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Chronic viral infection alters PD-1 locus subnuclear localization in cytotoxic CD8+ T cells
Sacristán C, Youngblood B, Lu P, Bally A, Xu J, McGary K, Hewitt S, Boss J, Skok J, Ahmed R, Dustin M. Chronic viral infection alters PD-1 locus subnuclear localization in cytotoxic CD8+ T cells. Cell Reports 2024, 43: 114547. PMID: 39083377, PMCID: PMC11522508, DOI: 10.1016/j.celrep.2024.114547.Peer-Reviewed Original ResearchProgrammed death ligand-1 expression on donor T cells drives graft-versus-host disease lethality
Saha A, O’Connor R, Thangavelu G, Lovitch S, Dandamudi D, Wilson C, Vincent B, Tkachev V, Pawlicki J, Furlan S, Kean L, Aoyama K, Taylor P, Panoskaltsis-Mortari A, Foncea R, Ranganathan P, Devine S, Burrill J, Guo L, Sacristan C, Snyder N, Blair I, Milone M, Dustin M, Riley J, Bernlohr D, Murphy W, Fife B, Munn D, Miller J, Serody J, Freeman G, Sharpe A, Turka L, Blazar B. Programmed death ligand-1 expression on donor T cells drives graft-versus-host disease lethality. Journal Of Clinical Investigation 2016, 126: 2642-2660. PMID: 27294527, PMCID: PMC4922691, DOI: 10.1172/jci85796.Peer-Reviewed Original ResearchAnimalsApoptosisB7-H1 AntigenBone Marrow CellsBone Marrow TransplantationCytokinesFemaleGlucoseGlutamineGlycolysisGraft vs Host DiseaseHumansInflammationLeukocytes, MononuclearMiceMice, Inbred BALB CMice, Inbred C57BLOxygenPhosphorylationProgrammed Cell Death 1 ReceptorSignal TransductionT-LymphocytesTreatment OutcomeSurface expression of the hRSV nucleoprotein impairs immunological synapse formation with T cells
Céspedes P, Bueno S, Ramírez B, Gomez R, Riquelme S, Palavecino C, Mackern-Oberti J, Mora J, Depoil D, Sacristán C, Cammer M, Creneguy A, Nguyen T, Riedel C, Dustin M, Kalergis A. Surface expression of the hRSV nucleoprotein impairs immunological synapse formation with T cells. Proceedings Of The National Academy Of Sciences Of The United States Of America 2014, 111: e3214-e3223. PMID: 25056968, PMCID: PMC4128097, DOI: 10.1073/pnas.1400760111.Peer-Reviewed Original ResearchAnimalsBrefeldin ACD4-Positive T-LymphocytesCell CommunicationCell LineCell MembraneDendritic CellsGolgi ApparatusHistocompatibility AntigensHumansImmunological SynapsesLipid BilayersLymphocyte ActivationMiceMice, Inbred C57BLNucleoproteinsPeptidesProtein TransportReceptors, Antigen, T-CellRespiratory Syncytial Virus InfectionsRespiratory Syncytial Virus, HumanSignal TransductionViral ProteinsVirus ReplicationMechanism of Bruton's Tyrosine Kinase-mediated Recruitment and Regulation of TFII-I*
Sacristán C, Tussié-Luna M, Logan S, Roy A. Mechanism of Bruton's Tyrosine Kinase-mediated Recruitment and Regulation of TFII-I*. Journal Of Biological Chemistry 2003, 279: 7147-7158. PMID: 14623887, DOI: 10.1074/jbc.m303724200.Peer-Reviewed Original ResearchAgammaglobulinaemia Tyrosine KinaseAmino Acid MotifsAmino AcidsAnimalsB-LymphocytesBlotting, WesternCell NucleusCOS CellsCytoplasmDimerizationFibroblastsGene Expression Regulation, EnzymologicGenes, ReporterGlutathione TransferaseLeucineLuciferasesMiceMicroscopy, FluorescenceMutationPhosphorylationPlasmidsPrecipitin TestsProtein BindingProtein IsoformsProtein Structure, TertiaryProtein-Tyrosine KinasesSignal TransductionTranscription Factors, TFIITransfectionTyrosineCharacterization of a novel interaction between transcription factor TFII‐I and the inducible tyrosine kinase in T cells
Sacristán C, Schattgen S, Berg L, Bunnell S, Roy A, Rosenstein Y. Characterization of a novel interaction between transcription factor TFII‐I and the inducible tyrosine kinase in T cells. European Journal Of Immunology 2009, 39: 2584-2595. PMID: 19701889, PMCID: PMC3014647, DOI: 10.1002/eji.200839031.Peer-Reviewed Original ResearchIn vivo assessment of hemocompatibility of a ventricular assist device in healthy swine.
Sacristán C, Escobedo C, Bojalil R, Izaguirre R, Cortina E, Aranda A, Catrip J, Lesprón M, Springall R, Sacristán E. In vivo assessment of hemocompatibility of a ventricular assist device in healthy swine. Archivos De Cardiología De México 2010, 80: 67-76. PMID: 21147568.Peer-Reviewed Original ResearchFunctional Anatomy of T Cell Activation and Synapse Formation
Fooksman D, Vardhana S, Vasiliver-Shamis G, Liese J, Blair D, Waite J, Sacristán C, Victora G, Zanin-Zhorov A, Dustin M. Functional Anatomy of T Cell Activation and Synapse Formation. Annual Review Of Immunology 2010, 28: 79-105. PMID: 19968559, PMCID: PMC2885351, DOI: 10.1146/annurev-immunol-030409-101308.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsPD-1 promotes immune exhaustion by inducing antiviral T cell motility paralysis
Zinselmeyer B, Heydari S, Sacristán C, Nayak D, Cammer M, Herz J, Cheng X, Davis S, Dustin M, McGavern D. PD-1 promotes immune exhaustion by inducing antiviral T cell motility paralysis. Journal Of Experimental Medicine 2013, 210: 757-774. PMID: 23530125, PMCID: PMC3620347, DOI: 10.1084/jem.20121416.Peer-Reviewed Original ResearchImmunology on chip: Promises and opportunities
Baratchi S, Khoshmanesh K, Sacristán C, Depoil D, Wlodkowic D, McIntyre P, Mitchell A. Immunology on chip: Promises and opportunities. Biotechnology Advances 2013, 32: 333-346. PMID: 24275489, DOI: 10.1016/j.biotechadv.2013.11.008.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsIn situ analysis of B7-2 costimulatory, major histocompatibility complex class II, and adhesion molecule expression in schistosomal egg granulomas.
Rathore A, Sacristán C, Ricklan DE, Flores Villanueva PO, Stadecker MJ. In situ analysis of B7-2 costimulatory, major histocompatibility complex class II, and adhesion molecule expression in schistosomal egg granulomas. Am J Pathol 1996, 149: 187-94. PMID: 8686742.Peer-Reviewed Original Research
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