Xingxing Wang, MD
Associate Research Scientist in NeuroscienceDownloadHi-Res Photo
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Associate Research Scientist in Neuroscience
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Neuroscience
Associate Research ScientistPrimary
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- MD
- Secondary Medical University (1983)
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Research at a Glance
Yale Co-Authors
Frequent collaborators of Xingxing Wang's published research.
Publications Timeline
A big-picture view of Xingxing Wang's research output by year.
Stephen Strittmatter, MD, PhD, AB
Richard Carson, PhD
Daniel Coman, PhD
David Labaree, PhD
D. S. Fahmeed Hyder, PhD
Yiyun Huang, PhD
6Publications
68Citations
Publications
2025
[18F]SynVesT-1 PET Detects SV2A Changes in the Spinal Cord and Brain of Rats with Spinal Cord Injury
Chen B, Zheng C, Balayeva T, Toyonaga T, Wang X, Tong J, Mennie W, Mihailovic J, Coman D, Hyder F, Strittmatter S, Carson R, Huang Y, Cai Z. [18F]SynVesT-1 PET Detects SV2A Changes in the Spinal Cord and Brain of Rats with Spinal Cord Injury. Journal Of Nuclear Medicine 2025, 66: 1440-1448. PMID: 40675757, PMCID: PMC12410297, DOI: 10.2967/jnumed.124.269291.Peer-Reviewed Original ResearchAltmetricMeSH Keywords and ConceptsConceptsSpinal cord injuryDistribution volume ratioDiffusion tensor imagingSpinal cordRat modelDay 1SUV ratioImmunohistochemical stainingSham controlsDay 9PET imagingRat model of spinal cord injuryContusion SCI rat modelSpinal cord injury ratsModel of spinal cord injuryCord injuryWestern blottingModerate contusion injuryBrain of ratsDiffusion tensor imaging analysisPost-mortem spinal cordTraumatic spinal cord injurySCI rat modelSynaptic vesicle glycoprotein 2ACervical cord
2023
Amino-terminal proteolytic fragment of the axon growth inhibitor Nogo-A (Rtn4A) is upregulated by injury and promotes axon regeneration
Sekine Y, Wang X, Kikkawa K, Honda S, Strittmatter S. Amino-terminal proteolytic fragment of the axon growth inhibitor Nogo-A (Rtn4A) is upregulated by injury and promotes axon regeneration. Journal Of Biological Chemistry 2023, 299: 105232. PMID: 37690690, PMCID: PMC10622843, DOI: 10.1016/j.jbc.2023.105232.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsAxon regenerationCentral nervous system injuryPersistent neurological deficitsCerebral cortical neuronsNervous system injuryNeurological deficitsSystem injuryCNS injuryCortical neuronsAmino-terminal fragmentInjuryExtracellular actionPhysiological productionNogoInhibitory proteinMiceNeuronsInhibitory domainOverexpression increasesVaried resultsProteolytic fragmentsAxotomyExpressionNogoAGene targetingSoluble Nogo-Receptor-Fc decoy (AXER-204) in patients with chronic cervical spinal cord injury in the USA: a first-in-human and randomised clinical trial
Maynard G, Kannan R, Liu J, Wang W, Lam T, Wang X, Adamson C, Hackett C, Schwab J, Liu C, Leslie D, Chen D, Marino R, Zafonte R, Flanders A, Block G, Smith E, Strittmatter S. Soluble Nogo-Receptor-Fc decoy (AXER-204) in patients with chronic cervical spinal cord injury in the USA: a first-in-human and randomised clinical trial. The Lancet Neurology 2023, 22: 672-684. PMID: 37479373, PMCID: PMC10410101, DOI: 10.1016/s1474-4422(23)00215-6.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsUpper extremity motor scoreSpinal cord injuryChronic spinal cord injuryTreatment-related adverse eventsAdverse eventsDay 169Intrathecal dosesCord injuryClinical trialsAmerican Spinal Injury Association Impairment Scale (AIS) gradeCervical traumatic spinal cord injuryChronic cervical spinal cord injuryCommon treatment-related adverse eventsCervical spinal cord injurySevere spinal cord injuryTraumatic spinal cord injuryPost-hoc subgroup analysesPersistent neurological deficitsDouble-blind comparisonKey secondary objectiveNational InstituteOpen labelAdvancing Translational SciencesPlacebo groupNeurological deficits
2022
Rabphilin3A reduces integrin-dependent growth cone signaling to restrict axon regeneration after trauma
Sekine Y, Kannan R, Wang X, Strittmatter SM. Rabphilin3A reduces integrin-dependent growth cone signaling to restrict axon regeneration after trauma. Experimental Neurology 2022, 353: 114070. PMID: 35398339, PMCID: PMC9555232, DOI: 10.1016/j.expneurol.2022.114070.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsAxon regenerationModerate spinal cord contusion injurySpinal cord contusion injuryTraumatic spinal cord injuryAdult mammalian central nervous systemGrowth conesRetinal ganglion cell axonsOptic nerve crushSpinal cord crush injuryGanglion cell axonsSpinal cord injuryMammalian central nervous systemCentral nervous systemCorticospinal axon regenerationContusion injuryAxonal sproutingCrush injuryNerve crushAxonal growth conesCord injuryAxon sproutingCell axonsProximal bodyNervous systemNeural repair
2018
Functional Genome-wide Screen Identifies Pathways Restricting Central Nervous System Axonal Regeneration
Sekine Y, Lin-Moore A, Chenette DM, Wang X, Jiang Z, Cafferty WB, Hammarlund M, Strittmatter SM. Functional Genome-wide Screen Identifies Pathways Restricting Central Nervous System Axonal Regeneration. Cell Reports 2018, 24: 269. PMID: 29972787, DOI: 10.1016/j.celrep.2018.06.079.Peer-Reviewed Original ResearchCitations
2008
PET Imaging of serotonin transporter as a biomarker for axon damage and regeneration in spinal cord injury
Huang Y, Nabulsi N, Weinzimmer D, Fung E, Ropchan J, Labaree D, Wang X, Gould G, Frost J, Carson R, Strittmatter S. PET Imaging of serotonin transporter as a biomarker for axon damage and regeneration in spinal cord injury. NeuroImage 2008, 41: t154. DOI: 10.1016/j.neuroimage.2008.04.122.Peer-Reviewed Original Research
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