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Nicholas Blondin, MD

Associate Professor
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Additional Titles

Neuro-Oncology Clinical Research Team Leader, Medical Oncology

Contact Info

Yale Cancer Center

Smilow Trumbull Care Center, 5520 Park Avenue

Trumbull, CT 06611

United States

About

Titles

Associate Professor

Neuro-Oncology Clinical Research Team Leader, Medical Oncology

Biography

Nicholas A. Blondin, MD, is an Associate Professor of Neurology at Yale School of Medicine. Dr. Blondin cares for patients at Smilow Cancer Hospital in New Haven and the Smilow Cancer Hospital Cancer Care Center in Trumbull. He received his Medical Degree from the University of Connecticut School of Medicine and completed his neurology residency at Yale New Haven Hospital, where he was Chief Resident in Neurology, followed by a fellowship in Neuro-Oncology at Yale New Haven Hospital. Before joining Smilow, he was the Director of the Neuro-Oncology Program at Associated Neurologists of Southern CT and the Medical Director of the St. Vincent’s Brain Tumor Center. Watch a video with Dr. Nicholas Blondin>>

Dr. Blondin’s clinical expertise is in treating benign and malignant brain tumors, brain and spine metastasis, and neurological symptoms of cancer, such as seizures, cognitive impairment, headaches, gait disturbance, and weakness. He has a particular interest in treating glioblastoma, IDH-mutant glioma, and leptomeningeal metastasis of cancer.

Dr. Blondin is the leader of the Neuro-Oncology Clinical Research Team, and serves as Principal Investigator of clinical trials at Yale and nationally. He is a member of the Developmental Therapeutics section of the Yale Cancer Center. He also is a member of the Yale Biomedical Imaging Institute and is the Clinical Principal Investigator for studies of Deuterium Metabolic Imaging of brain tumors.

Last Updated on November 13, 2025.

Appointments

Education & Training

Neuro-Oncology Fellow
Yale University (2013)
Chief Resident
Yale School of Medicine (2012)
Resident
Yale School of Medicine (2011)
Intern
Yale School of Medicine (2009)
MD
University of Connecticut School of Medicine
BA
Wesleyan University, Chemistry

Research

Overview

Dr. Blondin is the leader of the Yale Neuro-Oncology Clinical Research Team (CRT). In this role, he oversees the research team conducting clinical trials at Yale. Dr. Blondin serves as Principal Investigator in studies of glioblastoma, IDH-mutant glioma (astrocytoma), meningioma, and brain metastasis. Dr. Blondin is a member of the GBM AGILE Leadership Council and is the National co-PI of the ADI-PEG20 investigational arm.

Dr. Blondin is a member of the Yale Biomedical Imaging Institute, and is the Clinical Principal Investigator of the Deuterium Metabolic Imaging (DMI) project at Yale.

Dr. Blondin is studying the mechanisms of glioblastoma resistance to cancer-directed therapies, and is building a neuro-oncology "Brain Bank" of autopsy tissue donations.

Medical Research Interests

Astrocytoma; Glioblastoma; Meningioma

Public Health Interests

Clinical Trials; Cancer

Research at a Glance

Yale Co-Authors

Frequent collaborators of Nicholas Blondin's published research.

Publications

2025

2024

2023

Clinical Trials

Academic Achievements & Community Involvement

Activities

  • activity

    Yale University Protocol Review Committee (PRC)

  • activity

    National Brain Tumor Society

  • activity

    Society for Neuro-Oncology

  • activity

    Connecticut Brain Tumor Alliance

  • activity

    Musella Foundation

Honors

  • honor

    Connecticut Brain Tumor Alliance Humanitarian Award

  • honor

    Cigna Care Designation

  • honor

    UnitedHealth Premium Designation, Quality & Cost Efficiency

  • honor

    Palatucci Advocacy Leadership Forum Graduate

  • honor

    Gold Humanism Honor Society

Teaching & Mentoring

Teaching

  • Clinical

    MD 2025: MAP Neurology Component

    LecturerInpatient Clinical Setting

Clinical Care

Overview

Nicholas A. Blondin, MD, is a Yale Medicine neurologist who specializes in treating benign (noncancerous) and malignant (cancerous) brain tumors, brain and spine metastasis, and neurological symptoms of cancer such as seizures, cognitive impairment, headaches, gait disturbance, and weakness. He cares for patients at Smilow Cancer Hospital in New Haven and the Smilow Cancer Hospital Cancer Care Center in Trumbull.

“I love developing a strong doctor-patient relationship with my patients,” Dr. Blondin says. “I believe that a strong, trusting relationship is critical for me to help patients achieve their treatment goals and have the best possible quality of life.”

Dr. Blondin believes in “shared decision making,” a process he uses to create a treatment plan that will be best for each patient. “With a difficult diagnosis, I am open and honest but also work to provide hope that treatment will be effective,” Dr. Blondin says. “I let patients know that I will always be there for them, and I will support them in all phases of treatment.”

Together with a team of doctors at Smilow, he is able to help more patients achieve better outcomes. “In neuro-oncology, I rely on additional specialists such as neurosurgeons, radiation oncologists, pathologist, and neuro-radiologists in order to provide the best care for my patients,” he says.

Dr. Blondin is an active investigator for clinical trials for brain tumor patients through Yale Cancer Center and is an associate professor of neurology at Yale School of Medicine.

Clinical Specialties

Neuro-Oncology; Neurology

Fact Sheets

Board Certifications

  • Neuro-Oncology

    Certification Organization
    United Council for Neurologic Subspecialties
    Latest Certification Date
    2022
    Original Certification Date
    2015
  • Neurology

    Certification Organization
    AB of Psychiatry & Neurology
    Original Certification Date
    2012

Yale Medicine News

Get In Touch

Contacts

Appointment Number
Clinical Inquiry Number
Clinic Fax Number
Mailing Address

Yale Cancer Center

Smilow Trumbull Care Center, 5520 Park Avenue

Trumbull, CT 06611

United States

Administrative Support

Locations

  • Neuro-Oncology

    Academic Office

    Lippard Laboratory of Clinical Investigation (LLCI)

    15 York Street

    New Haven, CT 06510

    Business Office

    203.737.7084
  • Patient Care Locations

    Are You a Patient? View this doctor's clinical profile on the Yale Medicine website for information about the services we offer and making an appointment.