Wei Zhang, MBBS, PhD
Postdoctoral FellowAbout
Research
Publications
2026
Shear Preconditioning Restores Endothelial Function of HLHS Patient-Derived iPSC-ECs for Successful Conduit Implantation
Zhang W, Qin L, Fooladi S, Ménoret S, Johns A, Anegon I, Nelson T, Tellides G, Qyang Y. Shear Preconditioning Restores Endothelial Function of HLHS Patient-Derived iPSC-ECs for Successful Conduit Implantation. Arteriosclerosis Thrombosis And Vascular Biology 2026, 46: e324018. PMID: 42021735, DOI: 10.1161/atvbaha.125.324018.Peer-Reviewed Original ResearchValidation of Wound, Ischemia, and Foot Infection Classification in Infrapopliteal Arterial Disease Undergoing Endovascular Therapy
Guo J, Guo J, Gao X, Feng Z, Wu Z, He C, Li Q, Fang X, Sang H, Shi Z, Shi W, Zhuang H, Zhang W, Tong Z, Ye M, Guo L. Validation of Wound, Ischemia, and Foot Infection Classification in Infrapopliteal Arterial Disease Undergoing Endovascular Therapy. JACC Cardiovascular Interventions 2026, 19: 1004-1017. PMID: 42055647, DOI: 10.1016/j.jcin.2026.01.311.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overAmputation, SurgicalChinaChronic DiseaseDecision Support TechniquesEndovascular ProceduresFemaleHumansIschemiaLimb SalvageMaleMiddle AgedPeripheral Arterial DiseasePopliteal ArteryPredictive Value of TestsProgression-Free SurvivalProspective StudiesReproducibility of ResultsRisk AssessmentRisk FactorsTime FactorsTreatment OutcomeWound InfectionConceptsWIfI stageAll-cause deathAmputation-free survivalMajor amputationPrimary outcomeChronic limb threatening ischemia patientsWIfI classification systemIndependent predictorsEndovascular therapyWIfI classificationInfrapopliteal arterial occlusive diseaseFoot Infection classificationPredictors of MAEsSecondary outcomesWIfI stage 4Target lesion reinterventionStages 1 to 3Cox regression analysisMulticenter observational studyAmputationClassification systemObservational studyStage 4Arterial occlusive diseaseHigh risk
2025
3D bioprinting of cell-laden constructs: technologies, bioink design, and biomedical applications
Xing Q, Liu Y, Thomas J, Zhang W, Riaz M, Mak M, Qyang Y. 3D bioprinting of cell-laden constructs: technologies, bioink design, and biomedical applications. Biomedical Materials 2025, 21: 012001. PMID: 41330064, DOI: 10.1088/1748-605x/ae2725.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsCell printingBioprinting of cell-laden constructsCapability of 3D printingCell-laden structuresCell-laden constructsHigh-resolution capabilityDecellularized extracellular matrixPrinting parametersBio-inkTissue-like functionsCartilage repairBioink designTissue fabricationPrinting factorsBiomedical applicationsSeed cellsVascular graftsSkin regenerationOrgan-on-chip modelsThree-dimensionalPrintingDelivery of live cellsInert scaffoldBioinkExtracellular matrixReliable Surface Modification of ePTFE Using a Photoreactive Hemocompatible Peptide to Promote Endothelial Affinity and Antiplatelet Efficacy
Zhang W, Fukazawa K, Mahara A, Le H, Soni R, Yamaoka T. Reliable Surface Modification of ePTFE Using a Photoreactive Hemocompatible Peptide to Promote Endothelial Affinity and Antiplatelet Efficacy. ACS Biomaterials Science & Engineering 2025, 11: 3467-3476. PMID: 40325826, DOI: 10.1021/acsbiomaterials.5c00236.Peer-Reviewed Original ResearchConceptsEPTFE surfaceExpanded polytetrafluoroethyleneEPTFE graft surfacesMechanical propertiesUV exposure timeExpanded polytetrafluoroethylene graftsSurface modificationChemical inertnessEnhanced hemocompatibilityReduced platelet adhesionGraft surfacePrevent platelet adhesionChemical stabilityPhenylazide groupPlatelet adhesionSurfaceArgon plasmaEfficient modificationMedical devicesPhotoreactive peptides
2024
Vascular endothelial cells derived from transgene-free pig induced pluripotent stem cells for vascular tissue engineering
Batty L, Park J, Qin L, Riaz M, Lin Y, Xu Z, Gao X, Li X, Lopez C, Zhang W, Hoareau M, Fallon M, Huang Y, Luo H, Luo J, Ménoret S, Li P, Jiang Z, Smith P, Sachs D, Tellides G, Anegon I, Pober J, Liu P, Qyang Y. Vascular endothelial cells derived from transgene-free pig induced pluripotent stem cells for vascular tissue engineering. Acta Biomaterialia 2024, 193: 171-184. PMID: 39681154, PMCID: PMC12212065, DOI: 10.1016/j.actbio.2024.12.033.Peer-Reviewed Original ResearchInduced pluripotent stem cellsVascular tissue engineeringPig induced pluripotent stem cellsPluripotent stem cellsEndothelial cellsLarge animal modelStem cellsAnimal modelsTissue engineeringInferior vena cava graftHuman induced pluripotent stem cellsEffective differentiation protocolsPreclinical large animal modelExpression of endothelial markersCell-based therapiesExtensive preclinical testingPig endothelial cellsFunctional endothelial cellsIn vivo functional studiesTreatment of cardiovascular diseasesVascular endothelial cellsTissue engineering therapiesTransplant therapeuticsEfficacy of tissueImmunodeficient ratsFully biologic endothelialized-tissue-engineered vascular conduits provide antithrombotic function and graft patency
Park J, Riaz M, Qin L, Zhang W, Batty L, Fooladi S, Kural M, Li X, Luo H, Xu Z, Wang J, Banno K, Gu S, Yuan Y, Anderson C, Ellis M, Zhou J, Luo J, Shi X, Shin J, Liu Y, Lee S, Yoder M, Elder R, Mak M, Thorn S, Sinusas A, Gruber P, Hwa J, Tellides G, Niklason L, Qyang Y. Fully biologic endothelialized-tissue-engineered vascular conduits provide antithrombotic function and graft patency. Cell Stem Cell 2024, 32: 137-143.e6. PMID: 39644899, PMCID: PMC11698629, DOI: 10.1016/j.stem.2024.11.006.Peer-Reviewed Original ResearchTissue-engineered vascular conduitsSingle-ventricle congenital heart defectsEndothelial cellsBiodegradable polymeric scaffoldsGraft patencyAutologous bone marrow cellsAntithrombotic functionCongenital heart defectsInferior vena cava graftHiPSC-derived endothelial cellsBone marrow cellsHuman umbilical arteryDecellularized human umbilical arteriesPolymeric scaffoldsHost endothelial cellsHuman induced pluripotent stem cell (hiPSC)-derived endothelial cellsUmbilical arteryHeart defectsVascular conduitsMarrow cellsFlow bioreactorVena cava graftNude ratsGraft stenosisClinical trialsClinical outcomes of celiac artery coverage with vs. without revascularization in thoracic endovascular aortic repair
Xie X, Zhang W, Fu W, Zhang W, Wang L. Clinical outcomes of celiac artery coverage with vs. without revascularization in thoracic endovascular aortic repair. Chinese Medical Journal 2024, 137: 1750-1752. PMID: 38915239, PMCID: PMC11268804, DOI: 10.1097/cm9.0000000000003196.Peer-Reviewed Original ResearchDownregulation of RhoA/ROCK1/YAP/F-actin causing decreased aortic smooth muscle cell stiffness promotes aortic dissection formation
Zhang W, Wang M, Wang E, Lu W, Li Z, Zhang Y, Hu G, Zhang Q, Shan W, Dang Y, Zhao Z, Zheng L, Fu W, Wang L. Downregulation of RhoA/ROCK1/YAP/F-actin causing decreased aortic smooth muscle cell stiffness promotes aortic dissection formation. Life Metabolism 2024, 3: loae022. PMID: 39872140, PMCID: PMC11749839, DOI: 10.1093/lifemeta/loae022.Peer-Reviewed Original ResearchPhoto-induced universal modification of small-diameter decellularized blood vessels with a hemocompatible peptide improves in vivo patency
Zhang W, Fukazawa K, Mahara A, Jiang H, Yamaoka T. Photo-induced universal modification of small-diameter decellularized blood vessels with a hemocompatible peptide improves in vivo patency. Acta Biomaterialia 2024, 176: 116-127. PMID: 38232911, DOI: 10.1016/j.actbio.2024.01.012.Peer-Reviewed Original ResearchConceptsDecellularized vesselsDecellularized blood vesselsNatural collagenPhenylazide groupIn vivo patencyPromote endothelializationSurface modificationMultiple materialsImproved hemocompatibilityDecellularized graftsRat abdominal aortaFunctional endotheliaLuminal surface modificationSmall diameterHemocompatibilityPhotoreactive peptidesEfficient approachEarly outcomes of drug-coated balloon angioplasty of infrapopliteal lesions in diabetic foot
Guo J, Ye M, Zhang W, Wu Z, Feng Z, Fang X, Li Q, Sang H, Shi Z, Shi W, He C, Gao X, Guo J, Tong Z, Guo L. Early outcomes of drug-coated balloon angioplasty of infrapopliteal lesions in diabetic foot. Vascular Investigation And Therapy 2024, 7: 1-6. DOI: 10.4103/vit.vit_18_24.Peer-Reviewed Original ResearchAmputation-free survivalAll-cause deathDCB angioplastyComplete wound healingInfrapopliteal lesionsDiabetic footCD-TLREarly outcomesFollow-upRunoff scoreInfrapopliteal arterial occlusive diseasePrimary outcome componentsKaplan-Meier analysisFollow-up dataWound healingArterial occlusive diseaseAdverse eventsPrimary outcomeOcclusive diseaseSecondary outcomesPatientsLesionsMajor amputationOutcome componentsScore changes
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