Kanat Yalcin, MD
Associate Research ScientistCards
About
Research
Publications
2025
Subgroup of meningiomas involving FOS and FOSB gene fusions
Yalcin K, Alanya H, Gultekin B, Samper Figuera D, Barak T, Miyagishima D, Youngblood M, Hjerthen M, Brooks A, Samuel Lopez N, O’Brien J, Chavez M, Dincer A, Wu H, Omay S, Yasuno K, Bilguvar K, Ercan-Sencicek A, Mishra-Gorur K, McGuone D, Moliterno J, Gunel M, Erson-Omay E. Subgroup of meningiomas involving FOS and FOSB gene fusions. Nature Communications 2025, 16: 10532. PMID: 41298363, PMCID: PMC12657970, DOI: 10.1038/s41467-025-65549-7.Peer-Reviewed Original ResearchConceptsAP-1 target genesRecurrent genomic rearrangementsGene expression patternsGenomic rearrangementsChromosomal alterationsGene fusionsMolecular classificationGenetic driversTarget genesExpression patternsGenesFosB geneLow-grade behaviorTreated with surgerySubgroup of meningiomasClassification of meningiomasProtein levelsDriver mutationsTargeted treatment strategiesCentral nervous systemPrimary tumorBenign subtypeTargeted therapyClinical featuresMolecular subgroupsCase Report: Genomic characterization of a rare skull-base plasmacytoma
Alanya H, Kasturi S, Yalcin K, Gultekin B, Kumar D, Samuel N, Figuera D, Mishra-Gorur K, Gunel M, Erson-Omay E, Omay S. Case Report: Genomic characterization of a rare skull-base plasmacytoma. Frontiers In Oncology 2025, 15: 1645502. PMID: 41378284, PMCID: PMC12685666, DOI: 10.3389/fonc.2025.1645502.Peer-Reviewed Case Reports and Technical NotesWhole-exome sequencingMolecular landscapeSomatic copy number alteration burdenChromatin remodelingCopy number alteration burdenGenomic characterizationEvidence of systemic diseaseComprehensive genomic profilingPlasma cell neoplasmsPathogenic variantsOncogenic signalingSkull-base tumorsSkull-base lesionsTargeted therapy developmentPersonalized clinical managementMolecular underpinningsGenomic profilingProgressive headacheNeoplasm pathogenesisCell neoplasmsRisk stratificationB cellsClinical managementSystemic diseaseTherapy developmentImmune Characterization of Intracranial Aneurysms Using Noninvasive Endoluminal Biopsy With High-Dimensional Single-Cell Phenotyping
Antonios J, Gultekin B, Theriault B, Yalcin K, Miyagishima D, Adenu-Mensah N, Sujijantarat N, Koo A, Haynes J, Cedeno P, Johnson M, Hebert R, Matouk C, Barak T, Gunel M. Immune Characterization of Intracranial Aneurysms Using Noninvasive Endoluminal Biopsy With High-Dimensional Single-Cell Phenotyping. Neurology 2025, 105: e214185. PMID: 40997288, DOI: 10.1212/wnl.0000000000214185.Peer-Reviewed Original ResearchConceptsIntracranial aneurysmsEndoluminal biopsyImmune landscapeImmune characterizationSubarachnoid hemorrhageGroup 1Characterization of intracranial aneurysmsDilation of cerebral arteriesPathological dilatationProspective observational cohort studyUpregulation of CD38Neutrophil-dominated inflammationImmune regulatory mechanismsAssociated with aneurysm growthYale-New Haven HospitalPathological dilatations of cerebral arteriesFisher's exact testObservational cohort studyImmune-based biomarkersUnruptured intracranial aneurysmsNo significant associationImmune signaturesImmunomodulatory therapyHLA-DRNeutrophil predominanceSomatic SMARCB1 mutation in spinal meningioma represents branched evolution in a patient with multiple sporadic meningiomas
Gupta M, Samiappan S, Alanya H, Yalcin K, Gultekin B, Sharaf R, Elsamadicy A, Figuera D, Samuel N, Mishra-Gorur K, Kolb L, McGuone D, Gunel M, Erson-Omay E, Moliterno J, Mendel E. Somatic SMARCB1 mutation in spinal meningioma represents branched evolution in a patient with multiple sporadic meningiomas. Neuro-Oncology Advances 2025, 7: vdaf067. PMID: 40386121, PMCID: PMC12081948, DOI: 10.1093/noajnl/vdaf067.Peer-Reviewed Original Research
2024
Variations in the genomic profiles and clinical behavior of meningioma by racial and ethnic group.
Tabor J, Dincer A, O'Brien J, Lei H, Vetsa S, Vasandani S, Jalal M, Yalcin K, Morales-Valero S, Marianayagam N, Alanya H, Elsamadicy A, Millares Chavez M, Aguilera S, Mishra-Gorur K, McGuone D, Fulbright R, Jin L, Erson-Omay E, Günel M, Moliterno J. Variations in the genomic profiles and clinical behavior of meningioma by racial and ethnic group. Journal Of Neurosurgery 2024, 141: 664-672. PMID: 38518289, DOI: 10.3171/2024.1.jns231633.Peer-Reviewed Original ResearchBlack patientsSporadic meningiomasClinical outcomesGenomic profilingClinical behavior of meningiomasShorter progression-free survivalAnterior skull base tumorsClinical data of patientsHispanic patientsProgression-free survivalChromosome 1p deletionBehavior of meningiomasIncreased recurrence rateRate of recurrenceSkull base tumorsData of patientsSomatic driver mutationsNon-black patientsShorter PFSOverall survivalAggressive meningiomasTRAF7 mutationsIntracranial meningiomasMeningioma resectionNon-black group
2023
Application of novel PACS-based informatics platform to identify imaging based predictors of CDKN2A allelic status in glioblastomas
Tillmanns N, Lost J, Tabor J, Vasandani S, Vetsa S, Marianayagam N, Yalcin K, Erson-Omay E, von Reppert M, Jekel L, Merkaj S, Ramakrishnan D, Avesta A, de Oliveira Santo I, Jin L, Huttner A, Bousabarah K, Ikuta I, Lin M, Aneja S, Turowski B, Aboian M, Moliterno J. Application of novel PACS-based informatics platform to identify imaging based predictors of CDKN2A allelic status in glioblastomas. Scientific Reports 2023, 13: 22942. PMID: 38135704, PMCID: PMC10746716, DOI: 10.1038/s41598-023-48918-4.Peer-Reviewed Original ResearchConceptsInformatics platformDeep learning algorithmsImaging featuresCDKN2A alterationsLearning algorithmHeterozygous lossHomozygous deletionLarge datasetsDeep white matter invasionGBM molecular subtypesNew informaticsQualitative imaging biomarkersWhole-exome sequencingQualitative imaging featuresGBM resectionRadiographic evidenceWorse prognosisPACSMolecular subtypesPial invasionImaging biomarkersCDKN2A mutationsAllele statusNoninvasive identificationMagnetic resonance imagesThe clinical and genomic features of seizures in meningiomas
Dincer A, Jalal M, Gupte T, Vetsa S, Vasandani S, Yalcin K, Marianayagam N, Blondin N, Corbin Z, McGuone D, Fulbright R, Erson-Omay Z, Günel M, Moliterno J. The clinical and genomic features of seizures in meningiomas. Neuro-Oncology Advances 2023, 5: i49-i57. PMID: 37287582, PMCID: PMC10243847, DOI: 10.1093/noajnl/vdac110.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsPeritumoral brain edemaPostoperative seizuresBrain invasionSubtotal resectionBrain edemaLarge residual tumor volumeCentral nervous system tumorsCommon central nervous system tumorPersistent postoperative seizuresResidual tumor volumeHistory of seizuresHigh tumor gradeNervous system tumorsQuality of lifePreoperative seizuresAtypical histologyMost patientsSurgical resectionCortical hyperexcitabilityUncontrolled seizuresAggressive featuresSeizure activityEpileptogenic focusCortical irritationRisk factorsClinical and genomic differences in supratentorial versus infratentorial NF2 mutant meningiomas.
Tabor J, O'Brien J, Vasandani S, Vetsa S, Lei H, Jalal M, Marianayagam N, Jin L, Millares Chavez M, Haynes J, Dincer A, Yalcin K, Aguilera S, Omay S, Mishra-Gorur K, McGuone D, Morales-Valero S, Fulbright R, Gunel M, Erson-Omay E, Moliterno J. Clinical and genomic differences in supratentorial versus infratentorial NF2 mutant meningiomas. Journal Of Neurosurgery 2023, 139: 1648-1656. PMID: 37243548, DOI: 10.3171/2023.4.jns222929.Peer-Reviewed Original ResearchConceptsSubtotal resectionSupratentorial tumorsElevated Ki-67High-risk featuresProgression-free survivalChromosome 1p deletionInfratentorial counterpartsInfratentorial tumorsPostoperative managementSomatic driver mutationsCerebral convexityGrade IIInfratentorial meningiomasKi-67Posterior fossaLoss of heterozygosityMeningiomasResectionTumorsWhole-exome sequencing dataDriver mutationsHigh gradeSignificant differencesExome sequencing dataSporadic meningiomasSurgical strategies for intracranial meningioma in the molecular era
Dincer A, Morales-Valero S, Robert S, Tabor J, O’Brien J, Yalcin K, Fulbright R, Erson-Omay Z, Dunn I, Moliterno J. Surgical strategies for intracranial meningioma in the molecular era. Journal Of Neuro-Oncology 2023, 162: 253-265. PMID: 37010677, PMCID: PMC10167142, DOI: 10.1007/s11060-023-04272-z.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsExtent of resectionGrade 1 tumorsInfluence of surgeryTreatment of choiceHigh recurrence rateBiology of meningiomasIntroductionSurgical resectionSymptomatic recurrenceDisease recurrenceDefinitive managementRecurrence rateSurgical strategyWHO gradeIntracranial meningiomasClinical predictive powerMalignant transformationGrading scaleNatural historyMeningiomasUnexpected recurrenceRecurrence
2022
Correction: Genomic profiling of sporadic multiple meningiomas
Erson-Omay EZ, Vetsa S, Vasandani S, Barak T, Nadar A, Marianayagam NJ, Yalcin K, Miyagishima D, Aguilera SM, Robert S, Mishra-Gorur K, Fulbright RK, McGuone D, Günel M, Moliterno J. Correction: Genomic profiling of sporadic multiple meningiomas. BMC Medical Genomics 2022, 15: 131. PMID: 35698142, PMCID: PMC9190101, DOI: 10.1186/s12920-022-01273-1.Commentaries, Editorials and Letters