Jason Bini, PhD
Assistant Professor of Radiology and Biomedical ImagingDownloadHi-Res Photo
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Assistant Professor of Radiology and Biomedical Imaging
Biography
Jason earned his Ph.D. in Biomedical Engineering at The City College of New York, City University of New York in 2015. His dissertation focused on the validation and improvement of quantitative PET of atherosclerotic plaque metabolic activity using novel simultaneous PET/MR systems. Jason is currently using PET imaging to investigate mechanisms of disease and receptor/enzyme pharmacology in metabolic diseases, such as diabetes and obesity. Current projects include using PET to image dopamine in the pancreas both in type 1 and type 2 diabetes; whole-body distribution of the cortisol activating enzyme (11beta-hydroxysteroid dehydrogenase type 1); and method development (image reconstruction, attenuation and scatter correction) for whole-body kinetic modeling of novel PET radioligands in clinical and preclinical studies.
Last Updated on April 07, 2025.
Appointments
Radiology & Biomedical Imaging
Assistant ProfessorPrimary
Other Departments & Organizations
Education & Training
- Postdoctoral Fellowship
- Yale University (2018)
- PhD
- The City College of New York (CUNY), Biomedical Engineering (2015)
- MS
- Stevens Institute of Technology, Biomedical Engineering (2010)
- BS
- Fordham University, Physics (2006)
Research
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Overview
Medical Research Interests
Adipose Tissue; Biomedical Engineering; Brain; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Endocrinology; Liver; Neuroendocrinology; Obesity; Pancreas; Positron Emission Tomography Computed Tomography; Stress, Physiological; Whole Body Imaging
ORCID
0000-0003-4047-6575
Research at a Glance
Yale Co-Authors
Frequent collaborators of Jason Bini's published research.
Publications Timeline
A big-picture view of Jason Bini's research output by year.
Research Interests
Research topics Jason Bini is interested in exploring.
Richard Carson, PhD
Nabeel Nabulsi, PhD
Mika Naganawa, PhD
Jean-Dominique Gallezot, PhD
Michael Kapinos
Soheila Najafzadeh, MS, SC
35Publications
1,037Citations
Brain
Diabetes Mellitus, Type 1
Diabetes Mellitus, Type 2
Whole Body Imaging
Positron Emission Tomography Computed Tomography
Obesity
Publications
2025
Measurement of brain glucose metabolism in obesity and diabetes
Hwang J, Bini J, Belfort-DeAguiar R. Measurement of brain glucose metabolism in obesity and diabetes. Diabetologia 2025, 68: 1879-1888. PMID: 40711543, PMCID: PMC12361331, DOI: 10.1007/s00125-025-06491-7.Peer-Reviewed Original ResearchAltmetricMeSH Keywords and ConceptsConceptsBrain glucose metabolismNon-invasive neuroimaging techniquesMeasures of brain glucose metabolismGlucose metabolismNeuroimaging techniquesPathological state of diabetesPositron emission tomographyBrain imagingBrainState of diabetesEmission tomographyPathological statesPhysiological manipulationsInsulin levels
2024
The Importance of PET Imaging to Understanding Whole-Body Cortisol Metabolism in Alzheimer’s Disease
Bini J. The Importance of PET Imaging to Understanding Whole-Body Cortisol Metabolism in Alzheimer’s Disease. Journal Of Alzheimer’s Disease 2024, 99: 113-115. PMID: 38607759, PMCID: PMC12425132, DOI: 10.3233/jad-231463.Peer-Reviewed Original ResearchAltmetricMeSH Keywords and ConceptsQuantification of Multi-Organ 11β-Hydroxysteroid Dehydrogenase Type 1 Enzyme Levels in a Zucker Fatty Rat Model: A PET Imaging Study
Bini J, Strober J, Kapinos M, Zheng M, Li S, Ropchan J, Nabulsi N, Huang Y, Perry R, Vatner D, Carson R. Quantification of Multi-Organ 11β-Hydroxysteroid Dehydrogenase Type 1 Enzyme Levels in a Zucker Fatty Rat Model: A PET Imaging Study. Molecular Imaging 2024, 23: 15353508241301584. PMID: 40270581, PMCID: PMC12014946, DOI: 10.1177/15353508241301584.Peer-Reviewed Original ResearchAltmetricConceptsImage-derived input functionTime-activity curvesRat modelIntracellular glucocorticoid actionZucker fatty (ZFZucker fatty rat modelFatty acid metabolismInactive 11-dehydrocorticosteroneMetabolic disease statusFatty (ZFPET imaging studiesAcid metabolismObesity pathophysiologyPreclinical modelsLevels in vivoZF ratsGlucocorticoid actionRadioligand bindingRodent modelsImaging studiesObesityProtein expressionPET imagingMeasurement of glucoseDisease status
2023
The historical progression of positron emission tomography research in neuroendocrinology
Bini J. The historical progression of positron emission tomography research in neuroendocrinology. Frontiers In Neuroendocrinology 2023, 70: 101081. PMID: 37423505, PMCID: PMC10530506, DOI: 10.1016/j.yfrne.2023.101081.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsPositron emission tomographyPositron emission tomography researchEmission Tomography ImagingPositron emission tomography (PET) imagingNumber of radiopharmaceuticalsEndocrine organSystematic reviewEmission tomographyPET radioligandHormone actionTomography imagingPET imagingDifferent receptorsHuman brainPET researchImagingSystem actionsSteroidsCliniciansRadioligandHormoneBrainProgressionReceptors1541-P: Sympathetic Nervous System Activity in Response to Food Ingestion Is Impacted by Obesity
CHUNG T, DEAJON-JACKSON J, BINI J, SONG H, SANCHEZ RANGEL E, YECKEL C, HWANG J, STACHENFELD N, BELFORT-DEAGUIAR R. 1541-P: Sympathetic Nervous System Activity in Response to Food Ingestion Is Impacted by Obesity. Diabetes 2023, 72 DOI: 10.2337/db23-1541-p.Peer-Reviewed Original ResearchConceptsSympathetic nervous system activityMuscle sympathetic nerve activityMixed meal testNormal weightNervous system activityDistribution volume ratioPET-CTHeart rateSympathetic nerve activitySystem activityIngestion of foodMSNA increasesEndogenous NEMeal testNE releaseNerve activityOB subjectsObesity altersKidney diseaseDeltoid muscleLean individualsOB individualsNE transporterObeseFood ingestion
2022
Noninvasive Quantitative PET Imaging in Humans of the Pancreatic Beta-Cell Mass Biomarkers VMAT2 and Dopamine D2/D3 Receptors In Vivo
Bini J, Carson R, Cline G. Noninvasive Quantitative PET Imaging in Humans of the Pancreatic Beta-Cell Mass Biomarkers VMAT2 and Dopamine D2/D3 Receptors In Vivo. Methods In Molecular Biology 2022, 2592: 61-74. PMID: 36507985, DOI: 10.1007/978-1-0716-2807-2_4.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsPositron emission tomographyBeta-cell massFunctional beta-cell massDopamine D2/D3 receptorsD2/D3 receptorsBeta-cell lossType 2 diabetesEfficacy of therapeuticsQuantitative positron emission tomographyInsulin secretionDopamine receptorsD3 receptorsGlucose regulationPET radioligandEmission tomographyType 1Clinical usePET imagingReceptorsQuantitative PET imagingVMAT2Cellular transportersImagingVivoQuantitative imagingStress-level glucocorticoids increase fasting hunger and decrease cerebral blood flow in regions regulating eating
Bini J, Parikh L, Lacadie C, Hwang JJ, Shah S, Rosenberg SB, Seo D, Lam K, Hamza M, De Aguiar RB, Constable T, Sherwin RS, Sinha R, Jastreboff AM. Stress-level glucocorticoids increase fasting hunger and decrease cerebral blood flow in regions regulating eating. NeuroImage Clinical 2022, 36: 103202. PMID: 36126514, PMCID: PMC9486604, DOI: 10.1016/j.nicl.2022.103202.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsCerebral blood flowRegional cerebral blood flowBlood flowMetabolic hormonesRandomized double-blind cross-over designDouble-blind cross-over designStress level glucocorticoidsPrimary sensory cortexPerfusion magnetic resonanceCross-over designMedial temporal gyrusWhole-brain voxelMedial brainstemSaline daysOvernight infusionCBF responseHunger ratingsPlasma insulinGlucocorticoid effectsHedonic signalsObesity riskLimbic regionsFood intakeNeural regulationDistinct brain networksFeasibility of imaging synaptic density in the human spinal cord using [11C]UCB-J PET
Rossano S, Toyonaga T, Bini J, Nabulsi N, Ropchan J, Cai Z, Huang Y, Carson RE. Feasibility of imaging synaptic density in the human spinal cord using [11C]UCB-J PET. EJNMMI Physics 2022, 9: 32. PMID: 35503134, PMCID: PMC9065222, DOI: 10.1186/s40658-022-00464-0.Peer-Reviewed Original ResearchCitationsConceptsFull spinal cordSpinal cord injuryHuman spinal cordSpinal cordAmyotrophic lateral sclerosisDistribution volume ratioCervical SCSynaptic densitySynaptic vesicle protein 2ACervical spinal cordBrain gray matterUse of PETBaseline VTWhole-body imagesSynapse lossCord injuryLateral sclerosisInjury severityGray matterNeurodegenerative disordersCordProtein 2AHuman dataDVR valuesCurrent standard
2021
The Role of Positron Emission Tomography in Bariatric Surgery Research: a Review
Bini J, Norcross M, Cheung M, Duffy A. The Role of Positron Emission Tomography in Bariatric Surgery Research: a Review. Obesity Surgery 2021, 31: 4592-4606. PMID: 34304378, DOI: 10.1007/s11695-021-05576-7.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsPositron emission tomographyBariatric surgeryEmission tomographyBariatric surgery researchMalabsorption of foodBlood flowWhole-body PET imagingRadioligand developmentWeight lossPET imagingAmount of foodSurgery researchPhysiological effectsSurgeryPicomolar concentrationsTomographyRadioactive moleculesMetabolismMalabsorptionObesityPatientsFoodStomachPharmacologyReceptorsOptimized Methodology for Reference Region and Image-Derived Input Function Kinetic Modeling in Preclinical PET
Bini J, Lattin CR, Toyonaga T, Finnema SJ, Carson R. Optimized Methodology for Reference Region and Image-Derived Input Function Kinetic Modeling in Preclinical PET. IEEE Transactions On Radiation And Plasma Medical Sciences 2021, 6: 454-462. PMID: 36185820, PMCID: PMC9524424, DOI: 10.1109/trpms.2021.3088606.Peer-Reviewed Original ResearchCitationsAltmetric
Clinical Trials
Current Trials
Imaging cortisol metabolism in liver, adipose tissue and brain with a novel PET radioligand
HIC ID2000029576RolePrincipal InvestigatorPrimary Completion Date06/30/2024Recruiting ParticipantsImaging pancreatic beta-cells with PET neuroimaging agent 11C-PHNO
HIC ID2000021287RolePrincipal InvestigatorPrimary Completion Date07/31/2021Recruiting ParticipantsGenderBothAge18 years - 65 years
Academic Achievements & Community Involvement
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Honors
honor First Place in General Clinical Specialties
07/07/2022International AwardSociety for Nuclear Medicine and Molecular ImagingDetailsCanadahonor Janeway Society Member
07/01/2022Regional AwardYale UniversityDetailsUnited Stateshonor NIH NCATS YCCI Scholar Award
06/01/2020National AwardNIH/Yale Center for Clinical InvestigationDetailsUnited Stateshonor 3rd place, Young Investigator Award, Computer and Instrumentation Council
06/26/2018International AwardSociety of Nuclear Medicine and Molecular ImagingDetailsUnited States
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