Claudia Espinosa-Garcia
she/her/hers
Associate Research ScientistCards
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Featured Publications
Native-state proteomics of Parvalbumin interneurons identifies novel molecular signatures and metabolic vulnerabilities to early Alzheimer's disease pathology.
Kumar P, Goettemoeller AM, Espinosa-Garcia C, Tobin BR, Tfaily A, Nelson RS, Natu A, Dammer EB, Santiago JV, Malepati S, Cheng L, Xiao H, Duong D, Seyfried NT, Wood LB, Rowan MJ, Rangaraju S. Native-state proteomics of Parvalbumin interneurons identifies novel molecular signatures and metabolic vulnerabilities to early Alzheimer's disease pathology. BioRxiv 2023 PMID: 37292756, DOI: 10.1101/2023.05.17.541038.Peer-Reviewed Original ResearchStress primes microglial polarization after global ischemia: Therapeutic potential of progesterone
Espinosa-Garcia C, Sayeed I, Yousuf S, Atif F, Sergeeva E, Neigh G, Stein D. Stress primes microglial polarization after global ischemia: Therapeutic potential of progesterone. Brain Behavior And Immunity 2017, 66: 177-192. PMID: 28648389, DOI: 10.1016/j.bbi.2017.06.012.Peer-Reviewed Original ResearchConceptsAnti-inflammatory cytokinesGlobal ischemiaDays of social defeat stressIncreased pro-inflammatory cytokine expressionPost-ischemiaIntraperitoneal injections of progesteroneNeuroprotective effects of progesteroneMale Sprague-Dawley ratsIschemic strokeAssociated with increased riskMicroglial polarizationSocial defeat stressCA1 hippocampal regionEffects of progesteroneAssociated with increased risk of strokePro-inflammatory cytokine expressionSprague-Dawley ratsNeurotrophic factor expressionInjection of progesteroneAnti-inflammatory mediatorsPro-inflammatory cytokinesExacerbate neuronal lossRisk of strokeM2 phenotype markersPotential therapeutic strategyImpact of Stress on Epilepsy: Focus on Neuroinflammation—A Mini Review
Espinosa-Garcia C, Zeleke H, Rojas A. Impact of Stress on Epilepsy: Focus on Neuroinflammation—A Mini Review. International Journal Of Molecular Sciences 2021, 22: 4061. PMID: 33920037, PMCID: PMC8071059, DOI: 10.3390/ijms22084061.Peer-Reviewed Original ResearchConceptsImpact of stressChronic stressPsychiatric comorbidityPsychiatric comorbiditiesStressor durationDepressive stateAcute stressPoor quality of lifeBrain damageSeizure occurrencePreclinical researchSeizure triggersOutcome severityDisordersEpilepsy outcomeEpilepsy patientsRecurrent seizuresEpilepsyNeurological disordersQuality of lifeSeizuresDeleterious impactDepressionComorbidity
2025
Progesterone restores blood-brain barrier and memory after chronic cerebral hypoperfusion in male rats
Espadín M, Cervantes M, Coyoy-Salgado A, Espinosa-Garcia C, Gómez-González B, Moralí G. Progesterone restores blood-brain barrier and memory after chronic cerebral hypoperfusion in male rats. Brain Behavior And Immunity Integrative 2025, 11: 100132. DOI: 10.1016/j.bbii.2025.100132.Peer-Reviewed Original ResearchChronic cerebral hypoperfusionBlood-brain barrierTight junction proteinsSpatial learningMale ratsJunction proteinsCerebral hypoperfusionSprague-Dawley ratsBlood-brain barrier dysfunctionEffects of P4Inflammatory factor levelsAge-related alterationsBrain injury modelInjury modelInflammation factorsRatsHypoperfusionNeuroprotective effectsFactor levelsIntroduction AgingProgesteroneMemoryAlterationsBrainDaysDirect quantification of cell type-specific proteins using Luminex assays with TurboID-labeled cells and tissues
Bitarafan S, Tobin B, Espinosa-Garcia C, Rangaraju S, Wood L. Direct quantification of cell type-specific proteins using Luminex assays with TurboID-labeled cells and tissues. Methods In Cell Biology 2025, 200: 89-103. PMID: 41276355, DOI: 10.1016/bs.mcb.2025.03.001.Peer-Reviewed Original ResearchCell type-specific proteinsBiotinylation of proteinsCell type-specificType-specific proteinsCell type contributionsCell culturesEfficient biotinylationTagged proteinsLabeling proteomicsPhospho-proteinsProteome labelingCellular functionsMulti-cellular systemsProteomic investigationsType-specificProteinIn vivo settingMouse linesCellsViral constructsTransgenic mouse linesTurboIDProteomicsImmunoassay platformImmunoprecipitationDisease modification upon 2 weeks of tofacitinib treatment in a mouse model of chronic epilepsy
Hoffman O, Koehler J, Espina J, Patterson A, Gohar E, Coleman E, Schoenike B, Espinosa-Garcia C, Paredes F, Varvel N, Dingledine R, Maguire J, Roopra A. Disease modification upon 2 weeks of tofacitinib treatment in a mouse model of chronic epilepsy. Science Translational Medicine 2025, 17: eadt0527. PMID: 40106581, DOI: 10.1126/scitranslmed.adt0527.Peer-Reviewed Original ResearchConceptsTranscriptome dataJanus kinase/signal transducer and activatorKinase/signal transducer and activatorReverse cognitive deficitsJAK/STAT activationJAK/STAT3 signalingChronic epilepsyModel of temporal lobe epilepsySpontaneous seizuresMouse models of chronic epilepsyMouse modelCognitive deficitsSpatial memoryTransient inductionTemporal lobe epilepsyMouse model of temporal lobe epilepsyModel of chronic epilepsyLobectomy samplesDisease modificationTreat symptomsLobe epilepsyWhole tissueDrug treatmentEpileptogenic insultTofacitinib treatment
2024
Neuroinflammatory Stress Exerts Distinct Proteomic Effects on Soma, Synapses and Mitochondria in Excitatory Neurons
Espinosa‐Garcia C, Srivastava U, Kumar P, Tobin B, Xiao H, Cheng L, Bagchi P, Duong D, Seyfried N, Faundez V, Wood L, Rangaraju S. Neuroinflammatory Stress Exerts Distinct Proteomic Effects on Soma, Synapses and Mitochondria in Excitatory Neurons. Alzheimer's & Dementia 2024, 20: e090723. PMCID: PMC11710382, DOI: 10.1002/alz.090723.Peer-Reviewed Original ResearchProteomic effectsLabel-free quantitative mass spectrometryCytoskeleton-related proteinsAlzheimer's disease pathogenesisProteome in vivoIncreased aerobic respirationCellular signaling pathwaysQuantitative mass spectrometryDisease pathogenesisCytoskeleton organizationSubcellular compartmentsOxidoreductase activitySynaptic vesiclesProteomic approachAerobic respirationBiological pathwaysNeuroinflammatory stressSignaling pathwaySynapse-related proteinsMAPK signalingMetabolic processesDifferential centrifugationMitochondriaSomatodendritic compartmentRegulating activityKv1.3 regulation of brain immune function in vitro and in vivo
Bowen C, Nguyen H, Lin Y, Bagchi P, Natu A, Xiao H, Espinosa‐Garcia C, Kumar P, Wulff H, Seyfried N, Rangaraju S. Kv1.3 regulation of brain immune function in vitro and in vivo. Alzheimer's & Dementia 2024, 20: e093042. PMCID: PMC11709668, DOI: 10.1002/alz.093042.Peer-Reviewed Original ResearchProtein processingN-terminusProximity-based proteomicsProtein-protein interactomePDZ-binding motifPDZ-binding domainPlasma membrane proteinsDeletion in vivoJurkat T cellsT cellsKO miceBiotin ligaseCMV-Cre miceRNA-seqTrafficking proteinsBiotinylated proteinsTranscriptome levelC-terminusMembrane proteinsInteractorsMicroglial signatureImmune signalingPlasma membraneLPS stimulationDifferential expressionATR-FTIR spectroscopy to evaluate serum protein expression in a murine cerebral ischemia model
Montes-Narváez O, García-Juárez M, Beltrán-Pérez G, Espinosa-García C, González-Flores O, Delgado-Macuil R. ATR-FTIR spectroscopy to evaluate serum protein expression in a murine cerebral ischemia model. Spectrochimica Acta Part A Molecular And Biomolecular Spectroscopy 2024, 326: 125261. PMID: 39395276, DOI: 10.1016/j.saa.2024.125261.Peer-Reviewed Original ResearchEditorial: Immune system mechanisms impacting the onset of epilepsy and spontaneous seizures
Espinosa-Garcia C, Bahramnejad E, Li Y. Editorial: Immune system mechanisms impacting the onset of epilepsy and spontaneous seizures. Frontiers In Molecular Neuroscience 2024, 17: 1487871. PMID: 39318421, PMCID: PMC11420127, DOI: 10.3389/fnmol.2024.1487871.Peer-Reviewed Original Research
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Yale University
300 George St, 8th floor
New Haven , CT 06511
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300 George Street, Fl 8th, Rm 8201
New Haven, CT 06511