Andrew Solomon, PhD
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2026
Superior visibility of paramagnetic rim lesions on filtered phase versus SWI.
Lee J, Renner B, Madhusoodhanan Nair S, Nakamura K, Luskin E, Shinohara R, Reich D, Solomon A, Sicotte N, Ontaneda D, Sati P. Superior visibility of paramagnetic rim lesions on filtered phase versus SWI. American Journal Of Neuroradiology 2026, ajnr.a9295. PMID: 41826064, DOI: 10.3174/ajnr.a9295.Peer-Reviewed Original ResearchParamagnetic rim lesionsPooled cohortMultiple sclerosisRim lesionsT2 hyperintense lesionsMulticenter observational studySuperior visibilityPrimary cohortMcDonald criteriaDiagnostic evaluationBrain MRI sequencesSecondary cohortMcNemar testObservational studyImaging biomarkersNodular appearanceCohortLesionsMRI sequencesClinical practiceClinical settingFiltered phase imagesPhase imagesStudy sampleSWIAccess and barriers to diagnosis of multiple sclerosis in Iran - A clinician survey
Khodadadi S, Bahrami S, Jahani S, Sahraian M, Solomon A. Access and barriers to diagnosis of multiple sclerosis in Iran - A clinician survey. Multiple Sclerosis And Related Disorders 2026, 109: 107089. PMID: 41832843, DOI: 10.1016/j.msard.2026.107089.Peer-Reviewed Original ResearchGeneral neurologistsMS diagnosisOptical coherence tomographyDiagnosis of multiple sclerosisVisual evoked potentialsHealthcare professional educationCross-sectional studyPerspectives of neurologistsMultiple sclerosisTimely diagnosisHealthcare providersResource-limited settingsTargeted educationPatient reluctanceNational guidelinesMS specialistsAQP4-IgG testingSocial stigmaMS symptomsAdequate resourcesMOG-IgGAQP4-IgGProfessional educationMcDonald criteriaCoherence tomographyAre neurofilament light chain levels ready for routine clinical use? - No.
Sotirchos E, Solomon A. Are neurofilament light chain levels ready for routine clinical use? - No. Multiple Sclerosis Journal 2026, 13524585261423029. PMID: 41711385, DOI: 10.1177/13524585261423029.Peer-Reviewed Original ResearchComparison of central FLAIR hypointensity and central vein sign on FLAIR* in a diagnostic cohort
Toljan K, Amin M, Daboul L, Nakamura K, Solomon A, Sicotte N, Shinohara R, Reich D, Sati P, Ontaneda D. Comparison of central FLAIR hypointensity and central vein sign on FLAIR* in a diagnostic cohort. European Journal Of Radiology 2026, 196: 112707. PMID: 41628503, DOI: 10.1016/j.ejrad.2026.112707.Peer-Reviewed Original ResearchConceptsCentral vein signMultiple sclerosisPost-contrast FLAIRT2 hyperintense lesionsDiagnosis of MSDetection of lesionsHyperintense lesionsCentral hypointensityDiagnostic cohortLesion rateLow specificityDiagnostic specificityFLAIR imagesHypointensityLesionsMRI sequencesFLAIRBlinded ratersConcurrent detection
2025
Lipoic Acid for Treatment of Progressive Multiple Sclerosis
Spain R, Paz Soldán M, Freedman M, Repovic P, Solomon A, Rinker J, Wallin M, Haselkorn J, Stuve O, Gross R, Waslo C, Hildebrand A, Morris C, Mitchell J, Turner A, Schwartz D, Metz J, Rooney W. Lipoic Acid for Treatment of Progressive Multiple Sclerosis. Neurology 2025, 106: e214454. PMID: 41397213, PMCID: PMC12714125, DOI: 10.1212/wnl.0000000000214454.Peer-Reviewed Original ResearchConceptsLA participantsDisease-modifying therapiesSecondary progressive MSExpanded Disability Status ScaleProgressive MSProgressive multiple sclerosisWalking speedAdverse eventsBrain atrophyGray matter volumeMultiple sclerosisLA groupT2-weighted lesion volumeWhole-brain volumePlacebo-controlled clinical trialTreatment of progressive multiple sclerosisDeep gray matter volumesTimed 25-Foot WalkIntention-to-treat analysisPatient-reported disabilityVeterans Affairs Medical CenterWhole-brain atrophyClass II evidenceMedian EDSS scoreMatter volumeThe revised 2024 McDonald criteria can solve the misdiagnosis problem in multiple sclerosis: Yes
Ramanathan S, Solomon A. The revised 2024 McDonald criteria can solve the misdiagnosis problem in multiple sclerosis: Yes. Multiple Sclerosis Journal 2025, 32: 163-164. PMID: 41388897, DOI: 10.1177/13524585251396284.Peer-Reviewed Original ResearchDiagnosis of multiple sclerosis: 2024 revisions of the McDonald criteria
Montalban X, Lebrun-Frénay C, Oh J, Arrambide G, Moccia M, Pia Amato M, Amezcua L, Banwell B, Bar-Or A, Barkhof F, Butzkueven H, Ciccarelli O, Chataway J, Cohen J, Comi G, Correale J, Deisenhammer F, Filippi M, Fiol J, Freedman M, Fujihara K, Granziera C, Green A, Hartung H, Hellwig K, Kappos L, Kimbrough D, Killestein J, Lublin F, Marignier R, Marrie R, Miller A, Otero-Romero S, Ontaneda D, Ramanathan S, Reich D, Rocca M, Rovira À, Saidha S, Salter A, Sastre-Garriga J, Saylor D, Solomon A, Sormani M, Stankoff B, Tintore M, Tremlett H, Van der Walt A, Viswanathan S, Wiendl H, Wildemann B, Yamout B, Zaratin P, Calabresi P, Coetzee T, Thompson A. Diagnosis of multiple sclerosis: 2024 revisions of the McDonald criteria. The Lancet Neurology 2025, 24: 850-865. PMID: 40975101, DOI: 10.1016/s1474-4422(25)00270-4.Peer-Reviewed Original ResearchConceptsDiagnosis of multiple sclerosisMultiple sclerosisMcDonald criteriaFree light chain concentrationsRadiologically isolated syndromeMcDonald diagnostic criteriaCentral vein signParamagnetic rim lesionsProgression of disabilityMultiple sclerosis diagnosisOptic nerveNeurological symptomsProgressive courseRim lesionsAnatomical locationDiagnostic criteriaDiagnosisRevision criteriaSclerosisOlder individualsSupportive evidenceThe 2024 revisions of the McDonald criteria pose risk of multiple sclerosis overdiagnosis
Solomon A, Brodersen J. The 2024 revisions of the McDonald criteria pose risk of multiple sclerosis overdiagnosis. Nature Reviews Neurology 2025, 21: 659-660. PMID: 40962996, DOI: 10.1038/s41582-025-01140-4.Peer-Reviewed Original ResearchQuantity and Volume of Perivascular Spaces Are Inversely Associated With Multiple Sclerosis Relative to Cerebrovascular Disease and Migraine
Levit E, Horwath E, Schwartz D, Silbert L, Shinohara R, Solomon A. Quantity and Volume of Perivascular Spaces Are Inversely Associated With Multiple Sclerosis Relative to Cerebrovascular Disease and Migraine. Annals Of Clinical And Translational Neurology 2025, 12: 2569-2574. PMID: 40954941, PMCID: PMC12698934, DOI: 10.1002/acn3.70193.Peer-Reviewed Original ResearchCerebrovascular diseaseMS diagnosisAssociated with MS diagnosisMultiple sclerosisPerivascular spacesPerivascular spaces numberMRI white matter abnormalitiesT2 hyperintense lesionsDiagnosis of MSLongitudinal cohortWhite matter abnormalitiesLogistic regressionPrimary outcomeMisdiagnosis of MSVascular comorbiditiesHyperintense lesionsFLAIR sequencesROC analysisT MRIT1-weightedBrain perivascular spacesMigraineParticipantsDiagnosisCohortA Novel Convolutional Neural Network for Automated Multiple Sclerosis Brain Lesion Segmentation
Dereskewicz E, La Rosa F, Dos Santos Silva J, Sizer E, Kohli A, Wynen M, Mullins W, Maggi P, Levy S, Onyemeh K, Ayci B, Solomon A, Assländer J, Al‐Louzi O, Reich D, Sumowski J, Beck E. A Novel Convolutional Neural Network for Automated Multiple Sclerosis Brain Lesion Segmentation. Journal Of Neuroimaging 2025, 35: e70085. PMID: 40937688, PMCID: PMC12426979, DOI: 10.1111/jon.70085.Peer-Reviewed Original Research
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