Hongmei Shi
Research Assistant Internal Medicine NephrologyAbout
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Titles
Research Assistant Internal Medicine Nephrology
Departments & Organizations
- Internal Medicine
- Menon Lab
Research
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Research at a Glance
Yale Co-Authors
Frequent collaborators of Hongmei Shi's published research.
Anand Chellappa Reghuvaran Nair, PhD
John Pell
Madhav Menon, MBBS, MD
Ashwani Kumar, PhD
Gabriel Barsotti, MD, MHA
Irene Chernova, MD, PhD
Publications
2026
APOL1-risk alleles modulate T-cell receptor signaling to promote allograft rejection
Pell J, Tanvir E, Sun Z, Chernova I, Reghuvaran A, Nagata S, Guerra M, Choi J, Al Chaar S, Mizuno H, Dong K, Tian X, Ishibe R, Franchin B, Cravedi P, Kumar A, Barsotti G, Shi H, De Kumar B, Smithson S, Song W, He J, Chong A, Pober J, Somlo S, Gibson I, Popik W, Zhang Z, Craft J, Azzi J, Murakami N, Ishibe S, Heeger P, Menon M. APOL1-risk alleles modulate T-cell receptor signaling to promote allograft rejection. Journal Of Clinical Investigation 2026 PMID: 42262888, DOI: 10.1172/jci193173.Peer-Reviewed Original ResearchAltmetricConceptsT cell receptorT cellsCD8+T cellsCanonical T cell receptorsSingle-cell transcriptomicsCD8+T cell activityCD8+T cell infiltrationT cell receptor stimulationBulk transcriptomesT cell functionT cell receptor signalingKidney transplant cohortPhysiological expressionAPOL1 risk allelesKidney transplant rejectionRisk of kidney diseaseExpression of wild typeTacrolimus levelsCardiac transplantationAllograft rejectionTransplant cohortER-Ca2Kidney rejectionTransplant rejectionCytokine production
2025
Design of precision therapeutics for a CKD risk allele by targeting Shroom3-Rock interaction
Reghuvaran A, Kumar A, Lin Q, Rajeevan N, Banu K, Sun Z, Shi H, Barsotti G, Tanvir E, Pell J, Perincheri S, Wei C, Bharathan B, Planoutene M, Eichmann A, Mas V, Zhang W, Cantley L, Xu L, Das B, He J, Menon M. Design of precision therapeutics for a CKD risk allele by targeting Shroom3-Rock interaction. Nature Communications 2025, 17: 1086. PMID: 41469391, PMCID: PMC12852734, DOI: 10.1038/s41467-025-67854-7.Peer-Reviewed Original ResearchAltmetricMeSH Keywords and ConceptsConceptsROCK activitySmall molecule inhibitorsSHROOM3Wild typeAssociated with renal fibrosisCo-expressionRisk allelesTransgenic toolsPleiotropic effectsROCK inhibitionRho-kinaseOverexpressionCell linesPrecision therapeuticsFibroblast linesProfibrotic functionProfibrotic signalingMotifKidney diseaseEnhanced variantRenal fibrosisTubular cellsAlbuminuriaIn vivoMice
2022
A Novel Role of APOL1 Risk-Alleles in T-Cell Activation and Focal Segmental Glomerulosclerosis
Pell J, Reghuvaran A, Nagata S, Banu K, Shi H, Chernova I, Ishibe S, Menon M. A Novel Role of APOL1 Risk-Alleles in T-Cell Activation and Focal Segmental Glomerulosclerosis. Journal Of The American Society Of Nephrology 2022, 33: 410-411. DOI: 10.1681/asn.20223311s1410d.Peer-Reviewed Original Research
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