Robert Kohler
Associate Research Scientist of PsychiatryCards
About
Research
Publications
2025
Genotype‐by‐sex interaction analyses for alcohol use disorder across biobanks
Zhou H, Wang L, Mao Z, Deans P, Kember R, Chen Q, Zakiniaeiz Y, Kohler R, Peltier M, Verplaetse T, Program V, Potenza M, Brennand K, Justice A, Kranzler H, Gelernter J, McKee S. Genotype‐by‐sex interaction analyses for alcohol use disorder across biobanks. Alcohol Clinical And Experimental Research 2025 PMID: 41017299, DOI: 10.1111/acer.70173.Peer-Reviewed Original ResearchExpression quantitative trait lociAlcohol use disorderMillion Veteran ProgramGenotype-by-sexSingle-nucleotide polymorphismsAlcohol use disorder casesAncestry samplesGenetic basisCross-ancestry meta-analysisUse disorderQuantitative trait lociAfrican ancestry samplesPhenome-wide association analysisAlcohol use disorder riskHistory of alcohol addictionSelf-reported historyCross-ancestryTrait lociGenetic variationAssociation analysisMultiple genesLociAlcohol addictionExpression changesBiological underpinningsEmpirical Derivation and Prediction of Treatment Trajectories in Harmonized AUD Clinical Trial Datasets
Kohler R, Zakiniaeiz Y, Verplaetse T, Chavez C, Peltier M, Zhou H, McKee S, Roberts W. Empirical Derivation and Prediction of Treatment Trajectories in Harmonized AUD Clinical Trial Datasets. Addiction Biology 2025, 30: e70069. PMID: 40700031, PMCID: PMC12285684, DOI: 10.1111/adb.70069.Peer-Reviewed Original ResearchConceptsAlcohol use disorderTreatment response phenotypesAlcohol use disorder treatmentTreatment response trajectoriesAUD-related phenotypesFollow-up analysisBaseline drinkingPhase of treatmentUse disorderAlcohol consumption patternsPhase 2 randomized clinical trialDrinking dataResponse trajectoriesAlcohol usePatient responsePhase 3 trialResponse phenotypesExploratory analysisAlcohol consumptionTreatment trajectoryDrinking ratesNIAAANo significant differenceMild drinkersPatient's clinical needsAlcohol use during pregnancy: the impact of social determinants of health on alcohol consumption among pregnant women
Peltier M, Verplaetse T, Bici V, Mokwuah A, Chavez C, Zakiniaeiz Y, Kohler R, Garcia-Rivas V, Banini B, Zhou H, Raval N, Pittman B, McKee S. Alcohol use during pregnancy: the impact of social determinants of health on alcohol consumption among pregnant women. Biology Of Sex Differences 2025, 16: 49. PMID: 40598644, PMCID: PMC12219128, DOI: 10.1186/s13293-025-00731-6.Peer-Reviewed Original ResearchConceptsSocial determinants of healthDeterminants of healthImpact of SDoHMonthly binge drinkingMonth alcohol useAlcohol useLikelihood of alcohol useSocial determinantsLikelihood of binge drinkingPregnant womenBinge drinkingImpact of social determinants of healthAlcohol consumptionNational Survey of Drug Use and HealthNational surveyMethodsCross-sectional dataDrug Use and HealthRates of prenatal alcohol exposureHigh school educationCriminal justice involvementPast-month alcohol useHealthcare providersSDOHTime of alcohol consumptionPrenatal alcohol exposureLinking Brain to Other Biological Variables in the Adolescent Brain and Cognitive Development (ABCD) Study: One Size Doesn’t Always Fit All
Yip S, Jelen M, Aksen D, Cheng A, Moles L, Babaeianjelodar M, Serio B, Riley S, Kohler R, Zhao Y, Fan C, Constable R, Lichenstein S. Linking Brain to Other Biological Variables in the Adolescent Brain and Cognitive Development (ABCD) Study: One Size Doesn’t Always Fit All. Biological Psychiatry 2025, 97: s38. DOI: 10.1016/j.biopsych.2025.02.106.Peer-Reviewed Original ResearchPreclinical and clinical sex differences in the effects of alcohol on measures of brain dopamine: a systematic review
Barrios N, Riordan W, Garcia-Rivas V, Peltier M, Roberts W, Verplaetse T, Kohler R, Zhou H, Banini B, McKee S, Cosgrove K, Zakiniaeiz Y. Preclinical and clinical sex differences in the effects of alcohol on measures of brain dopamine: a systematic review. Biology Of Sex Differences 2025, 16: 24. PMID: 40200334, PMCID: PMC11980350, DOI: 10.1186/s13293-025-00706-7.Peer-Reviewed Original ResearchConceptsAlcohol use disorderAlcohol-induced dopamine releaseEffects of alcoholSex differencesAlcohol exposureDopamine measurementsMu-opioid receptorsDopamine releaseEffects of sexProgression of alcohol use disorderDopamine D1 receptor availabilityAlcohol use disorder developmentEffects of prenatal alcohol exposureD1 receptor availabilityStriatal dopamine concentrationsAir-exposed controlsAlcohol-exposed animalsMu-opioid receptor activationPrenatal alcohol exposureDuration of alcohol exposureVentral striatumBrain dopamineReward processingNeurobiological mechanismsReceptor availabilitySex-based Influences on White Matter Tract Integrity in Alcohol Use Disorder: a Systematic Review
Barrios N, Nartey N, Yue J, Riordan W, Kohler R, Verplaetse T, Roberts W, Carretta R, Banini B, Zhou H, Garcia-Rivas V, Blackford J, Zakiniaeiz Y. Sex-based Influences on White Matter Tract Integrity in Alcohol Use Disorder: a Systematic Review. Current Addiction Reports 2025, 12: 10. PMID: 40343159, PMCID: PMC12058214, DOI: 10.1007/s40429-025-00624-z.Peer-Reviewed Original ResearchWhite matter tract integrityAlcohol use disorderTract integritySex differencesUse disorderNeurotoxic effects of alcoholAlcohol-related health consequencesExamined sex differencesEffects of alcoholAlcohol use historyWell-characterized sampleDiffusion magnetic resonance imagingEvidence of sex-related differencesNeurobiological mechanismsPsychiatric comorbiditiesSubstance useSystematic reviewSex-related differencesNeurotoxic effectsIndividualized treatment optionsMagnetic resonance imagingDisordersAlcoholGoogle Scholar databasesTreatment options
2024
COCAINE SELF-ADMINISTRATION BEHAVIOR IS ASSOCIATED WITH SUBCORTICAL AND CORTICAL GRAY MATTER IN INDIVIDUALS WITH COCAINE USE DISORDER
Kohler R, Zhornitsky S, Potenza M, Yip S, Worhunsky P, Angarita G. COCAINE SELF-ADMINISTRATION BEHAVIOR IS ASSOCIATED WITH SUBCORTICAL AND CORTICAL GRAY MATTER IN INDIVIDUALS WITH COCAINE USE DISORDER. Drug And Alcohol Dependence 2024, 260: 110081. DOI: 10.1016/j.drugalcdep.2023.110081.Peer-Reviewed Original Research304. Multidimensional Components of Impulsivity in Youth: Insights From the Baseline Adolescent Brain and Cognitive Development Study Data
Riley S, Kohler R, Lichenstein S, Potenza M, Holmes A, Bzdok D, Yip S. 304. Multidimensional Components of Impulsivity in Youth: Insights From the Baseline Adolescent Brain and Cognitive Development Study Data. Biological Psychiatry 2024, 95: s224. DOI: 10.1016/j.biopsych.2024.02.803.Peer-Reviewed Original Research499. Identification of a Composite Latent Dimension of Reward and Impulsivity Across Clinical, Behavioral and Neurobiological Domains Among Youth
Kohler R, Lichenstein S, Cheng R, Holmes A, Bzdok D, Pearlson G, Yip S. 499. Identification of a Composite Latent Dimension of Reward and Impulsivity Across Clinical, Behavioral and Neurobiological Domains Among Youth. Biological Psychiatry 2024, 95: s303. DOI: 10.1016/j.biopsych.2024.02.998.Peer-Reviewed Original ResearchCocaine self-administration behavior is associated with subcortical and cortical morphometry measures in individuals with cocaine use disorder
Kohler R, Zhornitsky S, Potenza M, Yip S, Worhunsky P, Angarita G. Cocaine self-administration behavior is associated with subcortical and cortical morphometry measures in individuals with cocaine use disorder. The American Journal Of Drug And Alcohol Abuse 2024, 50: 345-356. PMID: 38551365, PMCID: PMC11305926, DOI: 10.1080/00952990.2024.2318585.Peer-Reviewed Original ResearchGray-matter volumeSelf-administer cocaineSelf-administration behaviorCocaine use disorderSelf-AdministrationGray-matterFrontal cortexUse disorderCocaine self-administration behaviorSelf-administered cocaine infusionsCocaine Self-AdministrationSelf-administration paradigmInfusions self-administeredSelf-report assessmentsCortical brain regionsStructural MRI dataFR1 scheduleInsular thicknessCocaine infusionsPredisposing vulnerabilitiesCocaine consumptionCocaine useBrain regionsBilateral regionsLimbic system