Mohammad Abdullah Zafar, MBBS
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Associate Research Scientist
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Dr. Mohammad Abdullah Zafar is an Associate Research Scientist, the Research Director, and Yale-Masone Aortic Research Fellow at the Aortic Institute at Yale-New Haven Hospital, Section of Cardiac Surgery, Department of Surgery. The Aortic Institute at Yale-New Haven Hospital is one of the world's largest multidisciplinary clinical and research centers dedicated to the care of patients with thoracic aortic disease. It includes experts in cardiothoracic surgery, cardiology, vascular surgery, vascular radiology, interventional radiology, cardiovascular anesthesiology, bioengineering, epidemiology, molecular genetics, and basic science research in vascular medicine. It is among the first such formally designated centers.
After completing his medical degree with honors and an internship in thoracic surgery in Pakistan, Dr. Zafar joined the Aortic Institute in 2015. Over the past nine years, his research has been focused on advancing the fundamental biomedical understanding of thoracic aortic disease via scientific studies targeted at fostering a better understanding of the natural history and risk prediction, early detection and diagnosis, molecular genetics, and optimal therapies of thoracic aortic disease. Dr. Zafar's work has directly informed the latest U.S. and European Aortic Disease Clinical Practice Guidelines.
As the Aortic Research Fellow and Research Director, Dr. Zafar's role is to bridge the academic, clinical, and research arms of the Aortic Institute to continue to ensure the delivery of state-of-the-art expert and personalized care to aneurysm patients at Yale. Dr. Zafar supervises all investigations at the Institute and leads, mentors, and aids the recruitment of diverse members of the research team that includes high school students, undergraduate students, Yale and visiting medical students, residents, physician associates, postdoctoral fellows, physicians, and surgeons from across the United States and the world. Dr. Zafar has helped establish the Aortic Institute clinical database, tissue bank, and advanced thoracic aortic aneurysm and dissection genetic testing program and database, some of the largest repositories of their kind in the world.
Dr. Zafar has published over one hundred twenty peer-reviewed scientific articles, book chapters, editorials, and commentaries on thoracic aortic disease. He has presented his research work at leading national and international conferences, delivered lectures and Grand Rounds at the Yale School of Medicine, Yale-New Haven Hospital, and other institutions, serves as a peer-reviewer for journals, and serves as an editor for the journal AORTA. Dr. Zafar is completing a Master of Health Science (Clinical Investigation Track) degree from the Yale School of Medicine.
An avid Manchester United fan, Dr. Zafar enjoys playing and watching soccer, strength training, British crime and sci-fi shows, mindful productivity, brunch, and spending time with friends and family.
Appointments
Cardiac Surgery
Associate Research ScientistPrimary
Other Departments & Organizations
- Cardiac Surgery
- Surgery
Education & Training
- MBBS
- University of Health Sciences (2013)
Research
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Overview
Medical Research Interests
ORCID
0000-0003-1666-199X
Research at a Glance
Yale Co-Authors
Publications Timeline
Research Interests
John Elefteriades, MD
Sandip Mukherjee, MD, FACC
Syed Usman Bin Mahmood, MBBS
Hamid Mojibian, MD
Roland Assi, MD, MMS, FACS
Gabe Weininger
Aorta
Cardiac Surgical Procedures
Dissection, Thoracic Aorta
Publications
2025
Endovascular Repair vs Medical Therapy for Uncomplicated Acute Type B Dissection: Aortic Remodeling
Higaki A, Hameed I, Erez E, Hu K, Asmelash S, Chatterjee D, Shou B, Zafar M, Assi R, Vallabhajosyula P. Endovascular Repair vs Medical Therapy for Uncomplicated Acute Type B Dissection: Aortic Remodeling. Annals Of Thoracic Surgery Short Reports 2025, 3: 555-560. DOI: 10.1016/j.atssr.2025.01.012.Peer-Reviewed Original ResearchConceptsUncomplicated acute type B aortic dissectionThoracic endovascular aortic repairOptimal medical therapyMedical therapyAortic remodelingAortic levelsClinical outcomesClinical outcomes of thoracic endovascular aortic repairLumen diameterPatients treated with thoracic endovascular aortic repairOutcomes of thoracic endovascular aortic repairUncomplicated acute type B dissectionAcute type B aortic dissectionOMT patientsAcute type B dissectionType B aortic dissectionFavorable aortic remodelingOptimal initial managementInitial treatment modalityMedian Follow-UpType B dissectionEndovascular aortic repairB aortic dissectionFalse lumen thrombosisLeft subclavian arteryNovel Aortic Root Measurement Technique Utilizing the Laplace Diameter for Identifying Patients At-Risk for Type A Dissection
Kalyanasundaram A, Harling L, Zafar M, Ellauzi H, Ziganshin B, Elefteriades J. Novel Aortic Root Measurement Technique Utilizing the Laplace Diameter for Identifying Patients At-Risk for Type A Dissection. Annals Of Thoracic Surgery Short Reports 2025 DOI: 10.1016/j.atssr.2025.06.032.Peer-Reviewed Original ResearchThromboexclusion Procedure for a Recurrent Descending Aortic Pseudoaneurysm in the Pre-Stent Era
Strachan S, Zafar M, Ziganshin B, Elefteriades J. Thromboexclusion Procedure for a Recurrent Descending Aortic Pseudoaneurysm in the Pre-Stent Era. Annals Of Thoracic Surgery Short Reports 2025 DOI: 10.1016/j.atssr.2025.07.015.Peer-Reviewed Original ResearchAltmetricEfficacy of beta-blocker agents on clinical outcomes in patients with thoracic aortic aneurysm: A systematic review and meta-analysis of randomized controlled trials
Tanriverdi L, Barrett A, Kalyanasundaram A, Zafar M, Ziganshin B, Elefteriades J. Efficacy of beta-blocker agents on clinical outcomes in patients with thoracic aortic aneurysm: A systematic review and meta-analysis of randomized controlled trials. Vascular Pharmacology 2025, 159: 107494. PMID: 40204023, DOI: 10.1016/j.vph.2025.107494.Peer-Reviewed Original ResearchMeSH Keywords and ConceptsConceptsThoracic aortic aneurysmRandomized Controlled TrialsPooled risk ratioB-blockersAortic dissectionClinical outcomesAortic aneurysmRisk ratioRisk of aortic dissectionMeta-analysis of randomized controlled trialsControlled TrialsB-blocker treatmentCompared to placeboBeta-blocking agentsCochrane Risk of Bias 2 toolRisk of Bias 2 toolRobust randomized controlled trialsInverse variance-weighted random-effects modelRisk of bias assessmentRandom-effects modelEvidence of benefitSystematic literature searchAortic eventsEvidence-based recommendationsFollow-upGenetic Overlap of Thoracic Aortic Aneurysms and Intracranial Aneurysms
Changez M, Nasir A, Sonsino A, Jeoffrey S, Kalyanasundaram A, Zafar M, Ziganshin B, Elefteriades J. Genetic Overlap of Thoracic Aortic Aneurysms and Intracranial Aneurysms. Genes 2025, 16: 154. PMID: 40004483, PMCID: PMC11855647, DOI: 10.3390/genes16020154.Peer-Reviewed Original ResearchCitationsMeSH Keywords and ConceptsConceptsGenome-wide association studiesThoracic aortic aneurysmGenetic overlapCell cycle pathwayIntracranial aneurysmsAortic aneurysmAssociation studiesEtiology of thoracic aortic aneurysmExtracellular matrix componentsGenetic interplayGenetic pathwaysCycle pathwayCausative genesExtracellular matrix remodelingThoracic aortic aneurysm patientsGenetic etiologyConnective tissue biologyRetrospective clinical studyMolecular mechanismsGenesIntracranial aneurysm patientsPhysiological pathwaysTissue biologyPathwayGenetic factorsMidterm outcomes of thoracic endovascular aortic repair versus optimal medical therapy for uncomplicated acute type B dissection
Hu K, Ma W, Pupovac S, Hameed I, Fereydooni S, Li E, Larson H, Zafar M, Tonnessen B, Cardella J, Aboian E, Guzman R, Chaar C, Strosberg D, Williams M, Nassiri N, Assi R, Vallabhajosyula P. Midterm outcomes of thoracic endovascular aortic repair versus optimal medical therapy for uncomplicated acute type B dissection. JTCVS Open 2025, 24: 67-76. PMID: 40309678, PMCID: PMC12039393, DOI: 10.1016/j.xjon.2024.12.013.Peer-Reviewed Original ResearchCitationsAltmetricConceptsThoracic endovascular aortic repairThoracic endovascular aortic repair groupOptimal medical therapyOptimal medical therapy groupMidterm outcomes of thoracic endovascular aortic repairOutcomes of thoracic endovascular aortic repairUncomplicated acute type B aortic dissectionEndovascular aortic repairAcute kidney injuryAortic repairMidterm outcomesMedical therapyUncomplicated acute type B dissectionAcute type B aortic dissectionAcute type B dissectionAssociated with improved survivalType B aortic dissectionThirty-day ratesType B dissectionB aortic dissectionPost-operative dataMidterm follow-upIn-hospital/30-day mortalityKaplan-Meier survivalB dissection
2024
Efficacy of beta blockers in patients with thoracic aortic aneurysm: meta-analysis of randomized controlled trials
Tanriverdi L, Barrett A, Kalyanasundaram A, Zafar M, Ziganshin B, Elefteriades J. Efficacy of beta blockers in patients with thoracic aortic aneurysm: meta-analysis of randomized controlled trials. European Heart Journal 2024, 45: ehae666.2256. DOI: 10.1093/eurheartj/ehae666.2256.Peer-Reviewed Original ResearchConceptsThoracic aortic aneurysmRandomized Controlled TrialsPooled risk ratioB-blockersAortic aneurysmAortic dissectionControlled TrialsAortic eventsRisk ratioPrimary outcomePooled risk estimatesRisk of aortic dissectionRisk of bias assessmentNo treatmentMeta-analysis of randomized controlled trialsInverse variance-weighted random-effects modelMeta-analysisLiterature searchB-blocker treatmentSystematic review protocolInternational Prospective RegisterCochrane Central Register of Controlled TrialsEfficacy of beta blockersCentral Register of Controlled TrialsSummary effect measuresGenetics of aortic aneurysm disease: 10 key points for the practitioner
Elefteriades J, Zafar M, Ziganshin B. Genetics of aortic aneurysm disease: 10 key points for the practitioner. JTCVS Open 2024, 21: 58-63. PMID: 39534337, PMCID: PMC11551243, DOI: 10.1016/j.xjon.2024.07.014.Peer-Reviewed Original ResearchCitationsSomatic Variants Acquired Later in Life Associated with Thoracic Aortic Aneurysms: JAK2 V617F
Waldron C, Zafar M, Ma D, Zhang H, Dykas D, Ziganshin B, Popa A, Jha A, Kwan J, Elefteriades J. Somatic Variants Acquired Later in Life Associated with Thoracic Aortic Aneurysms: JAK2 V617F. Genes 2024, 15: 883. PMID: 39062663, PMCID: PMC11276600, DOI: 10.3390/genes15070883.Peer-Reviewed Original ResearchCitationsConceptsThoracic aortic aneurysmDevelopment of thoracic aortic aneurysmAortic aneurysmJAK2 V617FMyeloproliferative neoplasmsSomatic variantsPrevalence of thoracic aortic aneurysmsDescending thoracic aortic aneurysmJAK2 V617F burdenAortic valve diseaseTarget of therapyDriver of myeloproliferative neoplasmsSurgical aortic replacementVariant allele fractionAscending thoracic aortic aneurysmAortic replacementAneurysm sizeAneurysm patientsValve diseaseVariant carriersIncreased riskJAK2 geneExome sequencing databaseAllele fractionAneurysmPilot study exploring artificial intelligence for facial-image-based diagnosis of Marfan syndrome
Saksenberg D, Mukherjee S, Zafar M, Ziganshin B, Elefteriades J. Pilot study exploring artificial intelligence for facial-image-based diagnosis of Marfan syndrome. Heliyon 2024, 10: e33858. PMID: 39055814, PMCID: PMC11269824, DOI: 10.1016/j.heliyon.2024.e33858.Peer-Reviewed Original ResearchCitationsAltmetricConceptsConvolutional neural networkFacial imagesArtificial intelligenceF1 scoreNeural networkUtilization of convolutional neural networksAccuracy of neural networksPotential of artificial intelligenceTest setMarfan syndromeFacial featuresIntelligenceOverall accuracyNetworkAccuracyDiagnosis of Marfan syndromeImagesROC curveDegree of accuracyArea under the ROC curveMarfan's diseaseClinical recognitionPilot studyThoracic aortaMarfan
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