Betty R. Lawton, PhD
Research Associate 2, MSCards
Additional Titles
Research Associate in Laboratory Medicine
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Titles
Research Associate 2, MS
Research Associate in Laboratory Medicine
Biography
Dr. Betty R. Lawton is a senior member of the Krause laboratory with expertise in pluripotent stem cell culture and differentiation, as well as cell and molecular biology. The predominant interest that has driven the direction of her scientific career is the regulation of gene expression. She came to the Krause laboratory from the University of Connecticut. Her graduate (Genetics, PhD) studies were focused on examining the regulation of gene expression at the Igf2/H19 locus in marsupials and live-bearing fishes. This region is genomically imprinted in mammals and critically important for normal development. The emergence of the Connecticut Stem Cell Initiative provided an opportunity to combine her scientific interests with the needs of patients for medical alternatives to incurable conditions. She was amongst the first group of trainees at UCONN in hESC when the initiative started. She performed post-doctoral studies focused differentiation of human embryonic stem cell to skeletal muscle. In addition to performing many aspects of laboratory management, Dr. Lawton performs multiple studies focused on parathyroid cell differentiation and function.
Departments & Organizations
Education & Training
- Postdoctoral Fellow
- University of Connecticut (2010)
- PhD
- University of Connecticut, Genetics (2006)
Research
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Overview
Medical Research Interests
ORCID
0000-0002-3164-4605
Research at a Glance
Yale Co-Authors
Publications Timeline
Research Interests
Diane Krause, MD, PhD
Courtney Elizabeth Gibson, MD, MS, FACS
Caroline Zeiss, DACVP, DACLAM
Madeline Mayday
Manju Prasad, MBBS, MD
Smita Krishnaswamy, PhD
Pluripotent Stem Cells
Parathyroid Glands
Publications
2024
Single-cell analysis reveals transcriptional dynamics in healthy primary parathyroid tissue
Venkat A, Carlino M, Lawton B, Prasad M, Amodio M, Gibson C, Zeiss C, Youlten S, Krishnaswamy S, Krause D. Single-cell analysis reveals transcriptional dynamics in healthy primary parathyroid tissue. Genome Research 2024, 34: 837-850. PMID: 38977309, PMCID: PMC11293540, DOI: 10.1101/gr.278215.123.Peer-Reviewed Original ResearchCitationsAltmetric
2022
Multiparameter analysis of timelapse imaging reveals kinetics of megakaryocytic erythroid progenitor clonal expansion and differentiation
Scanlon VM, Thompson EN, Lawton BR, Kochugaeva M, Ta K, Mayday MY, Xavier-Ferrucio J, Kang E, Eskow NM, Lu YC, Kwon N, Laumas A, Cenci M, Lawrence K, Barden K, Larsuel ST, Reed FE, Peña-Carmona G, Ubbelohde A, Lee JP, Boobalan S, Oppong Y, Anderson R, Maynard C, Sahirul K, Lajeune C, Ivathraya V, Addy T, Sanchez P, Holbrook C, Van Ho AT, Duncan JS, Blau HM, Levchenko A, Krause DS. Multiparameter analysis of timelapse imaging reveals kinetics of megakaryocytic erythroid progenitor clonal expansion and differentiation. Scientific Reports 2022, 12: 16218. PMID: 36171423, PMCID: PMC9519589, DOI: 10.1038/s41598-022-19013-x.Peer-Reviewed Original ResearchCitationsAltmetric
2020
Differentiation of PTH-Expressing Cells From Human Pluripotent Stem Cells
Lawton BR, Martineau C, Sosa JA, Roman S, Gibson CE, Levine MA, Krause DS. Differentiation of PTH-Expressing Cells From Human Pluripotent Stem Cells. Endocrinology 2020, 161: bqaa141. PMID: 32810225, PMCID: PMC7505176, DOI: 10.1210/endocr/bqaa141.Peer-Reviewed Original ResearchCitationsAltmetric
2013
Effect of a Matrigel Sandwich on Endodermal Differentiation of Human Embryonic Stem Cells
Lawton BR, Sosa JA, Roman S, Krause DS. Effect of a Matrigel Sandwich on Endodermal Differentiation of Human Embryonic Stem Cells. Stem Cell Reviews And Reports 2013, 9: 578-585. PMID: 23719997, DOI: 10.1007/s12015-013-9447-2.Peer-Reviewed Original ResearchCitationsMeSH KeywordsCell Culture TechniquesCell DifferentiationCell LineCell LineageCell MovementCell SurvivalCollagenDrug CombinationsEmbryonic Stem CellsEndodermFluorescent Antibody TechniqueGene Expression Regulation, DevelopmentalGlutamine-Fructose-6-Phosphate Transaminase (Isomerizing)Hepatocyte Nuclear Factor 3-alphaHepatocyte Nuclear Factor 3-betaHumansLamininProteoglycansReceptors, Cell SurfaceReverse Transcriptase Polymerase Chain ReactionSOXF Transcription FactorsTime Factors
2008
Genomic imprinting of IGF2 in marsupials is methylation dependent
Lawton BR, Carone BR, Obergfell CJ, Ferreri GC, Gondolphi CM, VandeBerg JL, Imumorin I, O'Neill RJ, O'Neill MJ. Genomic imprinting of IGF2 in marsupials is methylation dependent. BMC Genomics 2008, 9: 205. PMID: 18454865, PMCID: PMC2386826, DOI: 10.1186/1471-2164-9-205.Peer-Reviewed Original ResearchCitationsAltmetric
2007
Ancient and continuing Darwinian selection on insulin-like growth factor II in placental fishes
O'Neill MJ, Lawton BR, Mateos M, Carone DM, Ferreri GC, Hrbek T, Meredith RW, Reznick DN, O'Neill RJ. Ancient and continuing Darwinian selection on insulin-like growth factor II in placental fishes. Proceedings Of The National Academy Of Sciences Of The United States Of America 2007, 104: 12404-12409. PMID: 17636118, PMCID: PMC1941482, DOI: 10.1073/pnas.0705048104.Peer-Reviewed Original ResearchCitationsPhysical mapping of the IGF2 locus in the South American opossum Monodelphis domestica
Lawton BR, Obergfell C, O’Neill R, O’Neill M. Physical mapping of the IGF2 locus in the South American opossum Monodelphis domestica. Cytogenetic And Genome Research 2007, 116: 130-131. PMID: 17268191, DOI: 10.1159/000097431.Peer-Reviewed Original ResearchCitations
2005
Allelic expression of IGF2 in live-bearing, matrotrophic fishes
Lawton BR, Sevigny L, Obergfell C, Reznick D, O’Neill R, O’Neill M. Allelic expression of IGF2 in live-bearing, matrotrophic fishes. Discover Developmental Biology 2005, 215: 207-212. PMID: 15654625, DOI: 10.1007/s00427-004-0463-8.Peer-Reviewed Original ResearchCitations
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Media
- Primary parathyroid cells in culture.
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