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Hospital Resident
Biography
Shahyan Rehman, MD is a general surgery resident at Yale New Haven Hospital. He graduated from the University of Rochester with a dual degree (BA/BS) in Neuroscience and Religion with Highest Distinction. He obtained his M.D. with Distinction in Research from Rutgers Robert Wood Johnson Medical School. As a medical student, he co-founded the Rutgers RWJMS chapter of Global Surgery Student Alliance (GSSA) and collaborated with partners from Universidad de los Andes in Bogotá, Colombia on surgical systems strengthening research through Rutgers Global Surgery. He is currently a Board of Trustees member of GSSA. He was selected to spend a year between his third and fourth year of medical school at the National Institutes of Health through the NIH Medical Research Scholars Program. During this time in the Hernandez Lab, he had the opportunity to use ex vivo human tissue platforms to study the tumor microenvironment. As a resident at Yale, he discovered a passion for pediatric surgery. His research interests include cancer metabolism and targeted drug delivery. He plans to pursue a career as an academic pediatric surgeon with a special interest in pediatric surgical oncology. In his free time, he enjoys spending time with his family, playing basketball, and exploring the many theatre shows, museums, restaurants, and coffee shops in New Haven and the surrounding area.
Departments & Organizations
- Palade House Affiliates
- Vasquez Lab
Education & Training
- MD
- Rutgers Robert Wood Johnson Medical School (2022)
- Medical Research Scholars Program
- National Institutes of Health (2021)
- BS
- University of Rochester, Neuroscience (2016)
- BA
- University of Rochester, Religion (2016)
Research
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Overview
Public Health Interests
ORCID
0000-0002-9667-3255- View Lab Website
Vasquez Lab
Research at a Glance
Yale Co-Authors
Publications Timeline
Daniel Solomon, MD
Alexander Joseph Rossi, MD
Emily Christison-Lagay, MD
James Clune, MD
Adriana Ramirez, MD, MPH, FACS
David Su, MD
Publications
2025
Expression of IMPACT Curtails Metabolic Plasticity and Augments NK Cell Killing to Abrogate Metastatic Growth.
Sinha S, Panda A, Xavier das Neves R, Nwosu Z, Xu K, van Beek E, Desai P, Sindiri S, Chempati S, Remmert K, Gasmi B, Bojmar L, Zambirinis C, Rossi A, Ayabe R, Wach M, McDonald J, Ruff S, Verbus E, Saif A, Eade A, Larrain C, Friedman L, Gupta S, Ranjan A, Teke M, Khan T, Pu T, Sarvestani A, Ryan C, Lambdin J, Luberice K, Gregory S, Lux S, Hong H, Luna A, Alexander I, Akmal S, Rehman S, Rainey A, Prickett T, Koparde V, Sevilla S, Kuhn S, Chan K, Sun Z, Bubunenko N, Li E, Hannah C, Gaga G, Andresson T, Cam M, Wu X, Jenkins L, Blakely A, Davis J, Trinchieri G, Singh P, Yang J, Pasca di Magliano M, Lyssiotis C, Yaffe M, Shevach E, Hernandez J. Expression of IMPACT Curtails Metabolic Plasticity and Augments NK Cell Killing to Abrogate Metastatic Growth. Cancer Discovery 2025, of1-of30. PMID: 41025961, DOI: 10.1158/2159-8290.cd-24-1055.Peer-Reviewed Original ResearchAltmetricConceptsEndogenous competitive inhibitorTumor immunogenicityIntegrated stress responseImmune checkpoint blockadeExpression of MHC-I moleculesNK cell killingCell-mediated destructionAggressive epithelial tumorMetastatic tumor cellsMHC-I moleculesCheckpoint blockadeHepatic metastasesNK ligandsEpithelial tumorsNK cellsMetabolic plasticityMetastatic growthTumor cellsAmino acid transportDistant organsCell killingMetabolic controlTumorPancreatic cellsAcid transportArnold Schwarzenegger or Danny DeVito? The Fate of Twins with Necrotizing Enterocolitis in the NICU
Hellmann Z, Thaxton C, Sapir N, Rehman S, Cowles R, Christison-Lagay E, Solomon D. Arnold Schwarzenegger or Danny DeVito? The Fate of Twins with Necrotizing Enterocolitis in the NICU. Journal Of Pediatric Surgery 2025, 162526. PMID: 40812408, DOI: 10.1016/j.jpedsurg.2025.162526.Peer-Reviewed Original ResearchAltmetricConceptsMultiple gestation pregnanciesGestation pregnanciesSingleton birthsUncontrolled cohortIncidence of necrotizing enterocolitisNeonatal intensive care unitDevelopment of NECIncidence of NECPediatric Health Information SystemIntensive care unitSingleton gestationsGestational ageMultiple gestationsNICU populationSingleton infantsNecrotizing enterocolitisNICU infantsLow birthweightAverage birthweightInternal validityPrimary outcomeGestationCare unitShort gestationInfantsExpression of IMPACT curtails metabolic plasticity and augments NK cell killing to abrogate metastatic growth.
Sinha S, Panda A, Xavier das Neves R, Nwosu Z, Xu K, van Beek E, Desai P, Sindiri S, Chempati S, Remmert K, Gasmi B, Bojmar L, Zambirinis C, Rossi A, Ayabe R, Wach M, McDonald J, Ruff S, Verbus E, Saif A, Eade A, Larrain C, Friedman L, Gupta S, Ranjan A, Teke M, Khan T, Pu T, Sarvestani A, Ryan C, Lambdin J, Luberice K, Gregory S, Lux S, Hong H, Luna A, Alexander I, Akmal S, Rehman S, Rainey A, Prickett T, Koparde V, Sevilla S, Kuhn S, Chan K, Sun Z, Bubunenko N, Li E, Hannah C, Gaga G, Andresson T, Cam M, Wu X, Jenkins L, Blakely A, Davis J, Trinchieri G, Singh P, Yang J, Pasca di Magliano M, Lyssiotis C, Yaffe M, Shevach E, Hernandez J. Expression of IMPACT curtails metabolic plasticity and augments NK cell killing to abrogate metastatic growth. Cancer Discovery 2025, of1-of30. PMID: 40736016, DOI: 10.1158/2159-8290.cd-24-1055.Peer-Reviewed Original ResearchCitationsConceptsImmune checkpoint blockadeEndogenous competitive inhibitorNatural killerExpression of MHC-I moleculesNK cell killingAggressive epithelial tumorMHC-I moleculesCheckpoint blockadeTumor immunogenicityHepatic metastasesNK cellsEpithelial tumorsMetastatic growthAmino acid transportCell killingMetabolic controlPancreatic cellsAcid transportTumorMouse liverMetabolic plasticityCDNA screeningCellsExpressionMetastasisAn Open-Source Normothermic Perfusion System Designed for Research Scientists.
Friedman L, Stepp H, Lambdin J, Luna A, Rossi A, Lux S, Wach M, Luberice K, Ruff S, McDonald J, Ayabe R, Rehman S, Ryan C, Gregory S, Eade A, Larrain C, Victory J, Pursley R, Noel T, Freidlin M, Gupta S, Pu T, Rainey A, Verbus E, Teke M, Saif A, Khan T, Alexander I, Sinha S, Akmal S, Maram R, Sarvestani L, Hewitt S, Doroshow J, Remmert K, Smith E, Desai P, Miao N, Driscoll K, West K, Heller T, Levy E, Davis J, Blakely A, Kleiner D, Kakareka J, Pohida T, Hernandez J. An Open-Source Normothermic Perfusion System Designed for Research Scientists. Journal Of Visualized Experiments 2025 PMID: 40758600, DOI: 10.3791/68722.Peer-Reviewed Original ResearchCitationsMeSH Keywords and ConceptsPrevalence of Critical Congenital Heart Defects Among Neonates Born With Abdominal Wall Defects
Hellmann Z, Buu L, Rehman S, Thaxton C, Solomon D, Cowles R. Prevalence of Critical Congenital Heart Defects Among Neonates Born With Abdominal Wall Defects. Prenatal Diagnosis 2025, 45: 1115-1121. PMID: 40670328, DOI: 10.1002/pd.6861.Peer-Reviewed Original ResearchAltmetricMeSH Keywords and ConceptsConceptsCritical congenital heart defectsNeonatal intensive care unitPediatric Health Information SystemNeonatal intensive care unit admissionCongenital heart defectsOpen cardiac surgeryCardiac surgeryHeart defectsConcomitant diagnosisNeonatal intensive care unit populationPediatric Health Information System hospitalsDiagnosis of gastroschisisGeneral populationIntensive care unitRate of gastroschisisAbdominal wall defectsIndex hospital admissionHigher RatesLive birthsGastroschisisCare unitNeonatesWall defectsHospital admissionAdmissionUnplanned Readmission Rate Before Interval Appendectomy After Nonoperative Management of Complicated Appendicitis.
Hellmann Z, Rehman S, Hornick M, Solomon D. Unplanned Readmission Rate Before Interval Appendectomy After Nonoperative Management of Complicated Appendicitis. Journal Of The American College Of Surgeons 2025, 240: 908-913. PMID: 39655815, DOI: 10.1097/xcs.0000000000001255.Peer-Reviewed Original ResearchCitationsAltmetricConceptsNonoperative management of complicated appendicitisManagement of complicated appendicitisPediatric Health Information SystemComplicated appendicitisNonoperative managementInterval appendectomyIndex admissionRecurrent appendicitisReadmission ratesRisk of recurrent appendicitisKaplan-Meier survival analysisKaplan-Meier analysisConsecutive daysICD-10 diagnosis codesReceiving antibioticsAppendectomyAppendicitisClinical equipoisePatientsSurvival analysisNatural historyDay patientsDiagnosis codesAdmissionICD-10Relationship Between Total Parenteral Nutrition, Ventilation, and Hepatoblastoma: A Study of 258,929 Neonatal Intensive Care Unit Admissions
Hellmann Z, Rehman S, Brown L, Vasquez J, Solomon D, Christison‐Lagay E. Relationship Between Total Parenteral Nutrition, Ventilation, and Hepatoblastoma: A Study of 258,929 Neonatal Intensive Care Unit Admissions. Pediatric Blood & Cancer 2025, 72: e31741. PMID: 40275525, PMCID: PMC12209882, DOI: 10.1002/pbc.31741.Peer-Reviewed Original ResearchMeSH Keywords and ConceptsConceptsNeonatal intensive care unitPediatric Health Information SystemNeonatal intensive care unit admissionDays of TPNDiagnosis of hepatoblastomaMechanical ventilationGestational ageBirth weightNeonatal intensive care unit hospitalizationPediatric Health Information System hospitalsNICU interventionsDuration of TPNIntensive care unit admissionTotal parenteral nutritionLow birth weightDevelopment of hepatoblastomaIntensive care unitConditional logistic regressionParenteral nutritionUnit admissionClinical characteristicsHepatoblastomaOvergrowth syndromeVentilation exposureCare unitThe Impact of Medical School Experiences in Global Surgery on Perceptions and Career Plans Among U.S. Medical Students
Kersh L, Serrato P, Anderson C, Raguveer V, Peck C, Ally S, Gondi I, Subhedar S, Rollins A, Hauser B, Jayaram A, Hill S, Wariso B, Rehman S, Alliance G, Clune J. The Impact of Medical School Experiences in Global Surgery on Perceptions and Career Plans Among U.S. Medical Students. Journal Of Surgical Education 2025, 82: 103441. PMID: 39894006, DOI: 10.1016/j.jsurg.2025.103441.Peer-Reviewed Original ResearchAltmetricMeSH Keywords and ConceptsConceptsMedical school experienceGlobal surgeryMedical studentsMedical schoolsSurgical mission tripsCross-sectional survey studyAssociated with lower oddsMission tripsAssociated with increased oddsMedical school curriculumGlobal health researchU.S. medical studentsCareer planningSurgery researchGlobal surgery educationResponding medical studentsMultivariate regression modelHealth researchSurgery opportunitiesLower oddsSchool experiencesSurgeryOddsSurgery educationMedical institutions
2024
The Perceived Impact of Global Surgery Engagement on Career Advancement among US Medical Students
Serrato P, Solaiman R, Vohra H, Hu K, Jain A, Alamdeen Y, Fagla B, Peck C, Hill S, Wariso B, Rehman S, Subhedar S, Kersh L, Anderson C, Clune J, Alliance G. The Perceived Impact of Global Surgery Engagement on Career Advancement among US Medical Students. Journal Of Surgical Education 2024, 82: 103404. PMID: 39740592, DOI: 10.1016/j.jsurg.2024.103404.Peer-Reviewed Original ResearchMeSH Keywords and ConceptsConceptsAssociated with increased oddsGlobal surgeryResidency applicantsMultivariate logistic regression modelGlobal surgery programsAcademic global surgeryLogistic regression modelsUS medical studentsMultivariate analysisSurgeryMedical studentsSurgery interest groupSurgery programsSurgery trainingPerceived impactCross-sectional survey studyMedical school curriculumSurgeonsMedical institutionsMedical students' perceptionsSurgery participantsHealth equityOddsCareer advancementMedical schoolsLocal Infrastructure and Economy Predicts Traffic Related Fatalities in Children
Hellmann Z, Graetz E, Rehman S, Moore M, Schneider E, Christison-Lagay E, Solomon D. Local Infrastructure and Economy Predicts Traffic Related Fatalities in Children. Journal Of Pediatric Surgery 2024, 60: 162109. PMID: 39753412, DOI: 10.1016/j.jpedsurg.2024.162109.Peer-Reviewed Original ResearchCitationsConceptsMotor vehicle collisionsSocial Vulnerability IndexFatality Analysis Reporting SystemPoisson regressionRelated mortality rateMortality rateAverage annual mortality rateMultivariable Poisson regressionPoisson regression modelsTraffic fatalitiesArea deprivationWalking IndexUnivariate Poisson regressionAnnual mortality rateUS CensusDecile increaseMacroeconomic forcesPoor walkabilityState policy changesInclusion criteriaVehicle collisionsCrash-specific informationTraffic related fatalitiesRegression modelsWalkability
Academic Achievements & Community Involvement
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Honors
honor Resident Research Award
09/12/2025National AwardFrederick A. Coller Surgical SocietyDetailsUnited Stateshonor M. Judah Folkman Memorial Award Basic Science
05/09/2025National AwardAmerican Pediatric Surgical Association (APSA)honor ACS H.O.P.E. Clinical Congress Resident Scholarship
08/16/2024National Awardhonor Frederick A. Coller Surgical Society Research Fellow
07/29/2024National Awardhonor The Andrew J. Panettieri, M.D. Award for Professional Excellence - Burn Resident of the Year
06/15/2023Yale School of Medicine AwardBridgeport Hospital / YNHH Department of Surgery
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