Neill Epperson, MD
Director, Yale Program For Women’s Reproductive Behavioral Health (WRBH)About
Research
Publications
2025
The Trifecta of Industry, Academic, and Health System Partnership to Improve Mental Health Care Through Smartphone-Based Remote Patient Monitoring: Development and Usability Study
Epperson C, Davis R, Dempsey A, Haller H, Kupfer D, Love T, Villarreal P, Matthews M, Moore S, Muller K, Schneck C, Scott J, Zane R, Frank E. The Trifecta of Industry, Academic, and Health System Partnership to Improve Mental Health Care Through Smartphone-Based Remote Patient Monitoring: Development and Usability Study. JMIR Formative Research 2025, 9: e57624. PMID: 39773396, PMCID: PMC11751643, DOI: 10.2196/57624.Peer-Reviewed Original ResearchConceptsDigital mental health technologiesMental health careMental health technologiesMental health crisisHealth systemHealth careElectronic health record adaptationsHealth technologiesPatients' mental health statusClinic visitsMental health care providersHealth system partnershipsHealth care providersMental health statusElectronic health recordsMental health treatmentMonitoring patient symptomsHealth crisisPsychiatric outpatient clinicPatients' self-ratingsRemote patient monitoringCare providersDepressive disorderPatient experienceHealth records
2024
Field Notes from the Border: Lessons Learned in Conducting Mental Health Research Involving Newly Arrived Latinx Immigrants as Study Participants
Vargas L, Ariefdjohan M, Page C, Meisel Z, Ulrich C, Alegría M, Pimentel N, Epperson C, Richmond T. Field Notes from the Border: Lessons Learned in Conducting Mental Health Research Involving Newly Arrived Latinx Immigrants as Study Participants. Journal Of Immigrant And Minority Health 2024, 27: 181-189. PMID: 39503832, PMCID: PMC11781956, DOI: 10.1007/s10903-024-01643-0.Peer-Reviewed Original ResearchPublic health researchLatinx immigrantsImmigrant populationHealth researchCommunity partnersParticipant consentStudy participantsVulnerable populationsData collection proceduresStudy populationField notesResearch protocolParticipantsUnique issuesBest practicesCultural fluencyEthical considerationsCollection proceduresUS southern borderPopulationLatinxUnique perspectiveStress increases sperm respiration and motility in mice and men
Moon N, Morgan C, Marx-Rattner R, Jeng A, Johnson R, Chikezie I, Mannella C, Sammel M, Epperson C, Bale T. Stress increases sperm respiration and motility in mice and men. Nature Communications 2024, 15: 7900. PMID: 39261485, PMCID: PMC11391062, DOI: 10.1038/s41467-024-52319-0.Peer-Reviewed Original ResearchConceptsEpididymal epithelial cellsIncreased mitochondrial respirationIn vitro stress modelsCells secrete extracellular vesiclesSperm RNASperm respirationMouse spermSperm maturationDNA regionsSperm functionTranslational signaling pathwaysSperm motilitySemen qualitySpermMitochondrial respirationMetabolic pathwaysSignaling pathwayEnvironmental stressorsExtracellular vesiclesHuman cohort studiesEpithelial cellsMotilityCellular mechanismsEmbryo developmentCohort studyExtortion experiences of recent adult immigrants from Latin America: self-reported prevalence, associated costs, and current mental health
Vargas L, Epperson C, Richmond T, Sharif S, Berkowitz L, Giano Z, Hargarten S, Ungar M, Weigend-Vargas E, Sakai J. Extortion experiences of recent adult immigrants from Latin America: self-reported prevalence, associated costs, and current mental health. Injury Epidemiology 2024, 11: 43. PMID: 39238066, PMCID: PMC11376018, DOI: 10.1186/s40621-024-00524-2.Peer-Reviewed Original ResearchLatin AmericaLatinx immigrantsPost-traumatic stress disorderMental healthUS southern borderCurrent mental healthLatinx migrantsMigrant experienceImmigration officialsImmigrant adultsAdult immigrantsImmigrantsExtortionSeverity of post-traumatic stress disorderLatinLatinxViolencePerpetratorsSouthern borderSelf-reported prevalenceStress disorderSignificant stressorsUSAmericaAssociated with negative effectsMaternal adverse childhood experiences and infant visual-limbic white matter development
Demers C, Hankin B, Haase M, Todd E, Hoffman M, Epperson C, Styner M, Davis E. Maternal adverse childhood experiences and infant visual-limbic white matter development. Journal Of Affective Disorders 2024, 367: 49-57. PMID: 39191307, DOI: 10.1016/j.jad.2024.08.146.Peer-Reviewed Original ResearchMaternal adverse childhood experiencesAdverse childhood experiencesInferior longitudinal fasciculusFractional anisotropyLongitudinal fasciculusChildhood experiencesLeft inferior longitudinal fasciculusStructural magnetic resonance imagingPredictors of mental healthVisual processing networksNo group differencesExploratory analysisChildhood questionnaireEarly life adversity exposuresWhite matter microstructureMother-infant dyadsFollow-up analysisCognitive circuitsPreliminary supportNeural circuit developmentInfant brain developmentMagnetic resonance imagingGroup differencesSensory processingIntergenerational riskTrends in Individual Career Development Awards from National Institutes of Health to Physicians in Departments of Psychiatry (2013–2022)
Sakai J, Epperson C, Panchal Z, Ali D, Singhal S, Mikulich-Gilbertson S. Trends in Individual Career Development Awards from National Institutes of Health to Physicians in Departments of Psychiatry (2013–2022). Academic Psychiatry 2024, 49: 75-79. PMID: 39174721, DOI: 10.1007/s40596-024-02027-0.Peer-Reviewed Original ResearchDepartment of PsychiatryCareer development awardsDevelopment AwardNon-physician facultyNational InstituteNational Institutes of HealthNational Institutes of Health (NIHInstitutes of HealthPhysiciansPsychiatry facultyObjectiveThe authorsPsychiatryConclusionsThe numberDepartmentLinear regressionFacultyNationalMethodsDataHealthEstimated slopePsychiatristsLack of growthTreating new-onset cognitive complaints after risk-reducing salpingo-oophorectomy: A randomized controlled crossover trial of lisdexamfetamine
Metcalf C, Page C, Stocker B, Johnson R, Duffy K, Sammel M, Loughead J, Epperson C. Treating new-onset cognitive complaints after risk-reducing salpingo-oophorectomy: A randomized controlled crossover trial of lisdexamfetamine. Gynecologic Oncology 2024, 190: 62-69. PMID: 39146756, PMCID: PMC11702344, DOI: 10.1016/j.ygyno.2024.07.689.Peer-Reviewed Original ResearchRisk-reducing salpingo-oophorectomySelf-report measures of executive functionBrown Attention Deficit Disorder ScaleMeasures of executive functionMeasures of cognitive functionWorking memory performanceExecutive function difficultiesMeasures of attentionSelf-report measuresTrial completion ratesGenetically at-riskRandomized controlled crossover trialAttention/working memoryExecutive functionWorking memoryDisorder ScaleMemory performanceSustained attentionCognitive complaintsCognitive tasksLisdexamfetamineCognitive functionActive medicationTotal scoreFunctional difficultiesLuteal phase sertraline treatment of premenstrual dysphoric disorder (PMDD): Effects on markers of hypothalamic pituitary adrenal (HPA) axis activation and inflammation
Barone J, Ho A, Osborne L, Eisenlohr-Moul T, Morrow A, Payne J, Epperson C, Hantsoo L. Luteal phase sertraline treatment of premenstrual dysphoric disorder (PMDD): Effects on markers of hypothalamic pituitary adrenal (HPA) axis activation and inflammation. Psychoneuroendocrinology 2024, 169: 107145. PMID: 39096755, PMCID: PMC11381144, DOI: 10.1016/j.psyneuen.2024.107145.Peer-Reviewed Original ResearchPremenstrual dysphoric disorderSertraline treatmentMultilevel linear modelsDysphoric disorderHypothalamic pituitary gonadalHypothalamic pituitary adrenal (HPA) axisEffects of sertraline treatmentHypothalamic pituitary adrenal (HPA) axis activityPMDD patientsPMDD statusOpen-label sertralineMildly stressful tasksPremenstrual dysphoric disorder groupDaily symptom ratingsSevere affective symptomsEffect of groupPremenstrual symptom severityMenstrual cycle phaseAssociated with higher levelsALLO levelsInflammatory markersMenstrual cycleAffective symptomsAffective disordersClinical interviewTraumatic experiences and place of occurrence: An analysis of sex differences among a sample of recently arrived immigrant adults from Latin America
Vargas L, Sammel M, Richmond T, Ulrich C, Giano Z, Berkowitz L, Epperson C. Traumatic experiences and place of occurrence: An analysis of sex differences among a sample of recently arrived immigrant adults from Latin America. PLOS ONE 2024, 19: e0302363. PMID: 38875238, PMCID: PMC11178180, DOI: 10.1371/journal.pone.0302363.Peer-Reviewed Original ResearchConceptsHome countryLatin AmericaU.S. southern borderLatin American migrantsU.S.-Mexico borderCountry of originAmerican migrantsIncreased violenceMigration journeySexual assaultImmigrant adultsEconomic instabilitySexual traumaMigrantsGender differencesExposed to traumatic eventsSouthern borderCountriesAnalysis of sex differencesTraumatic experiencesTrauma exposureLatinTraumatic exposureCombat exposureHomeBeyond the serotonin deficit hypothesis: communicating a neuroplasticity framework of major depressive disorder
Page C, Epperson C, Novick A, Duffy K, Thompson S. Beyond the serotonin deficit hypothesis: communicating a neuroplasticity framework of major depressive disorder. Molecular Psychiatry 2024, 29: 3802-3813. PMID: 38816586, PMCID: PMC11692567, DOI: 10.1038/s41380-024-02625-2.Peer-Reviewed Original ResearchDepressive disorderTreatment of MDDEmotional brain circuitsMental health crisisMonoaminergic antidepressantsSerotonergic antidepressantsEmotional processingDeficit hypothesisBrain circuitsMDDBehavioral functionsHypothesis explanationAntidepressantsInsufficient supportive evidenceSerotoninNeuromodulation techniquesPreclinical researchNegative biasDisordersPersistent negative biasSupportive evidenceCliniciansPsychotherapyEffective treatmentPsychedelics
News
News
- May 18, 2018
Epperson named Chair of Psychiatry at CU School of Medicine
- October 01, 2006
Grants and contracts awarded to Yale School of Medicine
- June 01, 2006
Grants and contracts awarded to Yale School of Medicine, November/December 2005
- July 01, 2005
Grants and contracts awarded to Yale School of Medicine