Shannan Henry
Program Manager 1DownloadHi-Res Photo
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Publications Overview
- 49 Publications
- 3,104 Citations
- 31 Yale Co-Authors
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Program Manager 1
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Research at a Glance
Yale Co-Authors
Frequent collaborators of Shannan Henry's published research.
Publications Timeline
A big-picture view of Shannan Henry's research output by year.
Nabeel Nabulsi, PhD
Richard Carson, PhD
Mika Naganawa, PhD
David Matuskey, MD
Jean-Dominique Gallezot, PhD
Mark Dias
49Publications
3,104Citations
Publications
Featured Publications
Performance Characteristics of the NeuroEXPLORER, a Next-Generation Human Brain PET/CT Imager
Li H, Badawi R, Cherry S, Fontaine K, He L, Henry S, Hillmer A, Hu L, Khattar N, Leung E, Li T, Li Y, Liu C, Liu P, Lu Z, Majewski S, Matuskey D, Morris E, Mulnix T, Omidvari N, Samanta S, Selfridge A, Sun X, Toyonaga T, Volpi T, Zeng T, Jones T, Qi J, Carson R. Performance Characteristics of the NeuroEXPLORER, a Next-Generation Human Brain PET/CT Imager. Journal Of Nuclear Medicine 2024, 65: jnumed.124.267767. PMID: 38871391, PMCID: PMC11294061, DOI: 10.2967/jnumed.124.267767.Peer-Reviewed Original ResearchCitationsAltmetricConceptsPeak noise-equivalent count rateNoise-equivalent count rateTime-of-flight resolutionField of viewCount rateExtended axial field-of-viewTransverse field-of-viewAxial field-of-viewField-of-view centerMini-Derenzo phantomSpatial resolutionTangential spatial resolutionsCount rate performanceContrast recovery coefficientHuman brain PET imagingMeasurements of spatial resolutionNEMA sensitivityEnergy resolutionScatter fractionBrain phantomBackprojection reconstructionBrain PET imagingTime resolutionRadial offsetF-FDG imagingIncreased Dopamine D2/D3 Receptor Binding After Recovery from Anorexia Nervosa Measured by Positron Emission Tomography and [11C]Raclopride
Frank G, Bailer U, Henry S, Drevets W, Meltzer C, Price J, Mathis C, Wagner A, Hoge J, Ziolko S, Barbarich-Marsteller N, Weissfeld L, Kaye W. Increased Dopamine D2/D3 Receptor Binding After Recovery from Anorexia Nervosa Measured by Positron Emission Tomography and [11C]Raclopride. Biological Psychiatry 2005, 58: 908-912. PMID: 15992780, DOI: 10.1016/j.biopsych.2005.05.003.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsD2/D3 receptor bindingD3 receptor bindingControl womenAnorexia nervosaPositron emission tomographyDopamine D2/D3 receptor bindingD2/D3 receptor densityEmission tomographyReceptor bindingREC ANHealthy control womenD3 receptor densityEffects of malnutritionDorsal putamenAlterations of weightDorsal caudatePhysical activityReceptor densityDopamine functionMotor activityDA concentrationLines of evidenceWomenNervosaTomography
2025
Exceptional brain PET images from the NeuroEXPLORER: scans with targeted radiopharmaceuticals and comparison to HRRT.
Volpi T, Toyonaga T, Khattar N, Gallezot JD, Naganawa M, Vanderlinden G, Honhar P, Zeng T, Fontaine K, Mulnix T, Hu L, Sun X, Henry S, Matuskey D, Radhakrishnan R, Guo L, Hu Y, Zhang J, Zheng X, Nabulsi N, Huang Y, Badawi RD, Cherry SR, Hillmer AT, Jones T, Liu C, Morris E, Qi J, Li H, Carson RE. Exceptional brain PET images from the NeuroEXPLORER: scans with targeted radiopharmaceuticals and comparison to HRRT. Eur J Nucl Med Mol Imaging 2025 PMID: 41177836, DOI: 10.1007/s00259-025-07605-4.Peer-Reviewed Original ResearchCarotid Artery Image-Derived Blood Time-Activity Curves on the NeuroEXPLORER: Initial Multitracer Validation Against Arterial Sampling.
Volpi T, Gallezot JD, Henry S, Dias M, Khattar N, Toyonaga T, Fontaine K, Mulnix T, Zhang J, Guo L, Gravel P, Radhakrishnan R, Hillmer AT, Matuskey D, Carson RE. Carotid Artery Image-Derived Blood Time-Activity Curves on the NeuroEXPLORER: Initial Multitracer Validation Against Arterial Sampling. J Nucl Med 2025 PMID: 41043999, DOI: 10.2967/jnumed.125.270414.Peer-Reviewed Original Research
2024
Quantitative Accuracy Assessment of the NeuroEXPLORER for Diverse Imaging Applications: Moving Beyond Standard Evaluations.
Omidvari N, Shanina E, Leung E, Sun X, Li Y, Mulnix T, Gravel P, Henry S, Matuskey D, Volpi T, Jones T, Badawi R, Li H, Carson R, Qi J, Cherry S. Quantitative Accuracy Assessment of the NeuroEXPLORER for Diverse Imaging Applications: Moving Beyond Standard Evaluations. Journal Of Nuclear Medicine 2024, 66: 150-157. PMID: 39638433, PMCID: PMC11705792, DOI: 10.2967/jnumed.124.268309.Peer-Reviewed Original ResearchCitationsConceptsContrast recovery coefficientHoffman phantomUniform phantomIQ phantomRecovery coefficientBrain PET systemHoffman brain phantomBrain uptakeSpatial resolutionDiverse imaging applicationsCylindrical phantomPET systemBrain phantomNeuroimaging studiesImage qualityImaging conditionsPhantomReconstruction parametersImaging time pointsTime pointsImage-derived input functionHigher spatial resolutionQuantitative accuracyDelayed time pointsBrain disordersClinical correlates of dopamine transporter availability in cross-sectional and longitudinal studies with [18F]FE-PE2I PET: independent validation with new insights
Honhar P, Sadabad F, Tinaz S, Gallezot J, Dias M, Naganawa M, Yang Y, Henry S, Hillmer A, Gao H, Najafzadeh S, Comley R, Nabulsi N, Huang Y, Finnema S, Carson R, Matuskey D. Clinical correlates of dopamine transporter availability in cross-sectional and longitudinal studies with [18F]FE-PE2I PET: independent validation with new insights. Brain Communications 2024, 6: fcae345. PMID: 39429243, PMCID: PMC11487911, DOI: 10.1093/braincomms/fcae345.Peer-Reviewed Original ResearchCitationsConceptsDAT availabilityMotor severitySubstantia nigraDopamine transporter availabilityClinical trials of Parkinson's diseaseParkinson's diseaseLongitudinal studyTracking longitudinal changesClinical correlatesVentral striatumTransporter availabilityNigrostriatal regionParkinson's disease patientsPutamenMotor severity scoresAssociated with increasesSubstantiaDATLongitudinal changesTremor scoreNegative associationNigraSubstantia nigra of Parkinson's disease patientsTremor severityPET biomarkersNoninvasive quantification of [18F]SynVesT-1 binding using simplified reference tissue model 2
Naganawa M, Gallezot J, Li S, Nabulsi N, Henry S, Cai Z, Matuskey D, Huang Y, Carson R. Noninvasive quantification of [18F]SynVesT-1 binding using simplified reference tissue model 2. European Journal Of Nuclear Medicine And Molecular Imaging 2024, 52: 113-121. PMID: 39155309, DOI: 10.1007/s00259-024-06885-6.Peer-Reviewed Original ResearchCitationsConceptsPositron emission tomographyCentrum semiovaleReference regionPositron emission tomography scanTest-retest variabilityTest-retest reproducibilitySynaptic vesicle glycoprotein 2AOne-tissue compartmentArterial blood samplesRetest scansGold standardBrain uptakeEmission tomographyBlood samplesCerebellumNoninvasive quantificationSRTM2ConclusionOur findingsPopulation averageHealthy participantsMetabolite analysisScan timeBPNDSemiovaleAuthor Correction: Synaptic loss and its association with symptom severity in Parkinson’s disease
Holmes S, Honhar P, Tinaz S, Naganawa M, Hilmer A, Gallezot J, Dias M, Yang Y, Toyonaga T, Esterlis I, Mecca A, Van Dyck C, Henry S, Ropchan J, Nabulsi N, Louis E, Comley R, Finnema S, Carson R, Matuskey D. Author Correction: Synaptic loss and its association with symptom severity in Parkinson’s disease. Npj Parkinson's Disease 2024, 10: 55. PMID: 38472206, PMCID: PMC10933370, DOI: 10.1038/s41531-024-00674-6.Peer-Reviewed Original ResearchCitationsSynaptic loss and its association with symptom severity in Parkinson’s disease
Holmes S, Honhar P, Tinaz S, Naganawa M, Hilmer A, Gallezot J, Dias M, Yang Y, Toyonaga T, Esterlis I, Mecca A, Van Dyck C, Henry S, Ropchan J, Nabulsi N, Louis E, Comley R, Finnema S, Carson R, Matuskey D. Synaptic loss and its association with symptom severity in Parkinson’s disease. Npj Parkinson's Disease 2024, 10: 42. PMID: 38402233, PMCID: PMC10894197, DOI: 10.1038/s41531-024-00655-9.Peer-Reviewed Original ResearchCitationsAltmetricConceptsSynaptic density lossPositron emission tomographyBinds to synaptic vesicle glycoprotein 2AAssociated with symptom severityParkinson's diseaseHigh-resolution positron emission tomographySynaptic vesicle glycoprotein 2ADuration of illnessPositron emission tomography scanBrain perfusionIllness durationSymptom severitySeverity of symptomsHC groupSubstantia nigraSynaptic densityLiving brainPD individualsClinical insightsDensity lossPD patientsEmission tomographyBrainSynaptic lossSynapse lossFirst-in-Human Study of 18F-SynVesT-2: An SV2A PET Imaging Probe with Fast Brain Kinetics and High Specific Binding
Drake L, Wu Y, Naganawa M, Asch R, Zheng C, Najafzadeh S, Pracitto R, Lindemann M, Li S, Ropchan J, Labaree D, Emery P, Dias M, Henry S, Nabulsi N, Matuskey D, Hillmer A, Gallezot J, Carson R, Cai Z, Huang Y. First-in-Human Study of 18F-SynVesT-2: An SV2A PET Imaging Probe with Fast Brain Kinetics and High Specific Binding. Journal Of Nuclear Medicine 2024, 65: jnumed.123.266470. PMID: 38360052, PMCID: PMC10924160, DOI: 10.2967/jnumed.123.266470.Peer-Reviewed Original ResearchCitationsAltmetricConceptsFirst-in-human studyPlasma free fractionTime-activity curvesCentrum semiovaleNonhuman primate's resultsFirst-in-humanFree fractionNondisplaceable binding potentialRegional time-activity curvesLow nonspecific uptakeRegional distribution volumesHigh-resolution research tomograph scannerTest-retest reproducibilityCerebral blood flowSynaptic vesicle glycoprotein 2AHealthy volunteersArterial input functionNonspecific uptakePET imaging probeDistribution volumeSynapse densityIndividual MR imagesHighest specific bindingMR imagingPET imaging
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