Adjunct Faculty
Adjunct faculty typically have an academic or research appointment at another institution and contribute or collaborate with one or more School of Medicine faculty members or programs.
Adjunct rank detailsVanessa Scanlon, PhD
Assistant Professor AdjunctDownloadHi-Res Photo
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Assistant Professor Adjunct
Biography
Vanessa Scanlon is an Assistant Professor at the University of Connecticut. She is passionate about science and strengthening the pipeline of underrepresented individuals to successful research careers. Her research interests include hematopoiesis and the bone marrow microenvironment. In her spare time, she enjoys live music, gardening and star gazing.
Last Updated on January 02, 2024.
Appointments
Laboratory Medicine
Assistant Professor AdjunctPrimary
Other Departments & Organizations
Education & Training
- PhD
- UConn Health, Biomedical Science (2015)
- BS
- UConn, MCB (2006)
- BS
- UConn, DGS (2006)
Research
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Overview
Currently, I work on understanding extrinsic mechanisms that underly hematopoietic progenitor cell fate decisions. I have developed a novel method for time-lapse microscopy of bipotent progenitors dividing and committing to two potential lineages. I'm also interested in developing 3D engineered in vitro cell culture models to further investigate spatial regulation between cells of the bone marrow microenvironment.
I also study the function of specific domains within a co-transcriptional activator during megakaryocytopoiesis.
Medical Research Interests
Blood Cells; Hematopoietic System
ORCID
0000-0002-5569-6901
Research at a Glance
Yale Co-Authors
Frequent collaborators of Vanessa Scanlon's published research.
Publications Timeline
A big-picture view of Vanessa Scanlon's research output by year.
Diane Krause, MD, PhD
Madeline Mayday
Lin Wang, MS
Betty R. Lawton, PhD
Karin Finberg, MD, PhD
Max Carlino
22Publications
234Citations
Publications
Featured Publications
Multiparameter analysis of timelapse imaging reveals kinetics of megakaryocytic erythroid progenitor clonal expansion and differentiation
Scanlon VM, Thompson EN, Lawton BR, Kochugaeva M, Ta K, Mayday MY, Xavier-Ferrucio J, Kang E, Eskow NM, Lu YC, Kwon N, Laumas A, Cenci M, Lawrence K, Barden K, Larsuel ST, Reed FE, Peña-Carmona G, Ubbelohde A, Lee JP, Boobalan S, Oppong Y, Anderson R, Maynard C, Sahirul K, Lajeune C, Ivathraya V, Addy T, Sanchez P, Holbrook C, Van Ho AT, Duncan JS, Blau HM, Levchenko A, Krause DS. Multiparameter analysis of timelapse imaging reveals kinetics of megakaryocytic erythroid progenitor clonal expansion and differentiation. Scientific Reports 2022, 12: 16218. PMID: 36171423, PMCID: PMC9519589, DOI: 10.1038/s41598-022-19013-x.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsMegakaryocytic-erythroid progenitorsFate specificationLineage commitmentUnderstanding of hematopoiesisProgenitor cell biologyPrimary human hematopoietic progenitorsSingle-cell trackingSingle-cell assaysSingle-cell levelHuman hematopoietic progenitorsProgenitor cell dynamicsLineage specificationCell fateColony-forming unit assaysTimelapse imagingSitu fluorescence stainingCell biologyLineage tracingDivision rateCytokine thrombopoietinHematopoietic progenitorsProgenitorsFluorescence stainingCell dynamicsUnit assays
2025
Building a transparent and functional lab culture: Guidelines for creating a Laboratory Handbook for principal investigators
de Bock C, Bridge K, van Gastel N, Gleitz H, Kats L, King K, Machlus K, Psaila B, Scanlon V, Souroullas G, Kokkaliaris K. Building a transparent and functional lab culture: Guidelines for creating a Laboratory Handbook for principal investigators. Experimental Hematology 2025, 105265. PMID: 40976536, DOI: 10.1016/j.exphem.2025.105265.Peer-Reviewed Original ResearchAltmetricQuantification of intrinsic regulatory factors refines human hematopoietic progenitor definitions and reveals early erythroid lineage priming
Favaro P, Glass D, Borges L, Baskar R, Lam A, Reynolds W, Ho D, Bruce T, Tebaykin D, Koehnke T, Scanlon V, Shestopalov I, Bendall S. Quantification of intrinsic regulatory factors refines human hematopoietic progenitor definitions and reveals early erythroid lineage priming. Cell Reports 2025, 44: 115913. PMID: 40577131, DOI: 10.1016/j.celrep.2025.115913.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsHSPC subsetsCD34- cellsIntrinsic regulatory factorsCord bloodFetal liverHematopoietic stemPeripheral bloodMyeloid lineageHematological conditionsBone marrowProspective isolationEssential therapyProgenitor cellsHematopoietic tissueDifferentiation assaysHematopoietic modelLineage primingEpigenetic analysisHSPCsCross-tissueCross-tissue comparisonSurface proteinsRegulatory factorsBloodFunctional regulationProteoglycan-4 (PRG4) serum concentration is lower in aged mice, and genetic deficiency impacts survival probability, blood parameters, and bone during aging
Tanguay A, Menon N, Slavin E, Moody M, McEwen E, Jay G, Lorenzo J, Bartley J, Scanlon V, Deymier A, Schmidt T. Proteoglycan-4 (PRG4) serum concentration is lower in aged mice, and genetic deficiency impacts survival probability, blood parameters, and bone during aging. GeroScience 2025, 1-14. PMID: 40537697, DOI: 10.1007/s11357-025-01747-x.Peer-Reviewed Original ResearchAltmetricConceptsWT miceCamptodactyly-arthropathy-coxa vara-pericarditisProteoglycan 4Aged wild typeYoung WT miceComplete blood countLoss-of-function mutationsAssessed clinical relevanceProteoglycan 4 geneBlood countAged miceSerum concentrationsAnti-fibroticRare diseaseBlood gasesClinical relevanceImmunomodulatory propertiesMiceWild typeBlood parametersYounger ageSurvival probabilitySex-dependentSerumLower survival probability
2024
3109 – OPTIMIZING AND SIMPLIFYING READOUT OF HEMATOPOIETIC COLONY FORMING UNIT (CFU) ASSAYS
Krause D, Thompson E, Carlino M, Scanlon V. 3109 – OPTIMIZING AND SIMPLIFYING READOUT OF HEMATOPOIETIC COLONY FORMING UNIT (CFU) ASSAYS. Experimental Hematology 2024, 137: 104431. DOI: 10.1016/j.exphem.2024.104431.Peer-Reviewed Original ResearchConceptsColony forming unitsCell typesProportion of coloniesFluorescence Activated Cell SortingColony morphologyForming unitsColony typesIdentification of basophilsLineagesColony forming unit assayCell morphologyCell sortingColoniesIndividual stemsSemisolid mediumMK cellsMultipotent progenitorsDetect GProgenitor populationsLineage potentialCommon myeloid progenitorsCellsIL-3Megakaryocytic lineageCombination of G-CSF
2023
Assay optimization for the objective quantification of human multilineage colony-forming units
Thompson E, Carlino M, Scanlon V, Grimes H, Krause D. Assay optimization for the objective quantification of human multilineage colony-forming units. Experimental Hematology 2023, 124: 36-44.e3. PMID: 37271449, PMCID: PMC10527702, DOI: 10.1016/j.exphem.2023.05.007.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsFluorescence-activated cell sortingLineage potentialCommon myeloid progenitorsHigh-throughput microscopyMultilineage colony-forming unitsProportion of coloniesSpecific growth factorsCFU assayColony-forming unit assaysMultipotent progenitorsProgenitor populationsLineage outputSitu immunofluorescenceMegakaryocytic lineageMK cellsMegakaryocytic cellsCell typesMyeloid progenitorsProgenitor cellsCell morphologyCell sortingUnit assaysIL-3Colony typesCulture conditionsSATB1 Chromatin Loops Regulate Megakaryocyte/Erythroid Progenitor Expansion by Facilitating HSP70 and GATA1 Induction
Wilkes M, Chae H, Scanlon V, Cepika A, Wentworth E, Saxena M, Eskin A, Chen Z, Glader B, Roncarolo M, Nelson S, Sakamoto K. SATB1 Chromatin Loops Regulate Megakaryocyte/Erythroid Progenitor Expansion by Facilitating HSP70 and GATA1 Induction. Stem Cells 2023, 41: 560-569. PMID: 36987811, PMCID: PMC10267687, DOI: 10.1093/stmcls/sxad025.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsMegakaryocyte/erythroid progenitorsSpecial AT-rich sequence-binding protein 1Diamond-Blackfan anemiaInherited bone marrow failure syndromeChromatin loopsInduction of HSP70Hsp70 geneShock protein 70Progenitor expansionBiological functionsEarly myeloid progenitorsBone marrow failure syndromesErythroid factorsErythroid progenitorsMyeloid progenitorsMarrow failure syndromesProtein 1Protein 70Blackfan anemiaHSP70Specific sitesProgenitorsCell modelSATB1 expressionInduction
2022
Structure-function analysis of the role of megakaryoblastic leukemia 1 in megakaryocyte polyploidization.
Reed FE, Eskow NM, Min E, Carlino M, Mancuso R, Kwon N, Smith EC, Larsuel ST, Wang L, Scanlon V, Krause DS. Structure-function analysis of the role of megakaryoblastic leukemia 1 in megakaryocyte polyploidization. Haematologica 2022 PMID: 36005559.Peer-Reviewed Original ResearchStructure-function analysis of the role of megakaryoblastic leukemia 1 in megakaryocyte polyploidization
Reed F, Eskow N, Min E, Carlino M, Mancuso R, Kwon N, Smith E, Larsuel S, Wang L, Scanlon V, Krause D. Structure-function analysis of the role of megakaryoblastic leukemia 1 in megakaryocyte polyploidization. Haematologica 2022, 107: 2972-2976. PMID: 36453520, PMCID: PMC9713552, DOI: 10.3324/haematol.2021.280499.Peer-Reviewed Original ResearchCitationsAltmetricDownregulation of SATB1 by miRNAs reduces megakaryocyte/erythroid progenitor expansion in preclinical models of Diamond–Blackfan anemia
Wilkes MC, Scanlon V, Shibuya A, Cepika AM, Eskin A, Chen Z, Narla A, Glader B, Roncarolo MG, Nelson SF, Sakamoto KM. Downregulation of SATB1 by miRNAs reduces megakaryocyte/erythroid progenitor expansion in preclinical models of Diamond–Blackfan anemia. Experimental Hematology 2022, 111: 66-78. PMID: 35460833, PMCID: PMC9255422, DOI: 10.1016/j.exphem.2022.04.005.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsMegakaryocyte/erythroid progenitorsDiamond-Blackfan anemiaRibosomal proteinsPathogenesis of DBAErythroid progenitorsHuman hematopoietic stemInherited bone marrow failure syndromeChromatin regulatorsRibosomal insufficiencyErythroid differentiationProgenitor expansionBone marrow failure syndromesCancer predispositionHematopoietic stemMiR-30MiR-34Molecular pathwaysMegakaryocyte expansionMarrow failure syndromesNormal erythropoiesisProgenitor cellsCoordinated actionSATB1ProgenitorsDifferentiation
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