Yu Sun
Associate Research Scientist in NeuroscienceCards
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Research
Publications
2025
Construction of MOF-based mixed matrix membranes with multiple fluorine sites for low concentration CO2 separation under humid conditions
Wang Z, Sun Y, Qin Z, Yu Q, Zhang Z, Qiao Z. Construction of MOF-based mixed matrix membranes with multiple fluorine sites for low concentration CO2 separation under humid conditions. Separation And Purification Technology 2025, 369: 133149. DOI: 10.1016/j.seppur.2025.133149.Peer-Reviewed Original ResearchMOF-based mixed matrix membranesMetal-organic frameworksMixed matrix membranesFluorine sitesMatrix membranesHigh-performance gas separation membranesLow-concentration CO2CO2 separationBlend polymer matrixMembrane materialsGas separation membranesCO2/N2 selectivityCO2 permeabilityCO2 moleculesSeparation membranesGas separationEfficient separationPolymer matrixOptimized membraneFluorineMaterial hydrophobicityHumidity conditionsConcentration CO2Separation systemSeparationFigureYa: A Standardized Visualization Framework for Enhancing Biomedical Data Interpretation and Research Efficiency
Lu X, Li K, Li Z, Lin A, Zhao L, Shen R, Xu Z, Gao J, Lv D, Zhang Y, Ye T, Shen J, Chen Y, Huang H, Hao Z, Zeng D, Wang H, Guo S, Wang W, Xiong Y, Li Y, Li H, Gao J, Liu Q, Wei B, Shi J, Cheng S, Li G, Tang Y, Lin E, Xu H, Feng G, He Y, Sun Y, Liu X, Wang Y, Song W, Song J, Tian S, Zhang Y, Zhang J, Xu Z, Song C, Zhang Y, Wu H, Gao C, Hu E, Yang C, Lou J, Wang D, Wang X, Luo P, Yu G, Ge Y. FigureYa: A Standardized Visualization Framework for Enhancing Biomedical Data Interpretation and Research Efficiency. 2025 DOI: 10.1002/imm3.70005.Peer-Reviewed Original ResearchVisualization frameworkData visualizationComplex biomedical dataDesktop applicationsProgramming skillsWorkflow customizationProgramming backgroundVisualization solutionsBiomedical dataResearch efficiencyReal world needsStandalone softwareCombination moduleVisual supportVisual settingTechnical thresholdCodeTime allocationJournalism standardsScriptsScientific discoveryVisualizationInnovative toolUsersFrameworkMechanistic insights into deoxynivalenol-Induced hepatic cholestasis via IRE1α/HNF1α/FXR signaling dysregulation in mice
Wu Y, Lin R, Yuan Q, Sun Y, Yuan Y, Jiang T, Jiang J, Mu P, Wen J, Deng Y. Mechanistic insights into deoxynivalenol-Induced hepatic cholestasis via IRE1α/HNF1α/FXR signaling dysregulation in mice. Ecotoxicology And Environmental Safety 2025, 301: 118489. PMID: 40513317, DOI: 10.1016/j.ecoenv.2025.118489.Peer-Reviewed Original ResearchFarnesoid X receptorTotal bile acidsBile acidsFXR functionPro-inflammatory cytokine expressionPro-inflammatory cascadeDON-induced toxicityTarget of farnesoid X receptorEndoplasmic reticulum stressMurine modelUnfolded protein responseHepatocellular injuryNuclear receptor signalingCytokine expressionHepatic cholestasisHepatocellular damageReceptor signalingSignaling dysregulationLiver pathologyCholestasisPharmacological targetsCentral mechanismsTherapeutic targetSignaling AxisUpregulate pro-inflammatory cytokine expressionUremic toxin receptor NR1H3 contributes to hyperlipidemia- and chronic kidney disease-accelerated vascular inflammation, which is partially suppressed by novel YBX2 anti-ROS pathway
Lu Y, Sun Y, Saaoud F, Xu K, Shao Y, Han B, Jiang X, Martinez L, Vazquez-Padron R, Mohsin S, Zhao H, Wang H, Yang X. Uremic toxin receptor NR1H3 contributes to hyperlipidemia- and chronic kidney disease-accelerated vascular inflammation, which is partially suppressed by novel YBX2 anti-ROS pathway. Redox Biology 2025, 85: 103724. PMID: 40505347, PMCID: PMC12182350, DOI: 10.1016/j.redox.2025.103724.Peer-Reviewed Original ResearchChronic kidney diseaseReactive oxygen speciesROS regulationNephrectomy-induced chronic kidney diseaseVascular inflammationRNA-binding proteinsReactive oxygen species regulationPromote vascular inflammationPromotion of inflammationCellular ROS levelsTrained immunityDisease progressionKidney diseaseMouse modelCytokine genesMouse aortaProinflammatory genesTranscription factorsRisk factorsRegulating inflammationHyperlipidemiaCardiovascular diseaseInflammationNegative feedback mechanismYBX24-Anilinoquinolinylchalcone derivatives mediate antifibrotic effects through ERK/MRTF—a signaling pathway crosstalk
Selvam P, Tseng C, Wang C, Sun Y, Chen Y, Kao Y, Dahms H, Cheng C. 4-Anilinoquinolinylchalcone derivatives mediate antifibrotic effects through ERK/MRTF—a signaling pathway crosstalk. Environmental Science And Pollution Research 2025, 32: 11685-11696. PMID: 40234319, DOI: 10.1007/s11356-025-36382-8.Peer-Reviewed Original ResearchConceptsSide effectsAbnormal liver functionAnti-fibrosisSevere side effectsGroup of drugsAnti-inflammatory responseHuman immune systemSkin rashGenitourinary cancersMechanism of actionAntifibrotic effectsBreast cancerScreened 6Immunomodulatory qualitiesLiver functionPharmacological profileImmune systemSignaling pathwaySignaling pathway crosstalkQuinolone analoguesCancerAnti-cancerDerivativesBleedingRashFibronectin matrix assembly at a glance.
Sun Y, Hamlin A, Schwarzbauer J. Fibronectin matrix assembly at a glance. Journal Of Cell Science 2025, 138 PMID: 40130407, PMCID: PMC12050093, DOI: 10.1242/jcs.263834.Peer-Reviewed Original ResearchConceptsAbundant ECM proteinFibronectin matrix assemblyOrganization of FNExtracellular matrixMechanisms of extracellular matrixSecrete ECM componentsFN assemblyDomain organizationFN fibrilsFN matrixGlance articleECM proteinsMatrix assemblyECM componentsIntracellular pathwaysFibrillar matrixReceptor-mediated processFibronectinCell scienceProteinAssemblyCellsCell-mediated processPathwayMechanismA biomarker framework for auditory system aging: the Aging Biomarker Consortium consensus statement
Consortium A, Fu X, Wang S, Wu Y, Sun Y, Liu W, Xi X, Li G, Liu K, Yuan W, Chen F, Wang H, Yang T, Liu Y, Zheng J, Shi H, Qu J, Chen X, Suo L, Huang Y, Xu X, Tang X, Li X, Xu L, Gao X, Yu L, Shu Y, Zhang W, Sun J, Yuan H, Gong S, Li W, Ma X, Zha D, Gao J, Li H, He Z, Liu G, Pei G, Kong W, Wang H, Chai R. A biomarker framework for auditory system aging: the Aging Biomarker Consortium consensus statement. Life Medicine 2025, 4: lnaf011. PMID: 40226444, PMCID: PMC11992615, DOI: 10.1093/lifemedi/lnaf011.Peer-Reviewed Original ResearchAuditory healthAuditory systemAssociated with cognitive declineQuality of lifeHearing lossOlder adultsPsychosocial disordersSensory impairmentElderly populationConsensus statementCognitive declineHearingHealthAging societyVerbal communicationAgeSensory functionAbstract HearingHumoral biomarkersBiomarkers ConsortiumBiomarkersInterventionAging biomarkersAdultsComprehensive evaluationA positron emission tomography tracer for the imaging of oxidative stress in the central nervous system
Wilde J, Sun Y, Simpson S, Hill E, Fu Z, Bian E, Kinkaid M, Villanueva P, Weybright A, Terrell W, Qureshi Z, Perera S, Sheppard H, Stone J, Kundu B, Kuan C, Neumann K. A positron emission tomography tracer for the imaging of oxidative stress in the central nervous system. Nature Biomedical Engineering 2025, 9: 716-729. PMID: 40044816, PMCID: PMC12092265, DOI: 10.1038/s41551-025-01362-3.Peer-Reviewed Original ResearchCentral nervous systemPositron emission tomographyInjection of sodium nitroprussideOxidative stressNervous systemClinical trials of antioxidantsMiddle cerebral arteryBlood-brain barrierTrials of antioxidantsPositron emission tomography tracersIntrastriatal injectionParametric mappingSodium nitroprussideCerebral arteryLongitudinally in vivoIn vivo quantificationQuantification of oxidative stressEmission tomographyPET imagingAntioxidant edaravoneDynamic PET imagesHuman plasmaA force-sensitive adhesion GPCR is required for equilibrioception
Yang Z, Zhou S, Zhang Q, Song Z, Liu W, Sun Y, Wang M, Fu X, Zhu K, Guan Y, Qi J, Wang X, Sun Y, Lu Y, Ping Y, Xi Y, Teng Z, Xu L, Xiao P, Xu Z, Xiong W, Qin W, Yang W, Yi F, Chai R, Yu X, Sun J. A force-sensitive adhesion GPCR is required for equilibrioception. Cell Research 2025, 35: 243-264. PMID: 39966628, PMCID: PMC11958651, DOI: 10.1038/s41422-025-01075-x.Peer-Reviewed Original ResearchTransmembrane channel-like protein 1G protein-coupled receptorsUtricular hair cellsHair cellsIncreased open probabilityAdhesion GPCRsVestibular hair cellsGlutamate releaseOpen probabilityApical membraneMET responsesVestibular functionCalcium signalingApical surfaceProtein 1Lphn2Heterologous systemsMechanosensitive G-protein-coupled receptorsMetSMiceFunctional analysisCellsMicroglia modulate the cerebrovascular reactivity through ectonucleotidase CD39
Fu Z, Ganesana M, Hwang P, Tan X, Kinkaid M, Sun Y, Bian E, Weybright A, Chen H, Sol-Church K, Eyo U, Pridans C, Quintana F, Robson S, Kumar P, Venton B, Schaefer A, Kuan C. Microglia modulate the cerebrovascular reactivity through ectonucleotidase CD39. Nature Communications 2025, 16: 956. PMID: 39843911, PMCID: PMC11754601, DOI: 10.1038/s41467-025-56093-5.Peer-Reviewed Original ResearchConceptsCerebral blood flowEctonucleotidases CD39Whisker stimulationResponse to whisker stimulationCerebrovascular reactivityDeletion of CD39Blood flowInjection of adenosine triphosphateModulation of cerebral blood flowRegulation of cerebral blood flowExtracellular adenosine triphosphateInjection of adenosineBorder-associated macrophagesMicroglia repopulationExtracellular adenosineAdenosine triphosphateFemale miceBlood flow anomaliesP2RY12 receptorCo-transmitterMouse modelPharmacological inhibitionCD39MicrogliaMice
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