Chang Su
About
Research
Publications
2026
Validity of PEN-FAST as a clinical decision tool in pregnant patients
You L, Belmont A, Liao J, Su C, Trubiano J, Son M, Burn M, Kwah J. Validity of PEN-FAST as a clinical decision tool in pregnant patients. Journal Of Allergy And Clinical Immunology Global 2026, 5: 100671. PMID: 41852857, PMCID: PMC12993893, DOI: 10.1016/j.jacig.2026.100671.Peer-Reviewed Original ResearchPregnant patientsPenicillin allergyOral challengeGestational ageSkin testLow riskPredictive valueNegative predicative valueNegative predictive valuePenicillin allergy testingAssociated with adverse patient outcomesSevere adverse eventsNegative likelihood ratioArea under the curvePositive predictive valueClinical decision toolClinical decision-making toolImmunology clinicRisk stratificationAdverse eventsAllergy evaluationAllergy testingAdverse patient outcomesPatientsPatient outcomes
2025
Evaluating Penicillin Allergy Clinical Decision-Making Tools to Enhance Penicillin Allergy De-labeling
Su C, Belmont A, Kuster J, Liao J, Kwah J. Evaluating Penicillin Allergy Clinical Decision-Making Tools to Enhance Penicillin Allergy De-labeling. The Journal Of Allergy And Clinical Immunology 2025, 155: ab5. DOI: 10.1016/j.jaci.2024.12.021.Peer-Reviewed Original Research
2024
Improving cefazolin administration for surgical prophylaxis in reported penicillin allergy: A retrospective study of a health system intervention
Belmont A, Son M, Hyman J, You L, Su C, Kashyap N, Topal J, McManus D, Martinello R, Kwah J. Improving cefazolin administration for surgical prophylaxis in reported penicillin allergy: A retrospective study of a health system intervention. Journal Of Allergy And Clinical Immunology Global 2024, 4: 100377. PMID: 39830990, PMCID: PMC11742594, DOI: 10.1016/j.jacig.2024.100377.Peer-Reviewed Original ResearchPenicillin allergy labelHospital-wide guidelinesSurgical site infectionAllergy labelsSurgical patientsSevere allergic reactionsSurgical prophylaxisSite infectionAssociated with increased rates of surgical site infectionRate of surgical site infectionMulti-drug resistant infectionsAllergic reactionsPrevent surgical site infectionsFirst-line antibioticsFirst-line prophylaxisAdministration of cefazolinAssociated with increased ratesRetrospective cohort studyGuideline-directed therapyAdult surgical patientsPre-intervention groupPost-intervention groupPenicillin allergyPerioperative outcomesCefazolin administrationSingle-cell transcriptomic and proteomic analysis of Parkinson’s disease brains
Zhu B, Park J, Coffey S, Russo A, Hsu I, Wang J, Su C, Chang R, Lam T, Gopal P, Ginsberg S, Zhao H, Hafler D, Chandra S, Zhang L. Single-cell transcriptomic and proteomic analysis of Parkinson’s disease brains. Science Translational Medicine 2024, 16: eabo1997. PMID: 39475571, PMCID: PMC12372474, DOI: 10.1126/scitranslmed.abo1997.Peer-Reviewed Original ResearchConceptsProteomic analysisAlzheimer's diseasePrefrontal cortexBrain cell typesGenetics of PDParkinson's diseaseCell-cell interactionsChaperone expressionSingle-nucleus transcriptomesExpressed genesTranscriptional changesPostmortem human brainPostmortem brain tissueDiseased brainSynaptic proteinsSingle-cellDown-regulationBrain cell populationsBrain regionsCell typesNeurodegenerative disordersLate-stage PDParkinson's disease brainsDisease etiologyNeuronal vulnerabilityStatistical Inference of Cell-Type Proportions Estimated from Bulk Expression Data
Cai B, Zhang J, Li H, Su C, Zhao H. Statistical Inference of Cell-Type Proportions Estimated from Bulk Expression Data. Journal Of The American Statistical Association 2024, 119: 2521-2532. PMID: 40241938, PMCID: PMC12002418, DOI: 10.1080/01621459.2024.2382435.Peer-Reviewed Original ResearchCell-type proportionsEstimates cell-type proportionsGene expression dataCell type-specific analysisCell type-specificPost-mortem brain samplesGTEx projectExpression dataDownstream analysisGene expressionAlzheimer's disease patientsCell typesSubject-specific covariatesAccurate identificationBrain samplesStatistical inferenceSampling distributionSimulation studySupplementary materialsROSMAPGTExTranscriptionGenesEstimated proportionAlzheimerValidating PEN-FAST in Reported Penicillin Allergies in Pregnancy to Enhance De-Labeling
You L, Liao J, Su C, Burn M, Son M, Kwah J. Validating PEN-FAST in Reported Penicillin Allergies in Pregnancy to Enhance De-Labeling. The Journal Of Allergy And Clinical Immunology 2024, 153: ab155. DOI: 10.1016/j.jaci.2023.11.510.Peer-Reviewed Original ResearchEstimating Cell-Type-Specific Gene Co-Expression Networks from Bulk Gene Expression Data with an Application to Alzheimer’s Disease
Su C, Zhang J, Zhao H. Estimating Cell-Type-Specific Gene Co-Expression Networks from Bulk Gene Expression Data with an Application to Alzheimer’s Disease. Journal Of The American Statistical Association 2024, 119: 811-824. PMID: 39280354, PMCID: PMC11394578, DOI: 10.1080/01621459.2023.2297467.Peer-Reviewed Original Research
2023
Evaluating the PEN-FAST Clinical Decision-making Tool to Enhance Penicillin Allergy Delabeling
Su C, Belmont A, Liao J, Kuster J, Trubiano J, Kwah J. Evaluating the PEN-FAST Clinical Decision-making Tool to Enhance Penicillin Allergy Delabeling. JAMA Internal Medicine 2023, 183: 883-885. PMID: 37338869, PMCID: PMC10282954, DOI: 10.1001/jamainternmed.2023.1572.Peer-Reviewed Original ResearchCephalosporins can be safely administered to patients with verified penicillin allergy
Belmont A, Su C, Kwah J. Cephalosporins can be safely administered to patients with verified penicillin allergy. The Journal Of Allergy And Clinical Immunology In Practice 2023, 11: 2933-2935.e2. PMID: 37245737, DOI: 10.1016/j.jaip.2023.05.027.Peer-Reviewed Original Research
2020
Erythema nodosum due to Mycobacterium abscessus infection complicating autologous fat transfer
Su C, Cowper SE, Ramachandran S, Little AJ. Erythema nodosum due to Mycobacterium abscessus infection complicating autologous fat transfer. International Journal Of Women's Dermatology 2020, 6: 340-341. PMID: 33015302, PMCID: PMC7522915, DOI: 10.1016/j.ijwd.2020.05.011.Peer-Reviewed Case Reports and Technical Notes
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