Wenwen Tang, PhD
Research Scientist in PharmacologyCards
About
Research
Publications
2026
Vascular Endothelial Growth Factor-D Improves Lung Vascular Integrity During Acute Lung Injury.
Yoon Y, Sharma L, Tang W, Kirk S, Raredon M, Ahangari F, Khoury J, Qian H, Ke Y, Tulapurkar M, Liu R, Luan Y, Yuan Q, Chen L, Birukov K, Simons M, Wu D, Niklason L, Kaminski N, Yuan Y. Vascular Endothelial Growth Factor-D Improves Lung Vascular Integrity During Acute Lung Injury. Circulation Research 2026 PMID: 41822962, PMCID: PMC13007730, DOI: 10.1161/circresaha.124.326094.Peer-Reviewed Original ResearchVEGF-DAcute lung injuryBarrier-protective effectsVascular integrityLung injuryLipopolysaccharide-induced acute lung injury modelIntravenous administrationTNF-aParacrine signalingModel of acute lung injuryPulmonary vascular integrityLigand-receptor interactionsImmune cell infiltrationAcute lung injury modelLung vascular integrityVEGFR2-dependent signalingLung injury modelEndothelial barrier integrityEndothelial barrier functionRNA sequencing dataMicrovascular endothelial cellsInhibition of VEGFR2Microvascular nichePharmacological blockadeAssociated with pathways
2025
VEGF-D, unlike VEGF-A, improves vascular integrity in the lung and exerts a protective effect during acute lung injury
Yuan Y, Sharma L, Tang W, Yoon Y, Kirk S, Birukov K, Kaminski N. VEGF-D, unlike VEGF-A, improves vascular integrity in the lung and exerts a protective effect during acute lung injury. Physiology 2025, 40: 0734. DOI: 10.1152/physiol.2025.40.s1.0734.Peer-Reviewed Original ResearchAcute lung injuryAcute respiratory distress syndromeImmune cell infiltrationVEGF-DIdiopathic pulmonary fibrosisChronic obstructive pulmonary diseaseVEGF-AVascular integrityMicrovascular nicheAnti-inflammatory propertiesLung injuryCell infiltrationTNF-aLung tissueParacrine signalingPulmonary vascular integrityBarrier functionLung injury indexLevels of pro-inflammatory markersRespiratory distress syndromeTherapeutic targetTumor necrosis factor-aEffects of VEGF-ABronchoalveolar lavage fluidImproving vascular integrityMMP9High Neutrophils are Critical Mediators of Neutrophil Extracellular Traps Formation and Myocardial Ischemia/Reperfusion Injury
Hu S, Zhang F, Wang J, Zhang J, Li C, Lyu Y, Wang Y, Huang R, Gao Y, Yang H, Qian J, Tang W, Cao J, Ge J. MMP9High Neutrophils are Critical Mediators of Neutrophil Extracellular Traps Formation and Myocardial Ischemia/Reperfusion Injury. Advanced Science 2025, 12: 2415205. PMID: 40151877, PMCID: PMC12140383, DOI: 10.1002/advs.202415205.Peer-Reviewed Original ResearchConceptsNeutrophil extracellular trap formationNeutrophil extracellular trapsMyocardial ischemia/reperfusion injuryIschemia/reperfusion injuryBlood of healthy donorsNeutrophil-mediated reperfusion injuryTherapeutic targetExtracellular trap formationTranscription factor SPI1Potential therapeutic targetHealthy donors
2024
Single-cell RNA-seq analysis of cell-cell communications in human lung reveals a novel role of VEGF-D in acute lung injury
Yuan Y, Sharma L, Tang W, Raredon M, Ahangari F, Khoury J, Wu D, Niklason L, Kaminski N. Single-cell RNA-seq analysis of cell-cell communications in human lung reveals a novel role of VEGF-D in acute lung injury. Physiology 2024, 39: 1314. DOI: 10.1152/physiol.2024.39.s1.1314.Peer-Reviewed Original ResearchIdiopathic pulmonary fibrosisAcute lung injuryChronic obstructive pulmonary diseaseAcute respiratory distress syndromeAnalysis of cell-cell communicationVEGF-DMicrovascular nicheSingle-cell RNA-seqLung injury modelSingle-cell RNA-seq analysisLung injuryCell-cell communicationLigand-receptor pairsLPS-induced lung injury modelRNA-seqAdjacent cell typesPulmonary diseaseInjury modelHuman lung endothelial cellsBarrier functionImmune cell infiltrationTumor necrosis factor-aRespiratory distress syndromeLung vascular integrityGene expressionVEGF-D Is Enriched in the Human Lung Microvascular Niche and Improves Vascular Integrity During Acute Lung Injury
Yuan Y, Sharma L, Tang W, Raredon M, Ahangari F, Khoury J, Wu D, Niklason L, Kaminski N. VEGF-D Is Enriched in the Human Lung Microvascular Niche and Improves Vascular Integrity During Acute Lung Injury. American Journal Of Respiratory And Critical Care Medicine 2024, 209: a4694-a4694. DOI: 10.1164/ajrccm-conference.2024.209.1_meetingabstracts.a4694.Peer-Reviewed Original ResearchLDL receptor-related protein 5 selectively transports unesterified polyunsaturated fatty acids to intracellular compartments
Tang W, Luan Y, Yuan Q, Li A, Chen S, Menacherry S, Young L, Wu D. LDL receptor-related protein 5 selectively transports unesterified polyunsaturated fatty acids to intracellular compartments. Nature Communications 2024, 15: 3068. PMID: 38594269, PMCID: PMC11004178, DOI: 10.1038/s41467-024-47262-z.Peer-Reviewed Original ResearchConceptsLDL receptor-related protein 5Intracellular compartmentsPolyunsaturated fatty acidsProtein 5Ligand-binding repeatsBiologically important mechanismsAssociated with human healthImport mechanismExtracellular trap formationInhibit mTORC1Cell typesFatty acidsTrap formationN-3 polyunsaturated fatty acidsCompartmentProtect miceLDLAMyocardial injuryHomologyIschemia-reperfusionMTORC1LysosomesLRP6Human healthFATP2Wnt5 controls splenic myelopoiesis and neutrophil functional ambivalency during DSS-induced colitis
Luan Y, Hu J, Wang Q, Wang X, Li W, Qu R, Yang C, Rajendran B, Zhou H, Liu P, Zhang N, Shi Y, Liu Y, Tang W, Lu J, Wu D. Wnt5 controls splenic myelopoiesis and neutrophil functional ambivalency during DSS-induced colitis. Cell Reports 2024, 43: 113934. PMID: 38461416, PMCID: PMC11064424, DOI: 10.1016/j.celrep.2024.113934.Peer-Reviewed Original ResearchCD8+ T cell activationNeutrophil productionNeutrophil plasticitySplenic extramedullary myelopoiesisFamily member 5T cell activationInnate immune cellsSplenic stromal cellsDSS-Induced ColitisAnti-inflammatory protectionCD101 expressionPro-inflammatory activitySplenic myelopoiesisExtramedullary myelopoiesisBone marrowImmune cellsSplenic neutrophilsMember 5Autoimmune diseasesInflammatory outcomesCell activationStromal cellsColitisSplenic productionElevated numbersCell surface RNAs control neutrophil recruitment
Zhang N, Tang W, Torres L, Wang X, Ajaj Y, Zhu L, Luan Y, Zhou H, Wang Y, Zhang D, Kurbatov V, Khan S, Kumar P, Hidalgo A, Wu D, Lu J. Cell surface RNAs control neutrophil recruitment. Cell 2024, 187: 846-860.e17. PMID: 38262409, PMCID: PMC10922858, DOI: 10.1016/j.cell.2023.12.033.Peer-Reviewed Original ResearchConceptsCell surfaceMammalian homologOuter cell surfaceRNA transportGlycan modificationsMammalian cellsSID-1Cellular functionsRecruitment to inflammatory sitesGlycoRNARNAMurine neutrophilsFunctional significanceNeutrophil recruitmentNeutrophil recruitment to inflammatory sitesBiological importanceCellsNeutrophil adhesionReduced neutrophil adhesionHomologyGlycansGenesInflammatory sitesRecruitmentEndothelial cellsThe CUL5 E3 ligase complex negatively regulates central signaling pathways in CD8+ T cells
Liao X, Li W, Zhou H, Rajendran B, Li A, Ren J, Luan Y, Calderwood D, Turk B, Tang W, Liu Y, Wu D. The CUL5 E3 ligase complex negatively regulates central signaling pathways in CD8+ T cells. Nature Communications 2024, 15: 603. PMID: 38242867, PMCID: PMC10798966, DOI: 10.1038/s41467-024-44885-0.Peer-Reviewed Original ResearchConceptsCD8+ T cellsT cellsCancer immunotherapyMouse CD8+ T cellsAnti-tumor immunityTumor growth inhibition abilityAnti-tumor effectsInhibition of neddylationCD8Effector functionsTCR stimulationIL2 signalingCentral signaling pathwaysCore signaling pathwaysEffector activityNegative regulatory mechanismsTranslational implicationsImmunotherapyGrowth inhibition abilityCytokine signalingTCRProteomic alterationsSignaling pathwayCancerCRISPR-based screens
2023
Cell Surface RNAs Control Neutrophil Function
Zhang N, Tang W, Torres L, Zhu L, Wang X, Ajaj Y, Wang Y, Zhang D, Kurbatov V, Zhou H, Luan Y, Kumar P, Hidalgo A, Wu D, Lu J. Cell Surface RNAs Control Neutrophil Function. Blood 2023, 142: 674. DOI: 10.1182/blood-2023-187570.Peer-Reviewed Original ResearchExtracellular RNaseCell surfaceTotal RNABona fide ligandsEndothelial cellsOuter cell surfaceTransendothelial migrationMammalian cellsSuch RNAsGlycan modificationsCellular RNAGlycoRNARNase digestionLive cellsRNAHematopoietic cellsRNase treatmentSimilar defectsIntegrin levelsConfocal microscopyRNaseGlycan fractionImportant functionsHomologuesRecombinant E-selectin
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