Rebecca Brady, MD, PhD
Clinical FellowAbout
Research
Publications
Featured Publications
The Effects of Prenatal Exposure to Neighborhood Crime on Neonatal Functional Connectivity
Brady R, Rogers C, Prochaska T, Kaplan S, Lean R, Smyser T, Shimony J, Slavich G, Warner B, Barch D, Luby J, Smyser C. The Effects of Prenatal Exposure to Neighborhood Crime on Neonatal Functional Connectivity. Biological Psychiatry 2022, 92: 139-148. PMID: 35428496, PMCID: PMC9257309, DOI: 10.1016/j.biopsych.2022.01.020.Peer-Reviewed Original ResearchConceptsNeonatal functional connectivityPsychosocial stressMaternal exposure to adversityExposure to neighborhood crimeMaternal psychosocial stressNeighborhood violent crimeBlock group levelExposure to adversityTargeted public policy interventionHigh-crime neighborhoodsNeighborhood crimePregnant womenExposure to crimeFrontolimbic connectivityCrime exposurePublic policy interventionsLinear regressionAdversityGroup levelMagnetic resonance imagingNonsedated infantsMediation modelPregnancyHigh-quality dataNeonatal periodMaternal emotional intelligence and negative parenting affect are independently associated with callous-unemotional traits in preschoolers
Brady R, Donohue M, Waller R, Tillman R, Gilbert K, Whalen D, Rogers C, Barch D, Luby J. Maternal emotional intelligence and negative parenting affect are independently associated with callous-unemotional traits in preschoolers. European Child & Adolescent Psychiatry 2022, 32: 2303-2311. PMID: 36063216, PMCID: PMC10163950, DOI: 10.1007/s00787-022-02074-8.Peer-Reviewed Original ResearchConceptsChild CU traitsCU traitsNegative parentingCallous-unemotionalEmotional intelligenceAssociated with callous-unemotional traitsAssociated with CU traitsDevelopment of CU traitsCallous-unemotional traitsOppositional defiant disorderComorbid psychopathologyComorbid depressionObserved parentingPsychiatric diagnosisInfluence of parentsClinical depressionChildren's EIEmotional competenceImprove parentingTreatment trialsDepressionPreschoolEnvironmental mechanismsEmotionsTraitsNeighborhood Crime and Externalizing Behavior in Toddlers: A Longitudinal Study With Neonatal fMRI and Parenting
Brady R, Leverett S, Mueller L, Ruscitti M, Latham A, Smyser T, Gerstein E, Warner B, Barch D, Luby J, Rogers C, Smyser C. Neighborhood Crime and Externalizing Behavior in Toddlers: A Longitudinal Study With Neonatal fMRI and Parenting. Journal Of The American Academy Of Child & Adolescent Psychiatry 2023, 63: 733-744. PMID: 38070869, PMCID: PMC11156792, DOI: 10.1016/j.jaac.2023.09.547.Peer-Reviewed Original ResearchConceptsFunctional magnetic resonance imagingFrontolimbic connectivityObserved parenting behaviorsExternalizing symptomsPaper self-identifiesParenting behaviorsAbstractText Label="METHOD" NlmCategory="METHODS">ParticipantsNeighborhood crimeAssociated with higher externalizing symptomsMothers of 1-year-oldsExposure to neighborhood crimePromote sexEthnic groupsLongitudinal studyBrain functionNeighborhood crime dataResting-state functional magnetic resonance imagingAbstractText Label="DIVERSITY &Higher externalizing symptomsRecruitment of human participantsEarly life adversityEarly intervention targetsParent-infant dyadsStudy questionnaireLongitudinal associationsNewborn Brain Function and Early Emerging Callous-Unemotional Traits
Brady R, Donohue M, Waller R, Latham A, Ayala M, Smyser T, Warner B, Barch D, Luby J, Rogers C, Smyser C. Newborn Brain Function and Early Emerging Callous-Unemotional Traits. JAMA Psychiatry 2024, 81: 303-311. PMID: 38117491, PMCID: PMC10733851, DOI: 10.1001/jamapsychiatry.2023.4842.Peer-Reviewed Original ResearchConceptsCallous-unemotional traitsMedial prefrontal cortexChild externalizing symptomsCingulo-opercular networkFunctional connectivityExternalizing symptomsInventory of Callous-Unemotional TraitsChild callous-unemotional traitsBrain functionAssociated with lower empathyNovel intervention developmentPersistent conduct problemsExposure to socioeconomic disadvantageAt-risk childrenCallous-unemotionalNeurobiological underpinningsPrefrontal cortexLow empathyLow prosocialityNeural mechanismsBrain regionsConnectivity analysisDevelopment of novel treatmentsProsocialityLongitudinal cohort study
2025
Neonatal brain volumes and early parenting behavior as mediators in associations between prenatal social disadvantage and socioemotional problems in toddlers
Leverett S, Poolos O, Brady R, Tillman R, Lean R, Gerstein E, Anaya B, Triplett R, Alexopoulos D, Warner B, Luby J, Smyser C, Rogers C, Barch D. Neonatal brain volumes and early parenting behavior as mediators in associations between prenatal social disadvantage and socioemotional problems in toddlers. Biological Psychiatry 2025 PMID: 40414448, PMCID: PMC12396000, DOI: 10.1016/j.biopsych.2025.05.015.Peer-Reviewed Original ResearchNeonatal brain volumesAge 2 yearsEarly parenting behaviorsBrain volumeParenting behaviorsChildren aged 1 yearStructural magnetic resonance scansAge 1 yearMagnetic resonance scansSocioemotional difficultiesSocioemotional problemsBrain structural alterationsAssociated with increased externalizingChild socio-emotional problemsEarly risk factorsSocial disadvantageResonance scansRisk factorsMother-child dyadsSocio-emotional problemsPregnancyDysregulation symptomsExternalizing symptomsBrain metricsMediation model
2024
Functional Connectivity Relationships to Longitudinal Motor Outcomes Differ in Very Preterm Children With and Without Brain Injury
Cyr P, Lean R, Kenley J, Kaplan S, Meyer D, Neil J, Alexopoulos D, Brady R, Shimony J, Rodebaugh T, Rogers C, Smyser C. Functional Connectivity Relationships to Longitudinal Motor Outcomes Differ in Very Preterm Children With and Without Brain Injury. Neurology Clinical Practice 2024, 15: e200397. PMID: 39439574, PMCID: PMC11492901, DOI: 10.1212/cpj.0000000000200397.Peer-Reviewed Original ResearchTerm-equivalent ageVery preterm childrenVery pretermChildren born very pretermBayley Scales of Infant DevelopmentMotor deficitsObservational cohort studyBrain injuryLongitudinal observational cohort studyAge 2 yearsAge 5 yearsStructural MRI findingsFine motor scoresNeonatal periodMRI findingsFunctional connectivityBayley ScalesFollow-upCohort studySD decreaseIncreased oddsInjured groupOutcome differencesMotor scoresUninjured groupNeonatal Functional Brain Connectivity Is Associated With Observed Empathy and Callous-Unemotional Traits at Ages 1-3 Years
Brady R, Smyser T, Barch D, Luby J, Smyser C, Rogers C, Donohue M. Neonatal Functional Brain Connectivity Is Associated With Observed Empathy and Callous-Unemotional Traits at Ages 1-3 Years. Journal Of The American Academy Of Child & Adolescent Psychiatry 2024, 63: s307-s308. DOI: 10.1016/j.jaac.2024.08.491.Peer-Reviewed Original ResearchAssociations between Parenting and Cognitive and Language Abilities at 2 Years of Age Depend on Prenatal Exposure to Disadvantage
Leverett S, Brady R, Tooley U, Lean R, Tillman R, Wilson J, Ruscitti M, Triplett R, Alexopoulos D, Gerstein E, Smyser T, Warner B, Luby J, Smyser C, Rogers C, Barch D. Associations between Parenting and Cognitive and Language Abilities at 2 Years of Age Depend on Prenatal Exposure to Disadvantage. The Journal Of Pediatrics 2024, 276: 114289. PMID: 39233119, PMCID: PMC11927132, DOI: 10.1016/j.jpeds.2024.114289.Peer-Reviewed Original ResearchConceptsAssociated with lower cognitionMother-child dyadsSubcortical gray matterLanguage abilityNonsupportive parentingEarly cognitionParenting behaviorsBrain volumeExposure to disadvantageSocial disadvantageNeonatal brain volumesLower cognitionBrain magnetic resonance imagingLevels of disadvantageMediation effectCognitionParental observationsModerating factorsAge 1 yearCognition/languageAge 2 yearsGray matterMagnetic resonance imagingObstetric clinicsPregnant womenMaternal Prenatal Social Disadvantage and Neonatal Functional Connectivity: Associations With Psychopathology Symptoms at Age 12 Months
Herzberg M, Nielsen A, Brady R, Kaplan S, Alexopoulos D, Meyer D, Arora J, Miller J, Smyser T, Barch D, Rogers C, Warner B, Smyser C, Luby J. Maternal Prenatal Social Disadvantage and Neonatal Functional Connectivity: Associations With Psychopathology Symptoms at Age 12 Months. Developmental Psychology 2024, 60: 1562-1579. PMID: 38386382, PMCID: PMC11869658, DOI: 10.1037/dev0001708.Peer-Reviewed Original ResearchConceptsFunctional connectivityNeonatal functional connectivityRight amygdalaInfant-Toddler Social and Emotional AssessmentInfant brain functionSocioeconomically diverse sampleMotor-related regionsInfant neurobehavioral outcomesEffect of socioeconomic statusPsychopathological symptomsInfant externalizingInternalizing symptomsExternalizing symptomsNeonatal amygdalaBrain structuresInternalizing behaviorsBrain functionSocial disadvantageDiverse sampleAmygdalaInfant-ToddlerEmotional AssessmentNeurobehavioral developmentNeurobehavioral outcomesMagnetic resonance imagingBasic Environmental Supports for Positive Brain and Cognitive Development in the First Year of Life
Luby J, Herzberg M, Hoyniak C, Tillman R, Lean R, Brady R, Triplett R, Alexopoulos D, Loseille D, Smyser T, Rogers C, Warner B, Smyser C, Barch D. Basic Environmental Supports for Positive Brain and Cognitive Development in the First Year of Life. JAMA Pediatrics 2024, 178: 465-472. PMID: 38497981, PMCID: PMC10949150, DOI: 10.1001/jamapediatrics.2024.0143.Peer-Reviewed Original ResearchConceptsAge 3 yearsMidwestern academic medical centerEnvironmental supportProspective longitudinal cohort studyAssociated with children's cognitive abilityLongitudinal cohort studyYears of lifeAcademic medical centerNeighborhood safetyUtero substance exposurePsychosocial resourcesPositive caregivingEnhancing child developmentSingleton offspringSocial disadvantageAge 2 yearsBirth complicationsPsychosocial environmentPositive developmental trajectoriesInfant-ToddlerCohort studyInternalizing symptomsInfant-Toddler Social and Emotional AssessmentMedical CenterAssociated with children's externalizing