Saul S Siller, MD, PhD
Assistant ProfessorAbout
Research
Publications
2026
B76-22 Decrease of Ferroptosis Inhibitor Nupr1 in At2 Cells Affects Mitochondrial Function and Metabolism in COPD
Nouws J, Siller S, Yang T, Kim S, Kim S, Santofimia-Castano P, Iovanna J, Mcdonough J, Sauler M. B76-22 Decrease of Ferroptosis Inhibitor Nupr1 in At2 Cells Affects Mitochondrial Function and Metabolism in COPD. American Journal Of Respiratory And Critical Care Medicine 2026, 212: aamag286.133. DOI: 10.1093/ajrccm/aamag286.133.Peer-Reviewed Original ResearchAlveolar type 2Alveolar type 2 cellsChronic obstructive pulmonary diseaseCigarette smoke extractMetabolomic profilesGenetic deletionMitochondrial functionEpithelial cellsMitochondrial morphologyLoss of alveolar epithelial cellsPathogenesis of chronic obstructive pulmonary diseaseChronic lung injuryPatient lung samplesHuman bronchial epithelial cellsIron levelsAlveolar epithelial cellsBronchial epithelial cellsExpression of NUPR1Obstructive pulmonary diseaseDysregulation of ferroptosisMitochondrial membrane potentialTreated A549 cellsSingle cell RNA sequencingCell RNA sequencingLung injuryAberrant cellular communities underlying disease heterogeneity in chronic obstructive pulmonary disease
Zhang Y, Wei H, Nouws J, Jiang W, Brewster R, Nguyen J, Liang S, Pass S, Wang W, Collin F, Oill A, Kim S, Siller S, Liu J, Zhao A, Hansbro P, Dela Cruz C, Britto C, Gomez J, Cloonan S, Herzog E, Lam T, Banovich N, Raredon M, Zhang X, Mangiola S, Homer R, Kaminski N, McDonough J, Polverino F, Yan X, Sauler M. Aberrant cellular communities underlying disease heterogeneity in chronic obstructive pulmonary disease. Nature Genetics 2026, 58: 376-391. PMID: 41578022, PMCID: PMC12900648, DOI: 10.1038/s41588-025-02480-z.Peer-Reviewed Original ResearchConceptsChronic obstructive pulmonary diseaseObstructive pulmonary diseasePlasma biomarkersPulmonary diseaseComposite symptom scoreStudy participantsCell statesEarly COPDCellular landscapeNonimmune cellsCell communication analysisSymptom scoresImmune populationsSingle-nucleus RNA sequencingDisease progressionTherapeutic strategiesLung functionLung tissueChronic obstructive pulmonary disease heterogeneityMolecular driversDisease heterogeneityRegenerative stateCell compositionPathological cellsCell-autonomous
2024
Corrigendum: TAp73 is a central transcriptional regulator of airway multiciliogenesis
Nemajerova A, Kramer D, Siller S, Herr C, Shomroni O, Pena T, Gallinas Suazo C, Glaser K, Wildung M, Steffen H, Sriraman A, Oberle F, Wienken M, Hennion M, Vidal R, Royen B, Alevra M, Schild D, Bals R, Dönitz J, Riedel D, Bonn S, Takemaru K, Moll U, Lizé M. Corrigendum: TAp73 is a central transcriptional regulator of airway multiciliogenesis. Genes & Development 2024, 38: 784-784. PMID: 39299906, PMCID: PMC11444168, DOI: 10.1101/gad.352194.124.Peer-Reviewed Original Research
2021
nNOS regulates ciliated cell polarity, ciliary beat frequency, and directional flow in mouse trachea
Mikhailik A, Michurina T, Dikranian K, Hearn S, Maxakov V, Siller S, Takemaru K, Enikolopov G, Peunova N. nNOS regulates ciliated cell polarity, ciliary beat frequency, and directional flow in mouse trachea. Life Science Alliance 2021, 4: e202000981. PMID: 33653689, PMCID: PMC8008965, DOI: 10.26508/lsa.202000981.Peer-Reviewed Original ResearchConceptsCiliary beat frequencyMulticiliated cellsMouse tracheaLevels of exhaled NONetwork of actinLow levels of exhaled NOApical networkAvailability of NOPlanar polarityRhoA activationCell polarityExhaled NOMucociliary epitheliumNNOSGuanylate cyclaseHuman disordersNO donorCiliary activityCiliated cellsDeficient flowTrachea
2019
Endocrine Management in the Neurosurgical Patient
Gruenbaum S, Guay C, Siller S, Bilotta F. Endocrine Management in the Neurosurgical Patient. 2019, 205-216. DOI: 10.1007/978-981-13-3390-3_15.Peer-Reviewed Original ResearchEndocrine dysfunctionNeurosurgical patientsRisk of perioperative complicationsPituitary adenoma resectionAdenoma resectionPreoperative workupPerioperative complicationsPostoperative outcomesEndocrine managementEndocrine systemPerioperative managementPerioperative considerationsLife-threateningPatientsPerioperative careRelevant anatomyComplicationsNervous systemDysfunctionPhysiological principlesPhysiological functions
2017
Conditional knockout mice for the distal appendage protein CEP164 reveal its essential roles in airway multiciliated cell differentiation
Siller S, Sharma H, Li S, Yang J, Zhang Y, Holtzman M, Winuthayanon W, Colognato H, Holdener B, Li F, Takemaru K. Conditional knockout mice for the distal appendage protein CEP164 reveal its essential roles in airway multiciliated cell differentiation. PLOS Genetics 2017, 13: e1007128. PMID: 29244804, PMCID: PMC5747467, DOI: 10.1371/journal.pgen.1007128.Peer-Reviewed Original ResearchConceptsMulticiliated cell differentiationMulticiliated cellsCiliary targetingIntraflagellar transportPrimary ciliogenesisDistal appendage protein CEP164Transport of membrane vesiclesCiliary vesicle formationSmall GTPase Rab8Basal body dockingCentral regulatorCell differentiationMembrane-associated proteinsGTPase Rab8Vesicle recruitmentFemale reproductive tractMulticiliated tissuesCiliary compartmentCEP164Ciliary baseConditional mouse modelMale infertilityVesicle formationMulticiliaMulticiliogenesis
2016
BAR Domain-Containing FAM92 Proteins Interact with Chibby1 To Facilitate Ciliogenesis
Li F, Chen X, Fisher C, Siller S, Zelikman K, Kuriyama R, Takemaru K. BAR Domain-Containing FAM92 Proteins Interact with Chibby1 To Facilitate Ciliogenesis. Molecular And Cellular Biology 2016, 36: 2668-2680. PMID: 27528616, PMCID: PMC5064215, DOI: 10.1128/mcb.00160-16.Peer-Reviewed Original ResearchConceptsBAR domainCentriolar localizationCentrioles/basal bodiesEarly stages of ciliogenesisEfficient recruitmentMembrane-remodeling processesSmall GTPase Rab8Basal body dockingTandem affinity purificationCoiled-coil proteinsBase of ciliaAirway multiciliated cellsStages of ciliogenesisFunction of ciliaGTPase Rab8Sequence similarityCultured cell linesAffinity purificationMulticiliated cellsRPE1 cellsFAM92ACby1Primary ciliaCiliogenesisPlasma membraneTAp73 is a central transcriptional regulator of airway multiciliogenesis and protects bronchial function
Nemajerova A, Kramer D, Siller S, Herr C, Shomroni O, Pena T, Gallinas Suazo C, Glaser K, Wildung M, Steffen H, Sriraman A, Oberle F, Wienken M, Hennion M, Vidal R, Royen B, Alevra M, Schild D, Bals R, Dönitz J, Riedel D, Bonn S, Takemaru K, Moll U, Lizé M. TAp73 is a central transcriptional regulator of airway multiciliogenesis and protects bronchial function. Pneumologie 2016, 70 DOI: 10.1055/s-0036-1592291.Peer-Reviewed Original ResearchTAp73 is a central transcriptional regulator of airway multiciliogenesis
Nemajerova A, Kramer D, Siller S, Herr C, Shomroni O, Pena T, Suazo C, Glaser K, Wildung M, Steffen H, Sriraman A, Oberle F, Wienken M, Hennion M, Vidal R, Royen B, Alevra M, Schild D, Bals R, Dönitz J, Riedel D, Bonn S, Takemaru K, Moll U, Lizé M. TAp73 is a central transcriptional regulator of airway multiciliogenesis. Genes & Development 2016, 30: 1300-1312. PMID: 27257214, PMCID: PMC4911929, DOI: 10.1101/gad.279836.116.Peer-Reviewed Original ResearchConceptsCentral transcriptional regulatorAssociated with human ciliopathiesCross-species genomic analysisBasal body dockingCentral regulatorLoss of mucociliary clearanceGenomic analysisHuman ciliopathiesCiliary genesP53 homologAxoneme extensionMulticiliated cellsTranscriptional controlMulticiliogenesisTAp73Human diseasesTP73MotilityProfound defectsRFX2DifferentiationAirway culturesHomologyCiliogenesisRFX3
2015
Chibby functions to preserve normal ciliary morphology through the regulation of intraflagellar transport in airway ciliated cells
Siller S, Burke M, Li F, Takemaru K. Chibby functions to preserve normal ciliary morphology through the regulation of intraflagellar transport in airway ciliated cells. Cell Cycle 2015, 14: 3163-3172. PMID: 26266958, PMCID: PMC4825556, DOI: 10.1080/15384101.2015.1080396.Peer-Reviewed Original ResearchConceptsMouse tracheal epithelial cellsAirway ciliated cellsBardet-Biedl syndromeIFT-BIntraflagellar transportMouse embryonic fibroblastsCiliated cellsChronic upper airway infectionsPrimary culturesPrimary cultures of mouse tracheal epithelial cellsAirway ciliaIFT-AUpper airway infectionsRegulator of intraflagellar transportCultures of mouse tracheal epithelial cellsChronic pulmonary disordersCiliary morphologyTracheal epithelial cellsCiliated cell differentiationAccumulation of mucusAirway infectionBidirectional intraflagellar transportPulmonary disordersIFT-B componentsDistribution of proteins
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