Hobart Patrick Young, PhD
Research ScientistCards
About
Research
Publications
2026
Quantum Machine Learning and Data Re-Uploading: Evaluation on Benchmark and Laboratory Medicine Data Sets
Durant TJS, Lee SJ, Dudgeon SN, Knight E, Nelson B, Young HP, Ohno-Machado L, Schulz WL. Quantum Machine Learning and Data Re-Uploading: Evaluation on Benchmark and Laboratory Medicine Data Sets. Clinical Chemistry 2026, hvaf192. DOI: 10.1093/clinchem/hvaf192.Peer-Reviewed Original ResearchQuantum Machine Learning and Data Re-Uploading: Evaluation on Benchmark and Laboratory Medicine Data Sets
Durant T, Lee S, Dudgeon S, Knight E, Nelson B, Young H, Ohno-Machado L, Schulz W. Quantum Machine Learning and Data Re-Uploading: Evaluation on Benchmark and Laboratory Medicine Data Sets. Clinical Chemistry 2026, hvaf192. PMID: 41728802, DOI: 10.1093/clinchem/hvaf192.Peer-Reviewed Original ResearchQuantum machine learningReal-world healthcare dataMachine learningClassification performanceML algorithmsQuantum machine learning methodsComparison of classification performanceData setsBenchmark data setsLow-dimensional dataClassical machine learningInput dimensionalityRe-uploadingF1 scoreF-scoreClassic algorithmConfiguration parametersAlgorithmAlgorithm developmentLinear algorithmQuantum hardwareImpact of optimismQuantum machinesBaseline comparisonLearningClinical Trial Patient Matching: A Real-Time, Common Data Model and Artificial Intelligence–Driven System for Semiautomated Patient Prescreening in Cancer Clinical Trials
Gong G, Liu J, Pandya S, Taborda C, Wiesendanger N, Price N, Byron W, Coppi A, Young P, Wiess C, Dunning H, Barganier C, Brodeur R, Fischbach N, LoRusso P, Pusztai L, Kim S, Rozenblit M, Cecchini M, Mongiu A, Mendez L, Kaftan E, Torre C, Krumholz H, Krop I, Schulz W, Lustberg M, Kunz P. Clinical Trial Patient Matching: A Real-Time, Common Data Model and Artificial Intelligence–Driven System for Semiautomated Patient Prescreening in Cancer Clinical Trials. JCO Clinical Cancer Informatics 2026, 10: e2500262. PMID: 41512229, DOI: 10.1200/cci-25-00262.Peer-Reviewed Original ResearchConceptsObservational Medical Outcomes PartnershipHealth systemColorectal cancerElectronic health record dataCancer clinical trial enrollmentChart reviewHealth record dataManual chart reviewClinical trial recruitmentClinical trialsCancer clinical trialsCancer specialtiesCommon data modelScreen timeColorectal cancer trialsClinical trial enrollmentTrial recruitmentClinical chart reviewConsent ratesPatient accessExhaustive chart reviewMetastatic colorectal cancerEnrollment challengesRecord dataTrial enrollmentAssessment of the integrity of real-time electronic health record data used in clinical research
Liu J, Pandya S, Coppi A, Young H, Krumholz H, Schulz W, Gong G. Assessment of the integrity of real-time electronic health record data used in clinical research. PLOS ONE 2026, 21: e0340287. PMID: 41511976, PMCID: PMC12788664, DOI: 10.1371/journal.pone.0340287.Peer-Reviewed Original ResearchConceptsElectronic health recordsEHR dataReal-time electronic health recordsElectronic health record dataSecondary useHealth record dataClinical actionsIntegration of real-time dataClinical trial readinessCommon data modelHealth recordsHealth systemOMOP Common Data ModelDischarge informationClinical careResearch readinessRecord dataTrial readinessSynthetic datasetsEHR datasetData warehouseDemographic variablesReal-time dataPost-encounterAutomated framework
2025
Association Between Neighborhood-Level Social Vulnerability and Hypertension Outcomes
Brush J, Kim C, Liu Y, Xin X, Huang C, Lundy I, Asher J, Sawano M, Young P, McPadden J, Anderson M, Burrows J, Krumholz H, Lu Y. Association Between Neighborhood-Level Social Vulnerability and Hypertension Outcomes. JACC Advances 2025, 4: 101912. PMID: 40627892, PMCID: PMC12272890, DOI: 10.1016/j.jacadv.2025.101912.Peer-Reviewed Original ResearchNeighborhood-level social vulnerabilitySocial Vulnerability IndexAssociated with hypertension prevalenceDiverse cohortSocial Vulnerability Index quartilesElectronic health dataIncident myocardial infarctionBaseline body mass indexDiverse cohort of patientsSocial vulnerabilityBody mass indexPoor BP controlCardiovascular outcomesHypertension prevalenceBlood pressureHypertension outcomesRacial disparitiesHealth dataHypertension managementAssociated with adverse cardiovascular outcomesLongitudinal cohortMass indexWhite raceBlack raceComposite endpointDelayed Hypertension Diagnosis and Its Association With Cardiovascular Treatment and Outcomes
Lu Y, Brush J, Kim C, Liu Y, Xin X, Huang C, Sawano M, Young P, McPadden J, Anderson M, Burrows J, Asher J, Krumholz H. Delayed Hypertension Diagnosis and Its Association With Cardiovascular Treatment and Outcomes. JAMA Network Open 2025, 8: e2520498. PMID: 40658418, PMCID: PMC12261005, DOI: 10.1001/jamanetworkopen.2025.20498.Peer-Reviewed Original ResearchConceptsElectronic health recordsHypertension diagnosisIntegrated health care systemHazard ratioNon-Hispanic black raceAntihypertensive medication prescribingMedication prescription ratesClinical diagnosis of hypertensionHealth care systemCardiovascular outcomesRisk of myocardial infarctionCox proportional hazards regression modelsAssociated with younger ageOutpatient blood pressureBlood pressureCardiovascular riskProportional hazards regression modelsAntihypertensive medication prescriptionsDiagnosis of hypertensionMultivariate Cox proportional hazards regression modelsAssociated with delayHazards regression modelsMedication prescribingHealth recordsNon-HispanicNasal biomarker testing to rule out viral respiratory infection and triage samples: a test performance study
Amat J, Dudgeon S, Cheemarla N, Watkins T, Green A, Young H, Peaper D, Landry M, Schulz W, Foxman E. Nasal biomarker testing to rule out viral respiratory infection and triage samples: a test performance study. EBioMedicine 2025, 117: 105820. PMID: 40543450, PMCID: PMC12216728, DOI: 10.1016/j.ebiom.2025.105820.Peer-Reviewed Original ResearchRespiratory virus infectionsHigh-risk settingsRespiratory infectionsRoutine screeningVirus infectionViral respiratory infectionsLow viral loadViral prevalenceGold standard testRespiratory virus diagnosisNasal biomarkersViral loadPractical screening testNasal mucosaRespiratory virusesHost biomarkersChemotherapeutic drugsVirus-positiveBiomarker testingNasopharyngeal samplesCXCL10Medical recordsScreening testElectronic medical recordsPCR panelCorrection: Computational phenotypes for patients with opioid-related disorders presenting to the emergency department
Taylor R, Gilson A, Schulz W, Lopez K, Young P, Pandya S, Coppi A, Chartash D, Fiellin D, D'Onofrio G. Correction: Computational phenotypes for patients with opioid-related disorders presenting to the emergency department. PLOS ONE 2025, 20: e0324877. PMID: 40378111, PMCID: PMC12083821, DOI: 10.1371/journal.pone.0324877.Peer-Reviewed Original Research
2024
Use of electronic health records to characterize patients with uncontrolled hypertension in two large health system networks
Lu Y, Keeley E, Barrette E, Cooper-DeHoff R, Dhruva S, Gaffney J, Gamble G, Handke B, Huang C, Krumholz H, McDonough C, Schulz W, Shaw K, Smith M, Woodard J, Young P, Ervin K, Ross J. Use of electronic health records to characterize patients with uncontrolled hypertension in two large health system networks. BMC Cardiovascular Disorders 2024, 24: 497. PMID: 39289597, PMCID: PMC11409735, DOI: 10.1186/s12872-024-04161-x.Peer-Reviewed Original ResearchConceptsElectronic health recordsHealth recordsHealth systemUncontrolled hypertensionUse of electronic health recordsHypertension managementElectronic health record systemsOneFlorida Clinical Research ConsortiumElectronic health record dataYale New Haven Health SystemBP measurementsICD-10-CM codesHealth system networkPublic health priorityICD-10-CMIncidence rate of deathElevated BP measurementsElevated blood pressure measurementsHealthcare visitsAmbulatory careHealth priorityRetrospective cohort studyEHR dataOneFloridaBlood pressure measurementsA primer for quantum computing and its applications to healthcare and biomedical research
Durant T, Knight E, Nelson B, Dudgeon S, Lee S, Walliman D, Young H, Ohno-Machado L, Schulz W. A primer for quantum computing and its applications to healthcare and biomedical research. Journal Of The American Medical Informatics Association 2024, 31: 1774-1784. PMID: 38934288, PMCID: PMC11258415, DOI: 10.1093/jamia/ocae149.Peer-Reviewed Original Research
Academic Achievements & Community Involvement
News
News
- June 24, 2025Source: Yale News
Screen Saver: Simpler, Less Costly Virus Testing in High-Risk Settings
- July 02, 2024
Lab Medicine faculty publish primer for quantum computing in healthcare
- May 28, 2024
Next Generation Research Uses Real-World Data to Identify Most Effective Hypertension Drugs for Patients