2025
Haptoglobin in pregnancy: Trimester-specific reference intervals
Rivera M, Choucair I, Vera M, Lee E, El-Khoury J, Villalba C. Haptoglobin in pregnancy: Trimester-specific reference intervals. American Journal Of Clinical Pathology 2025, aqaf012. PMID: 40037777, DOI: 10.1093/ajcp/aqaf012.Peer-Reviewed Original ResearchThird trimesterFirst-trimesterHaptoglobin valuesTrimester-specific reference intervalsReference intervalsRemnant serum samplesTrimester of pregnancyMann-Whitney testPregnancy patientsNonpregnant populationNonpregnant counterpartsImmunological markersIntravascular hemolysisTrimesterDecreased haptoglobinPregnancyPregnant individualsMann-WhitneyRoche Cobas 8000Nonparametric reference intervalsSerum samplesCobas 8000Quality improvement projectHemolysisPhysiological changes
2024
Puzzling undetectable haptoglobin in a transfused pregnant patient
Chaves Rivera M, Choucair I, Vera M, El-Khoury J, Figueroa Villalba C. Puzzling undetectable haptoglobin in a transfused pregnant patient. Clinica Chimica Acta 2024, 561: 119829. PMID: 38917868, DOI: 10.1016/j.cca.2024.119829.Peer-Reviewed Original ResearchAcute hemolytic transfusion reactionUndetectable haptoglobin levelUndetectable haptoglobinPregnant patientsHaptoglobin levelsB-cell acute lymphocytic leukemiaPregnancy-related physiological changesTrimester-specific reference intervalsReference intervalsCenters for Disease Control (CDC) criteriaDiagnosis of hemolysisNon-pregnant counterpartsTrimester of pregnancyAcute lymphocytic leukemiaHemolytic transfusion reactionsMultidisciplinary approach to patient careFollow-up visitRed cell unitsLactate dehydrogenasePhysiological changesRBC transfusionThird trimesterLymphocytic leukemiaLaboratory findingsImmunological markers
2022
Low haptoglobin in pregnancy: physiological or intravascular hemolysis?
Villalba C, Choucair I, Vera M, Lee E, El-Khoury J. Low haptoglobin in pregnancy: physiological or intravascular hemolysis? American Journal Of Clinical Pathology 2022, 158: s6-s6. DOI: 10.1093/ajcp/aqac126.009.Peer-Reviewed Original ResearchAcute hemolytic transfusion reactionTrimester-specific reference intervalsNormal lactate dehydrogenaseSecond trimesterThird trimesterFirst trimesterReference intervalsIntravascular hemolysisLactate dehydrogenaseLow haptoglobinB-cell acute lymphoblastic leukemiaRemnant serum samplesDisease Control criteriaElevated total bilirubinRed cell transfusionNon-pregnant populationHemolytic transfusion reactionsHigh estrogen statesAcute lymphoblastic leukemiaLow haptoglobin levelsCombination of pregnancyQuality improvement projectOverall reference intervalRed cell unitsInduction chemotherapyValue Ranges and Clinical Comparisons of Serum DHEA-S, IL-6, and TNF-α in Western Lowland Gorillas
Edes AN, Zimmerman D, Jourdan B, Brown JL, Edwards KL. Value Ranges and Clinical Comparisons of Serum DHEA-S, IL-6, and TNF-α in Western Lowland Gorillas. Animals 2022, 12: 2705. PMID: 36230446, PMCID: PMC9559573, DOI: 10.3390/ani12192705.Peer-Reviewed Original ResearchInterleukin-6Assessment of healthSerum DHEAClinical symptomsTumor necrosisAdditional biomarkersClinical comparisonImmune responseHealth statusClinical variationDHEATNFBiomarkersSpecies-typical levelsReference intervalsClinical samplesAvailable kitsWestern lowland gorillasSignificant differencesNon-clinical sampleAgeLowland gorillasHealthLack of informationHuman careProneuropeptide Y and neuropeptide Y metabolites in healthy volunteers and patients with a pheochromocytoma or paraganglioma
Eugster PJ, Maurer J, Vocat C, Abid K, Matter M, Wuerzner G, Trepp R, Fischli S, Henzen C, Kolb W, Bilz S, Sigrist S, Beuschlein F, Nölting S, Reul A, Schütze I, Hubers SA, Brown NJ, Grouzmann E. Proneuropeptide Y and neuropeptide Y metabolites in healthy volunteers and patients with a pheochromocytoma or paraganglioma. Clinica Chimica Acta 2022, 534: 146-155. PMID: 35905838, DOI: 10.1016/j.cca.2022.07.018.Peer-Reviewed Original ResearchConceptsUpper reference limitPlasma free metanephrinesNeuropeptide YSevere kidney impairmentFree metanephrinesNPY3-36Kidney impairmentSympathetic nervesCatecholamine reuptakeVasoconstrictor peptideNPY2-36NPY1-36Early diagnosisHealthy volunteersPPGL patientsAdrenal medullaTumor localizationPatientsNPYReference limitsDiagnostic sensitivityPPGLsGold standardReference intervalsPheochromocytoma
2021
Noninvasive detection of human dehydroepiandrosterone, progesterone and testosterone using LC-MS/MS revealed effects of birth control pills/devices and body weight on ovulatory prediction
Han L, Wemm SE, Shen L, Spink DC, Wulfert E, Cao ZT. Noninvasive detection of human dehydroepiandrosterone, progesterone and testosterone using LC-MS/MS revealed effects of birth control pills/devices and body weight on ovulatory prediction. Journal Of Chromatography B 2021, 1174: 122716. PMID: 33946036, DOI: 10.1016/j.jchromb.2021.122716.Peer-Reviewed Original Research
2020
First- and Second-Trimester Reference Intervals for Thyroid Function Testing in a US Population
Bunch DR, Firmender K, Harb R, El-Khoury JM. First- and Second-Trimester Reference Intervals for Thyroid Function Testing in a US Population. American Journal Of Clinical Pathology 2020, 155: 776-780. PMID: 33210132, DOI: 10.1093/ajcp/aqaa165.Peer-Reviewed Original ResearchConceptsThyroid-stimulating hormoneTrimester-specific reference intervalsThyroid function testsMIU/LPmol/LReference intervalsFunction testsUS populationSecond trimester prenatal screeningRoche analyzersThyroid function testingNegative screening resultsSpecific reference intervalsRoche Modular E170Singleton pregnanciesThyroglobulin antibodiesThyroid dysfunctionFirst trimesterSecond trimesterAdverse outcomesFunction testingFree thyroxineTotal triiodothyronineTotal thyroxineModular E170
2019
Quantification of Neuropeptide Y and Four of Its Metabolites in Human Plasma by Micro-UHPLC-MS/MS
Vocat C, Dunand M, Hubers SA, Bourdillon N, Millet G, Brown NJ, Wuerzner G, Grouzmann E, Eugster PJ. Quantification of Neuropeptide Y and Four of Its Metabolites in Human Plasma by Micro-UHPLC-MS/MS. Analytical Chemistry 2019, 92: 859-866. PMID: 31790196, PMCID: PMC8541045, DOI: 10.1021/acs.analchem.9b03505.Peer-Reviewed Original ResearchConceptsNeuropeptide YNPY3-36Hypertensive patientsHealthy volunteersConcentrations of NPYEndogenous neuropeptide YHuman plasmaNPY2-36Pathological processesReference intervalsEndogenous peptidesChromatography-tandem mass spectrometryPatientsAcid peptideMS/MSVolunteersMetabolitesInter-assay precisionPeptidesPrototype peptideTandem mass spectrometryDistinct effectsOrthostasisCatecholaminesSubpicomolar concentrations
2018
SERUM BIOCHEMISTRY VALUES AND SELECT SEROLOGIC SCREENING OF BROWN HYENAS (PARAHYAENA BRUNNEA) FROM THE NAMIB DESERT, NAMIBIA
Wiesel I, Zimmerman DM, Suedmeyer K. SERUM BIOCHEMISTRY VALUES AND SELECT SEROLOGIC SCREENING OF BROWN HYENAS (PARAHYAENA BRUNNEA) FROM THE NAMIB DESERT, NAMIBIA. Journal Of Zoo And Wildlife Medicine 2018, 49: 931-942. PMID: 30592906, DOI: 10.1638/2017-0121.1.Peer-Reviewed Original ResearchConceptsBrown hyenasCanine adenovirus-2Years of samplingCanine adenovirus-1Domestic dogsCaptive populationsHyena speciesPrevalence of antibodiesProportion of seraAdenovirus 2Namib DesertBiochemical analysisSerologic screeningEpizootic outbreaksCreatinine kinaseAdenovirus 1Immune systemBiochemical reference intervalsHyenasBiochemical parametersEffects of sexSpeciesDistemper virusMost pathogensReference intervals
2016
Hypercalcemia in Patients with Williams-Beuren Syndrome
Sindhar S, Lugo M, Levin MD, Danback JR, Brink BD, Yu E, Dietzen DJ, Clark AL, Purgert CA, Waxler JL, Elder RW, Pober BR, Kozel BA. Hypercalcemia in Patients with Williams-Beuren Syndrome. The Journal Of Pediatrics 2016, 178: 254-260.e4. PMID: 27574996, PMCID: PMC5085847, DOI: 10.1016/j.jpeds.2016.08.027.Peer-Reviewed Original ResearchConceptsAcute life-threatening eventsLife-threatening eventsPlasma calcium levelsWilliams-Beuren syndromeCalcium levelsHigh plasma calcium levelsOccurrence of hypercalcemiaMulticenter retrospective studyPediatric reference intervalsGastrointestinal complaintsRelevant comorbiditiesRetrospective studyRenal anomaliesSubgroup analysisCardiovascular diseaseQT intervalHypercalcemiaDisease processEvidence of dehydrationAvailable normative dataOlder individualsSmall childrenCalcium concentrationInverse correlationReference intervals
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