- March 04, 2021
Yale Study Shows Combined Liver–Cytokine Humanization Rescues Circulating Red Blood Cells for Testing of Novel Therapeutics
- August 25, 2020
Three members in the Department of Immunobiology have received awards from ICIS, the International Cytokine and Interferon Society
- April 01, 2020
Suspect cells' 'neighbor' implicated in colorectal cancer
- March 12, 2020
How T Cells Make Sure They Have Quiet Time
The Flavell Lab
The Flavell Lab is interested in the molecular and cellular basis of the immune response. Our research leverages transgenic and gene-targeted mice to study the innate and adaptive arms of the immune system, and how these reciprocally regulate a broad range of biological processes. Our recent study by Jarret, Jackson et al. has shown that enteric neurons produce a pro-inflammatory cytokine IL-18 which plays a profound role in coordinating the immune state of intestinal tissues, promoting barrier immunity and protection against invasive bacterial pathogens. This highlights the paradigm that frames our research of the immune system as a highly integrated network constantly interacting with other physiological processes on multiple scales to produce complex biological systems able to adapt to environmental stresses and pathogens. (image by Holly Steach)
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