Gerard Sanacora, PhD, MD

George D. and Esther S. Gross Professor of Psychiatry; Director, Yale Depression Research Program; Co-Director, Yale New Haven Hospital Interventional Psychiatry Service

Departments & Organizations

Psychiatry: Adult Psychiatry | Clinical Neuroscience Research Unit | Connecticut Mental Health Center | Mood Disorders Research Program | Neuroscience Research Training Program (NRTP) | Obsessive Compulsive Disorder Research Clinic | VA National Center for PTSD | Yale Depression Research Program

Dean's Workshops

Yale Medicine

Office of Cooperative Research


Dr. Sanacora completed an NIH sponsored Medical Scientist Training Program at the State University New York at Stony Brook, earning his Ph.D. in Physiology and Biophysics in 1992 and his M.D. degree in 1994. He then moved to Yale University where he completed his internship at Yale-New Haven Hospital, the Clinical Neuroscientist Training Program Residency in the Department of Psychiatry, and an NIH funded Neuroimaging Scientist Training Program Fellowship. He is currently an Associate Professor and the Director of the Yale Depression Research Program. Dr. Sanacora’s work is concentrated largely on elucidating the pathophysiological mechanisms associated with mood and other neuropsychiatric disorders. Much of his recent research has focused on identifying the contributions of the amino acid neurotransmitter systems (GABA and Glutamate) to the neurobiology of mood disorders and the mechanism of antidepressant action. Specifically, his basic science laboratory employs rodent models to explore the effects of chronic stress on cellular and molecular biology, and examines the molecular, cellular and behavioral effects of novel treatment strategies targeting these affected systems. His clinical laboratory employs novel magnetic resonance spectroscopy methodologies and pharmacological challenge paradigms to identify abnormalities in the function of the amino acid neurotransmitter systems in individuals suffering from mood and anxiety disorders. In addition, he is involved in several early phase clinical trials designed to test the clinical efficacy of newly developed therapeutic agents.

Education & Training

MD SUNY at Stonybrook (1994)
PhD SUNY at Stonybrook (1992)
Fellow Yale University School of Medicine
Resident Yale University School of Medicine
Post Doctoral SUNY Stony Brook
Board Certification AB of Neurological Surgery, Psychiatry (1999)

Honors & Recognition

  • Joel Elkes Research Award for outstanding contributions to PsychopharmacologyAmerican College of Neuropsychopharmacology (2011)

  • ANNA-MONIKA-FOUNDATION Award for the investigation of the biological substrate and functional disturbances of depressionANNA-MONIKA-FOUNDATION (2009)

  • Klerman Award, Honorable Mention Breakthroughs in Basic Brian & Behavior ScienceNARSAD (2005)

  • Klerman Award, Honorable Mention Outstanding Research ProjectNARSAD (2003)

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Contact Info

Gerard Sanacora, PhD, MD
Patient Care Locations
Clinical Neuroscience Research UnitConnecticut Mental Health Center
34 Park Street

New Haven, CT 06519
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Yale Depression Research Clinic100 York Street, Ste 2J
New Haven, CT 06511
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Office Locations
Connecticut Mental Health Center
34 Park Street, Ste 333 A

New Haven, CT 06519
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Yale Depression Research Clinic100 York Street, Ste 2J
New Haven, CT 06511
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Mailing Address
Psychiatry100 York St.
Suite 2J

New Haven, CT 06511

Yale Depression Program