Yoshiaki Yasumizu, MD, PhD
Associate Research ScientistCards
About
Research
Publications
Featured Publications
Single-cell transcriptome landscape of circulating CD4+ T cell populations in autoimmune diseases
Yasumizu Y, Takeuchi D, Morimoto R, Takeshima Y, Okuno T, Kinoshita M, Morita T, Kato Y, Wang M, Motooka D, Okuzaki D, Nakamura Y, Mikami N, Arai M, Zhang X, Kumanogoh A, Mochizuki H, Ohkura N, Sakaguchi S. Single-cell transcriptome landscape of circulating CD4+ T cell populations in autoimmune diseases. Cell Genomics 2024, 4: 100473. PMID: 38359792, PMCID: PMC10879034, DOI: 10.1016/j.xgen.2023.100473.Peer-Reviewed Original ResearchMyasthenia gravis-specific aberrant neuromuscular gene expression by medullary thymic epithelial cells in thymoma
Yasumizu Y, Ohkura N, Murata H, Kinoshita M, Funaki S, Nojima S, Kido K, Kohara M, Motooka D, Okuzaki D, Suganami S, Takeuchi E, Nakamura Y, Takeshima Y, Arai M, Tada S, Okumura M, Morii E, Shintani Y, Sakaguchi S, Okuno T, Mochizuki H. Myasthenia gravis-specific aberrant neuromuscular gene expression by medullary thymic epithelial cells in thymoma. Nature Communications 2022, 13: 4230. PMID: 35869073, PMCID: PMC9305039, DOI: 10.1038/s41467-022-31951-8.Peer-Reviewed Original ResearchVIRTUS: a pipeline for comprehensive virus analysis from conventional RNA-seq data
Yasumizu Y, Hara A, Sakaguchi S, Ohkura N. VIRTUS: a pipeline for comprehensive virus analysis from conventional RNA-seq data. Bioinformatics 2020, 37: 1465-1467. PMID: 33017003, PMCID: PMC7745649, DOI: 10.1093/bioinformatics/btaa859.Peer-Reviewed Original ResearchRegulatory T Cell-Specific Epigenomic Region Variants Are a Key Determinant of Susceptibility to Common Autoimmune Diseases
Ohkura N, Yasumizu Y, Kitagawa Y, Tanaka A, Nakamura Y, Motooka D, Nakamura S, Okada Y, Sakaguchi S. Regulatory T Cell-Specific Epigenomic Region Variants Are a Key Determinant of Susceptibility to Common Autoimmune Diseases. Immunity 2020, 52: 1119-1132.e4. PMID: 32362325, DOI: 10.1016/j.immuni.2020.04.006.Peer-Reviewed Original ResearchAutoimmune DiseasesBiomarkersCell DifferentiationComputational BiologyCpG IslandsDNA MethylationEpigenesis, GeneticEpigenomicsGene Expression ProfilingGenetic Predisposition to DiseaseGenetic VariationHumansImmunophenotypingPolymorphism, Single NucleotideT-Lymphocyte SubsetsT-Lymphocytes, RegulatoryTranscriptomeGenome-Wide Natural Selection Signatures Are Linked to Genetic Risk of Modern Phenotypes in the Japanese Population
Yasumizu Y, Sakaue S, Konuma T, Suzuki K, Matsuda K, Murakami Y, Kubo M, Palamara P, Kamatani Y, Okada Y. Genome-Wide Natural Selection Signatures Are Linked to Genetic Risk of Modern Phenotypes in the Japanese Population. Molecular Biology And Evolution 2020, 37: 1306-1316. PMID: 31957793, PMCID: PMC7182208, DOI: 10.1093/molbev/msaa005.Peer-Reviewed Original ResearchSingle-nucleus multiome shows motor neuron glutamate overactivation in amyotrophic lateral sclerosis
Takeuchi E, Yasumizu Y, Morita J, Ishikawa M, Ogawa K, Motooka D, Okuzaki D, Nagata M, Ishihara Y, Miyashita Y, Asano Y, Mori K, Morii E, Beck G, Saito Y, Murayama S, Mochizuki H, Nagano S. Single-nucleus multiome shows motor neuron glutamate overactivation in amyotrophic lateral sclerosis. Brain 2025, 149: 2480-2494. PMID: 41218062, PMCID: PMC13337230, DOI: 10.1093/brain/awaf426.Peer-Reviewed Original Research
2026
Anti-CD20 B cell depletion is associated with elevated mucosal-originating circulating regulatory IgA B cells in multiple sclerosis
Neziraj T, Pössnecker E, Wang A, Saary P, Schumacher A, Ingelfinger F, Mathias A, Galli E, Häfelfinger M, Zuo M, Jones S, Pantazou V, Killestein J, Schädelin S, Benkert P, Granziera C, Pot C, Bischof A, Niess J, Filipowicz Sinnreich M, Derfuss T, Teunissen C, Kuhle J, Hafler D, Du Pasquier R, Yasumizu Y, Gommerman J, Pröbstel A. Anti-CD20 B cell depletion is associated with elevated mucosal-originating circulating regulatory IgA B cells in multiple sclerosis. Science Translational Medicine 2026, 18: eaee1580. PMID: 42485437, DOI: 10.1126/scitranslmed.aee1580.Peer-Reviewed Original ResearchPD-1 antibody-bound progenitor-exhausted CD8+ T cells in lymph nodes boost PD-1-blockade anti-tumor immunity in gastrointestinal cancer
Nose Y, Yasumizu Y, Saito T, Nakamura Y, Jinushi K, Fujikawa K, Momose K, Yamashita K, Tanaka K, Yamamoto K, Makino T, Takahashi T, Ueyama A, Kurokawa Y, Sato E, Ohkura N, Sakaguchi S, Wada H, Eguchi H, Doki Y. PD-1 antibody-bound progenitor-exhausted CD8+ T cells in lymph nodes boost PD-1-blockade anti-tumor immunity in gastrointestinal cancer. Nature Communications 2026, 17: 4969. PMID: 41951588, PMCID: PMC13237225, DOI: 10.1038/s41467-026-70751-2.Peer-Reviewed Original ResearchEBV grants B cells a license for immortality in the CNS.
Yasumizu Y. EBV grants B cells a license for immortality in the CNS. Science Immunology 2026, 11: eaeg7147. PMID: 41790932, DOI: 10.1126/sciimmunol.aeg7147.Peer-Reviewed Original Research
2025
Pathogenesis of thymoma-associated myasthenia gravis: a narrative review
Okuno T, Koizumi N, Yasumizu Y. Pathogenesis of thymoma-associated myasthenia gravis: a narrative review. Mediastinum 2025, 9: 26-26. PMID: 41098393, PMCID: PMC12518592, DOI: 10.21037/med-25-28.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statements