Hong Li
Associate Research Scholar in NeuroscienceCards
About
Research
Publications
2023
Origin and development of the claustrum in rhesus macaque
Li H, Duque A, Rakic P. Origin and development of the claustrum in rhesus macaque. Proceedings Of The National Academy Of Sciences Of The United States Of America 2023, 120: e2220918120. PMID: 37406098, PMCID: PMC10334778, DOI: 10.1073/pnas.2220918120.Peer-Reviewed Original Research
2019
Maturation of thalamocortical synapses in the somatosensory cortex depends on neocortical AKAP5 expression.
Zhang M, Lu M, Huang H, Liu X, Su H, Li H. Maturation of thalamocortical synapses in the somatosensory cortex depends on neocortical AKAP5 expression. Neuroscience Letters 2019, 709: 134374. PMID: 31310785, DOI: 10.1016/j.neulet.2019.134374.Peer-Reviewed Original ResearchDisruption of TCF4 regulatory networks leads to abnormal cortical development and mental disabilities
Li H, Zhu Y, Morozov YM, Chen X, Page SC, Rannals MD, Maher BJ, Rakic P. Disruption of TCF4 regulatory networks leads to abnormal cortical development and mental disabilities. Molecular Psychiatry 2019, 24: 1235-1246. PMID: 30705426, PMCID: PMC11019556, DOI: 10.1038/s41380-019-0353-0.Peer-Reviewed Original ResearchConceptsPitt-Hopkins syndromeNeuropsychiatric diseasesUpper layer cortical neuronsTransient embryonic zonesAbnormal cortical developmentTCF4 geneEarlier gestational ageRegion-specific mannerGestational ageCortical neuronsCortical developmentNeuronal proliferationPrecise molecular mechanismsRadial gliaExpression of TCF4Abnormal dendritesNeuronal migrationNeocortical developmentDiseaseNormal functionMolecular pathwaysSignificant increaseMental disabilitiesMiceStem cells
2018
Differential gene regulatory plasticity between upper and lower layer cortical excitatory neurons.
Yang L, Chen L, Cai C, Li H. Differential gene regulatory plasticity between upper and lower layer cortical excitatory neurons. Molecular And Cellular Neurosciences 2018, 90: 22-32. PMID: 29802938, DOI: 10.1016/j.mcn.2018.05.007.Peer-Reviewed Original Research
2013
Laminar and Columnar Development of Barrel Cortex Relies on Thalamocortical Neurotransmission
Li H, Fertuzinhos S, Mohns E, Hnasko TS, Verhage M, Edwards R, Sestan N, Crair MC. Laminar and Columnar Development of Barrel Cortex Relies on Thalamocortical Neurotransmission. Neuron 2013, 79: 970-986. PMID: 24012009, PMCID: PMC3768017, DOI: 10.1016/j.neuron.2013.06.043.Peer-Reviewed Original ResearchConceptsThalamocortical neurotransmissionCortical developmentNeuronal differentiationGlutamatergic synaptic transmissionSuperficial cortical laminaeEarly cortical developmentActivity-dependent factorsThalamocortical neuronsSomatosensory cortexCortical cytoarchitectureCortical laminationSynaptic transmissionNeuronal activityCortical laminaeCytoarchitectonic criteriaExtrinsic activityNeurotransmissionCortical columnsMolecular cuesNeuronsMorphologic developmentLittle evidenceColumnar developmentGene expressionExtrinsic factors
2011
How do barrels form in somatosensory cortex?
Li H, Crair MC. How do barrels form in somatosensory cortex? Annals Of The New York Academy Of Sciences 2011, 1225: 119-129. PMID: 21534999, PMCID: PMC4700879, DOI: 10.1111/j.1749-6632.2011.06024.x.Peer-Reviewed Original Research
2008
Somatostatin receptor subtype 1 is a PDZ ligand for synapse-associated protein 97 and a potential regulator of growth cone dynamics
Cai C, Li H, Kangasniemi A, Pihlajamaa T, Von Ossowski L, Kerkelä K, Schulz S, Rivera C, Keinänen K. Somatostatin receptor subtype 1 is a PDZ ligand for synapse-associated protein 97 and a potential regulator of growth cone dynamics. Neuroscience 2008, 157: 833-843. PMID: 18951956, DOI: 10.1016/j.neuroscience.2008.09.048.Peer-Reviewed Original ResearchMeSH KeywordsAdaptor Proteins, Signal TransducingAmino Acid SequenceAnimalsAnimals, NewbornCells, CulturedChlorocebus aethiopsDiscs Large Homolog 1 ProteinEmbryo, MammalianGreen Fluorescent ProteinsGrowth ConesHumansImmunoprecipitationLigandsMembrane ProteinsMiceMicrotubule-Associated ProteinsMutationNeuronsPDZ DomainsProsencephalonReceptors, SomatostatinTransfectionConceptsPostsynaptic density-95/discs large/zona occludens-1Binding motifClass I PDZ-binding motifMembrane-associated guanylate kinase homologsGrowth conesHuman embryonic kidneyPull-down experimentsSomatostatin receptor subtypes 1Growth cone dynamicsNeuronal growth conesStructural organizationSst1 immunoreactivitySynapse-associated protein 97Receptor subtype 1Growth cone collapseKinase homologDomain proteinsProtein SAPScaffold proteinCone collapseMembrane complexDevelopmental roleSubtype 1SAP97Postnatal day 5
2007
KCC2 Interacts with the Dendritic Cytoskeleton to Promote Spine Development
Li H, Khirug S, Cai C, Ludwig A, Blaesse P, Kolikova J, Afzalov R, Coleman S, Lauri S, Airaksinen M, Keinänen K, Khiroug L, Saarma M, Kaila K, Rivera C. KCC2 Interacts with the Dendritic Cytoskeleton to Promote Spine Development. Neuron 2007, 56: 1019-1033. PMID: 18093524, DOI: 10.1016/j.neuron.2007.10.039.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnimals, NewbornCells, CulturedCerebral CortexCytoskeletal ProteinsCytoskeletonDendritesDendritic SpinesEmbryo, MammalianExcitatory Postsynaptic PotentialsGreen Fluorescent ProteinsHumansIn Vitro TechniquesK Cl- CotransportersLysineMembrane ProteinsMiceMice, KnockoutMutationNerve Tissue ProteinsNeuronsNeuropeptidesPatch-Clamp TechniquesSymportersSynaptic TransmissionTransfectionConceptsNeuron-specific K-Cl cotransporterDevelopment of excitatory synapsesK-Cl cotransportMaturation of dendritic spinesGABAergic transmissionGABAergic synapsesKCC2Excitatory synapsesSpine cytoskeletonCortical neuronsDendritic spinesSpineMorphogenic roleSpine developmentTransport functionFunctional developmentSynapsesDendritic cytoskeletonCotransporterC-terminal domain
2005
Interaction between SAP97 and PSD-95, Two Maguk Proteins Involved in Synaptic Trafficking of AMPA Receptors*
Cai C, Li H, Rivera C, Keinänen K. Interaction between SAP97 and PSD-95, Two Maguk Proteins Involved in Synaptic Trafficking of AMPA Receptors*. Journal Of Biological Chemistry 2005, 281: 4267-4273. PMID: 16332687, DOI: 10.1074/jbc.m505886200.Peer-Reviewed Original ResearchMeSH KeywordsAdaptor Proteins, Signal TransducingAnimalsBinding SitesCell LineCells, CulturedDiscs Large Homolog 1 ProteinDisks Large Homolog 4 ProteinGuanylate KinasesHumansIntracellular Signaling Peptides and ProteinsMembrane ProteinsMiceProtein TransportRatsReceptors, AMPAReceptors, GlutamateSynapsesConceptsSrc homology 3 domainN-terminal segmentMembrane-associated guanylate kinase homologsPSD-95Glutathione S-transferase pull-downClustering of AMPA receptorsAMPA receptorsSynaptic traffickingSynapse-associated protein 97Kinase homologMAGUK proteinsCultured hippocampal neuronsImmunoprecipitation experimentsDetergent extractsPostsynaptic density 95MAGUKHeteromeric complexesPull-downSAP97Functional roleGluR-AGlutamate receptorsOligomeric natureSynaptic targetsHippocampal neurons
2004
Mechanism of Activity-Dependent Downregulation of the Neuron-Specific K-Cl Cotransporter KCC2
Rivera C, Voipio J, Thomas-Crusells J, Li H, Emri Z, Sipilä S, Payne J, Minichiello L, Saarma M, Kaila K. Mechanism of Activity-Dependent Downregulation of the Neuron-Specific K-Cl Cotransporter KCC2. Journal Of Neuroscience 2004, 24: 4683-4691. PMID: 15140939, PMCID: PMC6729393, DOI: 10.1523/jneurosci.5265-03.2004.Peer-Reviewed Original ResearchMeSH KeywordsAdaptor Proteins, Signal TransducingAdaptor Proteins, Vesicular TransportAnimalsBinding SitesBiotinylationBrain-Derived Neurotrophic FactorCell MembraneChloridesCyclic AMP Response Element-Binding ProteinDown-RegulationHippocampusIn Vitro TechniquesK Cl- CotransportersMagnesiumMiceMice, Mutant StrainsNeuronsPhospholipase C gammaPhosphorylationPyramidal CellsRatsRats, WistarReceptor, trkBRNA, MessengerShc Signaling Adaptor ProteinsSignal TransductionSrc Homology 2 Domain-Containing, Transforming Protein 1SymportersSynaptic TransmissionType C PhospholipasesConceptsNeuron-specific K-Cl cotransporter KCC2Neuron-specific K-Cl cotransporterK-Cl cotransporter KCC2Downregulation of KCC2Extrusion of chlorideTyrosine receptor kinase BK-Cl cotransportCA1 pyramidal neuronsInterictal-like activityDiverse manifestationsKCC2 mRNACotransporter KCC2KCC2 expressionDown-stream cascadesCl- extrusionEndogenous BDNFHippocampal slicesKCC2Pyramidal neuronsNeuronal plasticityNeuron-specificProtein expressionNeuronal traumaEarly responseKinase B