Krista Fowles
Research Associate PET CenterDownloadHi-Res Photo
Cards
Contact Info
About
Copy Link
Titles
Research Associate PET Center
Research
Copy Link
Research at a Glance
Yale Co-Authors
Frequent collaborators of Krista Fowles's published research.
Publications Timeline
A big-picture view of Krista Fowles's research output by year.
Richard Carson, PhD
Daniel Holden
Nabeel Nabulsi, PhD
Jean-Dominique Gallezot, PhD
John Seibyl, MD
Irina Esterlis, PhD
28Publications
582Citations
Publications
2025
In Vivo PET Imaging of Preynaptic Density Reveals Stress-Associated Synaptic Deficits Related to Behavioral and Molecular Alterations in Rats
Asch R, Martin N, Garcia-Milian R, Fowles K, DiLeone R, Cai Z, Liston C, Esterlis I. In Vivo PET Imaging of Preynaptic Density Reveals Stress-Associated Synaptic Deficits Related to Behavioral and Molecular Alterations in Rats. Biological Psychiatry Cognitive Neuroscience And Neuroimaging 2025 PMID: 41038318, PMCID: PMC12614775, DOI: 10.1016/j.bpsc.2025.09.021.Peer-Reviewed Original ResearchConceptsNovel object recognitionPrefrontal cortexPositron emission tomographySucrose preferenceSynaptic densityChronic stressExposed to chronic unpredictable stressIn vivo PET imagingRodent models of chronic stressModel of chronic stressFemale Long-Evans ratsChronic unpredictable stressIn vivo positron emission tomographyStress-related pathologiesLong-Evans ratsRodent modelsRats relative to controlsIn vivo quantificationRelative to controlsUnpredictable stressBehavioral phenotypesSynaptic deficitsHippocampal proteinsSynaptic density changesSynaptic vesicle protein 2AToward Imaging of the GABA Transporter Type 1 In Vivo: Quantitative Evaluation of 4 Novel PET Radiotracers in Nonhuman Primates
Gravel P, Gu J, Wang C, Volpi T, Gallezot J, Holden D, Fowles K, Zheng M, Zhang L, Borroni E, Honer M, Gobbi L, Tamagnan G, Huang Y, Carson R. Toward Imaging of the GABA Transporter Type 1 In Vivo: Quantitative Evaluation of 4 Novel PET Radiotracers in Nonhuman Primates. Journal Of Nuclear Medicine 2025, 66: 1652-1658. PMID: 40908122, PMCID: PMC12487869, DOI: 10.2967/jnumed.125.270332.Peer-Reviewed Original ResearchAltmetricConceptsGABA transporter type 1Nonhuman primatesGAT-1Brain uptakeNondisplaceable binding potentialSubcortical gray matter regionsHuman studiesG-aminobutyric acidLow brain uptakeGray matter structuresLow specific bindingConclusion:Methods:Gray matter regionsType 1Results:Neuropsychiatric disordersPET radiotracersBinding potentialGABA signalingVolume of distributionMatter structuresRhesus monkeysBlock scanningGABA receptorsPET Imaging of Sphingosine-1-Phosphate Receptor 1 with [18F]TZ4877 in Nonhuman Primates
Gu J, Zheng M, Holden D, Fowles K, Qiu L, Felchner Z, Zhang L, Ropchan J, Gropler R, Carson R, Tu Z, Huang Y, Hillmer A. PET Imaging of Sphingosine-1-Phosphate Receptor 1 with [18F]TZ4877 in Nonhuman Primates. Molecular Imaging And Biology 2025, 27: 54-63. PMID: 39779653, PMCID: PMC12207061, DOI: 10.1007/s11307-024-01979-x.Peer-Reviewed Original ResearchCitationsMeSH Keywords and ConceptsConceptsSphingosine-1-phosphate receptor 1Absorbed radiation dose estimatesReceptor 1Nonhuman primatesFree fractionPlasma free fractionRadiation dose estimatesMetabolite-corrected input functionF-18 labeled radiotracersArterial blood samplesCritical organsPET/CT systemBolus injectionF-18Anesthetized nonhuman primatesDosimetry studiesHuman studiesDose estimatesVT/fPPET imaging dataS1PR1PET imagingInput functionBlood samplesPonesimod
2024
Pilot PET study of vaginally administered bioadhesive nanoparticles in cynomolgus monkeys: Kinetics and safety evaluation
Grun M, Honhar P, Wang Y, Rossano S, Khang M, Suh H, Fowles K, Kliman H, Cavaliere A, Carson R, Marquez‐Nostra B, Saltzman W. Pilot PET study of vaginally administered bioadhesive nanoparticles in cynomolgus monkeys: Kinetics and safety evaluation. Bioengineering & Translational Medicine 2024, 9: e10661. PMID: 39553429, PMCID: PMC11561825, DOI: 10.1002/btm2.10661.Peer-Reviewed Original ResearchCitationsAltmetricConceptsVaginal dosage formsBioadhesive nanoparticlesCynomolgus monkeysAnalysis of inflammatory biomarkersVaginal microbicidesVaginal canalMultiple dosesInflammatory biomarkersTherapeutic efficacyVaginal fluidSystemic circulationLong-term deliveryNoninvasive imagingClinical translationDosage formsNon-human primatesDelivery vehiclesMonkeysDeliveryVaginitisUterusMicrobicidesSafety evaluationBiodistributionDose
2023
Preclinical evaluation of a brain penetrant PARP PET imaging probe in rat glioblastoma and nonhuman primates
Chen B, Ojha D, Toyonaga T, Tong J, Pracitto R, Thomas M, Liu M, Kapinos M, Zhang L, Zheng M, Holden D, Fowles K, Ropchan J, Nabulsi N, De Feyter H, Carson R, Huang Y, Cai Z. Preclinical evaluation of a brain penetrant PARP PET imaging probe in rat glioblastoma and nonhuman primates. European Journal Of Nuclear Medicine And Molecular Imaging 2023, 50: 2081-2099. PMID: 36849748, DOI: 10.1007/s00259-023-06162-y.Peer-Reviewed Original ResearchCitationsMeSH Keywords and ConceptsConceptsPositron emission tomographyHealthy nonhuman primatesVolume of distributionDistribution volume ratioBrain kineticsRat glioblastoma modelPreclinical evaluationBrain regionsGlioblastoma modelPET tracersNonhuman primatesTumor-bearing ratsEx vivo biodistributionPET imaging resultsActive clinical trialsTreatment of glioblastomaHigh specific uptakeDynamic PET scansNoninvasive quantificationBrain positron emission tomographyNondisplaceable volumeBrain penetrationLow nonspecific uptakePrognostic informationClinical trialsExamining mGlu5 Receptor Availability as a Predictor of Vulnerability to PTSD: An [18F]FPEB and PET Study in Male and Female Rats
Asch R, Fowles K, Pietrzak R, Taylor J, Esterlis I. Examining mGlu5 Receptor Availability as a Predictor of Vulnerability to PTSD: An [18F]FPEB and PET Study in Male and Female Rats. Chronic Stress 2023, 7: 24705470231215001. PMID: 38024327, PMCID: PMC10666551, DOI: 10.1177/24705470231215001.Peer-Reviewed Original ResearchCitationsConceptsPost-traumatic stress disorderReceptor availabilityFemale ratsPathophysiology of PTSDFootshock exposureMetabotropic glutamate receptor 5Recent preclinical findingsGlutamate receptor 5Positron emission tomographyPreclinical findingsClinical findingsFe ratsReceptor 5Lower baselineEmission tomographyGreater riskPET studiesRatsStress disorderDifferential involvementPassive copingSex differencesMalesPTSD susceptibilityBaseline
2022
Examining sex differences in responses to footshock stress and the role of the metabotropic glutamate receptor 5: an [18F]FPEB and positron emission tomography study in rats
Asch RH, Pothula S, Toyonaga T, Fowles K, Groman SM, Garcia-Milian R, DiLeone RJ, Taylor JR, Esterlis I. Examining sex differences in responses to footshock stress and the role of the metabotropic glutamate receptor 5: an [18F]FPEB and positron emission tomography study in rats. Neuropsychopharmacology 2022, 48: 489-497. PMID: 36100654, PMCID: PMC9852230, DOI: 10.1038/s41386-022-01441-y.Peer-Reviewed Original ResearchCitationsImaging the fetal nonhuman primate brain with SV2A positron emission tomography (PET)
Rossano S, Toyonaga T, Berg E, Lorence I, Fowles K, Nabulsi N, Ropchan J, Li S, Ye Y, Felchner Z, Kukis D, Huang Y, Benveniste H, Tarantal AF, Groman S, Carson RE. Imaging the fetal nonhuman primate brain with SV2A positron emission tomography (PET). European Journal Of Nuclear Medicine And Molecular Imaging 2022, 49: 3679-3691. PMID: 35633376, PMCID: PMC9826644, DOI: 10.1007/s00259-022-05825-6.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsPositron emission tomographySynaptic densityFetal brainThird trimesterEmission tomographyBrain developmentGravid rhesus monkeysPost-mortem brain tissueEarly neonatal periodNonhuman primate brainLate gestational periodSubset of subjectsPostnatal brain developmentPost-mortem samplesGestational ageNeonatal periodPregnant monkeysSynapse numberGestational periodPrimary motorPrimate brainBrain growthSubcortical regionsBrain tissueCortical regionsImaging the effect of ketamine on synaptic density (SV2A) in the living brain
Holmes SE, Finnema SJ, Naganawa M, DellaGioia N, Holden D, Fowles K, Davis M, Ropchan J, Emory P, Ye Y, Nabulsi N, Matuskey D, Angarita GA, Pietrzak RH, Duman RS, Sanacora G, Krystal JH, Carson RE, Esterlis I. Imaging the effect of ketamine on synaptic density (SV2A) in the living brain. Molecular Psychiatry 2022, 27: 2273-2281. PMID: 35165397, PMCID: PMC9133063, DOI: 10.1038/s41380-022-01465-2.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsKetamine's therapeutic effectsMajor depressive disorderTherapeutic effectPositron emission tomographyPosttraumatic stress disorderHealthy controlsSynaptic connectionsSynaptic vesicle protein 2APost-synaptic mechanismsEffects of ketamineDiscovery of ketamineNon-human primatesAntidepressant effectsDepressive disorderSingle administrationSynaptic densityPsychiatric disordersDepression severityKetamineEmission tomographyTerminal densityLiving brainStress disorderRobust reductionDissociative symptomsTranslational PET Imaging of Spinal Cord Injury with the Serotonin Transporter Tracer [11C]AFM
Fang H, Rossano S, Wang X, Nabulsi N, Kelley B, Fowles K, Ropchan J, Strittmatter SM, Carson RE, Huang Y. Translational PET Imaging of Spinal Cord Injury with the Serotonin Transporter Tracer [11C]AFM. Molecular Imaging And Biology 2022, 24: 560-569. PMID: 35020138, PMCID: PMC9550197, DOI: 10.1007/s11307-021-01698-7.Peer-Reviewed Original ResearchCitationsMeSH Keywords and ConceptsConceptsSpinal cord injurySpinal cordHealthy ratsHuman spinal cordCord injurySerotonin transporterRat modelRodent modelsPET imagingTranslational PET imagingSCI rat modelIntact spinal cordSpinal cord caudalRodent spinal cordSerotonin transporter tracerUse of PETCervical uptakeSERT changesSCI animalsSCI patientsPresynaptic serotonin transporterCord caudalAxon damageSerotonin systemSERT radioligand
Get In Touch
Copy Link