal contentCortical gray matterFetal brain growthDifferentiation of neuronsBehavioral problemsFalse discovery correctionSignificant DMRsSmoking exposureGestational ageSecond trimesterUtero exposurePrenatal exposureCortical developmentFetal brainExposure altersSmokingBrain growthGray matterCell proportionFetusesPrefrontal cortexDNA methylationMethylation profiles
2016
Discrimination and excessive weight gain during pregnancy among Black and Latina young women
Reid AE, Rosenthal L, Earnshaw VA, Lewis TT, Lewis JB, Stasko EC, Tobin JN, Ickovics JR. Discrimination and excessive weight gain during pregnancy among Black and Latina young women. Social Science & Medicine 2016, 156: 134-141. PMID: 27038321, PMCID: PMC4847945, DOI: 10.1016/j.socscimed.2016.03.012.Peer-Reviewed Original ResearchConceptsExcessive weight gainDepressive symptomsWeight gainRace/ethnicityWeight-related health disparitiesYoung womenLatina womenLater life obesityYoung pregnant womenPregnant young womenThird trimesterLife obesitySecond trimesterPregnant womenMedical recordsMedicine recommendationsLatina young womenHealth outcomesHealth disparitiesSymptomsPsychosocial determinantsPregnancyInfluence of discriminationWomenEnvironmental Affordances ModelParticulate air pollution, fetal growth and gestational length: The influence of residential mobility in pregnancy
Pereira G, Bracken MB, Bell ML. Particulate air pollution, fetal growth and gestational length: The influence of residential mobility in pregnancy. Environmental Research 2016, 147: 269-274. PMID: 26918840, PMCID: PMC4821760, DOI: 10.1016/j.envres.2016.02.001.Peer-Reviewed Original ResearchConceptsLow birth weightTerm low birth weightPreterm birthWhole pregnancySecond trimesterAddress historiesAdverse perinatal outcomesFetal growth restrictionEffects of PM10Particulate air pollutionPerinatal outcomesGestational agePregnancy cohortGestational lengthPregnant womenRetrospective studyBirth weightFetal growthGrowth restrictionPM10 exposureMaternal addressInsufficient evidencePregnancyLogistic regressionBirth
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