Francesca Mandino
Associate Research Scientist in Radiology and Biomedical ImagingAbout
Research
Publications
2025
Charting the path in rodent functional neuroimaging
Gozzi A, Stuefer A, Alvino F, Bedin V, Cover C, Kang C, Galbusera A, Gil R, Gini S, de Guzman E, Desrosiers-Grégoire G, Gutierrez-Barragan D, Mandino F, Mariani J, Micotti E, Reimann H, Pagani M, Pepe C, Sastre-Yagüe D, Urosevic M, Valente M, Vertullo R, Canese R, Devor A, Grandjean J, Kahn I, Keiholz S, Lake E, Li N, Shemesh N, Shih Y, Zerbi V, Zhang N. Charting the path in rodent functional neuroimaging. Imaging Neuroscience 2025, 3: imag.a.12. PMID: 40800991, PMCID: PMC12319733, DOI: 10.1162/imag.a.12.Peer-Reviewed Original ResearchSimultaneous WF-Ca2+ and BOLD-fMRI reveals modality-specific and sex-based differences in prodromal Alzheimer’s disease
Mandino F, Shen X, Fredericks C, Strittmatter S, Lake E. Simultaneous WF-Ca2+ and BOLD-fMRI reveals modality-specific and sex-based differences in prodromal Alzheimer’s disease. Proceedings Of The International Society For Magnetic Resonance In Medicine ... Scientific Meeting And Exhibition. 2025 DOI: 10.58530/2025/0828.Peer-Reviewed Original ResearchFunctional magnetic resonance imagingProdromal Alzheimer's diseaseBOLD fMRIAlzheimer's diseaseAD-related cognitive impairmentBlood oxygen levelAD-related changesMonths-of-ageModality-specificNetwork dysfunctionFemale wild-typeCognitive impairmentYoung adulthoodProdromal ADWild-typeCortical connectivityMagnetic resonance imagingNetwork disruptionAD miceSex-specific differencesSex-based differencesResonance imagingAnimal modelsLifetime riskBOLDNeural activity underpins dynamic BOLD signals: findings from simultaneous wide-field fluorescent calcium imaging and fMRI.
Mandino F, Horien C, Shen X, Papademetris X, Keilholz S, Xu N, Lake E. Neural activity underpins dynamic BOLD signals: findings from simultaneous wide-field fluorescent calcium imaging and fMRI. Proceedings Of The International Society For Magnetic Resonance In Medicine ... Scientific Meeting And Exhibition. 2025 DOI: 10.58530/2025/1012.Peer-Reviewed Original ResearchQuasi-periodic patternsBOLD fMRIMeasured whole brain activityBOLD fMRI dataCross-modal agreementWhole-brain activityDynamic activity patternsNeural underpinningsSpatiotemporal structureBOLD signalCalcium imagingFluorescence calcium imagingLow-frequencyBrain activityNeural activityCortical activitySubject levelFMRIActivity patternsBOLDNeural originInter-subject variabilityMultimodal identification of the mouse brain using simultaneous Ca2+ imaging and fMRI
Mandino F, Horien C, Shen X, Desrosiers-Grégoire G, Luo W, Markicevic M, Constable R, Papademetris X, Chakravarty M, Betzel R, Lake E. Multimodal identification of the mouse brain using simultaneous Ca2+ imaging and fMRI. Communications Biology 2025, 8: 665. PMID: 40287579, PMCID: PMC12033268, DOI: 10.1038/s42003-025-08037-4.Peer-Reviewed Original ResearchConceptsBOLD fMRIBOLD fMRI dataConnectome-based identificationCognitive neuroscientistsFMRI literatureHeterogeneous neurological conditionsWhole cortexFMRIMouse brainSimultaneous Ca2+ imagingCa2+ imagingAnimal modelsFluorescence calcium imagingCalcium imagingNeurological conditionsPersonalized treatmentNeuroimagingBOLDCortexNeuroscientistsBrainMiceMultimodal identificationCell-type specific signalsIdentifying dynamic reproducible brain states using a predictive modelling approach
O’Connor D, Horien C, Mandino F, Constable R. Identifying dynamic reproducible brain states using a predictive modelling approach. Imaging Neuroscience 2025, 3: imag_a_00540. PMID: 40800949, PMCID: PMC12319824, DOI: 10.1162/imag_a_00540.Peer-Reviewed Original ResearchMoment-to-moment changesBrain statesConnectome-based predictive modelingContinuous performance taskBrain-based modelsFunctional connectivity analysisModel of traitsFMRI-based functional connectivityDynamic functional connectivity analysisInternal mental processesFunctional connectivity mapsFunctional connectivity modelsLeft-out dataFMRI scanningPersonality traitsFunctional connectivityPerformance tasksConnectivity analysisScanning sessionMental processesModels of behaviorBrain-statesBrainConnectivity mapsTrait-based predictionsPTEN mutations impair CSF dynamics and cortical networks by dysregulating periventricular neural progenitors
DeSpenza T, Kiziltug E, Allington G, Barson D, McGee S, O’Connor D, Robert S, Mekbib K, Nanda P, Greenberg A, Singh A, Duy P, Mandino F, Zhao S, Lynn A, Reeves B, Marlier A, Getz S, Nelson-Williams C, Shimelis H, Walsh L, Zhang J, Wang W, Prina M, OuYang A, Abdulkareem A, Smith H, Shohfi J, Mehta N, Dennis E, Reduron L, Hong J, Butler W, Carter B, Deniz E, Lake E, Constable R, Sahin M, Srivastava S, Winden K, Hoffman E, Carlson M, Gunel M, Lifton R, Alper S, Jin S, Crair M, Moreno-De-Luca A, Luikart B, Kahle K. PTEN mutations impair CSF dynamics and cortical networks by dysregulating periventricular neural progenitors. Nature Neuroscience 2025, 28: 536-557. PMID: 39994410, PMCID: PMC12038823, DOI: 10.1038/s41593-024-01865-3.Peer-Reviewed Original ResearchConceptsNeural progenitor cellsCongenital hydrocephalusCSF dynamicsIncreased CSF productionDe novo mutationsFrequent monogenic causeEverolimus treatmentCSF shuntingNonsurgical treatmentPTEN mutationsAqueductal stenosisInhibitory interneuronsVentriculomegalyProgenitor cellsChoroid plexusMonogenic causeCortical networksIncreased SurvivalBrain ventriclesCortical deficitsNeural progenitorsGene PTENCSF productionNkx2.1PTEN
2024
Aging-dependent loss of functional connectivity in a mouse model of Alzheimer’s disease and reversal by mGluR5 modulator
Mandino F, Shen X, Desrosiers-Grégoire G, O’Connor D, Mukherjee B, Owens A, Qu A, Onofrey J, Papademetris X, Chakravarty M, Strittmatter S, Lake E. Aging-dependent loss of functional connectivity in a mouse model of Alzheimer’s disease and reversal by mGluR5 modulator. Molecular Psychiatry 2024, 30: 1730-1745. PMID: 39424929, PMCID: PMC12015114, DOI: 10.1038/s41380-024-02779-z.Peer-Reviewed Original ResearchFunctional connectivity deficitsConnectivity deficitsFunctional connectivityBrain connectivityAllosteric modulators of mGluR5Alzheimer's diseaseDefault-mode networkModulation of mGluR5Loss of functional connectivityResting-state fMRIApplication of fMRIWild-type controlsAged AD miceMouse model of Alzheimer's diseaseAD-related changesAD miceModel of Alzheimer's diseaseAssociated with synaptic damageMGluR5 modulationMonths of ageFMRI measurementsAmyloid accumulationDecreased connectivityBrain networksSilent allosteric modulatorsRepetitive Mild Closed-Head Injury Induced Synapse Loss and Increased Local BOLD-fMRI Signal Homogeneity
Markicevic M, Mandino F, Toyonaga T, Cai Z, Fesharaki-Zadeh A, Shen X, Strittmatter S, Lake E. Repetitive Mild Closed-Head Injury Induced Synapse Loss and Increased Local BOLD-fMRI Signal Homogeneity. Journal Of Neurotrauma 2024, 41: 2528-2544. PMID: 39096127, PMCID: PMC11698675, DOI: 10.1089/neu.2024.0095.Peer-Reviewed Original ResearchChronic variable stressRegional homogeneityFunctional brain abnormalitiesSynapse densityMild closed-head injuryClosed-head injuryTraumatic brain injuryTreat traumatic brain injuryNeurobiological alterationsMild head injuryVariable stressBrain abnormalitiesPositron emission tomographyMultimodal studiesSynaptic densityMagnetic resonance imagingBrain imagingBrain injuryInduce synapse lossFMRIInjured miceMouse modelEmission tomographyResonance imagingCompensatory mechanismsVentricular-subventricular zone stem cell niche adaptations in a mouse model of post-infectious hydrocephalus
Herman J, Rittenhouse N, Mandino F, Majid M, Wang Y, Mezger A, Kump A, Kadian S, Lake E, Verardi P, Conover J. Ventricular-subventricular zone stem cell niche adaptations in a mouse model of post-infectious hydrocephalus. Frontiers In Neuroscience 2024, 18: 1429829. PMID: 39145299, PMCID: PMC11322059, DOI: 10.3389/fnins.2024.1429829.Peer-Reviewed Original ResearchPost-infectious hydrocephalusVentricular-subventricular zoneInfluenza virusMouse modelMouse-adapted influenza virusIntact ependymaStem cellsPostnatal day 4Stem cell numbersStem cell nicheCell-to-cell transmissionOlfactory bulbMultiorgan hemorrhageLateral ventricleIntracerebroventricular injectionVentriculomegalyEmbryonic dayVentricular systemDay 4Cell nicheNo significant reductionHydrocephalusSignificant reductionVentricleCell numberBiphasic training for awake imaging using a dual-imaging system reveals neurovascular uncoupling and anesthesia effects in healthy mice
Mandino F, Shen X, Desrosiers-Gregoire G, O'Connor D, Mukherjee B, Ha Y, Qu A, Onofrey J, Papademetris X, Chakravarty M, Strittmatter S, Lake E. Biphasic training for awake imaging using a dual-imaging system reveals neurovascular uncoupling and anesthesia effects in healthy mice. Proceedings Of The International Society For Magnetic Resonance In Medicine ... Scientific Meeting And Exhibition. 2024 DOI: 10.58530/2024/0531.Peer-Reviewed Original Research