Huihong Li, MSc
Postgraduate AssociateDownloadHi-Res Photo
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Titles
Postgraduate Associate
Appointments
Education & Training
- MSc
- Yale University, Computational Biology and Biomedical Informatics (2026)
- BSc
- Technion - Israel Institute of Technology, Biotechnology and Food Engineering (2024)
Research
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Overview
Medical Research Interests
Computational Biology; Computer Simulation; Neural Networks, Computer
ORCID
0009-0006-4572-7176- View Lab Website
levensteinlab
Publications
Featured Publications
Genome-wide consensus transcriptional signatures identify synaptic pruning linking Alzheimer’s disease and epilepsy
Li H, Xie Z, Tian Y, Zhou R, Yang Y, Lin B, Chen S, Wu J, Deng Z, Li J, Chen M, Liu X, Sun Y, Wei N, Huang B, Ji X. Genome-wide consensus transcriptional signatures identify synaptic pruning linking Alzheimer’s disease and epilepsy. Molecular Psychiatry 2025, 31: 1774-1784. PMID: 41139712, DOI: 10.1038/s41380-025-03318-0.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsMeSH KeywordsAdaptor Proteins, Signal TransducingAlzheimer DiseaseAnimalsDisease Models, AnimalEpilepsyEpilepsy, Temporal LobeFemaleGene Expression ProfilingGene Regulatory NetworksGenome-Wide Association StudyHumansMaleMembrane GlycoproteinsMembrane ProteinsMiceMice, TransgenicMicrogliaReceptors, ImmunologicSynapsestau ProteinsTranscriptomeConceptsAlzheimer's diseaseGene regulatory network analysisGenome-wide transcriptome analysisRegulatory network analysisDifferential expression analysisAD transgenic modelsRegulatory signaturesTranscriptome analysisTranscriptional programsCross-species validationExpression analysisConsensus signaturesC1q complement componentMolecular mechanismsMouse modelUp-regulatedTranscriptional signaturePredominant expressionTYROBPHuman cohortsSynaptic pruningTherapeutic targetTransgenic modelsNetwork analysisLoss of inhibitory synapses
2025
Temporal Dynamics Dominates Microbiome and Resistome Assembly Despite Tetracycline Pressure in a Germfree Lettuce Model
Li H, Cao Y, Dong Y, Liu H, Chen L, Siame BA, Yaron S, Leung KY. Temporal Dynamics Dominates Microbiome and Resistome Assembly Despite Tetracycline Pressure in a Germfree Lettuce Model. 2025 DOI: 10.21203/rs.3.rs-8401048/v1.Peer-Reviewed Original ResearchReconstruction of 1,979 prokaryotic metagenome-assembled genomes from 37 global cave environments
Li H, Cao Y, Liu X, Ke Z, Chen L, Siame B, Yaron S, Leung K. Reconstruction of 1,979 prokaryotic metagenome-assembled genomes from 37 global cave environments. Scientific Data 2025, 12: 1896. PMID: 41339358, PMCID: PMC12675795, DOI: 10.1038/s41597-025-06191-2.Peer-Reviewed Original ResearchMeSH Keywords and ConceptsConceptsMetagenome-assembled genomesAverage nucleotide identityBiosynthetic gene clusterAntibiotic resistance genesEvolutionary originMicrobial diversityProkaryotic metagenome-assembled genomeOrigins of antibiotic resistanceCave environmentNutrient-limited environmentsPhyla of bacteriaGene clusterNucleotide identitySecondary metabolismGenomic levelCave microorganismsSubterranean ecosystemsMetabolic capabilitiesResistance genesGenomeRepresentative speciesAntibiotic resistanceArchaeaIndividual cavesTaxonomy classificationLocal homeostatic scaling supports stable rate propagation under noise and heterogeneity
Li H, McDougal RA. Local homeostatic scaling supports stable rate propagation under noise and heterogeneity. 2025 DOI: 10.1101/2025.11.25.689806.Peer-Reviewed Original Research
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