Xiangli Zhao
Associate Research ScientistCards
About
Research
Publications
2025
Exogenous pyruvate is therapeutic against colitis by targeting cytosolic phospholipase A2
Hasan S, Ghani N, Zhao X, Good J, Liu C. Exogenous pyruvate is therapeutic against colitis by targeting cytosolic phospholipase A2. Genes & Diseases 2025, 12: 101571. PMID: 40605975, PMCID: PMC12221594, DOI: 10.1016/j.gendis.2025.101571.Peer-Reviewed Original ResearchInflammatory bowel diseaseUlcerative colitisBowel diseaseDextran sodium sulfate-induced colitisChronic inflammatory bowel diseaseUlcerative colitis pathogenesisTight junction proteinsPhase of inflammationCytosolic phospholipase A2Immune dysregulationColitis pathogenesisReal-time PCRNFkB translocationCellular metabolitesColon histologyJunction proteinsInflammatory diseasesColitis modelQuantitative real-time PCRTherapeutic effectUlcerative colitis modelAction of pyruvateImmunofluorescence stainingColitisRNA sequencing analysis
2024
Intrinsic link between PGRN and Gba1 D409V mutation dosage in potentiating Gaucher disease
Lin Y, Zhao X, Liou B, Fannin V, Zhang W, Setchell K, Wang X, Pan D, Grabowski G, Liu C, Sun Y. Intrinsic link between PGRN and Gba1 D409V mutation dosage in potentiating Gaucher disease. Human Molecular Genetics 2024, 33: 1771-1788. PMID: 39101473, PMCID: PMC11458007, DOI: 10.1093/hmg/ddae113.Peer-Reviewed Original ResearchGaucher diseaseMutation dosageMouse modelDisease severityProgrammed Cell DeathRetinal gliosisBrain transcriptomic analysisGD pathogenesisPGRN deficiencyTissue fibrosisDisease progressionGrn-/- miceSevere phenotypeGlycosphingolipid accumulationTranscriptome analysisInflammatory responseGCase functionMiceCell deathShort life spanNeurobehavioral analysisDiseaseGCase activityNeurodegenerative diseasesPGRNAuthor Correction: Novel peptide inhibitor of human tumor necrosis factor-α has antiarthritic activity
Sahu D, Gupta C, Yennamalli R, Sharma S, Roy S, Hasan S, Gupta P, Sharma V, Kashyap S, Kumar S, Dwivedi V, Zhao X, Panda A, Das H, Liu C. Author Correction: Novel peptide inhibitor of human tumor necrosis factor-α has antiarthritic activity. Scientific Reports 2024, 14: 14306. PMID: 38907075, PMCID: PMC11192870, DOI: 10.1038/s41598-024-65261-4.Peer-Reviewed Original ResearchNovel peptide inhibitor of human tumor necrosis factor-α has antiarthritic activity
Sahu D, Gupta C, Yennamalli R, Sharma S, Roy S, Hasan S, Gupta P, Sharma V, Kashyap S, Kumar S, Dwivedi V, Zhao X, Panda A, Das H, Liu C. Novel peptide inhibitor of human tumor necrosis factor-α has antiarthritic activity. Scientific Reports 2024, 14: 12935. PMID: 38839973, PMCID: PMC11153517, DOI: 10.1038/s41598-024-63790-6.Peer-Reviewed Original ResearchConceptsProtein-protein interactionsGel mobility-shift assaysCollagen-induced arthritisMobility-shift assaysCell surface receptorsFluorescence-activated cell sortingSequence strandsBinding of TNFIn silico methodsCell deathMouse modelSurface receptorsNuclear translocationTrimer formationCell culture assaysRheumatoid arthritisVicious cycle of inflammationModel of collagen-induced arthritisTumor necrosis factor-aCell sortingMouse model of collagen-induced arthritisA549 cellsCycle of inflammationInflammatory bone destructionCulture assayDietary pyruvate targets cytosolic phospholipase A2 to mitigate inflammation and obesity in mice
Hasan S, Ghani N, Zhao X, Good J, Huang A, Wrona H, Liu J, Liu C. Dietary pyruvate targets cytosolic phospholipase A2 to mitigate inflammation and obesity in mice. Protein & Cell 2024, 15: 661-685. PMID: 38512816, PMCID: PMC11365557, DOI: 10.1093/procel/pwae014.Peer-Reviewed Original ResearchCytosolic phospholipase A2White adipose tissue inflammationAdipose tissue inflammationTissue inflammationState of chronic low-grade inflammationChronic low-grade inflammationHFD-induced weight gainLow-grade inflammationAttenuation of inflammationMolecular targetsPotential therapeutic optionDevelopment of metabolic disordersProtective effect of pyruvateAdipogenic differentiation in vitroDiet-induced obesityNonalcoholic fatty liver diseaseDifferentiation in vitroDrug affinity responsive target stabilityFatty liver diseasePhospholipase A2Meta-inflammationTherapeutic optionsDrug responseGlobal ablationMultifactorial etiologyProgranulin deficiency associates with postmenopausal osteoporosis via increasing ubiquitination of estrogen receptor α
Li G, Wang A, Tang W, Fu W, Tian Q, Jian J, Lata M, Hettinghouse A, Ding Y, Wei J, Zhao X, Wang M, Dong Q, Liu C, Xu Y. Progranulin deficiency associates with postmenopausal osteoporosis via increasing ubiquitination of estrogen receptor α. Genes & Diseases 2024, 12: 101221. PMID: 39559258, PMCID: PMC11570241, DOI: 10.1016/j.gendis.2024.101221.Peer-Reviewed Original ResearchPostmenopausal osteoporosisEstrogen receptorReceptor AEstrogen signalingTreatment of postmenopausal osteoporosisOvariectomy-induced bone lossEstrogen-mediated inhibitionRegulation of bone mineral densityBone mineral densityEstrogen receptor aPGRN-deficient miceInhibition of osteoclastogenesisPostmenopausal womenEstrogen deficiencyMineral densityLoss of progranulinEstrogen regulationBone lossBone massPositive feedback regulatory loopBone resorptionOsteoporosisTherapeutic approachesEstrogenOsteoporosis modelNav1.7 as a chondrocyte regulator and therapeutic target for osteoarthritis
Fu W, Vasylyev D, Bi Y, Zhang M, Sun G, Khleborodova A, Huang G, Zhao L, Zhou R, Li Y, Liu S, Cai X, He W, Cui M, Zhao X, Hettinghouse A, Good J, Kim E, Strauss E, Leucht P, Schwarzkopf R, Guo E, Samuels J, Hu W, Attur M, Waxman S, Liu C. Nav1.7 as a chondrocyte regulator and therapeutic target for osteoarthritis. Nature 2024, 625: 557-565. PMID: 38172636, PMCID: PMC10794151, DOI: 10.1038/s41586-023-06888-7.Peer-Reviewed Original ResearchVoltage-gated sodium channelsOA progressionDorsal root ganglion neuronsStructural joint damagePain relief treatmentHuman OA chondrocytesCommon joint diseaseMultiple mouse modelsNav1.7 blockersPain behaviorGanglion neuronsPharmacological blockadeJoint damageJoint degenerationChannel blockersJoint diseaseOA chondrocytesMouse modelTherapeutic targetOsteoarthritisIntracellular Ca2Nav1.7Nav1.7 channelsGenetic ablationLimited evidence
2023
Interaction with ERp57 is required for progranulin protection against Type 2 Gaucher disease
Liu Y, Zhao X, Jian J, Hasan S, Liu C. Interaction with ERp57 is required for progranulin protection against Type 2 Gaucher disease. BioScience Trends 2023, 17: 126-135. PMID: 36889696, PMCID: PMC10514708, DOI: 10.5582/bst.2023.01022.Peer-Reviewed Original ResearchConceptsHsp70-deficient cellsProtein disulfide isomerase A3Binding partnersDeficient cellsGaucher diseaseGrowth factor-like moleculesProgranulin regulationCo-purificationLysosomal proteinsERp57Molecular mechanismsE domainHeat shock protein 70Lysosomal storage diseaseND7Co-factorEffects of progranulinGCaseGCase activityProteinProgranulinL444P mutationHSP70MutationsProtein 70YQBS Improves Cognitive Dysfunction in Diabetic Rats: Possible Association with Tyrosine and Tryptophan Metabolism
Liu Y, Cai J, Wang Y, Zhao X, Qiao Y, Liu C. YQBS Improves Cognitive Dysfunction in Diabetic Rats: Possible Association with Tyrosine and Tryptophan Metabolism. Diabetes Metabolic Syndrome And Obesity 2023, 16: 901-912. PMID: 37021127, PMCID: PMC10069430, DOI: 10.2147/dmso.s401863.Peer-Reviewed Original ResearchDiabetic ratsSD ratsCognitive dysfunctionTryptophan metabolismMale Sprague-Dawley ratsDiabetic cognitive dysfunctionDiabetic animal modelsHealthy SD ratsShortening of latencySprague-Dawley ratsSD rat modelDiabetic SD ratsBu-ShenDawley ratsHippocampal tissueRat modelPathological changesProtective effectHippocampal regionPathological alterationsYi-QiAnimal modelsCognitive impairmentHigh dosesPossible associationEarlier-onset, more severe neurodegeneration in PGRN KO mice with a decreased dose of D409V Gba1
Lin Y, Zhao X, Liou B, Fannin V, Zhang W, Liu Y, Wang X, Pan D, Grabowski G, Liu C, Sun Y. Earlier-onset, more severe neurodegeneration in PGRN KO mice with a decreased dose of D409V Gba1. Molecular Genetics And Metabolism 2023, 138: 107207. DOI: 10.1016/j.ymgme.2022.107207.Peer-Reviewed Original Research