Saul S Siller, MD, PhD
Assistant ProfessorAbout
Research
Publications
2026
The ferroptosis inhibitor NUPR1 coordinates the mitochondrial response to oxidative stress and cell metabolism during COPD pathogenesis in the lung
Nouws J, Siller S, Yang T, Kim S, Kim S, Santofimia-Castaño P, Iovanna J, Herzog E, McDonough J, Sauler M. The ferroptosis inhibitor NUPR1 coordinates the mitochondrial response to oxidative stress and cell metabolism during COPD pathogenesis in the lung. American Journal Of Physiology - Lung Cellular And Molecular Physiology 2026 PMID: 42623300, DOI: 10.1152/ajplung.00098.2026.Peer-Reviewed Original ResearchAberrant cellular communities underlying disease heterogeneity in chronic obstructive pulmonary disease
Zhang Y, Wei H, Nouws J, Jiang W, Brewster R, Nguyen J, Liang S, Pass S, Wang W, Collin F, Oill A, Kim S, Siller S, Liu J, Zhao A, Hansbro P, Dela Cruz C, Britto C, Gomez J, Cloonan S, Herzog E, Lam T, Banovich N, Raredon M, Zhang X, Mangiola S, Homer R, Kaminski N, McDonough J, Polverino F, Yan X, Sauler M. Aberrant cellular communities underlying disease heterogeneity in chronic obstructive pulmonary disease. Nature Genetics 2026, 58: 376-391. PMID: 41578022, PMCID: PMC12900648, DOI: 10.1038/s41588-025-02480-z.Peer-Reviewed Original Research
2024
Corrigendum: TAp73 is a central transcriptional regulator of airway multiciliogenesis
Nemajerova A, Kramer D, Siller S, Herr C, Shomroni O, Pena T, Gallinas Suazo C, Glaser K, Wildung M, Steffen H, Sriraman A, Oberle F, Wienken M, Hennion M, Vidal R, Royen B, Alevra M, Schild D, Bals R, Dönitz J, Riedel D, Bonn S, Takemaru K, Moll U, Lizé M. Corrigendum: TAp73 is a central transcriptional regulator of airway multiciliogenesis. Genes & Development 2024, 38: 784-784. PMID: 39299906, PMCID: PMC11444168, DOI: 10.1101/gad.352194.124.Commentaries, Editorials and Letters
2021
nNOS regulates ciliated cell polarity, ciliary beat frequency, and directional flow in mouse trachea
Mikhailik A, Michurina T, Dikranian K, Hearn S, Maxakov V, Siller S, Takemaru K, Enikolopov G, Peunova N. nNOS regulates ciliated cell polarity, ciliary beat frequency, and directional flow in mouse trachea. Life Science Alliance 2021, 4: e202000981. PMID: 33653689, PMCID: PMC8008965, DOI: 10.26508/lsa.202000981.Peer-Reviewed Original Research
2019
Endocrine Management in the Neurosurgical Patient
Gruenbaum S, Guay C, Siller S, Bilotta F. Endocrine Management in the Neurosurgical Patient. 2019, 205-216. DOI: 10.1007/978-981-13-3390-3_15.Chapters
2017
Conditional knockout mice for the distal appendage protein CEP164 reveal its essential roles in airway multiciliated cell differentiation
Siller S, Sharma H, Li S, Yang J, Zhang Y, Holtzman M, Winuthayanon W, Colognato H, Holdener B, Li F, Takemaru K. Conditional knockout mice for the distal appendage protein CEP164 reveal its essential roles in airway multiciliated cell differentiation. PLOS Genetics 2017, 13: e1007128. PMID: 29244804, PMCID: PMC5747467, DOI: 10.1371/journal.pgen.1007128.Peer-Reviewed Original Research
2016
BAR Domain-Containing FAM92 Proteins Interact with Chibby1 To Facilitate Ciliogenesis
Li F, Chen X, Fisher C, Siller S, Zelikman K, Kuriyama R, Takemaru K. BAR Domain-Containing FAM92 Proteins Interact with Chibby1 To Facilitate Ciliogenesis. Molecular And Cellular Biology 2016, 36: 2668-2680. PMID: 27528616, PMCID: PMC5064215, DOI: 10.1128/mcb.00160-16.Peer-Reviewed Original ResearchTAp73 is a central transcriptional regulator of airway multiciliogenesis and protects bronchial function
Nemajerova A, Kramer D, Siller S, Herr C, Shomroni O, Pena T, Gallinas Suazo C, Glaser K, Wildung M, Steffen H, Sriraman A, Oberle F, Wienken M, Hennion M, Vidal R, Royen B, Alevra M, Schild D, Bals R, Dönitz J, Riedel D, Bonn S, Takemaru K, Moll U, Lizé M. TAp73 is a central transcriptional regulator of airway multiciliogenesis and protects bronchial function. Pneumologie 2016, 70 DOI: 10.1055/s-0036-1592291.Peer-Reviewed Original ResearchTAp73 is a central transcriptional regulator of airway multiciliogenesis
Nemajerova A, Kramer D, Siller S, Herr C, Shomroni O, Pena T, Suazo C, Glaser K, Wildung M, Steffen H, Sriraman A, Oberle F, Wienken M, Hennion M, Vidal R, Royen B, Alevra M, Schild D, Bals R, Dönitz J, Riedel D, Bonn S, Takemaru K, Moll U, Lizé M. TAp73 is a central transcriptional regulator of airway multiciliogenesis. Genes & Development 2016, 30: 1300-1312. PMID: 27257214, PMCID: PMC4911929, DOI: 10.1101/gad.279836.116.Peer-Reviewed Original Research
2015
Chibby functions to preserve normal ciliary morphology through the regulation of intraflagellar transport in airway ciliated cells
Siller S, Burke M, Li F, Takemaru K. Chibby functions to preserve normal ciliary morphology through the regulation of intraflagellar transport in airway ciliated cells. Cell Cycle 2015, 14: 3163-3172. PMID: 26266958, PMCID: PMC4825556, DOI: 10.1080/15384101.2015.1080396.Peer-Reviewed Original Research
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