2025
Glucagon-Like Peptide-1 Is Prognostic of Mortality in Acute Respiratory Failure
Hansell C, Aneis H, Kitsios G, Bain W, Zhao Y, Suber T, Evankovich J, Sharma L, Ramakrishnan S, Prendergast N, Hensley M, Malik S, Petro N, Patel J, Nouraie S, Dela Cruz C, Zhang Y, McVerry B, Shah F. Glucagon-Like Peptide-1 Is Prognostic of Mortality in Acute Respiratory Failure. Critical Care Explorations 2025, 7: e1247. PMID: 40126931, PMCID: PMC11936568, DOI: 10.1097/cce.0000000000001247.Peer-Reviewed Original ResearchConceptsGlucose-dependent insulinotropic peptide levelsGlucagon-like peptide-1 levelsGlucose-dependent insulinotropic peptideAcute respiratory failureGlucagon-like peptide-1Respiratory failureIncretin levelsResponse biomarkersMeasure glucagon-like peptide-1Intestinal permeabilityPrognosticator of adverse outcomeSequential Organ Failure Assessment scoreCritical illnessOrgan Failure Assessment scorePeptide-1Acute respiratory distress syndromeAssociated with systemic inflammationMarkers of intestinal permeabilityCirculating interleukin-6 levelsHost response biomarkersSystemic host responseIncretin hormone glucagon-like peptide-1Respiratory distress syndromeInterleukin-6 levelsCritically ill patients
2024
Abstract 106: Circulating Interleukin-6 Levels Early During Active Stroke Estimate Time of Stroke Onset: Potential New Clinical Biomarker Tool From a Mobile Stroke Unit
Kowalski R, Ledreux A, Violette J, Neumann R, Grotta J, Ornelas D, Thompson J, Monte A, Dylla L, Coughlan C, Yu X, Graner M, Jones W. Abstract 106: Circulating Interleukin-6 Levels Early During Active Stroke Estimate Time of Stroke Onset: Potential New Clinical Biomarker Tool From a Mobile Stroke Unit. Stroke 2024, 55: a106-a106. DOI: 10.1161/str.55.suppl_1.106.Peer-Reviewed Original ResearchInterleukin-6 levelsMobile stroke unitInterleukin-6Symptom onsetLesion volumeAcute strokeHealthy controlsMobile stroke unit patientsDevelopment of immunomodulatory therapiesMedian interleukin-6Circulating interleukin-6 levelsMeasurement of interleukin-6Associated with lesion volumeMedian initial NIHSS scoreDWI lesion volumeCirculating interleukin-6Plasma interleukin-6Stroke patientsOnset timeIL-6 responseTime of stroke onsetImmunomodulatory therapyMedian ageThrombolysis windowNIHSS score
2023
Leptin-Mediated Induction of IL-6 Expression in Hofbauer Cells Contributes to Preeclampsia Pathogenesis
Ozmen A, Nwabuobi C, Tang Z, Guo X, Larsen K, Guller S, Blas J, Moore M, Kayisli U, Lockwood C, Guzeloglu-Kayisli O. Leptin-Mediated Induction of IL-6 Expression in Hofbauer Cells Contributes to Preeclampsia Pathogenesis. International Journal Of Molecular Sciences 2023, 25: 135. PMID: 38203306, PMCID: PMC10778808, DOI: 10.3390/ijms25010135.Peer-Reviewed Original ResearchConceptsIL-6 expressionHofbauer cellsP65 NF-κBIL-6NF-κBLeptin levelsPreeclampsia pathogenesisElevated serum interleukin-6 levelsSerum interleukin-6 levelsERK1/2 MAPKInterleukin-6 levelsPro-inflammatory phenotypeAnti-inflammatory phenotypeLeptin receptor expressionIL-6 productionPathogenesis of PEPlacental leptin productionPhosphorylation levelsERK1/2 MAPK inhibitorIL-6 regulationConcentration-dependent mannerPE patientsHuman pregnancySecond trimesterLeptin concentrations
2020
Tear IL-6 and IL-10 levels in HLA-B27-Associated Uveitis and Its clinical Implications
Kumar A, Sharma S, Agarwal A, Gupta V, Katoch D, Sehgal S, Singh N. Tear IL-6 and IL-10 levels in HLA-B27-Associated Uveitis and Its clinical Implications. Ocular Immunology And Inflammation 2020, 29: 237-243. PMID: 31940227, DOI: 10.1080/09273948.2019.1704022.Peer-Reviewed Original ResearchConceptsIL-10 levelsInterleukin-6 levelsInterleukin-6Tear samplesIL-10Uveitis patientsActive diseaseCytokine levelsDisease episodesHLA-B27-associated uveitisAssociated with active diseaseMultiple disease episodesIL-6/IL-10 ratioLevels of interleukin-6Receiver operating characteristic analysisIL-6 levelsIL-6/IL-10Uveitis controlBead-based assayFlow cytometryQuiescent groupClinical implicationsUveitisCharacteristic analysisDisease control
2019
Associations Between Maternal Experiences of Discrimination and Biomarkers of Toxic Stress in School-Aged Children
Condon EM, Holland ML, Slade A, Redeker NS, Mayes LC, Sadler LS. Associations Between Maternal Experiences of Discrimination and Biomarkers of Toxic Stress in School-Aged Children. Maternal And Child Health Journal 2019, 23: 1147-1151. PMID: 31222595, PMCID: PMC6660374, DOI: 10.1007/s10995-019-02779-4.Peer-Reviewed Original ResearchMeSH KeywordsAdultBiomarkersBlack or African AmericanBlood PressureC-Reactive ProteinChildChild, PreschoolConnecticutCross-Sectional StudiesFemaleHair AnalysisHispanic or LatinoHumansInterleukin-1betaInterleukin-6Interleukin-8MaleMothersRacismSalivaSocioeconomic FactorsStress, PsychologicalTumor Necrosis Factor-alphaConceptsSalivary interleukin-6 levelsInterleukin-6 levelsMaternal experienceCross-sectional studyMaternal-child dyadsPoor health outcomesEthnic health inequitiesToxic stressSchool-aged childrenChild healthNoninvasive biomarkersImmune pathwaysChild biomarkersHealth outcomesHealth inequitiesBiomarkersChildrenIndirect exposureLow-income neighborhoodsVicarious racismBiological mechanismsAdditional researchMothersExperiences of discriminationPhysiological mechanismsVery Early Initiation of Antiretroviral Therapy During Acute HIV Infection Is Associated With Normalized Levels of Immune Activation Markers in Cerebrospinal Fluid but Not in Plasma
Hellmuth J, Slike BM, Sacdalan C, Best J, Kroon E, Phanuphak N, Fletcher JLK, Prueksakaew P, Jagodzinski LL, Valcour V, Robb M, Ananworanich J, Allen IE, Krebs SJ, Spudich S. Very Early Initiation of Antiretroviral Therapy During Acute HIV Infection Is Associated With Normalized Levels of Immune Activation Markers in Cerebrospinal Fluid but Not in Plasma. The Journal Of Infectious Diseases 2019, 220: 1885-1891. PMID: 30668739, PMCID: PMC6833977, DOI: 10.1093/infdis/jiz030.Peer-Reviewed Original ResearchConceptsAcute HIV infectionAntiretroviral therapyART initiationCerebrospinal fluidWeek 96Week 24HIV infectionImmune activationAHI groupHuman immunodeficiency virus (HIV) infectionEarly ART initiationPlasma CCL2 levelsTrajectory of HIVChronic immune activationImmune activation markersSuppressive antiretroviral therapyImmunodeficiency virus infectionInterleukin-6 levelsMarkers of inflammationPlasma neopterin levelsWeeks of treatmentCentral nervous systemART regimenCCL2 levelsNeopterin levels
2016
Virological and immunological characteristics of HIV-infected individuals at the earliest stage of infection
Ananworanich J, Sacdalan CP, Pinyakorn S, Chomont N, Souza M, Luekasemsuk T, Schuetz A, Krebs SJ, Dewar R, Jagodzinski L, Ubolyam S, Trichavaroj R, Tovanabutra S, Spudich S, Valcour V, Sereti I, Michael N, Robb M, Phanuphak P, Kim JH, Phanuphak N, Group O. Virological and immunological characteristics of HIV-infected individuals at the earliest stage of infection. Journal Of Virus Eradication 2016, 2: 43-48. PMID: 26889497, PMCID: PMC4754199, DOI: 10.1016/s2055-6640(20)30688-9.Peer-Reviewed Original ResearchCD4/CD8 ratioAcute HIV infectionWeeks of ARTCD4 cell countFiebig ICD8 ratioT cellsThai Red Cross Anonymous ClinicCell countEarly acute HIV infectionPlasma interleukin-6 levelsImmune activation levelsLow HIV burdenLow HIV RNALow immune activationMedian HIV DNAPlasma sCD14 levelsMedian CD4 countInterleukin-6 levelsYears of ARTI individualsAHI participantsAnonymous ClinicFiebig stagesCD4 count
2013
Periodontitis and Gestational Diabetes Mellitus in Non‐Smoking Females
Chokwiriyachit A, Dasanayake A, Suwannarong W, Hormdee D, Sumanonta G, Prasertchareonsuk W, Wara‐Aswapati N, Combellick J, Pitiphat W. Periodontitis and Gestational Diabetes Mellitus in Non‐Smoking Females. The Journal Of Periodontology 2013, 84: 857-862. PMID: 23075430, DOI: 10.1902/jop.2012.120344.Peer-Reviewed Original ResearchConceptsGestational diabetes mellitusClinical attachment levelC-reactive proteinLevels of CRPPrepregnancy body mass indexFull-mouth periodontal examinationPregnant femalesHigher mean PDInterleukin-6 levelsBody mass indexNon-smoking femalesCase-control studyConditional logistic regressionTumor necrosis factorPeriodontal conditionsPeriodontal examinationDiabetes mellitusInflammatory mediatorsMass indexChronic inflammationPeriodontal diseaseMean PDRisk factorsAttachment levelNecrosis factor
2010
Diet-Induced Obesity Accelerates Acute Lymphoblastic Leukemia Progression in Two Murine Models
Yun JP, Behan JW, Heisterkamp N, Butturini A, Klemm L, Ji L, Groffen J, Müschen M, Mittelman SD. Diet-Induced Obesity Accelerates Acute Lymphoblastic Leukemia Progression in Two Murine Models. Cancer Prevention Research 2010, 3: 1259-1264. PMID: 20823291, PMCID: PMC2955776, DOI: 10.1158/1940-6207.capr-10-0087.Peer-Reviewed Original ResearchConceptsAcute lymphoblastic leukemiaAKR miceLeukemia incidenceAKR/J miceOld obese miceSimilar median survivalEffect of obesityInterleukin-6 levelsObesity-related hormonesAcute lymphoblastic leukemia progressionDiet-induced obesityHigh-fat dietMedian survivalObese miceSpleen weightLymphoblastic leukemiaWBC countJ miceMurine modelObesityAnimal modelsLeukemia progressionLeukemia pathogenesisMiceObserved associations
2008
Fetal inflammatory response in women with proteomic biomarkers characteristic of intra‐amniotic inflammation and preterm birth
Buhimschi C, Dulay A, Abdel‐Razeq S, Zhao G, Lee S, Hodgson E, Bhandari V, Buhimschi I. Fetal inflammatory response in women with proteomic biomarkers characteristic of intra‐amniotic inflammation and preterm birth. BJOG An International Journal Of Obstetrics & Gynaecology 2008, 116: 257-267. PMID: 18947340, PMCID: PMC3791329, DOI: 10.1111/j.1471-0528.2008.01925.x.Peer-Reviewed Original ResearchConceptsEarly-onset neonatal sepsisCord blood IL-6 levelsBlood IL-6 levelsIntra-amniotic inflammationIL-6 levelsIL-6 ratioFetal inflammatory responseInflammatory statusCord bloodInflammatory responseProteomic biomarkersGestational ageAF IL-6 levelsCord blood IL-6Tertiary referral university hospitalAmniotic fluid biomarkersProspective observational cohortBlood IL-6Neonates of womenInterleukin-6 levelsReferral university hospitalIntra-amniotic infectionEarlier gestational ageDifferential inflammatory responsePositive blood culturesSelective effects of CPAP on sleep apnoea‐associated manifestations
Vgontzas A, Zoumakis E, Bixler E, Lin H, Collins B, Basta M, Pejovic S, Chrousos G. Selective effects of CPAP on sleep apnoea‐associated manifestations. European Journal Of Clinical Investigation 2008, 38: 585-595. PMID: 18627419, PMCID: PMC4528610, DOI: 10.1111/j.1365-2362.2008.01984.x.Peer-Reviewed Original ResearchConceptsContinuous positive airway pressureObstructive sleep apnoeaMonths of continuous positive airway pressureNon-obese controlsTNF-R1 levelsInterleukin-6Visceral adiposityObese controlsInsulin resistanceTNF-R1TNF-alphaDaytime sleepinessVisceral fatObstructive sleep apnoea patientsBlood pressurePositive airway pressureTumor necrosis factor-alphaMeasurement of interleukin-6Interleukin-6 levelsNecrosis factor-alphaAssociated with insulin resistanceMeasures of daytime sleepinessFasting blood glucoseTNF receptor 1Predicting insulin resistancePreeclampsia-Related Inflammatory Cytokines Regulate Interleukin-6 Expression in Human Decidual Cells
Lockwood CJ, Yen CF, Basar M, Kayisli UA, Martel M, Buhimschi I, Buhimschi C, Huang SJ, Krikun G, Schatz F. Preeclampsia-Related Inflammatory Cytokines Regulate Interleukin-6 Expression in Human Decidual Cells. American Journal Of Pathology 2008, 172: 1571-1579. PMID: 18467705, PMCID: PMC2408417, DOI: 10.2353/ajpath.2008.070629.Peer-Reviewed Original ResearchConceptsIL-6 levelsIL-6Decidual cellsGestational age-matched control placentasElevated IL-6 levelsIL-6 mRNA levelsCommon pregnancy disorderGenesis of preeclampsiaUteroplacental blood flowFetal-placental unitInterleukin-6 levelsPathogenesis of preeclampsiaPro-inflammatory cytokinesEndothelial cell dysfunctionInterleukin-6 expressionHuman decidual cellsReal-time quantitative RT-PCRTime quantitative RT-PCRQuantitative RT-PCRFetal morbidityDecidual macrophagesPreeclamptic womenSystemic inflammationPregnancy disordersControl placentas
2006
Plasma interleukin 6 levels are elevated in polycystic ovary syndrome independently of obesity or sleep apnea
Vgontzas A, Trakada G, Bixler E, Lin H, Pejovic S, Zoumakis E, Chrousos G, Legro R. Plasma interleukin 6 levels are elevated in polycystic ovary syndrome independently of obesity or sleep apnea. Metabolism 2006, 55: 1076-1082. PMID: 16839844, DOI: 10.1016/j.metabol.2006.04.002.Peer-Reviewed Original ResearchConceptsPolycystic ovary syndromePolycystic ovary syndrome groupNormal-weight controlsIL-6 levelsTNF-alphaObese controlsIL-6Sleep apneaInsulin resistanceObese womenPlasma concentrationsTumor necrosis factor-alpha valuesPlasma concentrations of IL-6Plasma interleukin-6 levelsTumor necrosis factor-alphaCytokine plasma concentrationsConcentrations of IL-6Indices of insulin resistanceInterleukin-6 levelsExcessive daytime sleepinessNecrosis factor-alphaBody mass indexInsulin resistance indexPremenopausal womenNighttime polysomnographyBortezomib (VELCADE®) in metastatic breast cancer: pharmacodynamics, biological effects, and prediction of clinical benefits
Yang CH, Gonzalez-Angulo AM, Reuben JM, Booser DJ, Pusztai L, Krishnamurthy S, Esseltine D, Stec J, Broglio KR, Islam R, Hortobagyi GN, Cristofanilli M. Bortezomib (VELCADE®) in metastatic breast cancer: pharmacodynamics, biological effects, and prediction of clinical benefits. Annals Of Oncology 2006, 17: 813-817. PMID: 16403809, DOI: 10.1093/annonc/mdj131.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedBone NeoplasmsBoronic AcidsBortezomibBreast NeoplasmsDisease ProgressionDisease-Free SurvivalFemaleHumansMaleMaximum Tolerated DoseMiddle AgedPleural NeoplasmsProtease InhibitorsPyrazinesReceptors, EstrogenReceptors, ProgesteroneSoft Tissue NeoplasmsSurvival RateTreatment OutcomeConceptsMetastatic breast cancerBreast cancerPlasma interleukin-6 levelsCommon grade 3Limited clinical activityClinical response ratePhase II studyInterleukin-6 levelsMedian survival timeWeek of restBroad antitumor activityStable diseaseII studyObjective responseSkin rashClinical effectsClinical benefitDisease progressionClinical activityGrade 3Pharmacodynamic dataSurvival timeMean inhibitionSingle agentResponse rate
2004
Obesity and the Metabolic Syndrome in Children and Adolescents
Weiss R, Dziura J, Burgert T, Tamborlane W, Taksali S, Yeckel C, Allen K, Lopes M, Savoye M, Morrison J, Sherwin R, Caprio S. Obesity and the Metabolic Syndrome in Children and Adolescents. Obstetrical & Gynecological Survey 2004, 59: 822-824. DOI: 10.1097/01.ogx.0000140472.10719.95.Peer-Reviewed Original ResearchDegree of obesityMetabolic syndromeC-reactive proteinInsulin resistanceType 2 diabetesCRP levelsGlucose toleranceIL-6Higher C-reactive proteinDegree of dyslipidemiaInsulin-resistant adultsImpaired glucose toleranceIndependent risk factorInterleukin-6 levelsSystolic blood pressureBody mass indexAdvanced cardiovascular diseaseProportion of subjectsHigh-density lipoproteinVascular complicationsAdiponectin levelsBlood pressureObese subjectsMass indexNonobese individuals
2003
Cytokines, insulin-like growth factor 1, sarcopenia, and mortality in very old community-dwelling men and women: the Framingham Heart Study
Roubenoff R, Parise H, Payette H, Abad L, D'Agostino R, Jacques P, Wilson P, Dinarello C, Harris T. Cytokines, insulin-like growth factor 1, sarcopenia, and mortality in very old community-dwelling men and women: the Framingham Heart Study. The American Journal Of Medicine 2003, 115: 429-435. PMID: 14563498, DOI: 10.1016/j.amjmed.2003.05.001.Peer-Reviewed Original ResearchConceptsIGF-1 levelsInsulin-like growth factor-1Growth factor-1Fat-free massFramingham Heart StudyMass indexInterleukin-6TNF-alphaHeart StudyHigh serum interleukin-6 levelsHigher serum IGF-1 levelsBlood mononuclear cell productionOlder community-dwelling menSerum IGF-1 levelsSerum interleukin-6 levelsCommunity-dwelling older personsFat-free mass indexCommunity-dwelling elderly adultsSerum interleukin-6Interleukin-6 levelsCommunity-dwelling menMononuclear cell productionBody mass indexCytokines TNF-alphaFactor 1
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply