2025
Revitalizing reproductive health: innovations and future frontiers in restorative medicine
Bulletti F, Giacomucci E, Guido M, Palagiano A, Coccia M, Bulletti C. Revitalizing reproductive health: innovations and future frontiers in restorative medicine. Therapeutic Advances In Reproductive Health 2025, 19: 26334941251345844. PMID: 40546415, PMCID: PMC12182620, DOI: 10.1177/26334941251345844.Peer-Reviewed Original ResearchFertility careThyroid dysfunctionReproductive medicineFactors affecting infertilityLive birth rateMedically Assisted ReproductionNewcastle-Ottawa ScaleCochrane risk of bias toolAssisted Reproductive TechnologyRisk of bias toolMulticenter trialPublic health challengeSurgical correctionReproductive-aged individualsEmbryo transferFertility outcomesART successSystem abnormalitiesBirth ratePregnancy rateAssisted reproductionNewcastle-OttawaWeb of ScienceReproductive technologyInclusion criteria
2024
Thyroid dysfunction caused by immune checkpoint inhibitors improves cancer outcomes.
García-Goñi M, Vázquez Gutiérrez B, Sanmamed M, Martín-Algarra S, Luis Pérez-Gracia J, Olmedo M, Chumbiauca E, Martín-Calvo N, Galofré J. Thyroid dysfunction caused by immune checkpoint inhibitors improves cancer outcomes. Endocrine Related Cancer 2024, 31 PMID: 39013402, DOI: 10.1530/erc-24-0064.Peer-Reviewed Original ResearchConceptsImmune checkpoint inhibitorsImmune-related adverse eventsRisk of progressionOverall survivalPrimary tumorThyroid dysfunctionPatients treated with immune checkpoint inhibitorsCancer patients treated with immune checkpoint inhibitorsAssociated with higher ORRImmune checkpoint inhibitor regimenTreated with atezolizumabLonger overall survivalCox proportional hazards modelsResponse to treatmentProbability of recurrenceMultivariable-adjusted regressionRisk of mortalityProportional hazards modelIndependent of ageCheckpoint inhibitorsRECIST v1.1Higher ORRCombination therapyUrothelial cancerClinical presentation
2020
First- and Second-Trimester Reference Intervals for Thyroid Function Testing in a US Population
Bunch DR, Firmender K, Harb R, El-Khoury JM. First- and Second-Trimester Reference Intervals for Thyroid Function Testing in a US Population. American Journal Of Clinical Pathology 2020, 155: 776-780. PMID: 33210132, DOI: 10.1093/ajcp/aqaa165.Peer-Reviewed Original ResearchConceptsThyroid-stimulating hormoneTrimester-specific reference intervalsThyroid function testsMIU/LPmol/LReference intervalsFunction testsUS populationSecond trimester prenatal screeningRoche analyzersThyroid function testingNegative screening resultsSpecific reference intervalsRoche Modular E170Singleton pregnanciesThyroglobulin antibodiesThyroid dysfunctionFirst trimesterSecond trimesterAdverse outcomesFunction testingFree thyroxineTotal triiodothyronineTotal thyroxineModular E170Comparative Effectiveness of Generic vs Brand-Name Levothyroxine in Achieving Normal Thyrotropin Levels
Brito JP, Ross JS, Sangaralingham L, Dutcher SK, Graham DJ, Wang Z, Wu Y, Yao X, Smallridge RC, Bernet V, Shah ND, Lipska KJ. Comparative Effectiveness of Generic vs Brand-Name Levothyroxine in Achieving Normal Thyrotropin Levels. JAMA Network Open 2020, 3: e2017645. PMID: 32997127, PMCID: PMC7527873, DOI: 10.1001/jamanetworkopen.2020.17645.Peer-Reviewed Original ResearchConceptsNormal thyrotropin levelsPropensity score-matched patientsThyrotropin levelsLevothyroxine prescriptionsThyrotropin valuesProportion of patientsAdministrative claims databaseMonths of initiationMIU/LMild thyroid dysfunctionLongitudinal cohort studyMedicare Advantage enrolleesNormal thyrotropin valuesEligible patientsInitial therapyLevothyroxine formulationsCohort studyThyroid dysfunctionClaims databaseGeneric levothyroxineLevothyroxineMAIN OUTCOMENormal rangePatientsNormal vsPrenatal exposure to perfluoroalkyl substances and behavioral difficulties in childhood at 7 and 11 years
Luo J, Xiao J, Gao Y, Ramlau-Hansen CH, Toft G, Li J, Obel C, Andersen SL, Deziel NC, Tseng WL, Inoue K, Bonefeld-Jørgensen EC, Olsen J, Liew Z. Prenatal exposure to perfluoroalkyl substances and behavioral difficulties in childhood at 7 and 11 years. Environmental Research 2020, 191: 110111. PMID: 32846178, PMCID: PMC7657987, DOI: 10.1016/j.envres.2020.110111.Peer-Reviewed Original ResearchConceptsPrenatal PFAS exposureMaternal thyroid hormonesThyroid hormonesOdds ratioPFAS exposureDanish National Birth CohortMaternal thyroid functionPrenatal perfluoroalkyl substancesMaternal thyroid dysfunctionFree thyroxine levelsNational Birth CohortAdjusted odds ratioBehavioral difficultiesPerfluoroalkyl substancesNatural indirect effectThyroid dysfunctionPFNA exposureFetal neurodevelopmentPrenatal exposureEpidemiological evidenceThyroid functionEarly gestationThyroxine levelsBirth cohortMaternal plasma
2019
Patterns of amiodarone-induced thyroid dysfunction in infants and children
Creo A, Anderson H, Cannon B, Lteif A, Kumar S, Tebben P, Iqbal A, Ramakrishna A, Pittock S. Patterns of amiodarone-induced thyroid dysfunction in infants and children. Heart Rhythm 2019, 16: 1436-1442. PMID: 30904484, DOI: 10.1016/j.hrthm.2019.03.015.Peer-Reviewed Original ResearchConceptsAmiodarone-induced thyroid dysfunctionThyroid function testsThyroid-stimulating hormoneThyroid dysfunctionPediatric patientsTSH valuesThyroid-stimulating hormone elevationHeart Rhythm Society guidelinesThyroid-stimulating hormone valuesDegree of TSH elevationPeak TSH valueBrain developmentOptimal screening frequencyType of heart diseaseLong-term groupAmiodarone therapyTSH elevationInotropic supportUntreated hypothyroidismHypothyroid childrenAmiodarone initiationRetrospective cohortSociety guidelinesAmiodaroneYoung children
2017
Treatment of Subclinical Hypothyroidism or Hypothyroxinemia in Pregnancy
Casey B, Thom E, Peaceman A, Varner M, Sorokin Y, Hirtz D, Reddy U, Wapner R, Thorp J, Saade G, Tita A, Rouse D, Sibai B, Iams J, Mercer B, Tolosa J, Caritis S, VanDorsten J. Treatment of Subclinical Hypothyroidism or Hypothyroxinemia in Pregnancy. Obstetrical & Gynecological Survey 2017, 72: 464-465. DOI: 10.1097/01.ogx.0000521861.32334.43.Peer-Reviewed Original Research
2010
Fetal Goiter Mimicking Anomalous Pulmonary Venous Connection
Vinocur JM, Sivanandam S. Fetal Goiter Mimicking Anomalous Pulmonary Venous Connection. Congenital Heart Disease 2010, 5: 482-485. PMID: 21087438, DOI: 10.1111/j.1747-0803.2010.00392.x.Peer-Reviewed Case Reports and Technical NotesConceptsAnomalous pulmonary venous connectionPulmonary venous connectionVenous connectionFetal goiterFetal thyroid dysfunctionSecondary cardiac diseaseStructural heart diseaseThyroid dysfunctionHeart diseasePediatric cardiologistsCardiac diseaseHydrops fetalisGoiterDiseaseDysfunctionArrhythmiasFetalisCardiologists
2003
Comparative study of Hepatitis C virus genotypes 1 and 3 in Salvador, Bahia
Codes L, de Freitas L, Jesus R, Vitvitski L, Silva L, Trepo C, Reis M, Paraná R. Comparative study of Hepatitis C virus genotypes 1 and 3 in Salvador, Bahia. The Brazilian Journal Of Infectious Diseases 2003, 7: 409-417. PMID: 14636481, DOI: 10.1590/s1413-86702003000600009.Peer-Reviewed Original ResearchConceptsHepatitis C virusC virusMost patientsSubtype 3aAverage agePositive anti-HCV resultsAnti-HCV resultsNecro-inflammatory activityDevelopment of cirrhosisOutpatient medical recordsSignificant differencesIllicit drug useMETAVIR classificationThyroid dysfunctionYounger patientsHistopathological findingsInflammatory activityLymphoid folliclesEpidemiological characteristicsRNA-HCVGenotype 3Medical recordsSubtype 1bAlcohol consumersGenotype 1
1997
Thyroid dysfunction in the preoperative period.
Wiklund R, Rosenbaum S. Thyroid dysfunction in the preoperative period. Current Opinion In Anaesthesiology 1997, 10: 244. DOI: 10.1097/00001503-199706000-00018.Peer-Reviewed Original Research
1995
Selective neuroanatomic abnormalities in Down's syndrome and their cognitive correlates: evidence from MRI morphometry.
Raz N, Torres I, Briggs S, Spencer W, Thornton A, Loken W, Gunning F, McQuain J, Driesen N, Acker J. Selective neuroanatomic abnormalities in Down's syndrome and their cognitive correlates: evidence from MRI morphometry. Neurology 1995, 45: 356-66. PMID: 7854539, DOI: 10.1212/wnl.45.2.356.Peer-Reviewed Original ResearchConceptsDS subjectsDown syndromeNeuroanatomic abnormalitiesParahippocampal gyrusWhite matterBrain regionsSex-matched healthy volunteersDisease hypothesisAnterior cingulate gyrusParietal white matterPrefrontal white matterPremature agingDorsolateral prefrontal cortexCerebral damageThyroid dysfunctionAge-related declineSeizure disorderSignificant group differencesBasal gangliaBrain abnormalitiesCardiovascular diseaseMammillary bodiesCerebellar hemispherePostcentral gyrusCingulate gyrus
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