Eriko Yasumizu, MD, PhD
Associate Research ScientistAbout
Research
Publications
2025
Single-nucleus multiome shows motor neuron glutamate overactivation in amyotrophic lateral sclerosis
Takeuchi E, Yasumizu Y, Morita J, Ishikawa M, Ogawa K, Motooka D, Okuzaki D, Nagata M, Ishihara Y, Miyashita Y, Asano Y, Mori K, Morii E, Beck G, Saito Y, Murayama S, Mochizuki H, Nagano S. Single-nucleus multiome shows motor neuron glutamate overactivation in amyotrophic lateral sclerosis. Brain 2025, awaf426. PMID: 41218062, DOI: 10.1093/brain/awaf426.Peer-Reviewed Original ResearchSpinal motor neuronsAmyotrophic lateral sclerosis pathologyGenome-wide association study dataCell type-specific enrichmentAmyotrophic lateral sclerosisMotor neuronsChromatin accessibility profilesGlutamate signalingVulnerability of motor neuronsMetabotropic glutamate receptorsRegulatory regionsMotor neuron degenerationRNA sequencingMultiomics analysisLateral sclerosisGene expressionAccessibility profilesPotential therapeutic targetGlutamate receptorsNeuronal cellsSpinal cordNeurodegenerative diseasesNeuronal degenerationCellular levelTherapeutic targetAlternative Splicing Alterations in Patients With Amyotrophic Lateral Sclerosis: Link to the Disruption of TAR DNA‐Binding Protein 43 kDa Functions
Miwa T, Takeuchi E, Ogawa K, Abdelhamid R, Morita J, Hiraki Y, Yasumizu Y, Nakamura Y, Ohkura N, Saito Y, Murayama S, Nagai Y, Mochizuki H, Nagano S. Alternative Splicing Alterations in Patients With Amyotrophic Lateral Sclerosis: Link to the Disruption of TAR DNA‐Binding Protein 43 kDa Functions. Neurology And Clinical Neuroscience 2025, 13: 187-194. DOI: 10.1111/ncn3.12880.Peer-Reviewed Original ResearchAlternative splicing alterationsAlternative splicingTDP-43Splicing changesSplicing alterationsAmyotrophic lateral sclerosis pathologyAmyotrophic lateral sclerosisDNA-binding proteinsDysregulation of alternative splicingTAR DNA-binding proteinAberrant alternative splicingTAR DNA-binding protein 43 kDaSH-SY5Y cellsRNA metabolismDNA-binding protein 43 kDaNovel genesSplicing patternsNeurons of patientsRNA sequencingSplicingLateral sclerosisMotor neuronsTreatment of amyotrophic lateral sclerosisPolymerase chain reaction analysisMotor neurons of patients
2022
Myasthenia gravis-specific aberrant neuromuscular gene expression by medullary thymic epithelial cells in thymoma
Yasumizu Y, Ohkura N, Murata H, Kinoshita M, Funaki S, Nojima S, Kido K, Kohara M, Motooka D, Okuzaki D, Suganami S, Takeuchi E, Nakamura Y, Takeshima Y, Arai M, Tada S, Okumura M, Morii E, Shintani Y, Sakaguchi S, Okuno T, Mochizuki H. Myasthenia gravis-specific aberrant neuromuscular gene expression by medullary thymic epithelial cells in thymoma. Nature Communications 2022, 13: 4230. PMID: 35869073, PMCID: PMC9305039, DOI: 10.1038/s41467-022-31951-8.Peer-Reviewed Original ResearchConceptsMedullary thymic epithelial cellsEctopic expressionCellular composition estimationSingle-cell RNA sequencingThymic epithelial cellsSubpopulation of medullary thymic epithelial cellsEpithelial cellsMG-thymomaRNA sequencingGene expressionCell-cell interaction analysisCell migrationComprehensive atlasEctopic germinal center formationInteraction analysisDendritic cell migrationGerminal center formationMyasthenia gravisCellsTranscriptomeCXCL12-CXCR4Cell accumulationT/B cells胸腺腫摘出術後の重症筋無力症増悪に対するエクリズマブの有効性
Takeuchi E, Kajiyama Y, Ando K, Funaki S, Okuno T, Shintani Y, Mochizuki H. 胸腺腫摘出術後の重症筋無力症増悪に対するエクリズマブの有効性. Rinsho Shinkeigaku 2022, 62: cn-001682. PMID: 35354724, DOI: 10.5692/clinicalneurol.cn-001682.Peer-Reviewed Original ResearchConceptsImmunoadsorption plasmapheresisPostoperative exacerbationMyasthenia gravisThymoma-associated myasthenia gravisAnti-complement therapyExacerbation of MGTreated with corticosteroidsImmunosuppressive drugsBulbar symptomsSymptomsThymectomyEculizumabIVIGRemissionThymomaCorticosteroidsPlasmapheresisDysphagiaTherapyGravispiRNA/PIWI Protein Complex as a Potential Biomarker in Sporadic Amyotrophic Lateral Sclerosis
Abdelhamid R, Ogawa K, Beck G, Ikenaka K, Takeuchi E, Yasumizu Y, Jinno J, Kimura Y, Baba K, Nagai Y, Okada Y, Saito Y, Murayama S, Mochizuki H, Nagano S. piRNA/PIWI Protein Complex as a Potential Biomarker in Sporadic Amyotrophic Lateral Sclerosis. Molecular Neurobiology 2022, 59: 1693-1705. PMID: 35015250, PMCID: PMC8882100, DOI: 10.1007/s12035-021-02686-2.Peer-Reviewed Original ResearchConceptsPIWI-interacting RNAsNon-coding RNAsBind to PIWI-interacting RNAsDysregulation of piRNAsControl postmortem brain samplesAmyotrophic lateral sclerosisTDP-43Biogenesis of RNAsAggregation of TAR DNA-binding protein 43RNA-binding proteinsTAR DNA-binding protein 43DNA-binding protein 43Abnormal RNA metabolismNcRNA biogenesisPIWI proteinsPiwi homologsSilencing 1Sporadic ALSRNA metabolismRNA-seqTDP-43 pathologyProtein complexesPIWIL1Sporadic amyotrophic lateral sclerosisPathological hallmark
2021
皮膚所見を欠いた抗nuclear matrix protein(NXP)-2抗体陽性皮膚筋炎の1例
Takeuchi E, Hirozawa D, Okiyama N, Inoue M, Nishino I, Sugai F. 皮膚所見を欠いた抗nuclear matrix protein(NXP)-2抗体陽性皮膚筋炎の1例. Rinsho Shinkeigaku 2021, 61: 258-261. PMID: 33762494, DOI: 10.5692/clinicalneurol.cn-001528.Peer-Reviewed Original ResearchConceptsAnti-nuclear matrix protein 2Intravenous methylprednisolone pulse therapyMyxovirus resistance protein AAnti-NXP-2Marker of DMNo skin rashMethylprednisolone pulse therapyIntravenous immunoglobulin therapyInflammatory muscle diseaseMatrix protein 2Proximal limbLeft biceps muscleProgressive myalgiaOral tacrolimusPulse therapyOral prednisoloneImmunoglobulin therapyBiopsy specimensSkin rashPerifascicular atrophyImmunohistochemical stainingInflammatory changesSkin lesionsDermatological symptomsMuscle disease