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Shivani Srivastava, PhD

Associate Research Scientist
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Associate Research Scientist

Biography

Shivani Srivastava earned her Ph.D. in Biochemistry from the Institute of Medical Sciences, BHU, India, where her doctoral research focused on the molecular mechanisms of diabetes, with particular emphasis on pancreatic β-cell & intestinal adaptation, incretin hormones, and phytotherapeutic modulation of metabolic pathways. This work provided rigorous training in metabolic and endocrine biology and established a long-standing interest in understanding how cellular stress responses contribute to metabolic disease.

In March 2020, she moved to the United States to further expand her research training. She initially worked at The Ohio State University and later at UCLA, where she explored the cellular and molecular pathways connecting metabolic dysregulation to cardiovascular disease progression.

She then joined Yale University, where her research has focused on rare skeletal and metabolic disorders, including Hutchinson-Gilford progeria syndrome, ENPP1-associated obesity, hearing loss (co-first author, PMID: 40495691), and ossification of the posterior longitudinal ligament (OPLL) (PMID: 41251406). Using genetically engineered mouse models, in vitro approaches, and stem cell differentiation assays, her work examines how metabolic enzymes and disease-associated genetic variants regulate skeletal mineralization, adipose biology, and systemic metabolic homeostasis. These studies aim to uncover disease mechanisms and evaluate therapeutic potential.

By integrating disease-relevant preclinical models with mechanistic studies, her research seeks to bridge basic science and clinical translation in the fields of bone disease, metabolic diseases (including diabetes and obesity), and cardiovascular disease.

Last Updated on January 21, 2026.

Appointments

Other Departments & Organizations

Education & Training

Postdoctoral Associate
School of Medicine, Yale University, USA
Postdoctoral Scholar
David Geffen School of Medicine, UCLA, USA
Postdoctoral Scholar
Wexner Medical Center, OSU, USA
PhD
Banaras Hindu University

Research

Overview

Medical Research Interests

Bone Diseases; Cardiovascular Diseases; Diabetes Complications; Diabetes Mellitus; Metabolic Diseases; Obesity

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