Kenji Ota, MD, PhD
Associate Research ScientistDownloadHi-Res Photo
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Associate Research Scientist
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Immunobiology
Associate Research ScientistPrimary
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- Immunobiology
Education & Training
- PhD
- Nagasaki University, Biomedical Science (2021)
- MD
- Kyushu University (2012)
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Overview
Public Health Interests
Biomarkers; COVID-19; Emerging Infectious Diseases; Immunology; Infectious Diseases; Microbiome; Respiratory Disease/Infections
ORCID
0000-0001-7180-0820- View Lab Website
Iwasaki
Research at a Glance
Publications Timeline
A big-picture view of Kenji Ota's research output by year.
35Publications
235Citations
Publications
Featured Publications
Rapid increase in salivary IgA and broad recognition of spike protein following SARS-CoV-2 vaccination
Ota K, Sakai H, Sasaki D, Mitsumoto-Kaseida F, Sakamoto K, Kosai K, Hasegawa H, Takazono T, Izumikawa K, Mukae H, Tun M, Morita K, Yanagihara K. Rapid increase in salivary IgA and broad recognition of spike protein following SARS-CoV-2 vaccination. Virus Research 2023, 339: 199294. PMID: 38056502, PMCID: PMC10749273, DOI: 10.1016/j.virusres.2023.199294.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsSARS-CoV-2 vaccinesSARS-CoV-2Immune response to severe acute respiratory syndrome coronavirus 2Response to severe acute respiratory syndrome coronavirus 2Recognition antigenMucosal immune responsesMucosal immune systemFunction of IgAS1 proteinOral cavitySevere acute respiratory syndrome coronavirus 2Acute respiratory syndrome coronavirus 2IgA responsesMucosal immunityRespiratory syndrome coronavirus 2Vaccine doseImmune responseSalivary IgAViral infectionIgG antibodiesImmune systemSyndrome coronavirus 2IgAImmunoglobulin GSaliva samplesThe evaluation of a rapid microfluidic immunofluorescence antigen test in detecting the infectiousness of COVID-19 patients
Ota K, Kodama H, Kawamoto Y, Sasaki D, Mitsumoto-Kaseida F, Sakamoto K, Kosai K, Hasegawa H, Takazono T, Izumikawa K, Mukae H, Tun M, Morita K, Yanagihara K. The evaluation of a rapid microfluidic immunofluorescence antigen test in detecting the infectiousness of COVID-19 patients. BMC Infectious Diseases 2023, 23: 823. PMID: 37996783, PMCID: PMC10668452, DOI: 10.1186/s12879-023-08821-9.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsNegative predictive valueVirus cultureAg testTest-based strategyAntigen testPredictive valuePositive predictive valueOnset of symptomsMild COVID-19Quantitative RT-PCR testsPrevention of infectionFalse negative resultsNasopharyngeal swab samplesCOVID-19 patientsLateral flow antigen testsQuantitative RT-PCRRT-PCR testPatientsImmunofluorescence methodMethodsThis studyRT-PCRSwab samplesNegative resultsCOVID-19 infectiousnessInfectionSerological response to a third dose of SARS-CoV-2 vaccine according to previous infection history
Ota K, Murakami S, Ishihara K, Sasaki D, Usui T, Mitsumoto-Kaseida F, Sakamoto K, Kosai K, Hasegawa H, Takazono T, Furumoto A, Asoh N, Yoshimine H, Sawai T, Onizuka M, Makimoto N, Izumikawa K, Mukae H, Kohno S, Yanagihara K. Serological response to a third dose of SARS-CoV-2 vaccine according to previous infection history. Vaccine X 2023, 13: 100282. PMID: 36960104, PMCID: PMC10022459, DOI: 10.1016/j.jvacx.2023.100282.Peer-Reviewed Original ResearchAltmetricPerformance of the GeneSoC Rapid PCR System in Detection of SARS-CoV-2 from Saliva Specimens
Ota K, Kurahara R, Tsukamoto C, Kawamoto Y, Akamatsu N, Sasaki D, Mitsumoto-Kaseida F, Sakamoto K, Kosai K, Hasegawa H, Yamamoto K, Izumikawa K, Mukae H, Yanagihara K. Performance of the GeneSoC Rapid PCR System in Detection of SARS-CoV-2 from Saliva Specimens. Microbiology Spectrum 2023, 11: e03259-22. PMID: 36779750, PMCID: PMC10101093, DOI: 10.1128/spectrum.03259-22.Peer-Reviewed Original ResearchCitationsDetection of SARS-CoV-2 using qRT-PCR in saliva obtained from asymptomatic or mild COVID-19 patients, comparative analysis with matched nasopharyngeal samples
Ota K, Yanagihara K, Sasaki D, Kaku N, Uno N, Sakamoto K, Kosai K, Miyazaki T, Hasegawa H, Fujita A, Tashiro M, Tanaka T, Izumikawa K, Ariyoshi K, Mukae H, Yasuda J, Morita K, Kohno S. Detection of SARS-CoV-2 using qRT-PCR in saliva obtained from asymptomatic or mild COVID-19 patients, comparative analysis with matched nasopharyngeal samples. PLOS ONE 2021, 16: e0252964. PMID: 34111203, PMCID: PMC8191987, DOI: 10.1371/journal.pone.0252964.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsNasopharyngeal swabsSaliva specimensSARS-CoV-2Mild COVID-19 patientsLate phaseViral load detectionDiagnosis of coronavirus diseasePhase of infectionCOVID-19 patientsQuantitative RT-PCRAcute respiratory syndrome-coronavirus-2Severe acute respiratory syndrome-coronavirus-2Late phase of infectionMild patientsNasopharyngeal samplesSwabsRT-PCRDetection of SARS-CoV-2SARS-CoV-2 detectionSalivaPositive rateViral copiesPatientsDiagnosisCoronavirus diseaseEfficacy of meropenem and amikacin combination therapy against carbapenemase-producing Klebsiella pneumoniae mouse model of pneumonia
Ota K, Kaku N, Yanagihara K. Efficacy of meropenem and amikacin combination therapy against carbapenemase-producing Klebsiella pneumoniae mouse model of pneumonia. Journal Of Infection And Chemotherapy 2020, 26: 1237-1243. PMID: 32868198, DOI: 10.1016/j.jiac.2020.07.002.Peer-Reviewed Original ResearchCitationsMeSH Keywords and ConceptsConceptsCarbapenem-resistant Klebsiella pneumoniaeCarbapenem-resistant EnterobacteriaceaeBroncho-alveolar lavage fluidAmikacin combination therapyEfficacy of meropenemCombination therapyMouse modelNeutrophil countCarbapenem-resistant Klebsiella pneumoniae clinical isolatesCRKP pneumoniaSpread of carbapenem-resistant EnterobacteriaceaeCombination therapy of meropenemMouse model of pneumoniaProgression of lung inflammationCombination antimicrobial therapyCombination therapy groupLimited treatment optionsAlveolar neutrophil infiltrationModel of pneumoniaTrachea of BALB/c miceGlobal health problemAntimicrobial therapyClinical isolatesLung inflammationUntreated control group
2025
Efficacy of Lactococcus lactis Strain Plasma in Patients with Mild COVID-19: A Multicenter, Double-Blinded, Randomized-Controlled Trial (PLATEAU Study)
Yamamoto K, Inoue T, Ikeda T, Sawai T, Nagayoshi Y, Hashiguchi K, Futsuki Y, Matsubara Y, Harada Y, Ashizawa N, Fukahori S, Iwanaga N, Takazono T, Kido T, Ishimoto H, Hosogaya N, Sakamoto N, Tashiro M, Tanaka T, Fukushima C, Jounai K, Tsuji R, Fujiwara D, Ota K, Kosai K, Furumoto A, Yanagihara K, Izumikawa K, Mukae H. Efficacy of Lactococcus lactis Strain Plasma in Patients with Mild COVID-19: A Multicenter, Double-Blinded, Randomized-Controlled Trial (PLATEAU Study). Infectious Diseases And Therapy 2025, 14: 2835-2851. PMID: 41138036, PMCID: PMC12602773, DOI: 10.1007/s40121-025-01246-8.Peer-Reviewed Original ResearchAltmetricConceptsPlasmacytoid dendritic cellsLC-Plasma groupSARS-CoV-2 viral loadMild COVID-19Viral loadLC-PlasmaPrimary endpointSARS-CoV-2Lactococcus lactis strain PlasmaHuman plasmacytoid dendritic cellsResultsThe primary endpointMild adverse eventsProportion of patientsCough-variant asthmaStrain plasmaAntiviral immune responseRandomized-controlled trialsDouble-blindPlacebo groupTaste disturbanceSecondary endpointsDendritic cellsBetween-group differencesTaste disordersAdverse eventsP-311. Shifts in Methicillin-Resistant Staphylococcus aureus Types in Bloodstream Infections: Nationwide and Regional Influences and Their Impact on Mortality
Kaku N, Ishige M, Yasutake G, Sasaki D, Ota K, Mitsumoto-Kaseida F, Kosai K, Hasegawa H, Izumikawa K, Mukae H, Yanagihara K. P-311. Shifts in Methicillin-Resistant Staphylococcus aureus Types in Bloodstream Infections: Nationwide and Regional Influences and Their Impact on Mortality. Open Forum Infectious Diseases 2025, 12: ofae631.514. PMCID: PMC11777953, DOI: 10.1093/ofid/ofae631.514.Peer-Reviewed Original ResearchConceptsMethicillin-resistant Staphylococcus aureus typesMethicillin-resistant Staphylococcus aureusST8-IVBloodstream infectionsIn-Hospital MortalityNew York/Japan cloneSCCmec type IISCCmec type IVWhole-genome sequencingCore genome MLSTSOFA scorePatient backgroundDevice-related bloodstream infectionsCore genomeSpa typesPhylogenetic featuresVirulence genesYork/Japan cloneST5-IIMRSA strainsPhylogenetic analysisType IVSequence typingSCCmecPredominant STClinical Evaluation of a Rapid Reciprocal-Flow PCR Assay and Real-Time PCR Assay with Quenching Probe for Detection of Mycobacterium tuberculosis Complex
Kosai K, Matsumoto K, Ishikawa T, Kawamoto Y, Akamatsu N, Ota K, Mitsumoto-Kaseida F, Kaku N, Hasegawa H, Izumikawa K, Mukae H, Yanagihara K. Clinical Evaluation of a Rapid Reciprocal-Flow PCR Assay and Real-Time PCR Assay with Quenching Probe for Detection of Mycobacterium tuberculosis Complex. Microorganisms 2025, 13: 201. PMID: 39858969, PMCID: PMC11767626, DOI: 10.3390/microorganisms13010201.Peer-Reviewed Original ResearchConceptsPCR assayCobas TaqMan MTB assayDetection of Mycobacterium tuberculosis complexIndependent assaysReal-time PCR assayMycobacterium tuberculosis complexAssay of multiple samplesReal-time PCRTuberculosis complexNegative percent agreementQuenching probeClinical samplesGENECUBEAssayClinical evaluationMultiple samplesDiagnostic efficiencyPercent agreementPositive samplesIndividual samplesSpecimen typesLong-term impact of molecular epidemiology shifts of methicillin-resistant Staphylococcus aureus on severity and mortality of bloodstream infection
Kaku N, Ishige M, Yasutake G, Sasaki D, Ota K, Mitsumoto-Kaseida F, Kosai K, Hasegawa H, Izumikawa K, Mukae H, Yanagihara K. Long-term impact of molecular epidemiology shifts of methicillin-resistant Staphylococcus aureus on severity and mortality of bloodstream infection. Emerging Microbes & Infections 2025, 14: 2449085. PMID: 39789882, PMCID: PMC11727054, DOI: 10.1080/22221751.2024.2449085.Peer-Reviewed Original ResearchCitationsMeSH Keywords and ConceptsConceptsMethicillin-resistant Staphylococcus aureusST8-MRSA-IVMethicillin-resistant Staphylococcus aureus typesSequential Organ Failure AssessmentBloodstream infectionsLong-term single-center studyPatient characteristicsSequence typingMortality of bloodstream infectionsST5-MRSA-IIDrug resistance patternsSingle-center studyOrgan Failure AssessmentNagasaki University HospitalIn-Hospital MortalityResults of molecular analysisCA-MRSA/JMRSA strainsBlood culturesPatient demographicsPhylogenetic featuresResistance patternsFailure AssessmentNationwide surveillanceUniversity Hospital
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