Mark Solomon, PhD
Professor of Molecular Biophysics and BiochemistryDownloadHi-Res Photo
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Molecular Biophysics and Biochemistry
PO Box 208114, 266 Whitney Avenue
New Haven, CT 06520-8114
United States
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Professor of Molecular Biophysics and Biochemistry
Appointments
Molecular Biophysics and Biochemistry
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Education & Training
- Postdoctoral Fellow
- University of California, San Francisco, CA (1991)
- PhD
- Massachusetts Institute of Technology (1986)
- BA
- Princeton University, Biochemistry (1981)
Research
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Overview
Medical Research Interests
Cell Cycle; Cell Division; Cell Nucleus Division; Genetics; Molecular Biology; Saccharomyces cerevisiae
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Solomon Lab
Research at a Glance
Publications Timeline
A big-picture view of Mark Solomon's research output by year.
Research Interests
Research topics Mark Solomon is interested in exploring.
28Publications
4,354Citations
Cell Cycle
Saccharomyces cerevisiae
Publications
2007
Identification of Yeast IQGAP (Iqg1p) as an Anaphase-Promoting-Complex Substrate and Its Role in Actomyosin-Ring-Independent Cytokinesis
Ko N, Nishihama R, Tully GH, Ostapenko D, Solomon MJ, Morgan DO, Pringle JR. Identification of Yeast IQGAP (Iqg1p) as an Anaphase-Promoting-Complex Substrate and Its Role in Actomyosin-Ring-Independent Cytokinesis. Molecular Biology Of The Cell 2007, 18: 5139-5153. PMID: 17942599, PMCID: PMC2096582, DOI: 10.1091/mbc.e07-05-0509.Peer-Reviewed Original ResearchCitationsMeSH Keywords and ConceptsMeSH KeywordsActomyosinAmino Acid MotifsAnaphase-Promoting Complex-CyclosomeCytokinesisGene Expression Regulation, FungalMicrotubule-Associated ProteinsMutationMyosin Heavy ChainsPhenotypeProtein Bindingras GTPase-Activating ProteinsSaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsSubstrate SpecificityUbiquitinUbiquitin-Protein Ligase ComplexesConceptsActomyosin ringAPC/C mutantsAPC/C functionSeptin-dependent mannerAnaphase-promoting complexYeast Saccharomyces cerevisiaeOnset of cytokinesisDeletion of genesBud neckMitotic exitAPC/Mitotic cyclinsSaccharomyces cerevisiaeSeptum formationIqg1pCytokinesisNovel recognition sequenceC mutantsNonessential componentsSame phenotypeRecognition sequenceLate G1Rich mediumStrain backgroundComplex substratesMethods in cell cycle research
Solomon M, Cohen-Fix O. Methods in cell cycle research. Methods 2007, 41: 141-142. PMID: 17189855, DOI: 10.1016/j.ymeth.2006.07.021.Peer-Reviewed Original Research
2002
The anaphase-promoting complex: it's not just for mitosis any more
Harper J, Burton J, Solomon M. The anaphase-promoting complex: it's not just for mitosis any more. Genes & Development 2002, 16: 2179-2206. PMID: 12208841, DOI: 10.1101/gad.1013102.Peer-Reviewed Original ResearchCitationsAltmetricMeSH KeywordsAnaphase-Promoting Complex-CyclosomeAnimalsCdc20 ProteinsCdh1 ProteinsCell CycleCell Cycle ProteinsCyclin-Dependent KinasesHumansLigasesMitosisModels, BiologicalModels, MolecularPeptide SynthasesPhosphorylationProteinsSaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsSchizosaccharomycesSKP Cullin F-Box Protein LigasesUbiquitinUbiquitin-Protein Ligase Complexes
2001
CAK-independent Activation of CDK6 by a Viral Cyclin
Kaldis P, Ojala P, Tong L, Mäkelä T, Solomon M. CAK-independent Activation of CDK6 by a Viral Cyclin. Molecular Biology Of The Cell 2001, 12: 3987-3999. PMID: 11739795, PMCID: PMC60770, DOI: 10.1091/mbc.12.12.3987.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsMeSH KeywordsApoptosisCyclin-Dependent Kinase 6Cyclin-Dependent Kinase Inhibitor p16Cyclin-Dependent Kinase-Activating KinaseCyclin-Dependent KinasesCyclinsEnzyme ActivationFluorescent Antibody TechniqueHerpesvirus 8, HumanHumansPhosphorylationProtein ConformationProtein Serine-Threonine KinasesTumor Cells, CulturedViral ProteinsConceptsKSHV-cyclinSarcoma-associated herpesvirusKaposi's sarcoma-associated herpesvirusCell cycle progression independentAbsence of phosphorylationCyclin-dependent kinasesD-type cyclinsCAK phosphorylationExpression of CDK6CDK6 activationMitogenic signalsSubstrate specificityCell-based assaysCDK inhibitorsViral cyclinConformational changesCell deathPhosphorylationCAKCDK inhibitionKinaseCyclinCDK6Ternary complexNormal cellsThe role of Thr160 phosphorylation of Cdk2 in substrate recognition
Holmes J, Solomon M. The role of Thr160 phosphorylation of Cdk2 in substrate recognition. The FEBS Journal 2001, 268: 4647-4653. PMID: 11532001, DOI: 10.1046/j.1432-1327.2001.02392.x.Peer-Reviewed Original ResearchCitations
2000
Dephosphorylation of Human Cyclin-dependent Kinases by Protein Phosphatase Type 2Cα and β2 Isoforms*
Cheng A, Kaldis P, Solomon M. Dephosphorylation of Human Cyclin-dependent Kinases by Protein Phosphatase Type 2Cα and β2 Isoforms*. Journal Of Biological Chemistry 2000, 275: 34744-34749. PMID: 10934208, DOI: 10.1074/jbc.m006210200.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsMeSH KeywordsAmino Acid SequenceAnimalsChromatography, Ion ExchangeCyclin-Dependent KinasesCyclinsHeLa CellsHumansIsoenzymesMiceMolecular Sequence DataPhosphoprotein PhosphatasesPhosphorylationProtein Phosphatase 2Protein Phosphatase 2CRatsSaccharomyces cerevisiae ProteinsSequence Homology, Amino AcidSubstrate SpecificityConceptsHeLa cell extractsCyclin-dependent kinasesPP2C alphaType 2C protein phosphatasesHuman cyclin-dependent kinaseCell extractsBeta 2 isoformBinding of cyclinsDephosphorylation of cdk2Mono Q chromatographyBeta 2 proteinProtein phosphataseThreonine residuesSubstrate preferenceBeta 2Beta isoformsΒ2 isoformPhosphatase activityIsoformsDephosphorylationDEAE-SepharoseSuperdex 200KinasePhosphorylationCDK6Kinetic Analysis of the Cyclin-dependent Kinase-activating Kinase (Cak1p) from Budding Yeast*
Enke D, Kaldis P, Solomon M. Kinetic Analysis of the Cyclin-dependent Kinase-activating Kinase (Cak1p) from Budding Yeast*. Journal Of Biological Chemistry 2000, 275: 33267-33271. PMID: 10934199, DOI: 10.1074/jbc.m004748200.Peer-Reviewed Original ResearchCitationsThe Effects of Changing the Site of Activating Phosphorylation in CDK2 from Threonine to Serine*
Kaldis P, Cheng A, Solomon M. The Effects of Changing the Site of Activating Phosphorylation in CDK2 from Threonine to Serine*. Journal Of Biological Chemistry 2000, 275: 32578-32584. PMID: 10931829, DOI: 10.1074/jbc.m003212200.Peer-Reviewed Original ResearchCitationsMeSH Keywords and ConceptsMeSH KeywordsAmino Acid SubstitutionCDC2-CDC28 KinasesCyclin-Dependent Kinase 2Cyclin-Dependent Kinase-Activating KinaseCyclin-Dependent KinasesHumansKineticsMutagenesis, Site-DirectedPhosphorylationProtein Serine-Threonine KinasesRecombinant Fusion ProteinsRecombinant ProteinsSerineSubstrate SpecificityThreonineConceptsWild-type Cdk2Cyclin-dependent kinasesThreonine residuesRNA polymerase IIDegradation of cyclinsHeLa cell extractsCell cycle progressionEssential phosphorylationHuman CDK2Efficient phosphorylationActivating PhosphorylationPolymerase IICyclin HTerminal domainHistone H1Cycle progressionCell extractsPhosphorylationCyclinCDK2General defectCAKKinaseSerineThreonineHsl1p, a Swe1p Inhibitor, Is Degraded via the Anaphase-Promoting Complex
Burton J, Solomon M. Hsl1p, a Swe1p Inhibitor, Is Degraded via the Anaphase-Promoting Complex. Molecular And Cellular Biology 2000, 20: 4614-4625. PMID: 10848588, PMCID: PMC85864, DOI: 10.1128/mcb.20.13.4614-4625.2000.Peer-Reviewed Original ResearchCitationsMeSH Keywords and ConceptsMeSH KeywordsAmino Acid MotifsAnaphase-Promoting Complex-CyclosomeApc8 Subunit, Anaphase-Promoting Complex-CyclosomeBase SequenceCdc20 ProteinsCdh1 ProteinsCell CycleCell Cycle ProteinsCyclin-Dependent KinasesFungal ProteinsGenes, DominantLigasesMolecular Sequence DataMutationPrecipitin TestsProtein KinasesProtein Serine-Threonine KinasesProtein-Tyrosine KinasesSaccharomyces cerevisiae ProteinsTwo-Hybrid System TechniquesUbiquitin-Protein Ligase ComplexesUbiquitin-Protein LigasesYeastsConceptsAnaphase-promoting complexDestruction box motifCell cycle eventsProtein kinaseBox motifCycle eventsCyclin-dependent kinase Cdc28pCritical cell cycle regulatorsAPC-dependent mannerCell cycle regulatorsSwe1p degradationMorphogenesis checkpointAPC substratesHsl1pLate mitosisProper progressionProtein substratesUbiquitin ligaseCoimmunoprecipitation studiesSequence homologyCycle regulatorsUbiquitinationSubsequent degradationKinaseCdc20pAnalysis of CAK activities from human cells
Kaldis P, Solomon M. Analysis of CAK activities from human cells. The FEBS Journal 2000, 267: 4213-4221. PMID: 10866826, DOI: 10.1046/j.1432-1327.2000.01455.x.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsCDK-Activating KinaseCAK activityHuman cellsTranscription factor IIHRNA polymerase IICyclin-dependent kinasesCell cycle progressionPolymerase IIThreonine residuesLarge subunitCyclin HTerminal domainSubstrate specificityCak1pKinase activityMonomeric enzymeMO15HeLa cellsATP analogKinaseSubunits
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Molecular Biophysics and Biochemistry
PO Box 208114, 266 Whitney Avenue
New Haven, CT 06520-8114
United States