2024
Analysis of changes in social isolation, loneliness, or both, and subsequent cognitive function among older adults: Findings from a nationwide cohort study
Huang Q, Zhang P, Shen D, Gao J, Li Z, Lv Y, Shi X, Mao C. Analysis of changes in social isolation, loneliness, or both, and subsequent cognitive function among older adults: Findings from a nationwide cohort study. Alzheimer's & Dementia 2024, 20: 5674-5683. PMID: 38946708, PMCID: PMC11350036, DOI: 10.1002/alz.14080.Peer-Reviewed Original ResearchAssociated with accelerated cognitive declineCognitive impairment riskPersistent lonelinessSocial isolationCognitive declineOlder adultsImpairment riskChinese Longitudinal Healthy Longevity SurveyIncident cognitive impairmentCognitive impairmentAssociation of changesNationwide cohort studyAccelerated cognitive declineCognitive functionLongevity SurveyCohort studyChanging statusLonelinessRisk factorsRegression modelsTobit regression modelCox modelShort-termRiskAdults
2023
Perceived Stress and Depressive Symptoms Are Associated With Emotional Eating but Not Nutritional Intake During Pregnancy: A Prospective Cohort Study
Carandang R, Epel E, Radin R, Lewis J, Ickovics J, Cunningham S. Perceived Stress and Depressive Symptoms Are Associated With Emotional Eating but Not Nutritional Intake During Pregnancy: A Prospective Cohort Study. Journal Of Midwifery & Women's Health 2023, 69: 64-70. PMID: 37358371, DOI: 10.1111/jmwh.13537.Peer-Reviewed Original ResearchThird trimesterNutritional intakeDepressive symptomsPregnant womenPsychological distressEmotional eatingProspective cohort studySocial supportAssociation of changesDiverse pregnant womenHigher depressive symptomsLogistic regression modelsCohort studyProspective studySecond trimesterPregnancyTrimesterClinical sitesSymptomsIntakeMajor life eventsMental healthChange scoresWomenGreater likelihoodExercise and epigenetic ages in older adults with myeloid malignancies
Loh K, Sanapala C, Jensen-Battaglia M, Rana A, Sohn M, Watson E, Gilmore N, Klepin H, Mendler J, Liesveld J, Huselton E, LoCastro M, Susiarjo M, Netherby-Winslow C, Williams A, Mustian K, Vertino P, Janelsins M. Exercise and epigenetic ages in older adults with myeloid malignancies. European Journal Of Medical Research 2023, 28: 180. PMID: 37254221, PMCID: PMC10227405, DOI: 10.1186/s40001-023-01145-z.Peer-Reviewed Original ResearchConceptsAccelerated DNAm ageBaseline to post-interventionPost-interventionEffects of exerciseAccelerated GrimAgeExercise interventionGrip strengthOlder adultsDNA methylation ageDNAm ageConclusionsAmong older adultsWeeks of exerciseIncrease physical performanceOlder patientsAssociation of changesCognitive functionBiomarker of biological agingExercise programBackgroundOlder adultsPaired t-testMobile healthWalk testMyeloid malignanciesPhysical performanceDunedinPACE
2021
Stability in BMI over time is associated with a better cognitive trajectory in older adults
Beeri M, Tirosh A, Lin H, Golan S, Boccara E, Sano M, Zhu C. Stability in BMI over time is associated with a better cognitive trajectory in older adults. Alzheimer's & Dementia 2021, 17 DOI: 10.1002/alz.057574.Peer-Reviewed Original ResearchBody mass indexRate of cognitive declineNon-demented older adultsOlder adultsCognitive trajectoriesCognitive declineBMI stabilizationRisk of incident cognitive impairmentLongitudinal associations of changesBody mass index changeAlzheimer's Disease CenterIncident cognitive impairmentFollow-up body mass indexAssociation of changesDisease CenterYears of educationRelevance of body mass indexSpecific cognitive domainsLinear mixed effects modelsBMI changeLongitudinal associationsYears of ageGlobal cognitionLongitudinal clinical dataFollow-up visitNeonatal and Adolescent Adipocytokines as Predictors of Adiposity and Cardiometabolic Risk in Adolescence
Buck CO, Li N, Eaton CB, Kelsey KT, Cecil KM, Kalkwarf HJ, Yolton K, Lanphear BP, Chen A, Braun JM. Neonatal and Adolescent Adipocytokines as Predictors of Adiposity and Cardiometabolic Risk in Adolescence. Obesity 2021, 29: 1036-1045. PMID: 34029449, PMCID: PMC8567116, DOI: 10.1002/oby.23160.Peer-Reviewed Original ResearchConceptsCardiometabolic risk scoreAge 12 yearsAdiponectin/leptin ratioCardiometabolic risk factorsCardiometabolic riskRisk scoreAdipocytokine concentrationsLeptin ratioAdiponectin concentrationsLeptin concentrationsRisk factorsHigher cardiometabolic risk scoreIndividual cardiometabolic risk factorsDual-energy X-ray absorptiometryCardiometabolic risk outcomesPredictors of AdipositySerum adipocytokine concentrationsProspective birth cohortAssociation of changesX-ray absorptiometrySex-standardized z-scoresAdiposity outcomesExcess adiposityAdolescent adipositySerum biomarkers
2020
Identification of NPTX2 as a prognostic biomarker of Alzheimer’s disease through a longitudinal CSF proteomics study in ADNI subjects
Libiger O, Shaw L, Watson M, Nairn A, Umaña K, Canet‐Avilés R, Jack C, Breton Y, Cortes L, Chelsky D, Spellman D, Baker S, Raghavan N, Potter W. Identification of NPTX2 as a prognostic biomarker of Alzheimer’s disease through a longitudinal CSF proteomics study in ADNI subjects. Alzheimer's & Dementia 2020, 16 DOI: 10.1002/alz.047605.Peer-Reviewed Original ResearchP-Tau 181Alzheimer's diseasePrognostic biomarkerRate of declineADNI subjectsLongitudinal changesTau-tangle pathologyBaseline clinical diagnosisAssociation of changesPre-specified analysis planMild cognitive impairmentTangle pathologyClinical progressionMixed-effects linear modelNegative subjectsClinical prognosisDisease continuumAdditional biomarkersAmyloid plaquesDrug development effortsNormal subjectsSubset of individualsRetrospective investigationBiomarker profilesPathologic processes
2019
Predictors of Post-Discharge Suicide Attempt Among Veterans Receiving Specialized Intensive Treatment for Posttraumatic Stress Disorder.
Stefanovics EA, Rosenheck RA. Predictors of Post-Discharge Suicide Attempt Among Veterans Receiving Specialized Intensive Treatment for Posttraumatic Stress Disorder. The Journal Of Clinical Psychiatry 2019, 80 PMID: 31412170, DOI: 10.4088/jcp.19m12745.Peer-Reviewed Original ResearchConceptsPost-discharge suicide attemptsPosttraumatic stress disorderSuicide attemptsAlcohol useSuicidal ideationStress disorderSubstance abuse comorbidityMultivariable logistic regressionNational program evaluation dataVeterans Health AdministrationAssociation of changesIntensive treatment programViolent behaviorBaseline characteristicsClinical correlatesUS veteransClinical changesIntensive treatmentHigh riskHealth AdministrationAdmissionBivariate analysisPTSD programTreatment programGreater risk
2018
Does improvement in symptoms and quality of life in chronic schizophrenia reduce family caregiver burden?
Rhee TG, Rosenheck RA. Does improvement in symptoms and quality of life in chronic schizophrenia reduce family caregiver burden? Psychiatry Research 2018, 271: 402-404. PMID: 30530058, PMCID: PMC6382537, DOI: 10.1016/j.psychres.2018.12.005.Peer-Reviewed Original ResearchConceptsFamily caregiver burdenQuality of lifeCaregiver burdenPatient's symptomsClinical changesExperience of burdenCATIE schizophrenia trialAssociation of changesSmall clinical changesIll adultsClinical statusSchizophrenia trialsChronic schizophreniaLongitudinal associationsSymptomsWeak associationBurdenSchizophreniaAssociationAdultsTrialsImproved Diet Quality Associates With Reduction in Liver Fat, Particularly in Individuals With High Genetic Risk Scores for Nonalcoholic Fatty Liver Disease
Ma J, Hennein R, Liu C, Long MT, Hoffmann U, Jacques PF, Lichtenstein AH, Hu FB, Levy D. Improved Diet Quality Associates With Reduction in Liver Fat, Particularly in Individuals With High Genetic Risk Scores for Nonalcoholic Fatty Liver Disease. Gastroenterology 2018, 155: 107-117. PMID: 29604292, PMCID: PMC6035111, DOI: 10.1053/j.gastro.2018.03.038.Peer-Reviewed Original ResearchConceptsMediterranean-style diet scoreNonalcoholic fatty liver diseaseAlternative Healthy Eating IndexGenetic risk scoreHigh genetic risk scoreDiet quality changesIncident fatty liverFatty liver diseaseLiver fat accumulationFatty liverDiet scoreLiver fatRisk scoreFramingham Heart StudyAHEI scoreLiver diseaseFat accumulationHeart StudyHarvard Food Frequency QuestionnaireDiet qualityFood frequency questionnaireThird Generation cohortsHealthy Eating IndexAssociation of changesStandard deviation increase
2017
Association of change in AFP > 15 ng/ml/month with stage at diagnosis and mortality in patients with hepatocellular carcinoma (HCC).
Ilagan-Ying Y, Kaplan D, Taddei T, Njei B. Association of change in AFP > 15 ng/ml/month with stage at diagnosis and mortality in patients with hepatocellular carcinoma (HCC). Journal Of Clinical Oncology 2017, 35: 255-255. DOI: 10.1200/jco.2017.35.4_suppl.255.Peer-Reviewed Original ResearchHepatocellular carcinomaCause mortalityVeterans Administration Corporate Data WarehouseStage of HCCBCLC stage BBCLC stage DLiver disease severityAdvanced-stage cancerUseful prognostic markerAssociation of changesDate of deathLogistic regression analysisPotential hepatocellular carcinomaManual chart abstractionRegression analysisCorporate Data WarehouseChart abstractionBCLC 0Tumor burdenLiver diseaseTumor stagingUS veteransPrognostic markerHCC casesDiagnostic confirmation
2015
Association of changes in measurable disease by RECIST with survival in metastatic castration-resistant prostate cancer (mCRPC).
Sonpavde G, Pond G, Templeton A, Petrylak D, Tombal B, Rosenthal M, Tannock I. Association of changes in measurable disease by RECIST with survival in metastatic castration-resistant prostate cancer (mCRPC). Journal Of Clinical Oncology 2015, 33: 186-186. DOI: 10.1200/jco.2015.33.7_suppl.186.Peer-Reviewed Original ResearchMetastatic castration-resistant prostate cancerProgressive diseaseOverall survivalPartial responseAssociation of changesMeasurable diseaseStable diseaseHazard ratioLandmark analysisDay 90Castration-resistant prostate cancerWorld Health Organization criteriaMeasurable disease responseUnconfirmed partial responseECOG performance statusMedian overall survivalNeutrophil-lymphocyte ratioPhase II trialResponse Evaluation CriteriaProportional hazards regressionAccrual of patientsType of progressionMeasurable lesionsRECIST 1.0VENICE trial
2003
Prospective study of the association of changes in dietary intake, physical activity, alcohol consumption, and smoking with 9-y gain in waist circumference among 16 587 US men
Koh-Banerjee P, Chu NF, Spiegelman D, Rosner B, Colditz G, Willett W, Rimm E. Prospective study of the association of changes in dietary intake, physical activity, alcohol consumption, and smoking with 9-y gain in waist circumference among 16 587 US men. American Journal Of Clinical Nutrition 2003, 78: 719-727. PMID: 14522729, DOI: 10.1093/ajcn/78.4.719.Peer-Reviewed Original ResearchConceptsWaist gainMetabolic equivalent taskWaist circumferenceAssociation of changesPhysical activityUS menAlcohol consumptionLifestyle factorsTrans fatsBody mass indexFiber/dVigorous physical activityAbdominal adipose tissueAbdominal obesityProspective cohortMass indexProspective studySmoking cessationProspective dataChronic diseasesDietary intakeSelf-report questionnairesAdipose tissueFiber consumptionEnergy intake
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