Sarah Lichenstein
Assistant Professor of PsychiatryCards
About
Research
Publications
2025
Impulsivity and neuroticism share distinct functional connectivity signatures with alcohol-use risk in youth
Cheng A, Lichenstein S, Chaarani B, Liang Q, Babaeianjelodar M, Riley S, Luo W, Horien C, Greene A, Banaschewski T, Bokde A, Desrivières S, Flor H, Grigis A, Gowland P, Heinz A, Brühl R, Martinot J, Martinot M, Artiges E, Nees F, Papadopoulos Orfanos D, Poustka L, Hohmann S, Holz N, Baeuchl C, Smolka M, Vaidya N, Walter H, Whelan R, Schumann G, Constable R, Pearlson G, Garavan H, Yip S. Impulsivity and neuroticism share distinct functional connectivity signatures with alcohol-use risk in youth. Molecular Psychiatry 2025, 1-10. PMID: 40913110, DOI: 10.1038/s41380-025-03196-6.Peer-Reviewed Original ResearchFunctional connectivity signaturesNeural signaturesConnectivity signaturesConnectome-based predictive modelingUnique neural mechanismsFunctional connectivity dataStudy of adolescent developmentDimensional traitsNegative affectDimensional phenotypesDefault modeNeural mechanismsNeuroticismAlcohol-useCerebellar networkYouth impulsivityAdolescent developmentCanonical networksAssociated with riskConnectivity dataNetwork anatomyComplex neural networksImpulseRisk behaviorsTraits602. Transdiagnostic Neural Signature of Reward Processing, and Its Relevance for Substance Use Abstinence
Cheng A, Silwal S, Day M, Lichenstein S, Grilo C, Potenza M, Yip S. 602. Transdiagnostic Neural Signature of Reward Processing, and Its Relevance for Substance Use Abstinence. Biological Psychiatry 2025, 97: s346-s347. DOI: 10.1016/j.biopsych.2025.02.841.Peer-Reviewed Original ResearchLinking Brain to Other Biological Variables in the Adolescent Brain and Cognitive Development (ABCD) Study: One Size Doesn’t Always Fit All
Yip S, Jelen M, Aksen D, Cheng A, Moles L, Babaeianjelodar M, Serio B, Riley S, Kohler R, Zhao Y, Fan C, Constable R, Lichenstein S. Linking Brain to Other Biological Variables in the Adolescent Brain and Cognitive Development (ABCD) Study: One Size Doesn’t Always Fit All. Biological Psychiatry 2025, 97: s38. DOI: 10.1016/j.biopsych.2025.02.106.Peer-Reviewed Original Research608. Problem Cannabis Risk Network Associated With Cannabis Cue-Induced Craving
Lichenstein S, Liu C, Fields S, Filbey F, Pearlson G, Yip S. 608. Problem Cannabis Risk Network Associated With Cannabis Cue-Induced Craving. Biological Psychiatry 2025, 97: s349. DOI: 10.1016/j.biopsych.2025.02.847.Peer-Reviewed Original ResearchIdentification and External Validation of a Problem Cannabis Risk Network
Lichenstein S, Kiluk B, Potenza M, Garavan H, Chaarani B, Banaschewski T, Bokde A, Desrivières S, Flor H, Grigis A, Gowland P, Heinz A, Brühl R, Martinot J, Paillère Martinot M, Artiges E, Nees F, Orfanos D, Poustka L, Hohmann S, Holz N, Baeuchl C, Smolka M, Vaidya N, Walter H, Whelan R, Schumann G, Pearlson G, Yip S. Identification and External Validation of a Problem Cannabis Risk Network. Biological Psychiatry 2025, 98: 586-596. PMID: 39909136, PMCID: PMC12318113, DOI: 10.1016/j.biopsych.2025.01.022.Peer-Reviewed Original ResearchAlcohol use outcomesCannabis useNeural mechanismsSample of treatment-seeking adultsNeural mechanisms of riskTreatment-seeking adultsCannabis use disorderNon-clinical sampleMechanisms of riskFunctional connectivity dataSample of adolescentsTreatment outcomesAssociated with harmful outcomesPoor treatment outcomesAddiction severityUse disorderEmerging adulthoodWhole-brainCannabisCollege studentsBrain developmentConnectivity dataIdentified networksTreatment approachesAdultsIdentification of a Neural Network Predicting Thrill-Seeking in College Students: Sex-Specific Associations With Alcohol and Substance Use
Aksen D, Potenza M, Lichenstein S, Pearlson G. Identification of a Neural Network Predicting Thrill-Seeking in College Students: Sex-Specific Associations With Alcohol and Substance Use. Drug And Alcohol Dependence 2025, 267: 112228. DOI: 10.1016/j.drugalcdep.2024.112228.Peer-Reviewed Original Research
2024
304. Multidimensional Components of Impulsivity in Youth: Insights From the Baseline Adolescent Brain and Cognitive Development Study Data
Riley S, Kohler R, Lichenstein S, Potenza M, Holmes A, Bzdok D, Yip S. 304. Multidimensional Components of Impulsivity in Youth: Insights From the Baseline Adolescent Brain and Cognitive Development Study Data. Biological Psychiatry 2024, 95: s224. DOI: 10.1016/j.biopsych.2024.02.803.Peer-Reviewed Original Research499. Identification of a Composite Latent Dimension of Reward and Impulsivity Across Clinical, Behavioral and Neurobiological Domains Among Youth
Kohler R, Lichenstein S, Cheng R, Holmes A, Bzdok D, Pearlson G, Yip S. 499. Identification of a Composite Latent Dimension of Reward and Impulsivity Across Clinical, Behavioral and Neurobiological Domains Among Youth. Biological Psychiatry 2024, 95: s303. DOI: 10.1016/j.biopsych.2024.02.998.Peer-Reviewed Original ResearchFunctional connectivity signatures of polygenic depression risk in youth
Moles L, Cheng A, Riley S, Lichenstein S, Babaeianjelodar M, Kohler R, Simon A, Horien C, Greene A, Zhao Y, Fan C, Constable R, Yip S. Functional connectivity signatures of polygenic depression risk in youth. Neuroscience Applied 2024, 3: 104803. DOI: 10.1016/j.nsa.2024.104803.Peer-Reviewed Original Research
2023
Identification of a Composite Latent Dimension of Reward and Impulsivity Across Clinical, Behavioral, and Neurobiological Domains Among Youth
Kohler R, Lichenstein S, Cheng A, Holmes A, Bzdok D, Pearlson G, Yip S. Identification of a Composite Latent Dimension of Reward and Impulsivity Across Clinical, Behavioral, and Neurobiological Domains Among Youth. Biological Psychiatry Cognitive Neuroscience And Neuroimaging 2023, 9: 407-416. PMID: 38052266, PMCID: PMC11149944, DOI: 10.1016/j.bpsc.2023.11.008.Peer-Reviewed Original ResearchAttention deficit hyperactivity disorderDisruptive behavior disordersAnterior cingulate responsesLatent dimensionsAnticipatory reward processingDeficit hyperactivity disorderSingle latent dimensionRisk-taking behaviorNegative urgencyExecutive functionIndividual differencesNeurobiological domainsReward anticipationCingulate responseReward processingAdolescent brainCognitive developmentNeural substratesHyperactivity disorderDevelopmental trajectoriesEarly adolescenceMultivariate patternsReward processesBehavioral variablesBehavior disorder
Clinical Trials
Current Trials
Connectivity While Coming of Age
HIC ID2000028368RolePrincipal InvestigatorPrimary Completion Date12/31/2026Recruiting ParticipantsGenderBothAge18 years - 25 years
News
News
- February 06, 2025Source: Biological Psychiatry
Identification and External Validation of a Problem Cannabis Risk Network
- April 22, 2024
Mentorship and Science
- September 08, 2023
WHRY Welcomes New Class of Undergraduate Fellows
- June 08, 2023
Yale Child Study Center welcomes 2023 summer interns