Joseph D. Deak, PhD
Assistant Professor of PsychiatryCards
About
Research
Publications
2025
Alcohol use and risk of dementia in diverse populations: evidence from cohort, case–control and Mendelian randomisation approaches
Topiwala A, Levey D, Zhou H, Deak J, Adhikari K, Ebmeier K, Bell S, Burgess S, Nichols T, Gaziano M, Stein M, Gelernter J. Alcohol use and risk of dementia in diverse populations: evidence from cohort, case–control and Mendelian randomisation approaches. BMJ Evidence-Based Medicine 2025, bmjebm-2025-113913. PMID: 40987604, DOI: 10.1136/bmjebm-2025-113913.Peer-Reviewed Original ResearchGenome-wide association studiesDementia riskAlcohol use disorderAlcohol consumptionGenome-wide association study consortiaIncident all-cause dementiaAlcohol intakeAll-cause dementiaAlcohol usePrevalence of alcohol use disordersHealth record linkageIncidence of dementiaRisk of dementiaMendelian randomisation approachLevels of alcohol consumptionPublic health strategiesAlcohol use disorder prevalenceUse disorderCase-control analysisDementia increaseMendelian randomisationGenetic proxiesHealth strategiesRecord linkageEarly dementiaGenetics of SSRI antidepressant use and relationship to psychiatric and medical traits
Levey D, Galimberti M, Deak J, Gupta P, Empke S, Adhikari K, Harrington K, Quaden R, Gaziano J, Program V, Stein M, Gelernter J. Genetics of SSRI antidepressant use and relationship to psychiatric and medical traits. Human Genetics And Genomics Advances 2025, 7: 100500. PMID: 40903904, DOI: 10.1016/j.xhgg.2025.100500.Peer-Reviewed Original ResearchGenome-wide association studiesMillion Veteran ProgramSSRI useX chromosomeMajor depressive disorderSerotonin reuptake inhibitorsSSRI antidepressant useIndividuals of European ancestryLinkage disequilibrium score regressionIndividuals of African ancestryDepressive disorderMajor depressionReuptake inhibitorsAnxiety symptomsPsychiatric traitsCognitive performanceSSRIsAntidepressant useLocus discoveryGenome-wideAssociation studiesGenomic varianceMDDUKB cohortVeteran ProgramMulti-ancestral genome-wide association study of clinically defined nicotine dependence reveals strong genetic correlations with other substance use disorders and health-related traits
Johnson E, Lai D, Balbona J, Miller A, Hatoum A, Deak J, Jennings M, Baranger D, Galimberti M, Sanichwankul K, Thorgeirsson T, Colbert S, Adhikari K, Docherty A, Degenhardt L, Edwards T, Fox L, Giannelis A, Jeffries P, Korhonen T, Morrison C, Nunez Y, Palviainen T, Su M, Villela P, Wetherill L, Willoughby E, Zellers S, Bierut L, Buchwald J, Copeland W, Corley R, Friedman N, Foroud T, Gillespie N, Gizer I, Heath A, Hickie I, Kaprio J, Keller M, Lee J, Lind P, Madden P, Maes H, Martin N, McGue M, Medland S, Nelson E, Pearson J, Porjesz B, Stallings M, Vrieze S, Wilhelmson K, Kranzler H, Walters R, Polimanti R, Malison R, Zhou H, Stefansson K, Sanchez-Roige S, Potenza M, Mutirangura A, Shotelersuk V, Kalayasiri R, Edenberg H, Gelernter J, Agrawal A. Multi-ancestral genome-wide association study of clinically defined nicotine dependence reveals strong genetic correlations with other substance use disorders and health-related traits. Psychological Medicine 2025, 55: e234. PMID: 40831304, PMCID: PMC12360691, DOI: 10.1017/s0033291725100883.Peer-Reviewed Original ResearchMeSH KeywordsAdultAlcoholismAsian PeopleBlack PeopleDiagnostic and Statistical Manual of Mental DisordersFemaleGenome-Wide Association StudyHumansMaleMiddle AgedNerve Tissue ProteinsPhenotypePolymorphism, Single NucleotideReceptors, NicotinicSubstance-Related DisordersTobacco Use DisorderWhite PeopleConceptsGenome-wide association studiesDiagnostic and Statistical ManualTobacco use disorderUse disorderNicotine dependenceAssociation studiesDiagnostic and Statistical Manual of Mental DisordersGenetic correlationsStatistical manual of mental disordersPolygenic scoresManual of mental disordersGenomic structural equation modelingCannabis use disorderNicotine-related phenotypesProblematic alcohol useSubstance use disordersNational Epidemiologic SurveyHealth-related traitsPositive genetic correlationIndividual diagnostic criteriaElectronic health recordsCriterion countsDSM-5Opioid use disorderPsychiatric disordersA contextual genomic perspective on physical activity and its relationship to health, well being and illness
Galimberti M, Levey D, Deak J, Adhikari K, Overstreet C, Gupta P, Nitin R, Zhou H, Lake N, Harrington K, Djousse L, Davis L, Gaziano J, Stein M, Gelernter J. A contextual genomic perspective on physical activity and its relationship to health, well being and illness. Nature Genetics 2025, 57: 1860-1871. PMID: 40691405, PMCID: PMC12339386, DOI: 10.1038/s41588-025-02260-9.Peer-Reviewed Original ResearchConceptsLeisure-time PAPhysical activityLeisure-timeHealth benefitsIndividuals of European ancestryMendelian randomization analysisMillion Veteran ProgramUK Biobank dataLatin American ancestryHealth outcomesVeteran ProgramRandomization analysisBiobank dataRespiratory system diseasesLead variantsCOVID-19 hospitalizationCross-ancestryEuropean ancestryHealthMeta-analysisGenetic analysisAmerican ancestryAfrican ancestryCross-ancestry meta-analysisMetabolic traitsThe genetic relationship between cannabis use disorder, cannabis use and psychiatric disorders
Galimberti M, Overstreet C, Gupta P, Beck S, Dao C, Deak J, Zhou H, Johnson E, Agrawal A, Stein M, Levey D, Gelernter J. The genetic relationship between cannabis use disorder, cannabis use and psychiatric disorders. Nature Mental Health 2025, 3: 700-708. DOI: 10.1038/s44220-025-00440-4.Peer-Reviewed Original ResearchGenomic structural equation modelingCannabis use disorderCannabis usePsychiatric disordersUse disorderStructural equation modelingIncreased rates of psychiatric disordersIncreasing prevalence of cannabis useRates of psychiatric disordersPrevalence of cannabis useThree-factor modelEquation modelingDepressive disorderPsychiatric traitsCannabisLocal genetic correlationDisordersGenetic correlationsMendelian randomization analysisTraitsRandomization analysisSchizophreniaADHDColocalization analysisIncreased riskEpigenetic and genetic profiling of comorbidity patterns among substance dependence diagnoses
Pathak G, Pietrzak R, Lacobelle A, Overstreet C, Wendt F, Deak J, Friligkou E, Nunez Y, Montalvo-Ortiz J, Levey D, Kranzler H, Gelernter J, Polimanti R. Epigenetic and genetic profiling of comorbidity patterns among substance dependence diagnoses. Molecular Psychiatry 2025, 30: 4435-4443. PMID: 40247127, PMCID: PMC12343199, DOI: 10.1038/s41380-025-03031-y.Peer-Reviewed Original ResearchSubstance dependence diagnosesLatent class analysisDependence diagnosisLatent classesComorbidity patternsPolygenic scoresPolygenic overlapSD diagnosisPsychosocial traitsEpigenetic mechanismsClass analysisEpigenome-wide significant associationsEpigenome-wide association analysisCo-occurrenceTraitsIndividualsAssociated with CpG sitesAssociationComorbidityTDSD patternSubstancesEpigenome-wide changesIndividuals of European descentSignificant association
2024
What Are the Genetic Building Blocks of Alcohol-Related Behaviors?
Gelernter J, Deak J. What Are the Genetic Building Blocks of Alcohol-Related Behaviors? American Journal Of Psychiatry 2024, 181: 952-954. PMID: 39482951, PMCID: PMC12201992, DOI: 10.1176/appi.ajp.20240885.Peer-Reviewed Original ResearchT4. RELATIONSHIP OF GENETICALLY-INDEXED PHYSICAL ACTIVITY WITH MENTAL DISORDERS
Galimberti M, Gupta P, Deak J, Dao C, Nitin R, Zhou H, Harrington K, Na P, Topiwala A, Davis L, Gaziano M, Levey D, Stein M, Gelernter J. T4. RELATIONSHIP OF GENETICALLY-INDEXED PHYSICAL ACTIVITY WITH MENTAL DISORDERS. European Neuropsychopharmacology 2024, 87: 157-158. DOI: 10.1016/j.euroneuro.2024.08.314.Peer-Reviewed Original ResearchProtective effect of PAMental health traitsMillion Veteran ProgramEffects of PAGenome-wide association studiesPhysical activityLocal genetic correlationAlcohol consumptionPosttraumatic stress disorderSmoking initiationLeisure time PARelationship of PAUse disorderMental health outcomesPsychiatric disordersSelf-reported informationSubstance useAttention-deficit/hyperactivity disorderGenetic correlation analysisLocal genetic correlation analysisTime PAGenome-wide association study statisticsHealth traitsMR analysisResults PAF96. ALCOHOL USE AND DEMENTIA IN DIVERSE POPULATIONS
Topiwala A, Levey D, Zhou H, Deak J, Adhikari K, Ebmeier K, Bell S, Burgess S, Nichols T, Gaziano M, Stein M, Gelernter J. F96. ALCOHOL USE AND DEMENTIA IN DIVERSE POPULATIONS. European Neuropsychopharmacology 2024, 87: 256-257. DOI: 10.1016/j.euroneuro.2024.08.507.Peer-Reviewed Original ResearchMillion Veteran ProgramDementia riskMendelian randomizationDementia casesAlcohol usePrevalence of alcohol use disordersImpact of alcohol useRandom-effects meta-analysisAlcohol use disorder prevalenceProspective cohort studyStandard deviation increaseObservational associationsUK BiobankVeteran ProgramLevels of drinkingPopulation prevalenceAlcohol consumptionAlcohol use disorderCohort studyDisorder prevalenceDementiaDependent drinkersDose-response relationshipGenetic associationLight drinkersAssociation patterns of antisocial personality disorder across substance use disorders
Low A, Stiltner B, Nunez Y, Adhikari K, Deak J, Pietrzak R, Kranzler H, Gelernter J, Polimanti R. Association patterns of antisocial personality disorder across substance use disorders. Translational Psychiatry 2024, 14: 346. PMID: 39198385, PMCID: PMC11358160, DOI: 10.1038/s41398-024-03054-z.Peer-Reviewed Original ResearchConceptsAntisocial personality disorderSubstance use disordersPersonality disorderUse disorderAssociation of antisocial personality disorderPresence of antisocial personality disorderPrevalence of antisocial personality disorderHazardous useDSM-5 SUD diagnosesSubstance use disorder severityDiagnostic criteriaInteraction effects with sexTobacco use disorderDSM-5Association of alcoholSUD diagnosisDisordersCocaineRacial/ethnic backgroundsIndividualsCocUDSeverityCannabisAssociation patternsAssociation
Academic Achievements & Community Involvement
News & Links
News
- December 02, 2025Source: Nature Communications
Multi-Ancestry Investigation of the Genomics of Erectile Dysfunction
- September 24, 2025Source: BMJ Evidence-Based Medicine
Alcohol Use and Risk of Dementia in Diverse Populations: Evidence from Cohort, Case–Control and Mendelian Randomisation Approaches
- September 24, 2025
New Study Reveals Genetic, Psychiatric, and Environmental Factors Contributing to Alcohol Use Disorder
- July 21, 2025
Yale Study: Physical Activity and its Relationship to Health, Well-Being, and Illness
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