Hitten Zaveri, PhD
Professor of NeurologyCards
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Titles
Professor of Neurology
Biography
Dr. Zaveri has received academic training in electrical engineering, computer engineering, biomedical engineering, neurology and epilepsy. He is the director of the Computational Neurophysiology Laboratory, co-director of the BioSense Laboratory and co-director of the Yale Clinical Neuroscience Group for Neuroanalytics (YNN). His research interests lie at the intersection of neuroscience, engineering and mathematics.
Appointments
Neurology
ProfessorPrimary
Other Departments & Organizations
- Center for Brain & Mind Health
- Epilepsy & Seizures
- Neurocritical Care & Emergency Surgery
- Neurology
- Yale Clinical Neuroscience Group for Neuroanalytics
Education & Training
- Postdoctoral Associate
- Yale University (1997)
- PhD
- University of Michigan, Bioengineering (1993)
- MSEE
- University of Michigan, Bioengineering (1987)
- MSEE
- University of Michigan, Electrical Engineering (1987)
- BSEE
- University of Michigan, Computer Engineering (1983)
- BSEE
- University of Michigan, Electrical Engineering (1982)
Research
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Overview
There are two aspects to our work on epilepsy. First, we seek to understand, through experiments and analysis, how seizures the seemingly random disruption of brain function, are generated and how they spread through the brain. Second, we are developing brain implantable devices to sense, analyze and control aberrant brain activity. These devices include a wireless, battery-free, multimodal intracranial sensor to continuously monitor brain neurochemistry and electrophysiology and devices to detect and predict the onset of a seizure and intervene to terminate a seizure once it has been detected or predicted. Further information on our research can be found in our publications.
- Understand how seizures are generated
- Develop implantable multimodal sensors for direct brain sensing
- Accurately locate the seizure onset area
- Detect and predict the onset of seizures in real-time
- Develop interventional methods to terminate or abort seizures
Medical Research Interests
ORCID
0000-0001-7830-0052- View Lab Website
Yale Clinical Neuroscience Group for Neuroanalytics
Research at a Glance
Yale Co-Authors
Publications Timeline
Research Interests
Robert Bradford Duckrow, MD
Lawrence Hirsch, MD
Tore Eid, MD, PhD
Dennis Spencer, MD
Roni Dhaher, PhD
Eyiyemisi Damisah, MD
Publications
2025
Multitask Language Mapping to Visualize the Spatial Configuration of Polyfunctional Language Cortex
Chishti O, Collins E, Mcgrath H, Bose-Roy R, Zhang T, Quraishi I, Hirsch L, Benjamin C, Damisah E, Zaveri H, Spencer D, Sivaraju A. Multitask Language Mapping to Visualize the Spatial Configuration of Polyfunctional Language Cortex. Neurology 2025, 105: e214256. PMID: 41124649, DOI: 10.1212/wnl.0000000000214256.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsVisual namingAuditory namingLanguage cortexLanguage mappingDirect electrical stimulationIntertask correlationsLanguage areasStructural connectivityAnterior supramarginal gyrusSuperior temporal gyrusAnterior language areasSuperior longitudinal fasciculusStructural connectivity analysisEloquent language cortexStructural connectivity dataLanguage involvementAuditory comprehensionSupramarginal regionsPars triangularisSupramarginal gyrusTemporal gyrusAslant tractArcuate fasciculusModality-specificConnectivity analysisRapid Multianalyte Quantification of Brain Chemistry Using Si-Nanoribbon Bio-Field-Effect Transistor Sensors
Maldonado J, Rajagopalan V, Gu Y, Eid T, Spencer D, Zaveri H. Rapid Multianalyte Quantification of Brain Chemistry Using Si-Nanoribbon Bio-Field-Effect Transistor Sensors. ACS Applied Materials & Interfaces 2025, 17: 59148-59160. PMID: 41104714, DOI: 10.1021/acsami.5c15695.Peer-Reviewed Original ResearchMeSH Keywords and ConceptsConceptsSemiconductor field effect transistorReal-time biosensingField-effect transistorsSi nanoribbonsLimit of detectionGamma-aminobutyric acidReal-time detection capabilityArtificial cerebrospinal fluidNanowire devicesComplex biological matricesContinuous real-time monitoringTransistor sensorsLabel-free detectionSurface functionalizationBiological matricesExcitatory-inhibitory balanceSensor surfaceAptamer bioreceptorsBuffer solutionSensorNanosensing platformDiffusion MRI Tractography to Reduce Risks of Postoperative Neurologic Deficits
Guberman G, Balasubramaniam N, Wilson L, Maes E, Chen J, Luigi M, Theaud G, Rheault F, Bou Assi E, Zaveri H, Westwick H, Nguyen D, Bouthillier A, Bojanowski M, Weil A, Dudley R, Bernhardt B, Yuan-Mou Yang J, Descoteaux M, Damisah E, Ibrahim G, Spencer D, Sarubbo S, Obaid S. Diffusion MRI Tractography to Reduce Risks of Postoperative Neurologic Deficits. Neurology 2025, 105: e214145. PMID: 41071968, DOI: 10.1212/wnl.0000000000214145.Peer-Reviewed Original ResearchAltmetricMeSH Keywords and ConceptsConceptsPostoperative neurological deficitsRisk of postoperative neurological deficitsNeurological deficitsResection surgeryLow riskSystematic reviewAge of patientsNewcastle-Ottawa Quality Assessment ScaleMeta-analysisIntraoperative neuronavigation systemMantel-Haenszel methodQuality of studiesRisk reductionMeta-analyses guidelinesElectrical stimulationQuality Assessment ScaleRisk of biasAssociated with lower proportionsRandom-effects modelStage of reviewPreoperative tractographyPeer-reviewed articlesAblative surgeryIntracranial proceduresFollow-upRelationship Between Brain Activity and Impaired Consciousness in Frontal Lobe Seizures
Salardini E, Vaddiparti A, Kumar A, Qu J, Martin R, Gebre R, Arencibia C, Dhakar M, Grover E, Quraishi I, Sternberg E, George I, Sivaraju A, Bonito J, Zaveri H, Gober L, Ahammad S, Ghoshal S, Wu K, Farooque P, Hirsch L, Damisah E, Gerrard J, Spencer D, Yoo J, Young J, Friedman D, Shum J, Blumenfeld H. Relationship Between Brain Activity and Impaired Consciousness in Frontal Lobe Seizures. Neurology 2025, 105: e213965. PMID: 40893057, PMCID: PMC12406365, DOI: 10.1212/wnl.0000000000213965.Peer-Reviewed Original ResearchAltmetricMeSH Keywords and ConceptsConceptsFocal to bilateral tonic-clonicCortical regionsCortical slow wavesFrontal lobeImpaired consciousnessFrontal lobe seizuresSlow-wave frequency rangeFocal temporal lobe epilepsyFocal to bilateral tonic-clonic seizuresSlow wavesQuality of lifeNegative consequencesTemporal lobe epilepsyBrain activityConsequences of epilepsyTemporal lobe seizuresBilateral tonic-clonicSubcortical arousalFocal seizure typesLobe epilepsyActivity patternsTonic-clonicFast activitySeizure typesPower increasesYale Brain Atlas to interactively explore multimodal structural and functional neuroimaging data
Collins E, Chishti O, McGrath H, Obaid S, King A, Qiu E, Gabriel E, Shen X, Arora J, Papademetris X, Constable R, Spencer D, Zaveri H. Yale Brain Atlas to interactively explore multimodal structural and functional neuroimaging data. Frontiers In Network Physiology 2025, 5: 1585019. PMID: 40607320, PMCID: PMC12217586, DOI: 10.3389/fnetp.2025.1585019.Peer-Reviewed Original ResearchAltmetricConceptsMultimodal neuroimaging dataNeuroimaging dataAnalysis of multimodal neuroimaging dataBrain structure-function relationshipsFunctional neuroimaging dataFMRI activation dataWhite matter connectomeHuman Connectome ProjectBrain atlasesCortical thickness profilesConnectome ProjectHuman brainAnatomical parcellationBrainConnectivity matrixAtlas spaceYaleInteractive explorationHealthy subjectsWeb toolCognitionInteractive pagesEmotionsSubjectsConnectomeIdentifying the epileptic network by linking interictal functional and structural connectivity
Boddeti U, Farooque P, McGrath H, Percy J, Chishti O, Duckrow R, Spencer D, Zaveri H, Ksendzovsky A. Identifying the epileptic network by linking interictal functional and structural connectivity. Scientific Reports 2025, 15: 9106. PMID: 40097693, PMCID: PMC11914057, DOI: 10.1038/s41598-025-93978-3.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsStructural connectivityFunctional connectivity findingsWhite matter connectivityConnectivity findingsSeizure networkMesial temporal lobe epilepsyHigher functional connectivityPost-operative seizure freedomResective epilepsy surgeryNetwork disorderTemporal lobe epilepsyIntracranial electrode contactsRetrospective Visual and Quantitative Assessment of Burst Suppression With and Without Identical Bursts in Patients After Cardiac Arrest
Fong M, Pu K, Beekman R, Kim N, Nguyen C, Gilmore E, Hirsch L, Zaveri H. Retrospective Visual and Quantitative Assessment of Burst Suppression With and Without Identical Bursts in Patients After Cardiac Arrest. Neurocritical Care 2025, 43: 157-167. PMID: 39900751, DOI: 10.1007/s12028-024-02208-7.Peer-Reviewed Original ResearchCitationsAltmetricConceptsIdentical burstsBurst suppressionCardiac arrest survivorsInterburst intervalClinical featuresNeurological outcomeCardiac arrestArrest survivorsAssociated with poor neurological outcomeContinuous electroencephalogramCerebral Performance Category scoreAssociated with poor outcomesCardiac arrest patientsPoor neurological outcomePost-cardiac arrestPredictors of mortalityUS academic medical centersEEG backgroundPrognostic significanceArrest patientsClinical outcomesPoor outcomeRetrospective analysisAcademic medical centerUS cohortAntiseizure Medications in Poststroke Seizures
Misra S, Wang S, Quinn T, Dawson J, Zelano J, Tanaka T, Grotta J, Khan E, Beriwal N, Funaro M, Perla S, Dev P, Larsson D, Hussain T, Liebeskind D, Yasuda C, Altalib H, Zaveri H, Elshahat A, Hitawala G, Wang E, Kitagawa R, Pathak A, Scalzo F, Ihara M, Sunnerhagen K, Walters M, Zhao Y, Jette N, Kasner S, Kwan P, Mishra N. Antiseizure Medications in Poststroke Seizures. Neurology 2025, 104: e210231. PMID: 39808752, DOI: 10.1212/wnl.0000000000210231.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsRisk of biasLow-certainty evidenceModerate to high certainty evidenceNon-randomized Studies of Interventions toolDrug discontinuation ratesCochrane risk of bias toolRisk of bias toolAntiseizure medicationsSeizure recurrenceHigh risk of biasAdverse eventsCertainty of evidenceHigh-certainty evidencePoststroke seizuresModerate-certainty evidenceMortality rateRandomized Controlled TrialsDiscontinuation ratesAntiseizure medication useRecommendations AssessmentCochrane riskBias toolElectronic databasesNon-randomized studiesAssociated with high mortality rates
2024
Modeling seizure networks in neuron-glia cultures using microelectrode arrays
Boddeti U, Langbein J, McAfee D, Altshuler M, Bachani M, Zaveri H, Spencer D, Zaghloul K, Ksendzovsky A. Modeling seizure networks in neuron-glia cultures using microelectrode arrays. Frontiers In Network Physiology 2024, 4: 1441345. PMID: 39290793, PMCID: PMC11405204, DOI: 10.3389/fnetp.2024.1441345.Peer-Reviewed Original ResearchCitationsAltmetricConceptsNetwork changesSeizure networkSeizure modelsDays of chronic treatmentDimensionality reductionNetwork developmentDrug-resistant epilepsyNeuron-glia culturesMean firing rateNetworkTreatment failureChronic treatmentMicroelectrode arraysResection surgeryRetrospective studyFiring rateSeizuresExperience seizuresNeurological disordersStability of infraslow correlation structure in time-shifted intracranial EEG signals
Joshi R, Duckrow R, Goncharova I, Hirsch L, Spencer D, Godwin D, Zaveri H. Stability of infraslow correlation structure in time-shifted intracranial EEG signals. Frontiers In Network Physiology 2024, 4: 1441294. PMID: 39258030, PMCID: PMC11384574, DOI: 10.3389/fnetp.2024.1441294.Peer-Reviewed Original ResearchCitationsAltmetricConceptsInfraslow activityContact pairsFrequency bandMagnitude-squared coherenceAntiseizure medicationsMedically refractory epilepsy patientsElectrode contact pairsHigher-frequency activityRefractory epilepsy patientsDC-coupled recordingsIcEEG epochsEEG frequency bandsEnvelope correlationOptimal parametersClinical relevanceSeizure riskIntracranial EEGEpilepsy patientsPatientsIntracranial EEG signalsTaperTraditional EEG frequency bands
Academic Achievements & Community Involvement
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Activities
activity Epilepsy networks
08/03/2015 - PresentLectureIWSP7DetailsMelbourne, VIC, AustraliaSponsored by University of MelbourneAbstract/SynopsisInternational workshop on seizure prediction
activity International Epilepsy Electrophysiology Portal
2010 - 2014CommitteesBoard Memberactivity Sixth International Workshop on Seizure Prediction
2013 - 2013CommitteesBoard Memberactivity Fifth International Workshop on Seizure Prediction
09/19/2011 - 09/23/2011CommitteesBoard Memberactivity American Epilepsy Society
2008 - 2010CommitteesCommittee MemberDetailsInvestigators' Workshop Committee
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Lippard Laboratory of Clinical Investigation (LLCI)
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15 York Street, Rm 714 A
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203.737.5407