Hang Shu
Postdoctoral FellowAbout
Research
Publications
2026
Fusobacterium nucleatum alleviates alcohol-associated liver disease through mannose-mediated elevation of Fbp1 and modulation of gut microbiota
Shu H, Wu D, Xie L, Wang G, Zhou H, Zhang H, Tian S, Zhang X, Li C, Wang C, Zhou L, Yang L, Hu Q, Wei X, Shen H, Xu L, Wang H. Fusobacterium nucleatum alleviates alcohol-associated liver disease through mannose-mediated elevation of Fbp1 and modulation of gut microbiota. Journal Of Hepatology 2026 PMID: 42002002, DOI: 10.1016/j.jhep.2026.04.001.Peer-Reviewed Original ResearchAlcohol-associated liver diseaseF. nucleatumALD patientsLiver injuryGut microbiotaLiver diseaseAbstractText Label="Background &Gluconeogenic enzymes Fbp1Modulation of gut microbiotaGut microbiota compositionGut microbiota modulationHuman stool samplesMulti-omics approachGut barrier integrityFusobacterium nucleatumTherapeutic optionsSystemic endotoxemiaRDNA sequencesMouse modelStool samplesAkkermansia muciniphilaMicrobiota compositionMicrobiota modulationBarrier integrityMicrobial species
2025
Lachnospiraceae bacterium alleviates alcohol-associated liver disease by enhancing N-acetyl-glutamic acid levels and inhibiting ferroptosis through the KEAP1-NRF2 pathway
Zhang H, Hu Q, Zhang Y, Yang L, Tian S, Zhang X, Shen H, Shu H, Xie L, Wu D, Zhou L, Wei X, Cheng C, Jiang J, Wang H, Shen C, Kong D, Xu L. Lachnospiraceae bacterium alleviates alcohol-associated liver disease by enhancing N-acetyl-glutamic acid levels and inhibiting ferroptosis through the KEAP1-NRF2 pathway. Gut Microbes 2025, 17: 2517821. PMID: 40511521, PMCID: PMC12169036, DOI: 10.1080/19490976.2025.2517821.Peer-Reviewed Original ResearchConceptsAlcohol-associated liver diseaseGut microbiotaKeap1-Nrf2 pathwayN-acetyl-glutamic acidKeap1-Nrf2Multi-omics analysisLiver diseaseProtective effectLachnospiraceae bacteriumRDNA sequencesHepatocyte cell lineHepatic neutrophil infiltrationMulti-OmicsAlcohol-induced liver damageEtOH-fed miceLachnospiraceaeGut-liverExcessive alcohol consumptionCell linesGutALD patientsEtOH-fedNeutrophil infiltrationMicrobiotaOral supplementationMannosylated neutrophil vesicles targeting macrophages alleviate liver inflammation by delivering CRISPR/Cas9 RNPs
Wu D, Shu H, Zhang M, Wei X, Ji J, Shen H, Zhang H, Xie L, Zhou L, Yang L, Jiang J, Chen C, Tian S, Zhang X, Long X, He X, Wang H. Mannosylated neutrophil vesicles targeting macrophages alleviate liver inflammation by delivering CRISPR/Cas9 RNPs. Theranostics 2025, 15: 6221-6235. PMID: 40521185, PMCID: PMC12159820, DOI: 10.7150/thno.107791.Peer-Reviewed Original Research
2024
Gut microbiota-produced vitamin B6 mitigates alcohol-associated liver disease by attenuating hepatic oxidative stress damage
Shen H, Zhou L, Yang Y, Shu H, Wu D, Yang S, Xie L, Yang L, Tian S, Zhang X, Ma R, Jiang L, Jiang M, Zhang H, Wang Y, Zhang H, Gao S, Xu L, Wang H. Gut microbiota-produced vitamin B6 mitigates alcohol-associated liver disease by attenuating hepatic oxidative stress damage. Hepatology Communications 2024, 9: e0599. PMID: 39670862, PMCID: PMC11637752, DOI: 10.1097/hc9.0000000000000599.Peer-Reviewed Original ResearchConceptsAlcohol-associated liver diseaseVitamin B6 synthesisVitamin B6Amino acid metabolismPlasma levelsAlcohol-associated liver disease pathogenesisAlcohol-associated liver disease progressionGut microbiotaLiver diseasePlasma levels of vitamin B6Pathogenesis of alcohol-associated liver diseasePlasma metabolomic profilesOxidative stress damageDisturbance of gut microbiotaPair-fed miceDisorders of amino acid metabolismIn vivo productionLevels of vitamin B6Acid metabolismGut microbiota disruptionSerum biochemical markersVitamin B6 deficiencyVitamin B6 levelsImbalance of gut microbiotaGut microbiota dysbiosisDietary fiber alleviates alcoholic liver injury via Bacteroides acidifaciens and subsequent ammonia detoxification
Shen H, Zhou L, Zhang H, Yang Y, Jiang L, Wu D, Shu H, Zhang H, Xie L, Zhou K, Cheng C, Yang L, Jiang J, Wang S, Han Y, Zhu J, Xu L, Liu Z, Wang H, Yin S. Dietary fiber alleviates alcoholic liver injury via Bacteroides acidifaciens and subsequent ammonia detoxification. Cell Host & Microbe 2024, 32: 1331-1346.e6. PMID: 38959900, DOI: 10.1016/j.chom.2024.06.008.Peer-Reviewed Original ResearchConceptsB. acidifaciensBile salt hydrolaseOrnithine aminotransferaseAlcohol-related liver diseaseAmmonia detoxificationBacteroides acidifaciensFibroblast growth factor 15Gut microbiotaMicrobiome compositionSynthesis pathwayLiver injuryDownstream targetsHepatocyte expressionLiver diseaseDiet-induced changesAlcohol-induced liver injuryUnconjugated bile acidsFGF15Alcoholic liver injuryBile acidsDietary fiber supplementationTherapeutic optionsTherapeutic strategiesDetoxificationFiber supplementation
2023
Associations of circulating immunomarkers with the efficacy of immunotherapy for primary hepatic carcinoma.
Liu S, Xu W, Shu H, Dai Y, Du Y, Liu Y, Huang L, Sun G. Associations of circulating immunomarkers with the efficacy of immunotherapy for primary hepatic carcinoma. Cancer Med 2023, 12: 21830-21848. PMID: 38054365, DOI: 10.1002/cam4.6754.Peer-Reviewed Original Research
2022
Endostar Synergizes with Radiotherapy to Inhibit Angiogenesis of Cervical Cancer in a Subcutaneous Xenograft Mouse Model.
Xu Z, Zhao X, Shu H, Luo W, Dong Y, Xu L, Zhu H, Zhao Q, Lv Y. Endostar Synergizes with Radiotherapy to Inhibit Angiogenesis of Cervical Cancer in a Subcutaneous Xenograft Mouse Model. Front Biosci (Landmark Ed) 2022, 27: 238. PMID: 36042171, DOI: 10.31083/j.fbl2708238.Peer-Reviewed Original Research
2021
The Efficacy and Safety of Continuous Intravenous Endostar Treatment Combined With Concurrent Chemoradiotherapy in Patients With Locally Advanced Cervical Squamous Cell Carcinoma: A Randomized Controlled Trial.
Shu H, Dong Y, Xu Z, Luo W, Xu L, Zhu H, Cheng L, Lv Y. The Efficacy and Safety of Continuous Intravenous Endostar Treatment Combined With Concurrent Chemoradiotherapy in Patients With Locally Advanced Cervical Squamous Cell Carcinoma: A Randomized Controlled Trial. Front Oncol 2021, 11: 723193. PMID: 34485157, DOI: 10.3389/fonc.2021.723193.Peer-Reviewed Original Research
2020
Nimotuzumab Combined With Irradiation Enhances the Inhibition to the HPV16 E6-Promoted Growth of Cervical Squamous Cell Carcinoma.
Xu Z, Shu H, Zhang F, Luo W, Li Y, Chu J, Zhao Q, Lv Y. Nimotuzumab Combined With Irradiation Enhances the Inhibition to the HPV16 E6-Promoted Growth of Cervical Squamous Cell Carcinoma. Front Oncol 2020, 10: 1327. PMID: 32850421, DOI: 10.3389/fonc.2020.01327.Peer-Reviewed Original Research
2018
Relationship between time elapsed since completion of radiotherapy and quality of life of patients with breast cancer
Zhang J, Shu H, Hu S, Yu Y, Sun Y, Lv Y. Relationship between time elapsed since completion of radiotherapy and quality of life of patients with breast cancer. BMC Cancer 2018, 18: 305. PMID: 29554869, PMCID: PMC5859708, DOI: 10.1186/s12885-018-4207-y.Peer-Reviewed Original ResearchConceptsQuality of lifeBreast cancer-specific questionnaireBreast cancerCompletion of RTPain symptomsCancer-specific questionnaireEORTC QLQ-30Quality of life of patientsBreast symptoms scoreGeneric cancer questionnaireCompletion of radiotherapyYear scoresEnjoyment of sexual activityLife of patientsQLQ-BR23First Affiliated HospitalCancer QuestionnaireRole functionQLQ-30Sexual activityFinancial difficultiesState of healthAffiliated Hospital of Anhui Medical UniversityFirst Affiliated Hospital of Anhui Medical UniversityHospital of Anhui Medical University
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