Walter Mowel, PhD
Postdoctoral AssociateAbout
Research
Publications
2024
IL-10 constrains sphingolipid metabolism to limit inflammation
York A, Skadow M, Oh J, Qu R, Zhou Q, Hsieh W, Mowel W, Brewer J, Kaffe E, Williams K, Kluger Y, Smale S, Crawford J, Bensinger S, Flavell R. IL-10 constrains sphingolipid metabolism to limit inflammation. Nature 2024, 627: 628-635. PMID: 38383790, PMCID: PMC10954550, DOI: 10.1038/s41586-024-07098-5.Peer-Reviewed Original ResearchActivity of RelCeramide productionVery long chainFatty acid synthesis pathwayCeramide synthase 2Fatty acid homeostasisMetabolic fluxAvailable to cellsRegulatory nodesTranscription factorsCeramide accumulationSynthesis pathwayVLC ceramidesIL-10 deficiencyGene expressionSphingolipid metabolismAcid homeostasisAberrant activationIL-10Cell types1Innate immune cellsInflammatory gene expressionCeramideSignaling resultsGenetic deletion
2022
Multiscale 3D genome organization underlies ILC2 ontogenesis and allergic airway inflammation
Michieletto M, Tello-Cajiao J, Mowel W, Chandra A, Yoon S, Joannas L, Clark M, Jimenez M, Wright J, Lundgren P, Williams A, Thaiss C, Vahedi G, Henao-Mejia J. Multiscale 3D genome organization underlies ILC2 ontogenesis and allergic airway inflammation. Nature Immunology 2022, 24: 42-54. PMID: 36050414, PMCID: PMC10134076, DOI: 10.1038/s41590-022-01295-y.Peer-Reviewed Original ResearchConceptsGenome organizationThree-dimensional genome organizationDistal regulatory elementsId2 promoterChromatin accessibilityGenome structureFunction of ILCsTissue homeostasisRegulatory elementsId2 expressionGene expressionIntegrative analysisILC biologyTranscription factor GATA-3Innate lymphoid cellsFunctional differentiationHost defenseAllergic airway inflammationMultiple interactionsMature ILCGATA-3Key roleExpressionAirway inflammationOntogenesis
2019
The gut microbiota regulates white adipose tissue inflammation and obesity via a family of microRNAs
Virtue AT, McCright SJ, Wright JM, Jimenez MT, Mowel WK, Kotzin JJ, Joannas L, Basavappa MG, Spencer SP, Clark ML, Eisennagel SH, Williams A, Levy M, Manne S, Henrickson SE, Wherry EJ, Thaiss CA, Elinav E, Henao-Mejia J. The gut microbiota regulates white adipose tissue inflammation and obesity via a family of microRNAs. Science Translational Medicine 2019, 11 PMID: 31189717, PMCID: PMC7050429, DOI: 10.1126/scitranslmed.aav1892.Peer-Reviewed Original ResearchConceptsWhite adipose tissueDevelopment of obesityGut microbiotaInsulin resistanceWAT functionWhite adipose tissue inflammationGut microbiota-derived metabolitesAdipose tissue inflammationContext of obesityMicrobiota-derived metabolitesPotential therapeutic targetGut dysbiosisWAT inflammationTissue inflammationInsulin sensitivityTherapeutic targetAdipose tissueObesityWhite adipocytesPlasma abundanceCentral mechanismsMetabolic fitnessHost metabolismEnergy expenditureMicrobiotaThe long noncoding RNA Morrbid regulates CD8 T cells in response to viral infection
Kotzin JJ, Iseka F, Wright J, Basavappa MG, Clark ML, Ali MA, Abdel-Hakeem MS, Robertson TF, Mowel WK, Joannas L, Neal VD, Spencer SP, Syrett CM, Anguera MC, Williams A, Wherry EJ, Henao-Mejia J. The long noncoding RNA Morrbid regulates CD8 T cells in response to viral infection. Proceedings Of The National Academy Of Sciences Of The United States Of America 2019, 116: 11916-11925. PMID: 31138702, PMCID: PMC6575676, DOI: 10.1073/pnas.1819457116.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCD8-Positive T-LymphocytesCell DifferentiationInterferon Type ILymphocyte ActivationLymphocytic ChoriomeningitisLymphocytic choriomeningitis virusMaleMiceMice, Inbred C57BLMice, TransgenicPhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-bcl-2Receptors, Antigen, T-CellRNA, Long NoncodingSignal TransductionConceptsCD8 T cellsT cell receptorT cellsViral infectionChronic lymphocytic choriomeningitis virus (LCMV) infectionCD8 T cell expansionLymphocytic choriomeningitis virus infectionCD8 T cell differentiationTumor immune surveillanceT cell expansionI IFN stimulationT cell differentiationImmune surveillanceVirus infectionEffector functionsI IFNInfectionPI3K-AktIFN stimulationProapoptotic factorsCell expansionCellsTranscriptional programsEarly stagesResponse
2017
Viruses hijack a host lncRNA to replicate
Kotzin J, Mowel W, Henao-Mejia J. Viruses hijack a host lncRNA to replicate. Science 2017, 358: 993-994. PMID: 29170219, DOI: 10.1126/science.aar2300.Peer-Reviewed Original ResearchControl of Immune Cell Homeostasis and Function by lncRNAs
Mowel W, Kotzin J, McCright S, Neal V, Henao-Mejia J. Control of Immune Cell Homeostasis and Function by lncRNAs. Trends In Immunology 2017, 39: 55-69. PMID: 28919048, PMCID: PMC5748345, DOI: 10.1016/j.it.2017.08.009.Peer-Reviewed Original ResearchConceptsCell gene expression programSpecific epigenetic landscapesGene expression programsLong non-coding RNAsDiverse molecular mechanismsDiverse cell typesNon-coding RNAsKey regulatory moleculesLncRNA mechanismsEpigenetic landscapeExpression programsExtracellular cuesTranscriptional regulationTranscriptional programsTissue homeostasisTranscriptional profilesRegulatory moleculesCell homeostasisMolecular mechanismsImmune cell homeostasisCell typesLncRNAsHomeostasisImmune systemCell populationsGroup 1 Innate Lymphoid Cell Lineage Identity Is Determined by a cis-Regulatory Element Marked by a Long Non-coding RNA
Mowel WK, McCright SJ, Kotzin JJ, Collet MA, Uyar A, Chen X, DeLaney A, Spencer SP, Virtue AT, Yang E, Villarino A, Kurachi M, Dunagin MC, Pritchard GH, Stein J, Hughes C, Fonseca-Pereira D, Veiga-Fernandes H, Raj A, Kambayashi T, Brodsky IE, O’Shea J, Wherry EJ, Goff LA, Rinn JL, Williams A, Flavell RA, Henao-Mejia J. Group 1 Innate Lymphoid Cell Lineage Identity Is Determined by a cis-Regulatory Element Marked by a Long Non-coding RNA. Immunity 2017, 47: 435-449.e8. PMID: 28930659, PMCID: PMC5761663, DOI: 10.1016/j.immuni.2017.08.012.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCell DifferentiationCell LineageChromatin Assembly and DisassemblyFemaleGene Expression ProfilingGene Expression RegulationGenetic LociHomeostasisImmunity, InnateInhibitor of Differentiation Protein 2Killer Cells, NaturalLymphocyte SubsetsLymphocytesMaleMicePromoter Regions, GeneticRegulatory Sequences, Nucleic AcidRNA, Long NoncodingSTAT5 Transcription FactorTranscription, GeneticConceptsCis-regulatory elements
2016
The long non-coding RNA Morrbid regulates Bim and short-lived myeloid cell lifespan
Kotzin JJ, Spencer SP, McCright SJ, Kumar DBU, Collet MA, Mowel WK, Elliott EN, Uyar A, Makiya MA, Dunagin MC, Harman CCD, Virtue AT, Zhu S, Bailis W, Stein J, Hughes C, Raj A, Wherry EJ, Goff LA, Klion AD, Rinn JL, Williams A, Flavell RA, Henao-Mejia J. The long non-coding RNA Morrbid regulates Bim and short-lived myeloid cell lifespan. Nature 2016, 537: 239-243. PMID: 27525555, PMCID: PMC5161578, DOI: 10.1038/nature19346.Peer-Reviewed Original ResearchShort-lived myeloid cell lifespan is regulated by a long non-coding RNA
Kotzin J, Spencer S, McCright S, Uthaya Kumar D, Mowel W, Makiya M, Klion A, Williams A, Flavell R, Henao-Mejia J. Short-lived myeloid cell lifespan is regulated by a long non-coding RNA. The Journal Of Immunology 2016, 196: 202.28-202.28. DOI: 10.4049/jimmunol.196.supp.202.28.Peer-Reviewed Original ResearchLong non-coding RNAsNon-coding RNAsNovel long non-coding RNAAllele-specific mannerPro-survival cytokinesLocus-specific regulationPro-apoptotic genesExtracellular signalsMyeloid cellsEnvironmental cuesPrecise regulationGene expressionRegulatory mechanismsCell homeostasisImmune cell homeostasisLncRNAsShort lifespanPotential therapeutic targetCell lifespanRNATherapeutic targetCellsLifespanRegulationHost response
2014
Influenza A virus infection in zebrafish recapitulates mammalian infection and sensitivity to anti-influenza drug treatment
Gabor K, Goody M, Mowel W, Breitbach M, Gratacap R, Witten P, Kim C. Influenza A virus infection in zebrafish recapitulates mammalian infection and sensitivity to anti-influenza drug treatment. Disease Models & Mechanisms 2014, 7: 1227-1237. PMID: 25190709, PMCID: PMC4213727, DOI: 10.1242/dmm.014746.Peer-Reviewed Original ResearchConceptsInfluenza infectionVirus infectionAnimal modelsSeasonal influenza virus infectionInfluenza virus infectionAnti-influenza compoundsCurrent animal modelsPotential antiviral drugsGlobal health concernInnate antiviral genesTherapeutic drug testingHost-pathogen interactionsEndothelial infectionInfluenza illnessViral burdenSubstantial morbidityClinical symptomsNew virus strainsSporadic pandemicsDrug treatmentImmune responseAntiviral drugsAntiviral resistanceEconomic burdenAnnual epidemics